{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:08Z","timestamp":1790812808364,"version":"4.1.0"},"reference-count":137,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:00:00Z","timestamp":1696636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education","award":["2017R1A6A1A03015876"],"award-info":[{"award-number":["2017R1A6A1A03015876"]}]},{"name":"Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education","award":["2021R1A2C1013213"],"award-info":[{"award-number":["2021R1A2C1013213"]}]},{"name":"Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education","award":["2021R1A6C101C369"],"award-info":[{"award-number":["2021R1A6C101C369"]}]},{"name":"Korea Basic Science Institute (National Research Facilities and Equipment Center)","award":["2017R1A6A1A03015876"],"award-info":[{"award-number":["2017R1A6A1A03015876"]}]},{"name":"Korea Basic Science Institute (National Research Facilities and Equipment Center)","award":["2021R1A2C1013213"],"award-info":[{"award-number":["2021R1A2C1013213"]}]},{"name":"Korea Basic Science Institute (National Research Facilities and Equipment Center)","award":["2021R1A6C101C369"],"award-info":[{"award-number":["2021R1A6C101C369"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Prion diseases are neurodegenerative disorders that are progressive, incurable, and deadly. The prion consists of PrPSc, the misfolded pathogenic isoform of the cellular prion protein (PrPC). PrPC is involved in a variety of physiological functions, including cellular proliferation, adhesion, differentiation, and neural development. Prion protein is expressed on the membrane surface of a variety of stem cells (SCs), where it plays an important role in the pluripotency and self-renewal matrix, as well as in SC differentiation. SCs have been found to multiply the pathogenic form of the prion protein, implying their potential as an in vitro model for prion diseases. Furthermore, due to their capability to self-renew, differentiate, immunomodulate, and regenerate tissue, SCs are prospective cell treatments in many neurodegenerative conditions, including prion diseases. Regenerative medicine has become a new revolution in disease treatment in recent years, particularly with the introduction of SC therapy. Here, we review the data demonstrating prion diseases\u2019 biology and molecular mechanism. SC biology, therapeutic potential, and its role in understanding prion disease mechanisms are highlighted. Moreover, we summarize preclinical studies that use SCs in prion diseases.<\/jats:p>","DOI":"10.3390\/cells12192413","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:17:26Z","timestamp":1696688246000},"page":"2413","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Potential Therapeutic Use of Stem Cells for Prion Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3361-0943","authenticated-orcid":false,"given":"Mohammed","family":"Zayed","sequence":"first","affiliation":[{"name":"Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea"},{"name":"Department of Bioactive Material Sciences, Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54896, Republic of Korea"},{"name":"Department of Surgery, College of Veterinary Medicine, South Valley University, Qena 83523, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1879-5927","authenticated-orcid":false,"given":"Sung-Ho","family":"Kook","sequence":"additional","affiliation":[{"name":"Department of Bioactive Material Sciences, Research Center of Bioactive Materials, Jeonbuk National University, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-9994","authenticated-orcid":false,"given":"Byung-Hoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea"},{"name":"Department of Bioactive Material Sciences, Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1096\/fj.05-4279fje","article-title":"Disparate evolution of prion protein domains and the distinct origin of Doppel- and prion-related loci revealed by fish-to-mammal comparisons","volume":"20","author":"Oidtmann","year":"2006","journal-title":"FASEB J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1212\/WNL.42.1.149","article-title":"Nearly ubiquitous tissue distribution of the scrapie agent precursor protein","volume":"42","author":"Bendheim","year":"1992","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1073\/pnas.0511290103","article-title":"Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis","volume":"103","author":"Steele","year":"2006","journal-title":"Proc. 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