{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:36:08Z","timestamp":1790840168840,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The induced membrane technique is an innovative approach for repairing critical bone defects and has been applied recently in patients with congenital pseudarthrosis of the tibia (CPT). CPT is frequently associated with neurofibromatosis type 1 (NF1). Here, we briefly describe the clinical results of the induced membrane technique in NF1-deficient patients with CPT and in an animal model of CPT. Furthermore, we discuss the hypotheses used to explain inconsistent outcomes for the induced membrane technique in CPT\u2013especially when associated with NF1.<\/jats:p>","DOI":"10.3390\/cells12141918","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T01:08:11Z","timestamp":1690160891000},"page":"1918","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Questions about Using the Induced Membrane Technique to Manage Cases of Congenital Tibial Pseudarthrosis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8939-1949","authenticated-orcid":false,"given":"C\u00e9line","family":"Klein","sequence":"first","affiliation":[{"name":"Department of Paediatric Orthopaedic Surgery, Amiens University Hospital, Jules Verne University of Picardie, F-80054 Amiens, France"},{"name":"MP3CV-EA7517, CURS\u2013Amiens University Medical Center, Jules Verne University of Picardie, F-80025 Amiens, France"},{"name":"Service D\u2019orthop\u00e9die et Traumatologie P\u00e9diatrique, CHU Amiens-Picardie, F-80054 Amiens CEDEX 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-6093","authenticated-orcid":false,"given":"Florelle","family":"Gindraux","sequence":"additional","affiliation":[{"name":"CHU Besan\u00e7on, Service de Chirurgie Orthop\u00e9dique, Traumatologique et Plastique, F-25000 Besan\u00e7on, France"},{"name":"Laboratoire de Nanom\u00e9decine, Imagerie, Universit\u00e9 de Franche-Comt\u00e9, Th\u00e9rapeutique EA 4662 (LNIT), F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain-Charles","family":"Masquelet","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Antoine, Sorbonne Universit\u00e9, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romuald","family":"Mentaverri","sequence":"additional","affiliation":[{"name":"MP3CV-EA7517, CURS\u2013Amiens University Medical Center, Jules Verne University of Picardie, F-80025 Amiens, France"},{"name":"CHU Besan\u00e7on, Service de Chirurgie Orthop\u00e9dique, Traumatologique et Plastique, F-25000 Besan\u00e7on, France"},{"name":"Laboratoire de Nanom\u00e9decine, Imagerie, Universit\u00e9 de Franche-Comt\u00e9, Th\u00e9rapeutique EA 4662 (LNIT), F-25000 Besan\u00e7on, France"},{"name":"H\u00f4pital Saint Antoine, Sorbonne Universit\u00e9, F-75006 Paris, France"},{"name":"Department of Biochemistry and Endocrine Biology, Amiens University Medical Center, Jules Verne University of Picardie, F-80025 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Gouron","sequence":"additional","affiliation":[{"name":"Department of Paediatric Orthopaedic Surgery, Amiens University Hospital, Jules Verne University of Picardie, F-80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/01.bpo.0000217719.10728.39","article-title":"Neurofibromatosis Update","volume":"26","author":"Crawford","year":"2006","journal-title":"J. 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