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China","award":["81874289"],"award-info":[{"award-number":["81874289"]}]},{"name":"National Natural Science Foundation of China","award":["CPU2022PZQ12"],"award-info":[{"award-number":["CPU2022PZQ12"]}]},{"name":"China Pharmaceutical University","award":["BK20192005"],"award-info":[{"award-number":["BK20192005"]}]},{"name":"China Pharmaceutical University","award":["BK20221051"],"award-info":[{"award-number":["BK20221051"]}]},{"name":"China Pharmaceutical University","award":["SZSM201801060"],"award-info":[{"award-number":["SZSM201801060"]}]},{"name":"China Pharmaceutical University","award":["82073928"],"award-info":[{"award-number":["82073928"]}]},{"name":"China Pharmaceutical University","award":["81970414"],"award-info":[{"award-number":["81970414"]}]},{"name":"China Pharmaceutical University","award":["82270272"],"award-info":[{"award-number":["82270272"]}]},{"name":"China Pharmaceutical University","award":["81874289"],"award-info":[{"award-number":["81874289"]}]},{"name":"China Pharmaceutical University","award":["CPU2022PZQ12"],"award-info":[{"award-number":["CPU2022PZQ12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD), an age-related degenerative disorder, is characterized by \u03b2-amyloid deposition, abnormal phosphorylation of tau proteins, synaptic dysfunction, neuroinflammation, and oxidative stress. Despite extensive research, there are no medications or therapeutic interventions to completely treat and reverse AD. Herein, we explore the potential of hydrocortisone (HC), a natural and endogenous glucocorticoid known to have potent anti-inflammatory properties, in an A\u03b21\u201342-induced AD mouse model. Our investigation highlights the beneficial effects of HC administration on cognitive impairment, synaptic function enhancement, and neuronal protection in A\u03b21\u201342-induced AD mice. Notably, HC treatment effectively suppresses the hyperactivation of microglia and astrocytes, leading to a reduction in proinflammatory factors and alleviation of neuroinflammation. Furthermore, HC intervention demonstrates the capacity to mitigate the generation of ROS and oxidative stress. These compelling findings underscore the potential therapeutic application of HC in AD and present promising opportunities for its utilization in AD prevention and treatment. The implications drawn from our findings indicate that hydrocortisone holds promise as a viable candidate for adjunctive use with other anti-AD drugs for the clinical management of patients presenting with moderate to severe AD.<\/jats:p>","DOI":"10.3390\/cells12192348","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T02:31:29Z","timestamp":1695695489000},"page":"2348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hydrocortisone Mitigates Alzheimer\u2019s-Related Cognitive Decline through Modulating Oxidative Stress and Neuroinflammation"],"prefix":"10.3390","volume":"12","author":[{"given":"Jinran","family":"Li","sequence":"first","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"},{"name":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"},{"name":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"},{"name":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"},{"name":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhen","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"},{"name":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2135-3812","authenticated-orcid":false,"given":"Zheying","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, The University of Nottingham, Nottingham NG7 2RD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangji","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"},{"name":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinuo","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"},{"name":"State Key Laboratory of Natural Medicines, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211166, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/461895a","article-title":"Neuroscience: Alzheimer\u2019s Disease","volume":"461","author":"Mucke","year":"2009","journal-title":"Nature"},{"key":"ref_2","first-page":"146","article-title":"\u00dcber Eine Eigenartige Erkrankung der Hirnrinde","volume":"64","author":"Alzheimer","year":"1907","journal-title":"Allg. 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