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Spain","award":["UMA20-FEDERJA-112"],"award-info":[{"award-number":["UMA20-FEDERJA-112"]}]},{"name":"Ministerio de Universidades from Spain","award":["PSI2017-83408-P"],"award-info":[{"award-number":["PSI2017-83408-P"]}]},{"name":"Ministerio de Universidades from Spain","award":["FPU16\/05308"],"award-info":[{"award-number":["FPU16\/05308"]}]},{"name":"Ministerio de Universidades from Spain","award":["FPU19\/03629"],"award-info":[{"award-number":["FPU19\/03629"]}]},{"name":"University of Malaga","award":["PID2020-117464RB-I00"],"award-info":[{"award-number":["PID2020-117464RB-I00"]}]},{"name":"University of Malaga","award":["P20_00460"],"award-info":[{"award-number":["P20_00460"]}]},{"name":"University of Malaga","award":["UMA20-FEDERJA-112"],"award-info":[{"award-number":["UMA20-FEDERJA-112"]}]},{"name":"University of Malaga","award":["PSI2017-83408-P"],"award-info":[{"award-number":["PSI2017-83408-P"]}]},{"name":"University of Malaga","award":["FPU16\/05308"],"award-info":[{"award-number":["FPU16\/05308"]}]},{"name":"University of Malaga","award":["FPU19\/03629"],"award-info":[{"award-number":["FPU19\/03629"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Intense stress, especially traumatic stress, can trigger disabling responses and in some cases even lead to the development of posttraumatic stress disorder (PTSD). PTSD is heterogeneous, accompanied by a range of distress symptoms and treatment-resistant disorders that may be associated with a number of other psychopathologies. PTSD is a very heterogeneous disorder with different subtypes that depend on, among other factors, the type of stressor that provokes it. However, the neurobiological mechanisms are poorly understood. The study of early stress responses may hint at the way PTSD develops and improve the understanding of the neurobiological mechanisms involved in its onset, opening the opportunity for possible preventive treatments. Proteomics is a promising strategy for characterizing these early mechanisms underlying the development of PTSD. The aim of the work was to understand how exposure to acute and intense stress using water immersion restraint stress (WIRS), which could be reminiscent of natural disaster, may induce several PTSD-associated symptoms and changes in the hippocampal proteomic profile. The results showed that exposure to WIRS induced behavioural symptoms and corticosterone levels reminiscent of PTSD. Moreover, the expression profiles of hippocampal proteins at 1 h and 24 h after stress were deregulated in favour of increased inflammation and reduced neuroplasticity, which was validated by histological studies and cytokine determination. Taken together, these results suggest that neuroplastic and inflammatory dysregulation may be a therapeutic target for the treatment of post-traumatic stress disorders.<\/jats:p>","DOI":"10.3390\/cells12182290","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:36:45Z","timestamp":1694932605000},"page":"2290","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling the Secrets of the Stressed Hippocampus: Exploring Proteomic Changes and Neurobiology of Posttraumatic Stress Disorder"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-1122","authenticated-orcid":false,"given":"Andrea","family":"Nieto-Quero","sequence":"first","affiliation":[{"name":"Departamento de Psicobiolog\u00eda y Metodolog\u00eda de las Ciencias del Comportamiento, Universidad de M\u00e1laga, 29010 Malaga, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma Bionand, 29590 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9472-985X","authenticated-orcid":false,"given":"Mar\u00eda Inmaculada","family":"Infantes-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma Bionand, 29590 Malaga, Spain"},{"name":"Departamento de Biolog\u00eda Celular, Gen\u00e9tica y Fisiolog\u00eda, Universidad de M\u00e1laga, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Zambrana-Infantes","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiolog\u00eda y Metodolog\u00eda de las Ciencias del Comportamiento, Universidad de M\u00e1laga, 29010 Malaga, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodr\u00edguez de Fonseca","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma Bionand, 29590 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-1361","authenticated-orcid":false,"given":"Mar\u00eda Inmaculada","family":"Garc\u00eda-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina-IBIMA Plataforma Bionand, 29590 Malaga, Spain"},{"name":"Departamento de Fisiolog\u00eda Humana, Histolog\u00eda Humana, Anatom\u00eda Patol\u00f3gica y Educaci\u00f3n F\u00edsica y Deportiva, Universidad de M\u00e1laga, 29010 Malaga, 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