{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:25:01Z","timestamp":1789467901421,"version":"build-2803163510"},"reference-count":161,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, New Delhi toMS","doi-asserted-by":"publisher","award":["DST\/WOS-A\/LS-61\/2021"],"award-info":[{"award-number":["DST\/WOS-A\/LS-61\/2021"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Avascular necrosis of the femoral head (ANFH) is a painful disorder characterized by the cessation of blood supply to the femoral head, leading to its death and subsequent joint collapse. Influenced by several risk factors, including corticosteroid use, excessive alcohol intake, hypercholesterolemia, smoking and some inflammatory disorders, along with cancer, its clinical consequences are thrombus formation due to underlying inflammation and endothelial dysfunction, which collaborates with coagulopathy and impaired angiogenesis. Nonetheless, angiogenesis resolves the obstructed free flow of the blood by providing alternative routes. Clinical manifestations of early stage of ANFH mimic cysts or lesions in subchondral bone, vasculitis and transient osteoporosis of the hip, rendering it difficult to diagnose, complex to understand and complicated to cure. To date, the treatment methods for ANFH are controversial as no foolproof curative strategy is available, and these depend upon different severity levels of the ANFH. From an in-depth understanding of the pathological determinants of ANFH, it is clear that impaired angiogenesis, coagulopathy and endothelial dysfunction contribute significantly. The present review has set two aims, firstly to examine the role and relevance of this molecular triad (impaired angiogenesis, coagulopathy and endothelial dysfunction) in ANFH pathology and secondly to propose some putative therapeutic strategies, delineating the fact that, for the better management of ANFH, a combined strategy to curtail this molecular triangle must be composed rather than focusing on individual contributions.<\/jats:p>","DOI":"10.3390\/cells12182278","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T03:50:10Z","timestamp":1694749810000},"page":"2278","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A Molecular Troika of Angiogenesis, Coagulopathy and Endothelial Dysfunction in the Pathology of Avascular Necrosis of Femoral Head: A Comprehensive Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Monica","family":"Singh","sequence":"first","affiliation":[{"name":"Division of Molecular Genetics, Department of Human Genetics, Punjabi University, Patiala 147002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baani","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetics, Department of Human Genetics, Punjabi University, Patiala 147002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetics, Department of Human Genetics, Punjabi University, Patiala 147002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetics, Department of Human Genetics, Punjabi University, Patiala 147002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9553-4886","authenticated-orcid":false,"given":"Sarabjit","family":"Mastana","sequence":"additional","affiliation":[{"name":"Human Genomics Laboratory, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2154-4261","authenticated-orcid":false,"given":"Puneetpal","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetics, Department of Human Genetics, Punjabi University, Patiala 147002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10721","DOI":"10.1038\/s41598-017-10817-w","article-title":"Avascular Necrosis of Femoral Head: A Metabolomic, Biophysical, Biochemical, Electron Microscopic and Histopathological Characterization","volume":"7","author":"Narayanan","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_2","first-page":"e21.00176","article-title":"Osteonecrosis of the Femoral Head","volume":"6","author":"George","year":"2022","journal-title":"J. Am. Acad. Orthop. Surg. Glob. Res. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1302\/2058-5241.4.180036","article-title":"Osteonecrosis of the Femoral Head: Pathophysiology and Current Concepts of Treatment","volume":"4","author":"Petek","year":"2019","journal-title":"EFORT Open Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10623320600904211","article-title":"Avascular Necrosis of the Femoral Head: Vascular Hypotheses","volume":"13","author":"Kerachian","year":"2006","journal-title":"Endothelium"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1014789","DOI":"10.3389\/fcell.2022.1014789","article-title":"The Therapeutic Effect of Adipose-Derived Lipoaspirate Cells in Femoral Head Necrosis by Improving Angiogenesis","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1359\/jbmr.040911","article-title":"Increased VEGF Expression in the Epiphyseal Cartilage after Ischemic Necrosis of the Capital Femoral Epiphysis","volume":"19","author":"Kim","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"515","DOI":"10.4103\/0019-5049.144643","article-title":"Overview of the Coagulation System","volume":"58","author":"Palta","year":"2014","journal-title":"Indian J. Anaesth."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e7047","DOI":"10.1097\/MD.0000000000007047","article-title":"Association between Plasminogen Activator Inhibitor Gene Polymorphisms and Osteonecrosis of the Femoral Head Susceptibility: A Case-Control Study","volume":"96","author":"Li","year":"2017","journal-title":"Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/s11999-008-0148-0","article-title":"Heritable Thrombophilia-Hypofibrinolysis and Osteonecrosis of the Femoral Head","volume":"466","author":"Glueck","year":"2008","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2174\/1874192401004010302","article-title":"The Endothelium and Its Role in Regulating Vascular Tone","volume":"4","author":"Sandoo","year":"2010","journal-title":"Open Cardiovasc. Med. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/0003319720987752","article-title":"Endothelial Dysfunction and Its Clinical Implications","volume":"72","author":"Poredos","year":"2021","journal-title":"Angiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"40L","DOI":"10.1016\/S0002-9149(02)02963-6","article-title":"Endothelial Function. From Vascular Biology to Clinical Applications","volume":"90","author":"Behrendt","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1586\/14779072.5.3.441","article-title":"Hypertension: Endothelial Dysfunction, the Prothrombotic State and Antithrombotic Therapy","volume":"5","author":"Kakar","year":"2007","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_14","first-page":"149","article-title":"Avascular Necrosis of the Femoral Head: Are Any Genes Involved?","volume":"3","author":"Pouya","year":"2015","journal-title":"Arch. Bone Jt. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kretschmer, M., R\u00fcdiger, D., and Zahler, S. (2021). Mechanical Aspects of Angiogenesis. Cancers, 13.","DOI":"10.3390\/cancers13194987"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/jcb.21523","article-title":"Vasculogenesis, Angiogenesis, and Arteriogenesis: Mechanisms of Blood Vessel Formation and Remodeling","volume":"102","author":"Semenza","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ashraf, J.V., and Al Haj Zen, A. (2021). Role of Vascular Smooth Muscle Cell Phenotype Switching in Arteriogenesis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910585"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/03009734.2015.1064501","article-title":"Vascular Permeability--the Essentials","volume":"120","year":"2015","journal-title":"Upsala J. Med. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1017\/S1431927611012402","article-title":"Endothelial Cell-Pericyte Interactions Stimulate Basement Membrane Matrix Assembly: Influence on Vascular Tube Remodeling, Maturation, and Stabilization","volume":"18","author":"Stratman","year":"2012","journal-title":"Microsc. Microanal."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"127170","DOI":"10.1155\/2013\/127170","article-title":"Angiogenesis and Its Therapeutic Opportunities","volume":"2013","author":"Yoo","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0306-9877(97)90067-0","article-title":"Is Avascular Necrosis of the Femoral Head the Result of Inhibition of Angiogenesis?","volume":"49","author":"Smith","year":"1997","journal-title":"Med. Hypotheses"},{"key":"ref_22","first-page":"294","article-title":"[Assessment of the local blood supply when femoral neck fracture occurs:advances in the anatomy research and its clinical application]","volume":"36","author":"Wu","year":"2023","journal-title":"Zhongguo Gu Shang"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/ca.23390","article-title":"Anatomic Characterization of the Femoral Nutrient Artery: Application to Fracture and Surgery of the Femur","volume":"33","author":"Kawasaki","year":"2020","journal-title":"Clin. Anat."},{"key":"ref_24","first-page":"AC01","article-title":"Cadaveric Study of Profunda Femoris Artery with Some Unique Variations","volume":"9","author":"Rajani","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1007\/s11999-017-5318-5","article-title":"Epiphyseal Arterial Network and Inferior Retinacular Artery Seem Critical to Femoral Head Perfusion in Adults With Femoral Neck Fractures","volume":"475","author":"Zhao","year":"2017","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/ten.teb.2020.0154","article-title":"Bone Microvasculature: Stimulus for Tissue Function and Regeneration","volume":"27","author":"Lee","year":"2021","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41584-019-0274-y","article-title":"Next-Generation Imaging of the Skeletal System and Its Blood Supply","volume":"15","author":"Kling","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s42255-018-0016-5","article-title":"A Network of Trans-Cortical Capillaries as Mainstay for Blood Circulation in Long Bones","volume":"1","author":"Hawwari","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of Angiogenesis and Osteogenesis by a Specific Vessel Subtype in Bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/jbm.b.35243","article-title":"Type H Blood Vessels in Coupling Angiogenesis-Osteogenesis and Its Application in Bone Tissue Engineering","volume":"111","author":"Xu","year":"2023","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/rheumatology\/keac539","article-title":"Type H Vessels-a Bridge Connecting Subchondral Bone Remodelling and Articular Cartilage Degeneration in Osteoarthritis Development","volume":"62","author":"Liu","year":"2023","journal-title":"Rheumatology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2106\/JBJS.20.00490","article-title":"Relationship Between Blood Flow and Collapse of Nontraumatic Osteonecrosis of the Femoral Head","volume":"104","author":"Zheng","year":"2022","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_33","first-page":"2224","article-title":"Angiogenesis and Signal Transduction in Endothelial Cells","volume":"61","author":"Quesada","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12079-017-0433-3","article-title":"Integration of Pro- and Anti-Angiogenic Signals by Endothelial Cells","volume":"12","author":"Kazerounian","year":"2018","journal-title":"J. Cell Commun. Signal."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ding, H., Gao, Y.-S., Hu, C., Wang, Y., Wang, C.-G., Yin, J.-M., Sun, Y., and Zhang, C.-Q. (2013). HIF-1\u03b1 Transgenic Bone Marrow Cells Can Promote Tissue Repair in Cases of Corticosteroid-Induced Osteonecrosis of the Femoral Head in Rabbits. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063628"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0195-668X(02)00635-8","article-title":"Angiogenesis: Basic Pathophysiology and Implications for Disease","volume":"24","author":"Felmeden","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-018-0019-6","article-title":"Paracrine and Endocrine Actions of Bone-the Functions of Secretory Proteins from Osteoblasts, Osteocytes, and Osteoclasts","volume":"6","author":"Han","year":"2018","journal-title":"Bone Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1050-1738(97)00091-1","article-title":"Ischemia-Driven Angiogenesis","volume":"7","author":"Dor","year":"1997","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Corrado, C., and Fontana, S. (2020). Hypoxia and HIF Signaling: One Axis with Divergent Effects. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165611"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bone.2016.06.013","article-title":"The Roles of Vascular Endothelial Growth Factor in Bone Repair and Regeneration","volume":"91","author":"Hu","year":"2016","journal-title":"Bone"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1177\/1947601911423031","article-title":"Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies","volume":"2","author":"Shibuya","year":"2011","journal-title":"Genes Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1093\/emboj\/18.14.3964","article-title":"VEGF Contributes to Postnatal Neovascularization by Mobilizing Bone Marrow-Derived Endothelial Progenitor Cells","volume":"18","author":"Asahara","year":"1999","journal-title":"EMBO J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ijos.2012.33","article-title":"The Role of Vascular Endothelial Growth Factor in Ossification","volume":"4","author":"Yang","year":"2012","journal-title":"Int. J. Oral Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1242\/dev.01053","article-title":"VEGFA Is Necessary for Chondrocyte Survival during Bone Development","volume":"131","author":"Zelzer","year":"2004","journal-title":"Development"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/jor.20097","article-title":"Expression of the Angiomatrix and Angiogenic Proteins CYR61, CTGF, and VEGF in Osteonecrosis of the Femoral Head","volume":"24","author":"Radke","year":"2006","journal-title":"J. Orthop. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/srep00650","article-title":"Regulation of VEGF Expression by HIF-1\u03b1 in the Femoral Head Cartilage Following Ischemia Osteonecrosis","volume":"2","author":"Zhang","year":"2012","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.152324099","article-title":"Vascular Endothelial Growth Factor Stimulates Bone Repair by Promoting Angiogenesis and Bone Turnover","volume":"99","author":"Street","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1172\/JCI82585","article-title":"Osteoblast-Derived VEGF Regulates Osteoblast Differentiation and Bone Formation during Bone Repair","volume":"126","author":"Hu","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1128\/MCB.01055-15","article-title":"The Endothelial Prolyl-4-Hydroxylase Domain 2\/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice","volume":"36","author":"Kapitsinou","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/ncb0808-883","article-title":"VE-Cadherin and Claudin-5: It Takes Two to Tango","volume":"10","author":"Gavard","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular Mechanisms and Clinical Applications of Angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1096\/fj.02-0691fje","article-title":"Extracellular Matrix-Bound Vascular Endothelial Growth Factor Promotes Endothelial Cell Adhesion, Migration, and Survival through Integrin Ligation","volume":"17","author":"Hutchings","year":"2003","journal-title":"FASEB J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.devcel.2008.12.009","article-title":"Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis","volume":"16","author":"Phng","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1215\/S1152851705000232","article-title":"The Role of Pericytes in Blood-Vessel Formation and Maintenance","volume":"7","author":"Bergers","year":"2005","journal-title":"Neuro-Oncology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/jcp.2003.014472","article-title":"Membrane Associated Proteases and Their Inhibitors in Tumour Angiogenesis","volume":"57","author":"Noel","year":"2004","journal-title":"J. Clin. Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5345673","DOI":"10.1155\/2017\/5345673","article-title":"Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis","volume":"2017","author":"Cantatore","year":"2017","journal-title":"BioMed Res. Int."},{"key":"ref_57","first-page":"37","article-title":"Different Contributions of Angiostatin and Endostatin in Angiogenesis Impairment in Systemic Sclerosis: A Cohort Study","volume":"34","author":"Almeida","year":"2016","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1161\/CIRCRESAHA.111.242057","article-title":"Overexpression of VEGF165b, an Inhibitory Splice Variant of Vascular Endothelial Growth Factor, Leads to Insufficient Angiogenesis in Patients with Systemic Sclerosis","volume":"109","author":"Manetti","year":"2011","journal-title":"Circ. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2478\/v10039-011-0025-z","article-title":"Peripheral Blood Mononuclear Cells from Patients with Systemic Sclerosis Spontaneously Secrete Increased Amounts of Vascular Endothelial Growth Factor (VEGF) Already in the Early Stage of the Disease","volume":"56","author":"Bielecki","year":"2011","journal-title":"Adv. Med. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s13075-015-0848-2","article-title":"Inhibition of Angiogenesis by Platelets in Systemic Sclerosis Patients","volume":"17","author":"Hirigoyen","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2106\/JBJS.I.00157","article-title":"Coagulation Abnormalities in Legg-Calv\u00e9-Perthes Disease","volume":"92","author":"Vosmaer","year":"2010","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1073\/pnas.90.3.1004","article-title":"Familial Thrombophilia Due to a Previously Unrecognized Mechanism Characterized by Poor Anticoagulant Response to Activated Protein C: Prediction of a Cofactor to Activated Protein C","volume":"90","author":"Carlsson","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1056\/NEJM199402243300801","article-title":"Resistance to Activated Protein C as a Basis for Venous Thrombosis","volume":"330","author":"Svensson","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.semnephrol.2004.06.004","article-title":"Plasma Levels of Plasminogen Activator Inhibitor Type 1, Factor VIII, Prothrombin Activation Fragment 1+2, Anticardiolipin, and Antiprothrombin Antibodies Are Risk Factors for Thrombosis in Hemodialysis Patients","volume":"24","author":"Molino","year":"2004","journal-title":"Semin. Nephrol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1182\/blood.V75.7.1498.1498","article-title":"High von Willebrand Factor Concentration Compensates a Relative Adhesion Defect in Uremic Blood","volume":"75","author":"Zwaginga","year":"1990","journal-title":"Blood"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1161\/01.CIR.95.2.295","article-title":"Lipoprotein(a), a Clinically Elusive Lipoprotein Particle","volume":"95","author":"Fortmann","year":"1997","journal-title":"Circulation"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0140-6736(93)91477-4","article-title":"The Antiphospholipid Syndrome: Ten Years On","volume":"342","author":"Hughes","year":"1993","journal-title":"Lancet"},{"key":"ref_68","first-page":"1117","article-title":"Nontraumatic Osteonecrosis of the Femoral Head: Ten Years Later","volume":"88","author":"Mont","year":"2006","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1001\/jama.1960.03030080028005","article-title":"Avascular (Aseptic) Bone Necrosis Associated with Systemic Lupus Erythematosus","volume":"174","author":"Dubois","year":"1960","journal-title":"JAMA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1302\/0301-620X.73B6.1955442","article-title":"Sickle Cell Disease and Silent Avascular Necrosis of the Hip","volume":"73","author":"Ware","year":"1991","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e202203473","DOI":"10.1002\/chem.202203473","article-title":"Activity Sensing of Coagulation and Fibrinolytic Proteases","volume":"29","author":"Sondag","year":"2023","journal-title":"Chemistry"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1182\/blood-2018-10-862243","article-title":"Neutrophils: Back in the Thrombosis Spotlight","volume":"133","author":"Noubouossie","year":"2019","journal-title":"Blood"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1161\/ATVBAHA.108.177402","article-title":"Tissue Factor in Coagulation: Which? Where? When?","volume":"29","author":"Butenas","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"113708","DOI":"10.1016\/j.ab.2020.113708","article-title":"Inhibitors of Blood Coagulation Factor XIII","volume":"605","author":"Schmitz","year":"2020","journal-title":"Anal. Biochem."},{"key":"ref_75","first-page":"319","article-title":"Mechanism Action of Platelets and Crucial Blood Coagulation Pathways in Hemostasis","volume":"11","author":"Periayah","year":"2017","journal-title":"Int. J. Hematol. Oncol. Stem Cell Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1055\/s-0042-1757562","article-title":"Markers of Hereditary Thrombophilia with Unclear Significance","volume":"42","author":"Sachs","year":"2022","journal-title":"Hamostaseologie"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1359-6101(98)00024-0","article-title":"Cytokine Regulation of Cellular Adhesion Molecule Expression in Inflammation","volume":"10","author":"Meager","year":"1999","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s40560-014-0065-0","article-title":"PAMPs and DAMPs as Triggers for DIC","volume":"2","author":"Ito","year":"2014","journal-title":"J. Intensive Care"},{"key":"ref_79","first-page":"417","article-title":"Role of Thrombosis in Osteonecrosis","volume":"2","author":"Glueck","year":"2003","journal-title":"Curr. Hematol. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1749-6632.1992.tb51616.x","article-title":"Correlation of in Vitro and in Vivo Decreased Fibrinolytic Activity Caused by Dexamethasone","volume":"667","author":"Jansen","year":"1992","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jsbmb.2009.02.007","article-title":"Glucocorticoids in Osteonecrosis of the Femoral Head: A New Understanding of the Mechanisms of Action","volume":"114","author":"Kerachian","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00003086-199909000-00017","article-title":"The Plasminogen Activator Inhibitor-1 Gene, Hypofibrinolysis, and Osteonecrosis","volume":"366","author":"Glueck","year":"1999","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/09537109876753","article-title":"Increased Platelet Activation and Decreased Fibrinolysis in the Pathogenesis of Aseptic Necrosis of the Femoral Head","volume":"9","author":"Szepesi","year":"1998","journal-title":"Platelets"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1177\/0300060517700299","article-title":"Role of Coagulopathy in Glucocorticoid-Induced Osteonecrosis of the Femoral Head","volume":"46","author":"Zhang","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Pacinella, G., Ciaccio, A.M., and Tuttolomondo, A. (2022). Endothelial Dysfunction and Chronic Inflammation: The Cornerstones of Vascular Alterations in Age-Related Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415722"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2840-5-4","article-title":"Endothelial Dysfunction: A Comprehensive Appraisal","volume":"5","author":"Esper","year":"2006","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/CIRCRESAHA.118.313591","article-title":"Immunity and Inflammation in Atherosclerosis","volume":"124","author":"Wolf","year":"2019","journal-title":"Circ. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3892\/mco.2015.684","article-title":"Adenocarcinoma of the Lung with Concomitant ALK Fusion Gene and EGFR Gene Mutation: A Case Report and Literature Review","volume":"4","author":"Fan","year":"2016","journal-title":"Mol. Clin. Oncol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1096\/fasebj.7.14.8224609","article-title":"Proatherosclerotic Events: Pathobiochemical Changes Occurring in the Arterial Wall before Monocyte Migration","volume":"7","author":"Simionescu","year":"1993","journal-title":"FASEB J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1161\/01.CIR.94.8.2013","article-title":"Stability and Instability: Two Faces of Coronary Atherosclerosis. The Paul Dudley White Lecture 1995","volume":"94","author":"Davies","year":"1996","journal-title":"Circulation"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/eurheartj\/ehv044","article-title":"TLR2 and Neutrophils Potentiate Endothelial Stress, Apoptosis and Detachment: Implications for Superficial Erosion","volume":"36","author":"Quillard","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/10623320490482664","article-title":"Endothelial Function and Oxidative Stress","volume":"11","author":"Ogita","year":"2004","journal-title":"Endothelium"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.atherosclerosis.2014.09.001","article-title":"Vascular Oxidative Stress, Nitric Oxide and Atherosclerosis","volume":"237","author":"Li","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric Oxide Synthases: Regulation and Function","volume":"33","author":"Sessa","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"9943","DOI":"10.1073\/pnas.180155397","article-title":"Relative Role of Heme Nitrosylation and Beta-Cysteine 93 Nitrosation in the Transport and Metabolism of Nitric Oxide by Hemoglobin in the Human Circulation","volume":"97","author":"Gladwin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pharmthera.2013.07.004","article-title":"Nitric Oxide Synthase Inhibition and Oxidative Stress in Cardiovascular Diseases: Possible Therapeutic Targets?","volume":"140","author":"Rochette","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"354517","DOI":"10.1155\/2015\/354517","article-title":"Human MiR-221\/222 in Physiological and Atherosclerotic Vascular Remodeling","volume":"2015","author":"Chistiakov","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11239-018-1684-4","article-title":"MicroRNAs Regulate Nitric Oxide Release from Endothelial Cells by Targeting NOS3","volume":"46","author":"Qin","year":"2018","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_99","first-page":"e35368","article-title":"Avascular Necrosis as a Sequela of COVID-19: A Case Series","volume":"15","author":"Parikh","year":"2023","journal-title":"Cureus"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e248583","DOI":"10.1136\/bcr-2021-248583","article-title":"Secondary Osteonecrosis of the Knee as a Part of Long COVID-19 Syndrome: A Case Series","volume":"15","author":"Agarwala","year":"2022","journal-title":"BMJ Case Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s00296-023-05373-8","article-title":"Femoral Head Avascular Necrosis in COVID-19 Survivors: A Systematic Review","volume":"43","author":"Hassan","year":"2023","journal-title":"Rheumatol. Int."},{"key":"ref_102","first-page":"5207","article-title":"Comparison of Core Decompression and Conservative Treatment for Avascular Necrosis of Femoral Head at Early Stage: A Meta-Analysis","volume":"8","author":"Hong","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s13018-020-01786-4","article-title":"Study on the Outcome of Patients with Aseptic Femoral Head Necrosis Treated with Percutaneous Multiple Small-Diameter Drilling Core Decompression: A Retrospective Cohort Study Based on Magnetic Resonance Imaging and Equivalent Sphere Model Analysis","volume":"15","author":"Tan","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"716538","DOI":"10.1155\/2014\/716538","article-title":"Efficacy of Alendronate for Preventing Collapse of Femoral Head in Adult Patients with Nontraumatic Osteonecrosis","volume":"2014","author":"Hong","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/scrt505","article-title":"Efficacy of Autologous Bone Marrow Buffy Coat Grafting Combined with Core Decompression in Patients with Avascular Necrosis of Femoral Head: A Prospective, Double-Blinded, Randomized, Controlled Study","volume":"5","author":"Ma","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e15119","DOI":"10.1097\/MD.0000000000015119","article-title":"Effectiveness of Extracorporeal Shock Wave Monotherapy for Avascular Necrosis of Femoral Head: A Systematic Review Protocol of Randomized Controlled Trial","volume":"98","author":"Tang","year":"2019","journal-title":"Medicine"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/SAP.0000000000001178","article-title":"Different Recipient Vessels for Free Microsurgical Fibula Flaps in the Treatment of Avascular Necrosis of the Femoral Head: A Systematic Review and Meta-Analysis","volume":"79","author":"Tu","year":"2017","journal-title":"Ann. Plast. Surg."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2174\/1389201024666230330100423","article-title":"Therapeutic Assessment of Crystalloid Fluid Resuscitation in Experimental Military Injury","volume":"25","author":"Li","year":"2023","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"28891","DOI":"10.1021\/acsami.3c01539","article-title":"Engineered Exosome-Functionalized Extracellular Matrix-Mimicking Hydrogel for Promoting Bone Repair in Glucocorticoid-Induced Osteonecrosis of the Femoral Head","volume":"15","author":"Chen","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"4006184","DOI":"10.1155\/2022\/4006184","article-title":"Vitamin B2 Prevents Glucocorticoid-Caused Damage of Blood Vessels in Osteonecrosis of the Femoral Head","volume":"2022","author":"Guo","year":"2022","journal-title":"BioMed Res. Int."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"713540","DOI":"10.3389\/fimmu.2021.713540","article-title":"Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease","volume":"12","author":"Ren","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Sarsenova, M., Issabekova, A., Abisheva, S., Rutskaya-Moroshan, K., Ogay, V., and Saparov, A. (2021). Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111592"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"23371","DOI":"10.1038\/s41598-021-02637-w","article-title":"Local Delivery of Hydrogel Encapsulated Vascular Endothelial Growth Factor for the Prevention of Medication-Related Osteonecrosis of the Jaw","volume":"11","author":"Sharma","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1039\/D0BM01821J","article-title":"Biomimetic Nanofibrous Hybrid Hydrogel Membranes with Sustained Growth Factor Release for Guided Bone Regeneration","volume":"9","author":"Yuan","year":"2021","journal-title":"Biomater. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.carrev.2020.04.031","article-title":"Hyperbaric Oxygen Therapy Following Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction","volume":"27","author":"Quintana","year":"2021","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"120223","DOI":"10.1016\/j.biomaterials.2020.120223","article-title":"Sequential Growth Factor Releasing Double Cryogel System for Enhanced Bone Regeneration","volume":"257","author":"Lee","year":"2020","journal-title":"Biomaterials"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1186\/s13287-019-1426-3","article-title":"Exosomes Derived from Human CD34+ Stem Cells Transfected with MiR-26a Prevent Glucocorticoid-Induced Osteonecrosis of the Femoral Head by Promoting Angiogenesis and Osteogenesis","volume":"10","author":"Zuo","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/joic.12539","article-title":"Adjunctive Laser-Stimulated Stem-Cells Therapy to Primary Reperfusion in Acute Myocardial Infarction in Humans: Safety and Feasibility Study","volume":"31","author":"Sud","year":"2018","journal-title":"J. Interv. Cardiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.actbio.2018.07.050","article-title":"Dual Release of Growth Factor from Nanocomposite Fibrous Scaffold Promotes Vascularisation and Bone Regeneration in Rat Critical Sized Calvarial Defect","volume":"78","author":"Kuttappan","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1002\/sctm.17-0039","article-title":"Acceleration of Fracture Healing by Overexpression of Basic Fibroblast Growth Factor in the Mesenchymal Stromal Cells","volume":"6","author":"Zhang","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"232","DOI":"10.7150\/ijbs.16951","article-title":"Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis","volume":"13","author":"Liu","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"ref_122","first-page":"80","article-title":"The Effect of HIF Stabilizer on Distraction Osteogenesis","volume":"49","year":"2015","journal-title":"Acta Orthop. Traumatol. Turc."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1021\/nn400171w","article-title":"Efficient Pro-Survival\/Angiogenic MiRNA Delivery by an MRI-Detectable Nanomaterial","volume":"7","author":"Gomes","year":"2013","journal-title":"ACS Nano"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/mt.2009.315","article-title":"Mesenchymal Stem Cells Expressing Osteogenic and Angiogenic Factors Synergistically Enhance Bone Formation in a Mouse Model of Segmental Bone Defect","volume":"18","author":"Kumar","year":"2010","journal-title":"Mol. Ther."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jor.20453","article-title":"Accelerated Fracture Healing in the Geriatric, Osteoporotic Rat with Recombinant Human Platelet-Derived Growth Factor-BB and an Injectable Beta-Tricalcium Phosphate\/Collagen Matrix","volume":"26","author":"Hollinger","year":"2008","journal-title":"J. Orthop. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.lfs.2006.11.023","article-title":"Erythropoietin (EPO): EPO-Receptor Signaling Improves Early Endochondral Ossification and Mechanical Strength in Fracture Healing","volume":"80","author":"Holstein","year":"2007","journal-title":"Life Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1359\/JBMR.050708","article-title":"VEGF Improves, Whereas SFlt1 Inhibits, BMP2-Induced Bone Formation and Bone Healing through Modulation of Angiogenesis","volume":"20","author":"Peng","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1365-2613.1999.00129.x","article-title":"New Vessels, New Approaches: Angiogenesis as a Therapeutic Target in Musculoskeletal Disorders","volume":"80","author":"Ballara","year":"1999","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"100343","DOI":"10.1016\/j.ocarto.2023.100343","article-title":"The Effect of Pentosan Polysulfate Sodium for Improving Dyslipidaemia and Knee Pain in People with Knee Osteoarthritis: A Pilot Study","volume":"5","author":"Liu","year":"2023","journal-title":"Osteoarthr. Cartil. Open."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1060733","DOI":"10.3389\/fneur.2023.1060733","article-title":"Efficacy and Safety of Low Dose Aspirin plus Clopidogrel in the Treatment of Elderly Patients with Symptomatic Intracranial Artery Stenosis","volume":"14","author":"Song","year":"2023","journal-title":"Front. Neurol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1165237","DOI":"10.3389\/fneur.2023.1165237","article-title":"Low-Dose vs. Standard-Dose Intravenous Alteplase for Acute Ischemic Stroke with Unknown Time of Onset","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Neurol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"191","DOI":"10.14715\/cmb\/2023.69.3.28","article-title":"Transitioning to Unfractionated Heparin in Treatment of Non-ST-Segment Elevation Myocardial Infarction Patients on Direct Oral Anti-Xa Inhibitors","volume":"69","author":"Tashani","year":"2023","journal-title":"Cell. Mol. Biol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1039\/D2BM00746K","article-title":"Urokinase Loaded Black Phosphorus Nanosheets for Sequential Thrombolysis and Reactive Oxygen Species Scavenging in Ischemic Stroke Treatment","volume":"10","author":"Wang","year":"2022","journal-title":"Biomater. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/ana.26445","article-title":"Intravenous Thrombolysis with Tenecteplase for the Treatment of Acute Ischemic Stroke","volume":"92","author":"Tsivgoulis","year":"2022","journal-title":"Ann. Neurol."},{"key":"ref_135","first-page":"11","article-title":"Rivaroxaban, a New Molecule with Potential to Balance Bleeding Risk and Ischemic Events in Patients with Chronic Coronary Syndrome","volume":"70","author":"Shirodkar","year":"2022","journal-title":"J. Assoc. Physicians India"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4330\/wjc.v14.i1.40","article-title":"Fondaparinux: A Cornerstone Drug in Acute Coronary Syndromes","volume":"14","author":"Khan","year":"2022","journal-title":"World J. Cardiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s11096-022-01383-x","article-title":"The Outcomes of Reperfusion Therapy with Streptokinase versus Tenecteplase in ST-Elevation Myocardial Infarction (STEMI): A Propensity-Matched Retrospective Analysis in an Asian Population","volume":"44","author":"Koh","year":"2022","journal-title":"Int. J. Clin. Pharm."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"967658","DOI":"10.3389\/fimmu.2022.967658","article-title":"Etanercept\/Celecoxib on Improving MRI Inflammation of Active Ankylosing Spondylitis: A Multicenter, Open-Label, Randomized Clinical Trial","volume":"13","author":"Tu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s41232-020-00128-5","article-title":"Roles of Fibrinolytic Factors in the Alterations in Bone Marrow Hematopoietic Stem\/Progenitor Cells during Bone Repair","volume":"40","author":"Okada","year":"2020","journal-title":"Inflamm. Regen."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2050313X19827747","DOI":"10.1177\/2050313X19827747","article-title":"Long-Term Direct Oral Anticoagulation in Primary Osteonecrosis with Elevated Plasminogen Activation Inhibitor","volume":"7","author":"Haydock","year":"2019","journal-title":"SAGE Open Med. Case Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1248\/bpb.b18-00683","article-title":"Applications of Liposomal Drug Delivery Systems to Develop Neuroprotective Agents for the Treatment of Ischemic Stroke","volume":"42","author":"Fukuta","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1080\/21691401.2019.1573177","article-title":"Antagonism of NK-1R Using Aprepitant Suppresses Inflammatory Response in Rheumatoid Arthritis Fibroblast-like Synoviocytes","volume":"47","author":"Liu","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11655-016-2407-3","article-title":"Effects of Modified Qing\u2019e Pill (\u52a0\u5473\u9752\u5a25\u4e38) on Expression of Adiponectin, Bone Morphogenetic Protein 2 and Coagulation-Related Factors in Patients with Nontraumatic Osteonecrosis of Femoral Head","volume":"23","author":"Li","year":"2017","journal-title":"Chin. J. Integr. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e6667","DOI":"10.1097\/MD.0000000000006667","article-title":"Efficacy and Safety of Desmoteplase in Acute Ischemic Stroke Patients: A Systematic Review and Meta-Analysis","volume":"96","author":"Li","year":"2017","journal-title":"Medicine"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/ccr3.895","article-title":"Providing Full Recovery with Single-Dose Intravenous Reteplase in a Patient Presented to Emergency Department with Acute Ischemic Stroke","volume":"5","author":"Avcil","year":"2017","journal-title":"Clin. Case Rep."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3892\/etm.2016.3322","article-title":"Vitamin E Slows down the Progression of Osteoarthritis","volume":"12","author":"Li","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Dou, C., Han, X., Xie, H., Liao, H., Xiao, X., Huang, Z., Luo, G., Zhang, X., and Yao, W. (2023). Protective Role of Nitric Oxide Donors on Endothelium in Ischemia-Reperfusion Injury: A Meta-Analysis of Randomized Controlled Trials. BMC Anesthesiol., 23.","DOI":"10.1186\/s12871-023-02117-w"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Shao, W., Li, Z., Wang, B., Gong, S., Wang, P., Song, B., Chen, Z., and Feng, Y. (2023). Dimethyloxalylglycine Attenuates Steroid-Associated Endothelial Progenitor Cell Impairment and Osteonecrosis of the Femoral Head by Regulating the HIF-1\u03b1 Signaling Pathway. Biomedicines, 11.","DOI":"10.3390\/biomedicines11040992"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"43","DOI":"10.17219\/acem\/153042","article-title":"CircHIPK3 Promotes Bone Microvascular Endothelial Cell Proliferation, Migration and Angiogenesis by Targeting MiR-7 and KLF4\/VEGF Signaling in Steroid-Induced Osteonecrosis of the Femoral Head","volume":"32","author":"Peng","year":"2023","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"5436771","DOI":"10.1155\/2023\/5436771","article-title":"Chromolaena odorata (L.) R. M. King and H. Robinson Leaves Aqueous Extract Improves the Femoral Head in Ethanol-Induced Osteonecrosis in Rats","volume":"2023","author":"Jouonzo","year":"2023","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Li, T., Li, Z., Lu, J., Wu, X., Gao, F., and Sun, W. (2022). Autocrine Activity of Extracellular Vesicles Induced by Icariin and Its Effectiveness in Glucocorticoid-Induced Injury of Bone Microvascular Endothelial Cells. Cells, 11.","DOI":"10.3390\/cells11121921"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Yu, Y., Lin, L., Liu, K., Jiang, Y., and Zhou, Z. (2022). Effects of Simvastatin on Cartilage Homeostasis in Steroid-Induced Osteonecrosis of Femoral Head by Inhibiting Glucocorticoid Receptor. Cells, 11.","DOI":"10.3390\/cells11243945"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e2001941","DOI":"10.1002\/adhm.202001941","article-title":"Oxidation-Responsive, Tunable Growth Factor Delivery from Polyelectrolyte-Coated Implants","volume":"10","author":"Martin","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13287-020-01658-y","article-title":"PTEN Inhibitor VO-OHpic Attenuates GC-Associated Endothelial Progenitor Cell Dysfunction and Osteonecrosis of the Femoral Head via Activating Nrf2 Signaling and Inhibiting Mitochondrial Apoptosis Pathway","volume":"11","author":"Yao","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Gambardella, J., Khondkar, W., Morelli, M.B., Wang, X., Santulli, G., and Trimarco, V. (2020). Arginine and Endothelial Function. Biomedicines, 8.","DOI":"10.3390\/biomedicines8080277"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Agidigbi, T.S., and Kim, C. (2019). Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143576"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.2147\/IJN.S159776","article-title":"Porous Se@SiO2 Nanocomposites Protect the Femoral Head from Methylprednisolone-Induced Osteonecrosis","volume":"13","author":"Deng","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e868","DOI":"10.3928\/01477447-20170907-01","article-title":"Vitamin D Use and Health Outcomes After Surgery for Hip Fracture","volume":"40","author":"Sprague","year":"2017","journal-title":"Orthopedics"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/0971-5916.195022","article-title":"Angiotensin Receptor Blockers & Endothelial Dysfunction: Possible Correlation & Therapeutic Implications","volume":"144","author":"Radenkovic","year":"2016","journal-title":"Indian J. Med. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"665","DOI":"10.6061\/clinics\/2013(05)14","article-title":"Effects of ACE Inhibition on Endothelial Progenitor Cell Mobilization and Prognosis after Acute Myocardial Infarction in Type 2 Diabetic Patients","volume":"68","author":"Sun","year":"2013","journal-title":"Clinics"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1210\/endo.138.7.5275","article-title":"Anabolic Effects of 1,25-Dihydroxyvitamin D3 on Osteoblasts Are Enhanced by Vascular Endothelial Growth Factor Produced by Osteoblasts and by Growth Factors Produced by Endothelial Cells","volume":"138","author":"Wang","year":"1997","journal-title":"Endocrinology"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/18\/2278\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:51:04Z","timestamp":1760129464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/18\/2278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":161,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["cells12182278"],"URL":"https:\/\/doi.org\/10.3390\/cells12182278","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]}}}