{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:10:23Z","timestamp":1787047823439,"version":"build-2736575974"},"reference-count":83,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Celiac disease (CD) is an intestinal disease that develops in genetically predisposed individuals and is triggered by the ingestion of gluten. CD was considered a Th1-disease. Today, the role of Th17, IL-21, and IL-17A lymphocytes is well known. Inflammation is regulated by the activity of gluten-specific CD4+ T lymphocytes that produce pro-inflammatory cytokines, including IFN-\u03b3, TNF-\u03b1, and IL-21, perpetuating the Th1 response. These cytokines determine an inflammatory state of the small intestine, with consequent epithelial infiltration of lymphocytes and an alteration of the architecture of the duodenal mucosa. B cells produce antibodies against tissue transglutaminase and against deamidated gliadin. Although the role of the adaptive immune response is currently known, the evidence about the role of innate immunity cells is still poorly understood. Epithelial damage determines the release of damage-associated molecular patterns (DAMPs), also known as alarmins. Together with the intestinal epithelial cells and the type 1 innate lymphoid cells (ILC1s), alarmins like TSLP, IL-33, and HMGB1 could have a fundamental role in the genesis and maintenance of inflammation. Our study aims to evaluate the evidence in the literature about the role of ILCs and alarmins in celiac disease, evaluating the possible future diagnostic and therapeutic implications.<\/jats:p>","DOI":"10.3390\/cells12141910","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T01:08:11Z","timestamp":1690160891000},"page":"1910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Emerging Role of Innate Lymphoid Cells (ILCs) and Alarmins in Celiac Disease: An Update on Pathophysiological Insights, Potential Use as Disease Biomarkers, and Therapeutic Implications"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6795-746X","authenticated-orcid":false,"given":"Angela","family":"Rizzi","sequence":"first","affiliation":[{"name":"UOSD Allergologia e Immunologia Clinica, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-5886","authenticated-orcid":false,"given":"Mario","family":"Di Gioacchino","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunotherapy and Advanced Biological Treatments, 65100 Pescara, Italy"},{"name":"Center for Advanced Studies and Technology, G. d\u2019Annunzio University, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-0103","authenticated-orcid":false,"given":"Luca","family":"Gammeri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-9966","authenticated-orcid":false,"given":"Riccardo","family":"Inchingolo","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine Unit, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Chini","sequence":"additional","affiliation":[{"name":"UOSD Allergologia e Immunologia Clinica, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Santilli","sequence":"additional","affiliation":[{"name":"Center for Advanced Studies and Technology, G. d\u2019Annunzio University, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Nucera","sequence":"additional","affiliation":[{"name":"UOSD Allergologia e Immunologia Clinica, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Gangemi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo Definitions for Coeliac Disease and Related Terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Aboulaghras, S., Piancatelli, D., Taghzouti, K., Balahbib, A., Alshahrani, M.M., Al Awadh, A.A., Goh, K.W., Ming, L.C., Bouyahya, A., and Oumhani, K. (2023). Meta-Analysis and Systematic Review of HLA DQ2\/DQ8 in Adults with Celiac Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021188"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.998","article-title":"Dense Genotyping Identifies and Localizes Multiple Common and Rare Variant Association Signals in Celiac Disease","volume":"43","author":"Trynka","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ng.102","article-title":"Newly Identified Genetic Risk Variants for Celiac Disease Related to the Immune Response","volume":"40","author":"Hunt","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jcmgh.2020.12.002","article-title":"Innate Lymphoid Cells and Celiac Disease: Current Perspective","volume":"11","author":"Yu","year":"2021","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1001\/jamapediatrics.2013.3858","article-title":"Celiac Disease: A Review","volume":"168","author":"Guandalini","year":"2014","journal-title":"JAMA Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate Lymphoid Cells: 10 Years On","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ochel, A., Tiegs, G., and Neumann, K. (2019). Type 2 Innate Lymphoid Cells in Liver and Gut: From Current Knowledge to Future Perspectives. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081896"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41385-020-0265-y","article-title":"The Role of Innate Lymphoid Cells in Response to Microbes at Mucosal Surfaces","volume":"13","author":"Seo","year":"2020","journal-title":"Mucosal. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","article-title":"DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation","volume":"15","author":"Zindel","year":"2020","journal-title":"Annu Rev. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/imr.12577","article-title":"Alarmins and Immunity","volume":"280","author":"Yang","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.clinthera.2016.03.021","article-title":"Alarmins and Antitumor Immunity","volume":"38","author":"Nie","year":"2016","journal-title":"Clin. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"103142","DOI":"10.1016\/j.autrev.2022.103142","article-title":"Alarmins in Autoimmune Diseases","volume":"21","author":"Danieli","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Rizzi, A., Lo Presti, E., Chini, R., Gammeri, L., Inchingolo, R., Lohmeyer, F.M., Nucera, E., and Gangemi, S. (2023). Emerging Role of Alarmins in Food Allergy: An Update on Pathophysiological Insights, Potential Use as Disease Biomarkers, and Therapeutic Implications. J. Clin. Med., 12.","DOI":"10.3390\/jcm12072699"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/1756283X11410770","article-title":"Novel Cytokine Signaling Pathways in Inflammatory Bowel Disease: Insight into the Dichotomous Functions of IL-33 during Chronic Intestinal Inflammation","volume":"4","author":"Pastorelli","year":"2011","journal-title":"Therap. Adv. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Stricker, S., M\u00fcller, M., Zimmer, K.-P., and Jacob, R. (2023). Altered Posttranslational Modification of Microtubules Contributes to Disturbed Enterocyte Morphology in Celiac Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032635"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Porpora, M., Conte, M., Lania, G., Bellomo, C., Rapacciuolo, L., Chirdo, F.G., Auricchio, R., Troncone, R., Auricchio, S., and Barone, M.V. (2022). Inflammation Is Present, Persistent and More Sensitive to Proinflammatory Triggers in Celiac Disease Enterocytes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23041973"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bracken, S., Byrne, G., Kelly, J., Jackson, J., and Feighery, C. (2008). Altered Gene Expression in Highly Purified Enterocytes from Patients with Active Coeliac Disease. BMC Genomics, 9.","DOI":"10.1186\/1471-2164-9-377"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/S0016-5085(96)70036-7","article-title":"Intestinal Epithelial Cells Both Express and Respond to Interleukin 15","volume":"111","author":"Reinecker","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"20518","DOI":"10.3390\/ijms151120518","article-title":"Gliadin Peptides as Triggers of the Proliferative and Stress\/Innate Immune Response of the Celiac Small Intestinal Mucosa","volume":"15","author":"Barone","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/gut.2005.068684","article-title":"Epithelium Derived Interleukin 15 Regulates Intraepithelial Lymphocyte Th1 Cytokine Production, Cytotoxicity, and Survival in Coeliac Disease","volume":"55","author":"Ciccocioppo","year":"2006","journal-title":"Gut"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0016-5085(98)70022-8","article-title":"Interleukin 15 Is a Potent Stimulant of Intraepithelial Lymphocytes","volume":"115","author":"Ebert","year":"1998","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Nanayakkara, M., Lania, G., Maglio, M., Kosova, R., Sarno, M., Gaito, A., Discepolo, V., Troncone, R., Auricchio, S., and Auricchio, R. (2013). Enterocyte Proliferation and Signaling Are Constitutively Altered in Celiac Disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076006"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"789788","DOI":"10.3389\/fimmu.2021.789788","article-title":"Innate Lymphoid Cells in Autoimmune Diseases","volume":"12","author":"Clottu","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature14189","article-title":"The Biology of Innate Lymphoid Cells","volume":"517","author":"Artis","year":"2015","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.3389\/fimmu.2017.01296","article-title":"Innate Lymphoid Cells in Intestinal Inflammation","volume":"8","author":"Geremia","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Marafini, I., Monteleone, I., Di Fusco, D., Cupi, M.L., Paoluzi, O.A., Colantoni, A., Ortenzi, A., Izzo, R., Vita, S., and De Luca, E. (2015). TNF-\u03b1 Producing Innate Lymphoid Cells (ILCs) Are Increased in Active Celiac Disease and Contribute to Promote Intestinal Atrophy in Mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126291"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/cei.13414","article-title":"Phenotypic Shift of Small Intestinal Intra-Epithelial Type 1 Innate Lymphoid Cells in Celiac Disease Is Associated with Enhanced Cytotoxic Potential","volume":"200","author":"Uhde","year":"2020","journal-title":"Clin. Exp. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"110956","DOI":"10.1016\/j.celrep.2022.110956","article-title":"Gliadin-Reactive Vitamin D-Sensitive Proinflammatory ILCPs Are Enriched in Celiac Patients","volume":"39","author":"Ercolano","year":"2022","journal-title":"Cell Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s10620-010-1363-6","article-title":"Immune Phenotype of Children with Newly Diagnosed and Gluten-Free Diet-Treated Celiac Disease","volume":"56","author":"Cseh","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.clim.2007.09.005","article-title":"Decreased Circulating INKT Cell Numbers in Refractory Coeliac Disease","volume":"126","author":"Bernardo","year":"2008","journal-title":"Clin. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Perez, F., Ruera, C.N., Miculan, E., Carasi, P., and Chirdo, F.G. (2021). Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147426"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1749-6632.2009.05128.x","article-title":"Thymic Stromal Lymphopoietin","volume":"1183","author":"He","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2332\/allergolint.11-RAI-0395","article-title":"TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms","volume":"61","author":"Takai","year":"2012","journal-title":"Allergol. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/ni1192","article-title":"Intestinal Immune Homeostasis Is Regulated by the Crosstalk between Epithelial Cells and Dendritic Cells","volume":"6","author":"Rimoldi","year":"2005","journal-title":"Nat. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1172\/JCI39134","article-title":"Dendritic Cells in Intestinal Homeostasis and Disease","volume":"119","author":"Rescigno","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.autrev.2016.09.014","article-title":"Insight into the Role of TSLP in Inflammatory Bowel Diseases","volume":"16","author":"Park","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Cayrol, C. (2021). IL-33, an Alarmin of the IL-1 Family Involved in Allergic and Non Allergic Inflammation: Focus on the Mechanisms of Regulation of Its Activity. Cells, 11.","DOI":"10.3390\/cells11010107"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/ni.3370","article-title":"Interleukin 33 Is a Guardian of Barriers and a Local Alarmin","volume":"17","author":"Martin","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/imr.12619","article-title":"Interleukin-33 (IL-33): A Nuclear Cytokine from the IL-1 Family","volume":"281","author":"Cayrol","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nri.2016.95","article-title":"Interleukin-33 in Health and Disease","volume":"16","author":"Liew","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s10020-021-00307-1","article-title":"Redox Modifications of Cysteine Residues Regulate the Cytokine Activity of HMGB1","volume":"27","author":"Yang","year":"2021","journal-title":"Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Taverna, S., Tonacci, A., Ferraro, M., Cammarata, G., Cuttitta, G., Bucchieri, S., Pace, E., and Gangemi, S. (2022). High Mobility Group Box 1: Biological Functions and Relevance in Oxidative Stress Related Chronic Diseases. Cells, 11.","DOI":"10.3390\/cells11050849"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1189\/jlb.0806540","article-title":"Hydrogen Peroxide Stimulates Macrophages and Monocytes to Actively Release HMGB1","volume":"81","author":"Tang","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1136\/gutjnl-2014-308876","article-title":"Abnormal Thymic Stromal Lymphopoietin Expression in the Duodenal Mucosa of Patients with Coeliac Disease","volume":"65","author":"Biancheri","year":"2016","journal-title":"Gut"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00428-014-1650-2","article-title":"Peroxisome Proliferator-Activated Receptor-\u03b3 and Thymic Stromal Lymphopoietin Are Involved in the Pathophysiology of Childhood Coeliac Disease","volume":"465","author":"Sziksz","year":"2014","journal-title":"Virchows Arch."},{"key":"ref_47","first-page":"282","article-title":"Thymic Stromal Lymphopoietin Levels Are Increased in Patients with Celiac Disease","volume":"19","author":"Uzman","year":"2019","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/cmi.2015.85","article-title":"Potential Role of the IL-33\/ST2 Axis in Celiac Disease","volume":"14","author":"Lorite","year":"2017","journal-title":"Cell Mol. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"581445","DOI":"10.3389\/fimmu.2020.581445","article-title":"IL-33 Alarmin and Its Active Proinflammatory Fragments Are Released in Small Intestine in Celiac Disease","volume":"11","author":"Perez","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.nut.2016.12.011","article-title":"HMGB1 as a New Biomarker of Celiac Disease in Children: A Multicenter Study","volume":"37","author":"Manti","year":"2017","journal-title":"Nutrition"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1016\/j.jmb.2013.09.038","article-title":"Antiviral Mechanisms of Human Defensins","volume":"425","author":"Wilson","year":"2013","journal-title":"J. Mol. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"114008","DOI":"10.1016\/j.addr.2021.114008","article-title":"Defensins: The Natural Peptide Antibiotic","volume":"179","author":"Gao","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrmicro2546","article-title":"Paneth Cells, Antimicrobial Peptides and Maintenance of Intestinal Homeostasis","volume":"9","author":"Bevins","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.aninu.2020.09.002","article-title":"Interplay between Gut Microbiota and Antimicrobial Peptides","volume":"6","author":"Zong","year":"2020","journal-title":"Anim. Nutr."},{"key":"ref_55","unstructured":"Shumatova, T.A., Zernova, E.S., Grigoryan, L.A., and Shishatskaya, S.N. (2015). Antimicrobial Peptides and Proteins in the Diagnosis of Malabsorption Syndrome in Children. Modern Prob. Sci. Educ., 3."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1007\/s11033-018-04576-8","article-title":"Effect of Gluten Diet on Blood Innate Immune Gene Expressions and Stool Consistency in Spix\u2019s Saddleback Tamarin (Leontocebus Fuscicollis) Raised in Captivity","volume":"46","author":"Almeida","year":"2019","journal-title":"Mol Biol Rep"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3390\/ph7050545","article-title":"Human Antimicrobial Peptides and Proteins","volume":"7","author":"Wang","year":"2014","journal-title":"Pharmaceuticals"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1046\/j.1365-2362.2000.00696.x","article-title":"Differential Expression of Human Alpha- and Beta-Defensins MRNA in Gastrointestinal Epithelia","volume":"30","author":"Frye","year":"2000","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1572-0241.2004.04157.x","article-title":"Presence of Bacteria and Innate Immunity of Intestinal Epithelium in Childhood Celiac Disease","volume":"99","author":"Forsberg","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s10620-005-2575-z","article-title":"Natural Antibiotic Expression in Celiac Disease\u2014Correlation with Villous Atrophy and Response to a Gluten-Free Diet","volume":"50","author":"Taha","year":"2005","journal-title":"Dig. Dis. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1309\/5ADNAR4VN11TTKQ6","article-title":"Distribution, Proliferation, and Function of Paneth Cells in Uncomplicated and Complicated Adult Celiac Disease","volume":"130","author":"Miceli","year":"2008","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/MPG.0b013e3181cd26cd","article-title":"Defensin-MRNA Expression in the Upper Gastrointestinal Tract Is Modulated in Children with Celiac Disease and Helicobacter Pylori-Positive Gastritis","volume":"50","author":"Pilic","year":"2010","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1515\/CCLM.2010.098","article-title":"Low Expression of Human Beta-Defensin 1 in Duodenum of Celiac Patients Is Partially Restored by a Gluten-Free Diet","volume":"48","author":"Intrieri","year":"2010","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.humimm.2010.05.012","article-title":"Analysis of Beta-Defensin and Toll-like Receptor Gene Copy Number Variation in Celiac Disease","volume":"71","author":"Gutierrez","year":"2010","journal-title":"Hum. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"873793","DOI":"10.3389\/fped.2022.873793","article-title":"The Activity of Antimicrobial Peptides in Pediatric Celiac Disease","volume":"10","author":"Kamilova","year":"2022","journal-title":"Front. Pediatr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1136\/gutjnl-2021-324855","article-title":"Calprotectin: From Biomarker to Biological Function","volume":"70","author":"Jukic","year":"2021","journal-title":"Gut"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2174\/156652413804486214","article-title":"Functions of S100 Proteins","volume":"13","author":"Donato","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/00365520601173632","article-title":"Faecal Calprotectin Concentrations in Untreated Coeliac Patients","volume":"42","author":"Montalto","year":"2007","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/MCG.0b013e3181cadbc0","article-title":"Fecal Calprotectin Concentration in Celiac Disease","volume":"44","author":"Ertekin","year":"2010","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4318\/tjg.2012.0366","article-title":"Fecal Calprotectin Concentration Is Increased in Children with Celiac Disease: Relation with Histopathological Findings","volume":"23","author":"Baysoy","year":"2012","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3748\/wjg.v20.i2.611","article-title":"Fecal Calprotectin in Coeliac Disease","volume":"20","author":"Capone","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_72","first-page":"44","article-title":"Faecal Calprotectin Concentration in Children with Coeliac Disease","volume":"15","year":"2020","journal-title":"Prz. Gastroenterol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.anai.2020.10.008","article-title":"Tezepelumab Improves Patient-Reported Outcomes in Patients with Severe, Uncontrolled Asthma in PATHWAY","volume":"126","author":"Corren","year":"2021","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e1241","DOI":"10.1002\/ctm2.1241","article-title":"TSLP-Targeting Therapy: Beyond Allergy?","volume":"13","author":"Leonard","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41577-022-00735-y","article-title":"Role of Thymic Stromal Lymphopoietin in Allergy and Beyond","volume":"23","author":"Leonard","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Tonner, H., Hunn, S., Auler, N., Schmelter, C., Beutgen, V.M., von Pein, H.D., Pfeiffer, N., and Grus, F.H. (2022). A Monoclonal Anti-HMGB1 Antibody Attenuates Neurodegeneration in an Experimental Animal Model of Glaucoma. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084107"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jphs.2019.04.006","article-title":"Anti-HMGB1 Monoclonal Antibody Therapy for a Wide Range of CNS and PNS Diseases","volume":"140","author":"Nishibori","year":"2019","journal-title":"J. Pharmacol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2183\/pjab.88.152","article-title":"Antimicrobial Peptide Defensin: Identification of Novel Isoforms and the Characterization of Their Physiological Roles and Their Significance in the Pathogenesis of Diseases","volume":"88","author":"Yamaguchi","year":"2012","journal-title":"Proc. Jpn Acad. Ser. B Phys. Biol. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/00042737-200306000-00008","article-title":"Crohn\u2019s Disease: A Defensin Deficiency Syndrome?","volume":"15","author":"Fellermann","year":"2003","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1189\/jlb.0904543","article-title":"Defensin Deficiency, Intestinal Microbes, and the Clinical Phenotypes of Crohn\u2019s Disease","volume":"77","author":"Wehkamp","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jaci.2016.06.038","article-title":"\u03b2-Defensin 2 Is a Responsive Biomarker of IL-17A-Driven Skin Pathology in Patients with Psoriasis","volume":"139","author":"Kolbinger","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/hum.2013.161","article-title":"Gene Therapy with Beta-Defensin 2 Induces Antitumor Immunity and Enhances Local Antitumor Effects","volume":"25","author":"Li","year":"2014","journal-title":"Hum. Gene Ther."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Cie\u015blik, M., Bagi\u0144ska, N., G\u00f3rski, A., and Jo\u0144czyk-Matysiak, E. (2021). Human \u03b2-Defensin 2 and Its Postulated Role in Modulation of the Immune Response. 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