{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:04:43Z","timestamp":1792033483265,"version":"4.4.0"},"reference-count":145,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Oradea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>This comprehensive review article dives deep into the Golgi apparatus, an essential organelle in cellular biology. Beginning with its discovery during the 19th century until today\u2019s recognition as an important contributor to cell function. We explore its unique organization and structure as well as its roles in protein processing, sorting, and lipid biogenesis, which play key roles in maintaining homeostasis in cellular biology. This article further explores Golgi biogenesis, exploring its intricate processes and dynamics that contribute to its formation and function. One key focus is its role in neurodegenerative diseases like Parkinson\u2019s, where changes to the structure or function of the Golgi apparatus may lead to their onset or progression, emphasizing its key importance in neuronal health. At the same time, we examine the intriguing relationship between Golgi stress and endoplasmic reticulum (ER) stress, providing insights into their interplay as two major cellular stress response pathways. Such interdependence provides a greater understanding of cellular reactions to protein misfolding and accumulation, hallmark features of many neurodegenerative diseases. In summary, this review offers an exhaustive examination of the Golgi apparatus, from its historical background to its role in health and disease. Additionally, this examination emphasizes the necessity of further research in this field in order to develop targeted therapeutic approaches for Golgi dysfunction-associated conditions. Furthermore, its exploration is an example of scientific progress while simultaneously offering hope for developing innovative treatments for neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/cells12151972","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T09:22:38Z","timestamp":1690795358000},"page":"1972","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The Golgi Apparatus: A Voyage through Time, Structure, Function and Implication in Neurodegenerative Disorders"],"prefix":"10.3390","volume":"12","author":[{"given":"Aurel George","family":"Mohan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Bihor County Emergency Clinical Hospital, 410167 Oradea, Romania"},{"name":"Faculty of Medicine, Oradea University, 410610 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Calenic","sequence":"additional","affiliation":[{"name":"Immunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Centre of Immunogenetics and Virology, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicu Adrian","family":"Ghiurau","sequence":"additional","affiliation":[{"name":"Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410610 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana-Maria","family":"Duncea-Borca","sequence":"additional","affiliation":[{"name":"Forensic Medical Service, 140090 Alexandria, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra-Elena","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Immunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Centre of Immunogenetics and Virology, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Saceleanu, V.M., Covache-Busuioc, R.A., Costin, H.P., Glavan, L.A., and Ciurea, A.V. (2022). An Important Step in Neuroscience: Camillo Golgiand His Discoveries. Cells, 11.","DOI":"10.3390\/cells11244112"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrm1003","article-title":"The sarcoplasmic reticulum: Its discovery and rediscovery","volume":"4","author":"Mazzarello","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1016\/j.febslet.2009.10.018","article-title":"How Camillo Golgi became \u201cthe Golgi\u201d","volume":"583","author":"Mazzarello","year":"2009","journal-title":"FEBS Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1076\/jhin.8.2.132.1847","article-title":"The Golgi stain: Invention, diffusion and impact on neurosciences","volume":"8","author":"Pannese","year":"1999","journal-title":"J. Hist. Neurosci."},{"key":"ref_5","first-page":"60","article-title":"Sur la structure des cellules nerveuses","volume":"30","author":"Golgi","year":"1898","journal-title":"Arch. Ital. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/33266","article-title":"The centenarian Golgi apparatus","volume":"392","author":"Mazzarello","year":"1998","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0962-8924(97)01187-2","article-title":"The Golgi apparatus: 100 years of progress and controversy","volume":"8","author":"Farquhar","year":"1998","journal-title":"Trends Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s004180050245","article-title":"Camillo Golgi and the discovery of the Golgi apparatus","volume":"109","year":"1998","journal-title":"Histochem. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"77s","DOI":"10.1083\/jcb.91.3.77s","article-title":"The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage","volume":"91","author":"Farquhar","year":"1981","journal-title":"J. Cell Biol."},{"key":"ref_10","unstructured":"Trautmann, J.C. (1988). Camillo Golgi (1843\u20131926) und die Entdeckung des \u201cApparato Reticolare Interno\u201d (Golgi-Apparat). [Ph.D. Thesis, Medizinische Universit\u00e4t]."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0361-9230(98)00080-X","article-title":"The history of the Golgi apparatus in neurones from its discovery in 1898 to electron microscopy","volume":"47","year":"1998","journal-title":"Brain Res. Bull."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/aja.1000940202","article-title":"Cytologic and cytochemical characteristics of the Golgi substance of epithelial cells of the epididymis\u2013insitu, in homogenates and after isolation","volume":"94","author":"Dalton","year":"1954","journal-title":"Am. J. Anat."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1083\/jcb.34.2.577","article-title":"Intracellular Transport of Secretory Proteins in The Pancreatic Exocrine Cell: I. Role of the Peripheral Elements of the Golgi Complex","volume":"34","author":"Jamieson","year":"1967","journal-title":"J. Cell Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.1096303","article-title":"Intracellular Aspects of the Process of Protein Synthesis","volume":"189","author":"Palade","year":"1975","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0092-8674(84)90459-8","article-title":"Sequential intermediates in the pathway of intercompartmental transport in a cell-free system","volume":"39","author":"Balch","year":"1984","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0092-8674(84)90019-9","article-title":"Reconstitution of the transport of protein between successive compartmentsof the Golgi measured by the coupled incorporation of N-acetylglucosamine","volume":"39","author":"Balch","year":"1984","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1073\/pnas.85.21.7852","article-title":"Purification of an N-ethylmaleimide-sensitive protein catalyzingvesicular transport","volume":"85","author":"Block","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bbamcr.2005.03.013","article-title":"Golgi tethering factors","volume":"1744","author":"Lupashin","year":"2005","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00425-005-0082-2","article-title":"Cell cycle-dependent changes in Golgi stacks, vacuoles, clathrin-coated vesicles and multivesicular bodies in meristematic cells of Arabidopsis thaliana: A quantitative and spatial analysis","volume":"223","author":"Staehelin","year":"2006","journal-title":"Planta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1083\/jcb.144.6.1135","article-title":"Golgi structure in three dimensions: Functional insightsfrom the normal rat kidney cell","volume":"144","author":"Ladinsky","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ceb.2010.10.004","article-title":"Structural organization of the Golgi apparatus","volume":"23","author":"Lowe","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/aja.1001790202","article-title":"Tridimensional architecture of the Golgi apparatus and its components inmucous cells of Brunner\u2019s glands of the mouse","volume":"179","author":"Rambourg","year":"1987","journal-title":"Am. J. Anat."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1768-322X.1987.tb00550.x","article-title":"Tridimensional structure of the Golgi apparatus of nonciliated epithelial cellsof the ductuli efferentes in rat: An electron microscope stereoscopic study","volume":"60","author":"Rambourg","year":"1987","journal-title":"Biol. Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0955-0674(00)00116-2","article-title":"Organization of the Golgi apparatus","volume":"12","author":"Glick","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"43843","DOI":"10.1126\/science.2945253","article-title":"The trans Golgi network: Sorting at the exit site of the Golgi complex","volume":"234","author":"Griffiths","year":"1986","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/PL00000922","article-title":"Trans-Golgi network sorting","volume":"58","author":"Gu","year":"2001","journal-title":"Cell Mol. Life Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev-cellbio-100913-013012","article-title":"Protein sorting at the trans-Golgi network","volume":"30","author":"Guo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1083\/jcb.111.3.893","article-title":"Compartmentation of the Golgi complex: Brefeldin-A distinguishes trans-Golgi cisternae from the transGolgi network","volume":"111","author":"Chege","year":"1990","journal-title":"J. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jemt.1060170103","article-title":"Perspectives on Golgi apparatus form and function","volume":"17","author":"Mollenhauer","year":"1991","journal-title":"J. Electron. Microsc. Tech."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1177\/30.7.6286754","article-title":"The internal reticular apparatus of Camillo Golgi: A complex, heterogeneous organelle, enriched in acid, neutral, and alkaline phosphatases, and involved in glycosylation, secretion, membrane flow, lysosome formation, and intracellular digestion","volume":"30","author":"Goldfischer","year":"1982","journal-title":"J. Histochem. Cytochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nrm3588","article-title":"Organization of the ER\u2013Golgi interface for membrane traffic control","volume":"14","author":"Brandizzi","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"32539","DOI":"10.1074\/jbc.274.46.32539","article-title":"Mannose-dependent endoplasmic reticulum (ER)-Golgi intermediate compartment-53-mediated ER to Golgi trafficking of coagulation factors, V and VIII","volume":"274","author":"Moussalli","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0092-8674(85)80097-0","article-title":"Compartmental organization of the Golgi stack","volume":"42","author":"Dunphy","year":"1985","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1073\/pnas.98.4.1625","article-title":"Physical and functional association of glycolipid N-acetyl-galactosaminyl and galactosyl transferases in the Golgi apparatus","volume":"98","author":"Giraudo","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0014-5793(90)80659-7","article-title":"Sphingomyelin is synthesized in the cis Golgi","volume":"261","author":"Jeckel","year":"1990","journal-title":"FEBS Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8650","DOI":"10.1016\/S0021-9258(19)38937-9","article-title":"Sphingomyelin synthesis in rat liver occurs predominantly at the cis andmedial cisternae of the Golgi apparatus","volume":"265","author":"Futerman","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1083\/jcb.200604058","article-title":"COPII\u2013Golgi protein interactions regulate COPII coat assembly and Golgi size","volume":"174","author":"Guo","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1083\/jcb.131.4.875","article-title":"Sequential coupling between COPII and COPI vesicle coats in endoplasmic reticulum to Golgi transport","volume":"131","author":"Aridor","year":"1995","journal-title":"J. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1152\/physiol.00017.2011","article-title":"COPII and COPI traffic at the ER-Golgi interface","volume":"26","author":"Szul","year":"2011","journal-title":"Physiology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"a013367","DOI":"10.1101\/cshperspect.a013367","article-title":"The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum andtargets it to the golgi","volume":"5","author":"Lord","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1242\/jcs.03019","article-title":"The ER-Golgi intermediate compartment (ERGIC): In search of its identity and function","volume":"119","author":"Hauri","year":"2006","journal-title":"J. Cell Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0092-8674(00)81146-0","article-title":"Mutations in the ER\u2013Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors, V and VIII","volume":"93","author":"Nichols","year":"1998","journal-title":"Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1534-5807(02)00203-4","article-title":"ER stress regulation of ATF6 localization by dissociation of BiP\/GRP78 binding andunmasking of Golgi localization signals","volume":"3","author":"Shen","year":"2002","journal-title":"Dev. Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1091\/mbc.5.10.1129","article-title":"Inhibition of endoplasmic reticulum (ER)-to-Golgi transport induces relocalization of bind ing protein (BiP) within the ER to form the BiP bodies","volume":"5","author":"Nishikawa","year":"1994","journal-title":"Mol. Biol. Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.1128\/JVI.75.16.7672-7682.2001","article-title":"Endoplasmic reticulum and cis-Golgi localization of human T-lymphotropic virus type 1 p12I: Association with calreticulin and calnexin","volume":"75","author":"Ding","year":"2001","journal-title":"J. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"39631","DOI":"10.1074\/jbc.M007684200","article-title":"Subunit structure of a mammalian ER\/Golgi SNARE complex","volume":"275","author":"Xu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1091\/mbc.e09-09-0801","article-title":"\u03b1-Synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER\/Golgi SNAREs","volume":"21","author":"Thayanidhi","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0092-8674(00)80608-X","article-title":"Vesicular tubular clusters between the ER and Golgi mediate concentration of soluble secretory proteins by exclusion from COPI-coated vesicles","volume":"98","author":"Geuze","year":"1999","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"a005231","DOI":"10.1101\/cshperspect.a005231","article-title":"COPI budding within the Golgi stack","volume":"3","author":"Popoff","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nrm1735","article-title":"The maturing role of COPI vesicles in intra-Golgi transport","volume":"6","author":"Rabouille","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1471-4159.2007.04717.x","article-title":"Glycosylation of glycolipids in the Golgi complex","volume":"103","author":"Maccioni","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0167-4889(98)00061-5","article-title":"The plant Golgi apparatus","volume":"1404","author":"Dupree","year":"1998","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Cell Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-arplant-042809-112315","article-title":"Hemicelluloses","volume":"61","author":"Scheller","year":"2010","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"a005199","DOI":"10.1101\/cshperspect.a005199","article-title":"Golgi glycosylation","volume":"3","author":"Stanley","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev.bi.56.070187.000431","article-title":"Topography of glycosylation in the rough endoplasmic reticulum and Golgi apparatus","volume":"56","author":"Hirschberg","year":"1987","journal-title":"Annu. Rev. Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41594-019-0225-y","article-title":"Structural basis for the delivery of activated sialic acid into Golgi for sial-yation","volume":"26","author":"Nji","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41467-017-02799-0","article-title":"Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain","volume":"9","author":"Hirata","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1074\/jbc.274.7.4474","article-title":"Identification and purification of the rat liver Golgi mem-brane UDP-N-acetylgalactosamine transporter","volume":"274","author":"Puglielli","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/nature04737","article-title":"Live imaging of yeast Golgi cisternal maturation","volume":"441","author":"Takeuchi","year":"2006","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-5793(97)00984-8","article-title":"A cisternal maturation mechanism can explain the asymmetry of the Golgi stack","volume":"414","author":"Glick","year":"1997","journal-title":"FEBS Lett."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00709-011-0361-7","article-title":"Retrograde vesicle transport in the Golgi","volume":"249","author":"Cottam","year":"2012","journal-title":"Protoplasma"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.carres.2008.01.034","article-title":"Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation","volume":"343","author":"Smith","year":"2008","journal-title":"Carbohydr. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00418-013-1117-6","article-title":"The Golgi puppet master: COG complex at center stage of membrane trafficking interactions","volume":"140","author":"Willett","year":"2013","journal-title":"Histochem. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1073\/pnas.0507685103","article-title":"Conserved oligomeric Golgi complex subunit 1 deficiency reveals a previously uncharacterized congenital disorder of glycosylation type II","volume":"103","author":"Foulquier","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","unstructured":"Varki, A., Esko, J.D., and Colley, K.J. (2009). Essentials of Glycobiology, Cold Spring. [2nd ed.]."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1091\/mbc.e03-03-0130","article-title":"Association of the Golgi UDP-galactose transporter with UDP-galactose: Ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum","volume":"14","author":"Sprong","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"13819","DOI":"10.1074\/jbc.275.18.13819","article-title":"Formation of insoluble oligomers correlates with ST6Gal I stable localization in the Golgi","volume":"275","author":"Chen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1126\/science.8362242","article-title":"Cholesterol and the Golgi apparatus","volume":"261","author":"Bretscher","year":"1993","journal-title":"Science"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1021\/bi972441+","article-title":"Hydrophobic mismatch and the incorporation of peptides into lipid bilayers: A possible mechanism for retention in the Golgi","volume":"37","author":"Webb","year":"1998","journal-title":"Biochemistry"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1016\/j.jmb.2016.02.030","article-title":"Glycosylation quality control by the Golgi structure","volume":"428","author":"Zhang","year":"2016","journal-title":"J. Mol. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nrmicro1087","article-title":"The humanization of N-glycosylation pathways in yeast","volume":"3","author":"Wildt","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1462-5822.2006.00874.x","article-title":"Golgi biogenesis in simple eukaryotes","volume":"9","author":"He","year":"2007","journal-title":"Cell Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"E223","DOI":"10.1038\/ncb1002-e223","article-title":"More than one way to replicate the Golgi apparatus","volume":"4","author":"Munro","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1078\/0171-9335-00191","article-title":"Structure and division of the Golgi complex in Trichomonas vaginalis and Tritrichomonas foetus","volume":"80","author":"Benchimol","year":"2001","journal-title":"Eur. J. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nature00946","article-title":"Golgi biogenesis in Toxoplasma gondii","volume":"418","author":"Pelletier","year":"2002","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/ncb852","article-title":"De novo formation of transitional ER sites and Golgi structures in Pichia pastoris","volume":"4","author":"Bevis","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1083\/jcb.145.1.69","article-title":"Golgi structure correlates with transitionalendoplasmic reticulum organization in Pichia pastoris and Saccharomyces cerevisiae","volume":"145","author":"Rossanese","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/38001","article-title":"ER-to-Golgi transport visualized in living cells","volume":"389","author":"Presley","year":"1997","journal-title":"Nature"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-0854.2008.00873.x","article-title":"Ultrastructural study of Golgi duplication in Trypanosoma brucei","volume":"10","author":"Yelinek","year":"2009","journal-title":"Traffic"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1126\/science.1119969","article-title":"Golgi duplication in Trypanosoma brucei requires Centrin2","volume":"310","author":"He","year":"2005","journal-title":"Science"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1083\/jcb.200311076","article-title":"Golgi duplication in Trypanosoma brucei","volume":"165","author":"He","year":"2004","journal-title":"J. Cell Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"7676","DOI":"10.1073\/pnas.0602595103","article-title":"Ordered assembly of the duplicating Golgi in Trypanosoma brucei","volume":"103","author":"Ho","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.149.3.603","article-title":"Casciola-complex and cleaves golgin-160 during apoptosis","volume":"149","author":"Mancini","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1074\/jbc.M007957200","article-title":"The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic","volume":"276","author":"Alvarez","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1247\/csf.16023","article-title":"TFE3, HSP47, and CREB3 pathways of the mammalian Golgi stress response","volume":"42","author":"Taniguchi","year":"2017","journal-title":"Cell Struct. Funct."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/ncb2865","article-title":"A CREB3\u2013ARF4 signalling pathway mediatesthe response to Golgi stress and susceptibility to pathogens","volume":"15","author":"Reiling","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1247\/csf.14015","article-title":"TFE3 is a bHLH-ZIP-type transcription factor that regulates the mammalian Golgi stress response","volume":"40","author":"Taniguchi","year":"2015","journal-title":"Cell Struct. Funct."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3389\/fnins.2015.00421","article-title":"The Golgi complex in stress and death","volume":"9","author":"Machamer","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2990.1981.tb00093.x","article-title":"Creutzfeldt-Jacob disease: A Golgi study","volume":"7","author":"Ferrer","year":"1981","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jns.2006.01.019","article-title":"Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death","volume":"246","author":"Gonatas","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.1523\/JNEUROSCI.0042-15.2015","article-title":"VPS35 in dopamine neurons is required for endosome-to-Golgi retrieval of Lamp2a, a receptor of chaperone-mediated autophagy that is critical for \u03b1-synuclein degradation and prevention of pathogenesis of Parkinson\u2019s disease","volume":"35","author":"Tang","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1242\/jcs.114.20.3685","article-title":"Misfolded growth hormone causes fragmentation of the Golgi apparatus and disrupts endoplasmic reticulum-to-Golgi traffic","volume":"114","author":"Graves","year":"2001","journal-title":"J. Cell Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80783-7","article-title":"Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain","volume":"97","author":"Doetsch","year":"1999","journal-title":"Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.887941","article-title":"Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs","volume":"197","author":"Kaplan","year":"1977","journal-title":"Science"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.neuro.28.051804.101459","article-title":"Adult neurogenesis in the mammalian central nervous system","volume":"28","author":"Ming","year":"2005","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1173215","article-title":"A functional role for adult hippocampal neurogenesis in spatial pattern separation","volume":"325","author":"Clelland","year":"2009","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.cell.2010.10.029","article-title":"Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment","volume":"143","author":"Matsuki","year":"2010","journal-title":"Cell"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroscience.2014.03.004","article-title":"Reelin, neuronal polarity and process orientation of cortical neurons","volume":"269","year":"2014","journal-title":"Neuroscience"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1523\/JNEUROSCI.1217-17.2017","article-title":"Repositioning of somatic Golgi apparatus is essential for the dendritic establishment of adult-born hippocampal neurons","volume":"38","author":"Rao","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.devcel.2018.02.025","article-title":"A Golgi lipid signaling pathway controls apical Golgi distribution and cell polarity during neurogenesis","volume":"44","author":"Xie","year":"2018","journal-title":"Dev. Cell"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"7701","DOI":"10.1007\/s12035-018-0954-7","article-title":"BIG2-ARF1-RhoA-mDia1 signaling regulates dendritic Golgi polarization in hippocampal neurons","volume":"55","author":"Hong","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cell.2007.06.032","article-title":"Growing dendrites and axons differ in their reliance on the secretory pathway","volume":"130","author":"Ye","year":"2007","journal-title":"Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"9297","DOI":"10.1523\/JNEUROSCI.1879-08.2008","article-title":"Protein kinase d regulates trafficking of dendritic membrane proteins in developing neurons","volume":"28","author":"Bisbal","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.neuron.2005.11.005","article-title":"Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis","volume":"48","author":"Horton","year":"2005","journal-title":"Neuron"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"8832","DOI":"10.1523\/JNEUROSCI.1291-08.2008","article-title":"Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus","volume":"28","author":"Yin","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Ciurea, A.V., Mohan, A.G., Covache-Busuioc, R.-A., Costin, H.-P., Glavan, L.-A., Corlatescu, A.-D., and Saceleanu, V.M. (2023). Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer\u2019s, Parkinson\u2019s, and Huntington\u2019s Diseases and Amyotrophic Lateral Sclerosis. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202305.1229.v1"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cger.2019.08.002","article-title":"Parkinson disease epidemiology, pathology, genetics, and pathophysiology","volume":"36","author":"Simon","year":"2020","journal-title":"Clin. Geriatr. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1007\/s12035-017-0525-3","article-title":"Tale of the good and the bad Cdk5: Remodeling of the actin cytoskeleton in the brain","volume":"55","author":"Shah","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.parkreldis.2022.05.012","article-title":"Prevalence of ten LRRK2 variants in Parkinson\u2019sdisease: A comprehensive review","volume":"98","author":"Simpson","year":"2022","journal-title":"Park. Relat. Disord."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Carri\u00f3n, M.D., Posadas, I., Solera, J., and Ce\u00f1a, V. (2022). LRRK2 and Proteostasis in Parkinson\u2019s Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126808"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0002-9440(10)62366-8","article-title":"Fragmentation of the Golgi apparatus induced by the overex-pression of wild-type and mutant human tau forms in neurons","volume":"166","author":"Liazoghli","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_113","unstructured":"Nguyen, A.P.T., and Moore, D.J. (2017). Leucine-Rich Repeat Kinase 2 (LRRK2), Springer."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Xu, L., Nagai, Y., Kajihara, Y., Ito, G., and Tomita, T. (2021). The regulation of rab gtpases by phosphorylation. Biomolecules, 11.","DOI":"10.3390\/biom11091340"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.bpj.2021.03.030","article-title":"Dual arginine recognition of LRRK2 phosphorylated Rab GTPases","volume":"120","author":"Purlyte","year":"2021","journal-title":"Biophys. J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/pbi.13929","article-title":"Spatial proteomics of vesicular trafficking: Coupling mass spectrometry and imaging approaches in membrane biology","volume":"21","author":"Zhang","year":"2023","journal-title":"Plant Biotechnol. J."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fnins.2020.00227","article-title":"The emerging functions of LRRK2 and Rab GTPases in the endolysosomal system","volume":"14","author":"Kuwahara","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Kong, I.C., Ko, K.S., and Koh, D.C. (2020). Evaluation of the effects of particle sizes of silver nanoparticles on various biological systems. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228465"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41586-020-1984-7","article-title":"Discriminating \u03b1-synuclein strains in Parkinson\u2019sdisease and multiple system atrophy","volume":"578","author":"Shahnawaz","year":"2020","journal-title":"Nature"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nrn1197","article-title":"14-3-3 proteins in the nervous system","volume":"4","author":"Berg","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Waschb\u00fcsch, D., Michels, H., Strassheim, S., Ossendorf, E., Kessler, D., Gloeckner, C.J., and Barnekow, A. (2014). LRRK2 transport is regulated by its novel interacting partner Rab32. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111632"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Waschb\u00fcsch, D., H\u00fcbel, N., Ossendorf, E., Lobbestael, E., Baekelandt, V., Lindsay, A.J., McCaffrey, M.W., Khan, A.R., and Barnekow, A. (2019). Rab32 interacts with SNX6 and affectsretromer-dependent Golgi trafficking. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0208889"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Paul, B.D. (2021). Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington\u2019s Disease. Antioxidants, 10.","DOI":"10.3390\/antiox10091468"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"23489","DOI":"10.1038\/s41598-021-02929-1","article-title":"Flavivirus infections induce a Golgi stress response in vertebrate and mosquito cells","volume":"11","author":"Viettri","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_125","first-page":"185","article-title":"Organelle autoregulation\u2014Stress responses in the ER, Golgi, mitochondria and lysosome","volume":"157","author":"Sasaki","year":"2015","journal-title":"J. Ofbiochem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1247\/csf.19009","article-title":"MGSE regulates crosstalk from the mucin pathway to the TFE3 pathway of the Golgi stress response","volume":"44","author":"Jamaludin","year":"2019","journal-title":"Cell Struct. Funct."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/dvdy.461","article-title":"Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice","volume":"251","author":"Yamaguchi","year":"2022","journal-title":"Dev. Dyn."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1091\/mbc.E20-01-0063","article-title":"Hydrogen peroxide induces Arl1 degradation and impairs Golgi-mediated traf-ficking","volume":"31","author":"Ireland","year":"2020","journal-title":"Mol. Biol. Cell."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1089\/ars.2018.7523","article-title":"Hypoxia and reactive oxygen species as modulators of endoplasmic reticulum and Golgi homeostasis","volume":"30","author":"Mennerich","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.sbi.2012.06.005","article-title":"Structure, mechanism and inhibition of Golgi \u03b1-mannosidase II","volume":"22","author":"Rose","year":"2012","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.freeradbiomed.2021.01.028","article-title":"Heme oxygenase-1 (HO-1) regulates Golgi stress and attenuates endotoxin- 929 induced acute lung injury through hypoxia inducible factor-1\u03b1 (HIF-1\u03b1)\/HO-1 signaling pathway","volume":"165","author":"Li","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1073\/pnas.1608576114","article-title":"Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice","volume":"114","author":"Liu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/s41598-018-38146-6","article-title":"Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons","volume":"9","author":"Wolzak","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1172\/JCI88736","article-title":"Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11","volume":"127","author":"Tan","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00418-016-1515-7","article-title":"Golgi apparatus dis-and reorganizations studied with the aid of 2-deoxy-D-glucose and visualized by 3D-electron tomography","volume":"147","author":"Ranftler","year":"2017","journal-title":"Histochem. Cell Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1083\/jcb.200110007","article-title":"Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis","volume":"156","author":"Lane","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1002\/1873-3468.13554","article-title":"Golgi stress response and organelle zones","volume":"593","author":"Sasaki","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_138","first-page":"13174","article-title":"Grasp proposal networks: An end-to-end solution for visual learning of robotic grasps","volume":"33","author":"Wu","year":"2020","journal-title":"Adv. Neural Inf. Process. Syst."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e143945","DOI":"10.1172\/JCI143945","article-title":"Targeting the mutant p53 secretome","volume":"131","author":"Sehgal","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Vlad, D.-B., Dumitrascu, D.-I., and Dumitrascu, A.-L. (2023). Golgi\u2019s Role in the Development of Possible New Therapies in Cancer. Cells, 12.","DOI":"10.3390\/cells12111499"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/tra.12403","article-title":"Monomerization and ER Relocalization of GRASP Is a Requisite for Unconventional Secretion of CFTR","volume":"17","author":"Kim","year":"2016","journal-title":"Traffic"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/cb600331e","article-title":"Rescuing defective vesicular trafficking protects against \u03b1-synuclein toxicity in cellular and animal models of Parkinson\u2019s disease","volume":"1","author":"Lashuel","year":"2006","journal-title":"ACS Chem. Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1038\/emboj.2010.167","article-title":"ADAM10 is the physiologically relevant, constitutive \u03b1-secretase of the amyloid precursor protein in primary neurons","volume":"29","author":"Kuhn","year":"2010","journal-title":"EMBO J."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1093\/brain\/awq217","article-title":"Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer\u2019s disease","volume":"133","author":"Epis","year":"2010","journal-title":"Brain"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e1547","DOI":"10.1038\/cddis.2014.492","article-title":"SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation","volume":"5","author":"Saraceno","year":"2014","journal-title":"Cell Death Dis."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/15\/1972\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:22:57Z","timestamp":1760127777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/15\/1972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":145,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["cells12151972"],"URL":"https:\/\/doi.org\/10.3390\/cells12151972","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,31]]}}}