{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:42:56Z","timestamp":1782978176703,"version":"3.54.5"},"reference-count":314,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fund Octave Dupont from the Royal Academy of Belgium","award":["FISR2020IP_04051"],"award-info":[{"award-number":["FISR2020IP_04051"]}]},{"name":"Fund Octave Dupont from the Royal Academy of Belgium","award":["PRIN2017 #2017J92TM5"],"award-info":[{"award-number":["PRIN2017 #2017J92TM5"]}]},{"name":"Italian Government","award":["FISR2020IP_04051"],"award-info":[{"award-number":["FISR2020IP_04051"]}]},{"name":"Italian Government","award":["PRIN2017 #2017J92TM5"],"award-info":[{"award-number":["PRIN2017 #2017J92TM5"]}]},{"name":"University of Bari","award":["FISR2020IP_04051"],"award-info":[{"award-number":["FISR2020IP_04051"]}]},{"name":"University of Bari","award":["PRIN2017 #2017J92TM5"],"award-info":[{"award-number":["PRIN2017 #2017J92TM5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Aquaporins (AQPs), transmembrane proteins permeable to water, are involved in gastrointestinal secretion. The secretory products of the glands are delivered either to some organ cavities for exocrine glands or to the bloodstream for endocrine glands. The main secretory glands being part of the gastrointestinal system are salivary glands, gastric glands, duodenal Brunner\u2019s gland, liver, bile ducts, gallbladder, intestinal goblet cells, exocrine and endocrine pancreas. Due to their expression in gastrointestinal exocrine and endocrine glands, AQPs fulfill important roles in the secretion of various fluids involved in food handling. This review summarizes the contribution of AQPs in physiological and pathophysiological stages related to gastrointestinal secretion.<\/jats:p>","DOI":"10.3390\/cells12172170","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T09:48:15Z","timestamp":1693388895000},"page":"2170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Insights into the Function of Aquaporins in Gastrointestinal Fluid Absorption and Secretion in Health and Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4666-9546","authenticated-orcid":false,"given":"Giuseppe","family":"Calamita","sequence":"first","affiliation":[{"name":"Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-5824","authenticated-orcid":false,"given":"Christine","family":"Delporte","sequence":"additional","affiliation":[{"name":"Laboratory of Pathophysiological and Nutritional Biochemistry, Faculty of Medicine, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1002\/anie.200460804","article-title":"Aquaporin Water Channels (Nobel Lecture)","volume":"43","author":"Agre","year":"2004","journal-title":"Angew. 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