{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:50:50Z","timestamp":1785336650358,"version":"3.55.0"},"reference-count":70,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi Science and Technology Key Research and Development Program","award":["AB16450012"],"award-info":[{"award-number":["AB16450012"]}]},{"name":"Guangxi Science and Technology Key Research and Development Program","award":["MRP\/027\/18X"],"award-info":[{"award-number":["MRP\/027\/18X"]}]},{"name":"Innovation and Technology Commission of Hong Kong","award":["AB16450012"],"award-info":[{"award-number":["AB16450012"]}]},{"name":"Innovation and Technology Commission of Hong Kong","award":["MRP\/027\/18X"],"award-info":[{"award-number":["MRP\/027\/18X"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Breast cancer (BC) is the most common cancer among women worldwide and the main cause of cancer deaths in women. Metabolic components are key risk factors for the development of non-alcoholic fatty liver disease (NAFLD), which may promote BC. Studies have reported that increasing PGC1\u03b1 levels increases mitochondrial biogenesis, thereby increasing cell proliferation and metastasis. Moreover, the PGC1\u03b1\/ERR\u03b1 axis is a crucial regulator of cellular metabolism in various tissues, including BC. However, it remains unclear whether NAFLD is closely associated with the risk of BC. Therefore, the present study aimed to determine whether hepatic PGC1\u03b1 promotes BC cell invasion via ERR\u03b1. Various assays, including ELISA, western blotting, and immunoprecipitation, have been employed to explore these mechanisms. According to the KM plot and TCGA data, elevated PGC1\u03b1 expression was highly associated with a shorter overall survival time in patients with BC. High concentrations of palmitic acid (PA) promoted PGC1\u03b1 expression, lipogenesis, and inflammatory processes in hepatocytes. Conditioned medium obtained from PA-treated hepatocytes significantly increased BC cell proliferation. Similarly, recombinant PGC1\u03b1 in E0771 and MCF7 cells promoted cell proliferation, migration, and invasion in vitro. However, silencing PGC1\u03b1 in both BC cell lines resulted in a decrease in this trend. As determined by immunoprecipitation assay, PCG1a interacted with ERR\u03b1, thereby facilitating the proliferation of BC cells. This outcome recognizes the importance of further investigations in exploring the full potential of hepatic PGC1\u03b1 as a prognostic marker for BC development.<\/jats:p>","DOI":"10.3390\/cells12182311","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T23:11:52Z","timestamp":1695165112000},"page":"2311","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unraveling the Role of Hepatic PGC1\u03b1 in Breast Cancer Invasion: A New Target for Therapeutic Intervention?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3198-6066","authenticated-orcid":false,"given":"Kumar","family":"Ganesan","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sui","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-5271","authenticated-orcid":false,"given":"Jianping","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, China"},{"name":"Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen 518057, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jhep.2020.02.020","article-title":"Update on NAFLD genetics: From new variants to the clinic","volume":"72","author":"Valenti","year":"2020","journal-title":"J. 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