{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:49:05Z","timestamp":1784335745677,"version":"3.55.0"},"reference-count":36,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Finish Academy","award":["324070"],"award-info":[{"award-number":["324070"]}]},{"name":"Finish Academy","award":["339560"],"award-info":[{"award-number":["339560"]}]},{"name":"Finish Academy","award":["337120"],"award-info":[{"award-number":["337120"]}]},{"name":"Finish Academy","award":["884382"],"award-info":[{"award-number":["884382"]}]},{"DOI":"10.13039\/501100000781","name":"European Research Council (ERC) Advanced","doi-asserted-by":"publisher","award":["324070"],"award-info":[{"award-number":["324070"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council (ERC) Advanced","doi-asserted-by":"publisher","award":["339560"],"award-info":[{"award-number":["339560"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council (ERC) Advanced","doi-asserted-by":"publisher","award":["337120"],"award-info":[{"award-number":["337120"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council (ERC) Advanced","doi-asserted-by":"publisher","award":["884382"],"award-info":[{"award-number":["884382"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biocentre Finland","award":["324070"],"award-info":[{"award-number":["324070"]}]},{"name":"Biocentre Finland","award":["339560"],"award-info":[{"award-number":["339560"]}]},{"name":"Biocentre Finland","award":["337120"],"award-info":[{"award-number":["337120"]}]},{"name":"Biocentre Finland","award":["884382"],"award-info":[{"award-number":["884382"]}]},{"name":"Kuopio University Foundation","award":["324070"],"award-info":[{"award-number":["324070"]}]},{"name":"Kuopio University Foundation","award":["339560"],"award-info":[{"award-number":["339560"]}]},{"name":"Kuopio University Foundation","award":["337120"],"award-info":[{"award-number":["337120"]}]},{"name":"Kuopio University Foundation","award":["884382"],"award-info":[{"award-number":["884382"]}]},{"name":"Heart Research Foundation and the Maire Taponen Foundation","award":["324070"],"award-info":[{"award-number":["324070"]}]},{"name":"Heart Research Foundation and the Maire Taponen Foundation","award":["339560"],"award-info":[{"award-number":["339560"]}]},{"name":"Heart Research Foundation and the Maire Taponen Foundation","award":["337120"],"award-info":[{"award-number":["337120"]}]},{"name":"Heart Research Foundation and the Maire Taponen Foundation","award":["884382"],"award-info":[{"award-number":["884382"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>This study aimed to show the significance of capillary function in post-ischemic recovery from the perspective of physiological parameters, such as blood flow, hemoglobin oxygenation and tissue regeneration. Muscle-level microvascular alterations of blood flow and hemoglobin oxygenation, and post-ischemic myofiber and capillary responses were analyzed in aged, healthy C57Bl\/6J mice (n = 48) and aged, hyperlipidemic LDLR\u2212\/\u2212ApoB100\/100 mice (n = 69) after the induction of acute hindlimb ischemia using contrast ultrasound, photoacoustic imaging and histological analyses, respectively. The capillary responses that led to successful post-ischemic muscle repair in C57Bl\/6J mice included an early capillary dilation phase, preceding the return of arterial driving pressure, followed by an increase in capillary density that further supported satellite cell-induced muscle regeneration. Initial capillary enlargement was absent in the LDLR\u2212\/\u2212ApoB100\/100 mice with lifelong moderate hypercholesterolemia and led to an inability to recover arterial driving pressure, with a resulting increase in distal necrosis, chronic tissue damage and a delay in the overall recovery after ischemia. To conclude, this manuscript highlights, beyond arterial collateralization, the importance of the proper function of the capillary endothelium in post-ischemic recovery and displays how post-ischemic capillary dynamics associate beyond tissue blood flow to both hemoglobin oxygenation and tissue regeneration.<\/jats:p>","DOI":"10.3390\/cells12162060","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T10:20:14Z","timestamp":1692008414000},"page":"2060","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia"],"prefix":"10.3390","volume":"12","author":[{"given":"Galina","family":"Wirth","sequence":"first","affiliation":[{"name":"Heart Center, Kuopio University Hospital, FI-70200 Kuopio, Finland"},{"name":"A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Juusola","sequence":"additional","affiliation":[{"name":"Heart Center, Kuopio University Hospital, FI-70200 Kuopio, Finland"},{"name":"A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santeri","family":"Tarvainen","sequence":"additional","affiliation":[{"name":"Heart Center, Kuopio University Hospital, FI-70200 Kuopio, Finland"},{"name":"A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-9727","authenticated-orcid":false,"given":"Johanna P.","family":"Laakkonen","sequence":"additional","affiliation":[{"name":"A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Korpisalo","sequence":"additional","affiliation":[{"name":"Heart Center, Kuopio University Hospital, FI-70200 Kuopio, Finland"},{"name":"A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7593-2708","authenticated-orcid":false,"given":"Seppo","family":"Yl\u00e4-Herttuala","sequence":"additional","affiliation":[{"name":"Heart Center, Kuopio University Hospital, FI-70200 Kuopio, Finland"},{"name":"A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1006\/jmcc.2002.2013","article-title":"Contribution of Arteriogenesis and Angiogenesis to Postocclusive Hindlimb Perfusion in Mice","volume":"34","author":"Scholz","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00395-008-0760-x","article-title":"Collateral Circulation. Past and Present","volume":"104","author":"Schaper","year":"2009","journal-title":"Basic Res. 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