{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:49:52Z","timestamp":1774464592087,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Soonchunhyang University and National Research Foundation of Korea","award":["NRF-2017R1D1A1B05036195"],"award-info":[{"award-number":["NRF-2017R1D1A1B05036195"]}]},{"name":"Soonchunhyang University and National Research Foundation of Korea","award":["NRF-2020R1A6A3A01099833"],"award-info":[{"award-number":["NRF-2020R1A6A3A01099833"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Febrile seizure (FS), which occurs as a response to fever, is the most common seizure that occurs in infants and young children. FS is usually accompanied by diverse neuropsychiatric symptoms, including impaired social behaviors; however, research on neuropsychiatric disorders and hippocampal inflammatory changes following febrile seizure occurrences is very limited. Here, we provide evidence linking FS occurrence with ASD pathogenesis in rats. We developed an FS juvenile rats model and found ASD-like abnormal behaviors including deficits in social novelty, repetitive behaviors, and hyperlocomotion. In addition, FS model juvenile rats showed enhanced levels of gliosis and inflammation in the hippocampal CA2 region and cerebellum. Furthermore, abnormal levels of social and repetitive behaviors persisted in adults FS model rats. These findings suggest that the inflammatory response triggered by febrile seizures in young children could potentially serve as a mediator of social cognitive impairments.<\/jats:p>","DOI":"10.3390\/cells12202446","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:07:26Z","timestamp":1697177246000},"page":"2446","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-6151","authenticated-orcid":false,"given":"Yeon Hee","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of New Drug Discovery & Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyuna","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Ran","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gun Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongho","family":"Ryu","sequence":"additional","affiliation":[{"name":"Soonchunhyang Institute of Med-Bio Science (SIMS), Soonchunhyang University, Cheonan-si 31151, Republic of Korea"},{"name":"Department of Pathology, College of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0147-2424","authenticated-orcid":false,"given":"Dae-Kyoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2956-3942","authenticated-orcid":false,"given":"Duk-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Postnikova, T.Y., Griflyuk, A.V., Amakhin, D.V., Kovalenko, A.A., Soboleva, E.B., Zubareva, O.E., and Zaitsev, A.V. 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