{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:50:15Z","timestamp":1788313815215,"version":"build-2803163510"},"reference-count":159,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes of Health Research (CIHR)","award":["437492"],"award-info":[{"award-number":["437492"]}]},{"name":"Canadian Institutes of Health Research (CIHR)","award":["333058"],"award-info":[{"award-number":["333058"]}]},{"name":"Canadian Institutes of Health Research (CIHR)","award":["33518"],"award-info":[{"award-number":["33518"]}]},{"name":"William James Henderson Foundation","award":["437492"],"award-info":[{"award-number":["437492"]}]},{"name":"William James Henderson Foundation","award":["333058"],"award-info":[{"award-number":["333058"]}]},{"name":"William James Henderson Foundation","award":["33518"],"award-info":[{"award-number":["33518"]}]},{"name":"Canadian Foundation for Innovation","award":["437492"],"award-info":[{"award-number":["437492"]}]},{"name":"Canadian Foundation for Innovation","award":["333058"],"award-info":[{"award-number":["333058"]}]},{"name":"Canadian Foundation for Innovation","award":["33518"],"award-info":[{"award-number":["33518"]}]},{"name":"Translational Institute of Medicine (TIME)","award":["437492"],"award-info":[{"award-number":["437492"]}]},{"name":"Translational Institute of Medicine (TIME)","award":["333058"],"award-info":[{"award-number":["333058"]}]},{"name":"Translational Institute of Medicine (TIME)","award":["33518"],"award-info":[{"award-number":["33518"]}]},{"name":"QCPU","award":["437492"],"award-info":[{"award-number":["437492"]}]},{"name":"QCPU","award":["333058"],"award-info":[{"award-number":["333058"]}]},{"name":"QCPU","award":["33518"],"award-info":[{"award-number":["33518"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>DNA methylation is an epigenetic mechanism that regulates gene expression without altering gene sequences in health and disease. DNA methyltransferases (DNMTs) are enzymes responsible for DNA methylation, and their dysregulation is both a pathogenic mechanism of disease and a therapeutic target. DNMTs change gene expression by methylating CpG islands within exonic and intergenic DNA regions, which typically reduces gene transcription. Initially, mutations in the DNMT genes and pathologic DNMT protein expression were found to cause hematologic diseases, like myeloproliferative disease and acute myeloid leukemia, but recently they have been shown to promote cardiovascular diseases, including coronary artery disease and pulmonary hypertension. We reviewed the regulation and functions of DNMTs, with an emphasis on somatic mutations in DNMT3A, a common cause of clonal hematopoiesis of indeterminant potential (CHIP) that may also be involved in the development of pulmonary arterial hypertension (PAH). Accumulation of somatic mutations in DNMT3A and other CHIP genes in hematopoietic cells and cardiovascular tissues creates an inflammatory environment that promotes cardiopulmonary diseases, even in the absence of hematologic disease. This review summarized the current understanding of the roles of DNMTs in maintenance and de novo methylation that contribute to the pathogenesis of cardiovascular diseases, including PAH.<\/jats:p>","DOI":"10.3390\/cells12212528","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T06:20:16Z","timestamp":1698301216000},"page":"2528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Role of Clonal Hematopoiesis of Indeterminant Potential and DNA (Cytosine-5)-Methyltransferase Dysregulation in Pulmonary Arterial Hypertension and Other Cardiovascular Diseases"],"prefix":"10.3390","volume":"12","author":[{"given":"Isaac M.","family":"Emon","sequence":"first","affiliation":[{"name":"Department of Medicine, Queen\u2019s University, Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruaa","family":"Al-Qazazi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen\u2019s University, Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-5537","authenticated-orcid":false,"given":"Michael J.","family":"Rauh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Queen\u2019s University, Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1106-3202","authenticated-orcid":false,"given":"Stephen L.","family":"Archer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen\u2019s University, Kingston, ON K7L 3N6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals","volume":"33","author":"Jaenisch","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1479-828X.2006.00506.x","article-title":"The developmental origins of adult disease (Barker) hypothesis","volume":"46","author":"Harding","year":"2006","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00018-008-8432-4","article-title":"Epigenetic mechanisms in mammals","volume":"66","author":"Kim","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg816","article-title":"The fundamental role of epigenetic events in cancer","volume":"3","author":"Jones","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mrfmmm.2008.10.011","article-title":"Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases","volume":"667","author":"Migliore","year":"2009","journal-title":"Mutat. Res.\/Fundam. Mol. Mech. Mutagen."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1139\/bcb-2019-0045","article-title":"The impact of epigenetics on cardiovascular disease","volume":"98","author":"Prasher","year":"2020","journal-title":"Biochem. Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrg3354","article-title":"DNA methylation: Roles in mammalian development","volume":"14","author":"Smith","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1101\/gad.2037511","article-title":"CpG islands and the regulation of transcription","volume":"25","author":"Deaton","year":"2011","journal-title":"Genes Dev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0022-2836(87)90689-9","article-title":"CpG islands in vertebrate genomes","volume":"196","author":"Frommer","year":"1987","journal-title":"J. Mol. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Li, Y., and Tollefsbol, T.O. (2011). Epigenetics Protocols, Springer.","DOI":"10.1007\/978-1-61779-316-5"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/bies.950160612","article-title":"Genes and genomes: Sequencing 5-methylcytosine residues in genomic DNA","volume":"16","author":"Grigg","year":"1994","journal-title":"Bioessays"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nature10960","article-title":"A unique regulatory phase of DNA methylation in the early mammalian embryo","volume":"484","author":"Smith","year":"2012","journal-title":"Nature"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Xi, Y., and Li, W. (2009). BSMAP: Whole genome bisulfite sequence MAPping program. BMC Bioinform., 10.","DOI":"10.1186\/1471-2105-10-232"},{"key":"ref_14","unstructured":"MacNeil, D. (2023, August 25). Brush Up: What Is Bisulfite Sequencing and How Do Researchers Use It to Study DNA Methylation?. Available online: https:\/\/www.the-scientist.com\/sponsored-article\/what-is-bisulfite-sequencing-and-how-do-researchers-use-it-to-study-dna-methylation-70495."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ng.3258","article-title":"Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells","volume":"47","author":"Liao","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nrg2651","article-title":"Rethinking how DNA methylation patterns are maintained","volume":"10","author":"Jones","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrg.2017.80","article-title":"The DNA methyltransferase family: A versatile toolkit for epigenetic regulation","volume":"19","author":"Lyko","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrg.2017.33","article-title":"TET-mediated active DNA demethylation: Mechanism, function and beyond","volume":"18","author":"Wu","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.exphem.2017.08.001","article-title":"Tet2 restrains inflammatory gene expression in macrophages","volume":"55","author":"Cull","year":"2017","journal-title":"Exp. Hematol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1161\/CIRCULATIONAHA.119.044320","article-title":"Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension","volume":"141","author":"Potus","year":"2020","journal-title":"Circulation"},{"key":"ref_21","first-page":"753","article-title":"DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions","volume":"130","author":"Buscarlet","year":"2017","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.exphem.2020.01.011","article-title":"Clonal hematopoiesis and inflammation: Partners in leukemogenesis and comorbidity","volume":"83","author":"Cook","year":"2020","journal-title":"Exp. Hematol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1158\/2643-3230.BCD-20-0094","article-title":"Large-scale identification of clonal hematopoiesis and mutations recurrent in blood cancers","volume":"2","author":"Feusier","year":"2021","journal-title":"Blood Cancer Discov."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Kessler, M.D., Damask, A., O\u2019Keeffe, S., Van Meter, M., Banerjee, N., Semrau, S., Li, D., Watanabe, K., Horowitz, J., and Houvras, Y. (2022). Exome sequencing of 628,388 individuals identifies common and rare variant associations with clonal hematopoiesis phenotypes. MedRxiv.","DOI":"10.1101\/2021.12.29.21268342"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.stem.2018.01.011","article-title":"Clonal hematopoiesis and evolution to hematopoietic malignancies","volume":"22","author":"Bowman","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_26","first-page":"375","article-title":"Clonal cytopenias of undetermined significance: Potential predictor of myeloid malignancies","volume":"20","author":"Vobugari","year":"2022","journal-title":"Clin. Adv. Hematol. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbcan.2017.12.003","article-title":"Fusion genes: A promising tool combating against cancer","volume":"1869","author":"Dai","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA)-Rev. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jmoldx.2021.07.010","article-title":"Validation, implementation, and clinical impact of the oncomine myeloid targeted-amplicon DNA and RNA ion semiconductor sequencing assay","volume":"23","author":"Ferrone","year":"2021","journal-title":"J. Mol. Diagn."},{"key":"ref_29","first-page":"2214","article-title":"A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets","volume":"141","author":"Vlasschaert","year":"2023","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_30","first-page":"9","article-title":"Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes","volume":"126","author":"Steensma","year":"2015","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.yjmcc.2021.07.004","article-title":"Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease","volume":"161","author":"Marnell","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/cncr.32566","article-title":"Impact of the variant allele frequency of ASXL1, DNMT3A, JAK2, TET2, TP53, and NPM1 on the outcomes of patients with newly diagnosed acute myeloid leukemia","volume":"126","author":"Sasaki","year":"2020","journal-title":"Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MOH.0000000000000688","article-title":"Clonal hematopoiesis driven by DNMT3A and TET2 mutations: Role in monocyte and macrophage biology and atherosclerotic cardiovascular disease","volume":"29","author":"Cobo","year":"2022","journal-title":"Curr. Opin. Hematol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease","volume":"377","author":"Jaiswal","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"j5492","DOI":"10.1136\/bmj.j5492","article-title":"Pulmonary arterial hypertension: Pathogenesis and clinical management","volume":"360","author":"Thenappan","year":"2018","journal-title":"BMJ"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cjco.2021.11.008","article-title":"TET2 variants in Japanese patients with pulmonary arterial hypertension","volume":"4","author":"Hiraide","year":"2022","journal-title":"CJC Open"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"100925","DOI":"10.1016\/j.gim.2023.100925","article-title":"Defining the clinical validity of genes reported to cause pulmonary arterial hypertension","volume":"25","author":"Welch","year":"2023","journal-title":"Genet. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1161\/CIRCULATIONAHA.109.916098","article-title":"Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: A basis for excessive cell proliferation and a new therapeutic target","volume":"121","author":"Archer","year":"2010","journal-title":"Circulation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1182\/blood.2019004143","article-title":"Oral cedazuridine\/decitabine for MDS and CMML: A phase 2 pharmacokinetic\/pharmacodynamic randomized crossover study","volume":"136","author":"Griffiths","year":"2020","journal-title":"Blood"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bbrc.2016.03.116","article-title":"MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression","volume":"473","author":"Zhang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/CIRCULATIONAHA.115.016382","article-title":"Downregulation of microRNA-126 contributes to the failing right ventricle in pulmonary arterial hypertension","volume":"132","author":"Potus","year":"2015","journal-title":"Circulation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e007572","DOI":"10.1161\/JAHA.117.007572","article-title":"Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells","volume":"7","author":"Li","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1161\/CIRCRESAHA.120.316443","article-title":"Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis","volume":"126","author":"Tian","year":"2020","journal-title":"Circ. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"eaba2470","DOI":"10.1126\/sciadv.aba2470","article-title":"DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension","volume":"6","author":"Yan","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1158\/2159-8290.CD-21-0560","article-title":"Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor","volume":"12","author":"Huang","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_46","first-page":"A2397","article-title":"DNMT3A and TET2 mutations: Linking genetics and epigenetics in pulmonary arterial hypertension","volume":"199","author":"Potus","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med. Conf."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1001\/jamacardio.2022.0386","article-title":"TET2-driven clonal hematopoiesis and response to canakinumab: An exploratory analysis of the CANTOS randomized clinical trial","volume":"7","author":"Svensson","year":"2022","journal-title":"JAMA Cardiol."},{"key":"ref_49","unstructured":"U.S. Food and Drug Administration (2020). FDA Approves First Treatment for Adult Onset Still\u2019s Disease, a Severe and Rare Disease."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13073-021-00891-1","article-title":"Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH","volume":"13","author":"Zhu","year":"2021","journal-title":"Genome Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Jacob, C., Kitagawa, A., Signoretti, C., Dzieciatkowska, M., D\u2019Alessandro, A., Gupte, A., Hossain, S., D\u2019Addario, C.A., Gupte, R., and Gupte, S.A. (2022). Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension. J. Biol. Chem., 298.","DOI":"10.1016\/j.jbc.2022.102691"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1093\/rheumatology\/keaa282","article-title":"Clonal haematopoiesis is increased in early onset in systemic sclerosis","volume":"59","author":"Ricard","year":"2020","journal-title":"Rheumatology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1093\/rheumatology\/keac108","article-title":"Clonal haematopoiesis of indeterminate potential and cardiovascular events in systemic lupus erythematosus (HEMATOPLUS study)","volume":"61","author":"David","year":"2022","journal-title":"Rheumatology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1146\/annurev.ph.57.030195.004043","article-title":"Cell biology of atherosclerosis","volume":"57","author":"Ross","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/abbs\/gms075","article-title":"The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE\u2212\/\u2212 mice","volume":"44","author":"Jiang","year":"2012","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1172\/JCI74792","article-title":"Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis","volume":"124","author":"Dunn","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.7150\/ijbs.15195","article-title":"Indoxyl Sulfate Enhance the Hypermethylation of Klotho and Promote the Process of Vascular Calcification in Chronic Kidney Disease","volume":"12","author":"Chen","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1210\/en.2018-00320","article-title":"Arterial calcification is regulated via an miR-204\/DNMT3a regulatory circuit both in vitro and in female mice","volume":"159","author":"Lin","year":"2018","journal-title":"Endocrinology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.18632\/aging.101973","article-title":"Aberration methylation of miR-34b was involved in regulating vascular calcification by targeting Notch1","volume":"11","author":"Lin","year":"2019","journal-title":"Aging"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1253\/circj.CJ-18-0410","article-title":"MicroRNA-377 Inhibits Atherosclerosis by Regulating Triglyceride Metabolism Through the DNA Methyltransferase 1 in Apolipoprotein E-Knockout Mice","volume":"82","author":"Chen","year":"2018","journal-title":"Circ. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.yjmcc.2019.11.145","article-title":"Homocysteine accelerates atherosclerosis by inhibiting scavenger receptor class B member1 via DNMT3b\/SP1 pathway","volume":"138","author":"Guo","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"30053","DOI":"10.1038\/srep30053","article-title":"DNMT1-PPARgamma pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice","volume":"6","author":"Yu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yjmcc.2019.01.009","article-title":"DNA methyltransferase 1 and Kruppel-like factor 4 axis regulates macrophage inflammation and atherosclerosis","volume":"128","author":"Tang","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.18632\/aging.101863","article-title":"Long non-coding RNA CDKN2B-AS1 reduces inflammatory response and promotes cholesterol efflux in atherosclerosis by inhibiting ADAM10 expression","volume":"11","author":"Li","year":"2019","journal-title":"Aging"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1089\/dna.2017.3651","article-title":"Reciprocal Regulation Between miR-148a\/152 and DNA Methyltransferase 1 Is Associated with Hyperhomocysteinemia-Accelerated Atherosclerosis","volume":"36","author":"Yang","year":"2017","journal-title":"DNA Cell Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1111\/jcmm.14341","article-title":"Aberrant MFN2 transcription facilitates homocysteine-induced VSMCs proliferation via the increased binding of c-Myc to DNMT1 in atherosclerosis","volume":"23","author":"Xu","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ncb1161","article-title":"Dysregulation of HSG triggers vascular proliferative disorders","volume":"6","author":"Chen","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41419-020-2240-7","article-title":"Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.immuni.2022.06.022","article-title":"DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages","volume":"55","author":"Cobo","year":"2022","journal-title":"Immunity"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e168597","DOI":"10.1172\/JCI168597","article-title":"Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular risk","volume":"133","author":"Yu","year":"2023","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.aag1381","article-title":"Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice","volume":"355","author":"Fuster","year":"2017","journal-title":"Science"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2017.12.037","article-title":"Tet2-mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1\u03b2\/NLRP3 inflammasome","volume":"71","author":"Sano","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_73","first-page":"5249367","article-title":"DNA Methyltransferase 3b Accelerates the Process of Atherosclerosis","volume":"2022","author":"Zhu","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3892\/mmr.2021.11950","article-title":"circRNA-0006896-miR1264-DNMT1 axis plays an important role in carotid plaque destabilization by regulating the behavior of endothelial cells in atherosclerosis","volume":"23","author":"Wen","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"112531","DOI":"10.1016\/j.jep.2019.112531","article-title":"Liuwei Dihuang prevents postmenopausal atherosclerosis and endothelial cell apoptosis via inhibiting DNMT1-medicated ERalpha methylation","volume":"252","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_76","first-page":"105719","article-title":"Helicobacter pylori infection and DNMT3a polymorphism are associated with the presence of premature coronary artery disease and subclinical atherosclerosis. Data from the GEA Mexican Study","volume":"170","year":"2020","journal-title":"Microb. Pathog."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/hel.12234","article-title":"A Meta-Analysis of the Association between H elicobacter pylori Infection and Risk of Coronary Heart Disease from Published Prospective Studies","volume":"21","author":"Sun","year":"2016","journal-title":"Helicobacter"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4330\/wjc.v7.i1.19","article-title":"Helicobacter pylori: Does it add to risk of coronary artery disease","volume":"7","author":"Sharma","year":"2015","journal-title":"World J. Cardiol."},{"key":"ref_79","first-page":"406","article-title":"Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis","volume":"17","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13148-018-0443-x","article-title":"Genomic 5-mC contents in peripheral blood leukocytes were independent protective factors for coronary artery disease with a specific profile in different leukocyte subtypes","volume":"10","author":"Deng","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1089\/dna.2007.0584","article-title":"Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs","volume":"26","author":"Yideng","year":"2007","journal-title":"DNA Cell Biol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Hindmarch, C.C., Potus, F., Al-Qazazi, R., Ring, B., Nichols, W., Rauh, M., and Archer, S.L. (2023). Humans with Pulmonary Arterial Hypertension display a global hypermethylation signature that worsens in patients who have a mutation in the gene encoding the methylation eraser, Tet Methylcytosine Dioxygenase 2 (TET2). medRxiv.","DOI":"10.1101\/2023.08.09.23293846"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5350","DOI":"10.1038\/s41467-022-33093-3","article-title":"Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease","volume":"13","author":"Uddin","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"B\u00fcttner, P., B\u00f6ttner, J., Krohn, K., Baber, R., Platzbecker, U., Cross, M., Desch, S., Thiele, H., Steiner, S., and Scheinert, D. (2023). Clonal Hematopoiesis Mutations Are Present in Atherosclerotic Lesions in Peripheral Artery Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043962"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Wang, S., Hu, S., Luo, X., Bao, X., Li, J., Liu, M., Lv, Y., Zhao, C., Zeng, M., and Chen, X. (2022). Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction. EBioMedicine, 78.","DOI":"10.1016\/j.ebiom.2022.103964"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e91810","DOI":"10.1172\/jci.insight.91810","article-title":"Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction","volume":"2","author":"Andre","year":"2017","journal-title":"JCI Insight"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"13145","DOI":"10.1096\/fj.201900310R","article-title":"Methylation-dependent transcriptional repression of RUNX3 by KCNQ1OT1 regulates mouse cardiac microvascular endothelial cell viability and inflammatory response following myocardial infarction","volume":"33","author":"Wang","year":"2019","journal-title":"FASEB J."},{"key":"ref_88","first-page":"35","article-title":"MiR-29a and miR-30c negatively regulate DNMT 3a in cardiac ischemic tissues: Implications for cardiac remodelling","volume":"1","author":"Gambacciani","year":"2014","journal-title":"MicroRNA Diagn. Ther."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.3324\/haematol.2022.281705","article-title":"Clonal hematopoiesis by DNMT3A mutations as a common finding in idiopathic splanchnic vein thrombosis","volume":"108","author":"Carra","year":"2023","journal-title":"Haematologica"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1055\/s-0041-1733856","article-title":"Is hematopoietic clonality of indetermined potential a risk factor for pulmonary embolism?","volume":"5","author":"Soudet","year":"2021","journal-title":"TH Open"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Segura-Diaz, A., Stuckey, R., Florido, Y., Gonzalez-Martin, J.M., Lopez-Rodriguez, J.F., Sanchez-Sosa, S., Gonzalez-Perez, E., Perdomo, M.N.S., del Mar Perera, M., and de la Iglesia, S. (2020). Thrombotic risk detection in patients with polycythemia vera: The predictive role of DNMT3A\/TET2\/ASXL1 mutations. Cancers, 12.","DOI":"10.3390\/cancers12040934"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1161\/STROKEAHA.121.037388","article-title":"Clonal hematopoiesis is associated with higher risk of stroke","volume":"53","author":"Bhattacharya","year":"2022","journal-title":"Stroke"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1161\/STROKEAHA.122.041416","article-title":"Prevalence and Therapeutic Implications of Clonal Hematopoiesis of Indeterminate Potential in Young Patients With Stroke","volume":"54","author":"Mayerhofer","year":"2023","journal-title":"Stroke"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1038\/s41598-018-38057-6","article-title":"micro-RNAs dependent regulation of DNMT and HIF1alpha gene expression in thrombotic disorders","volume":"9","author":"Vijay","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12959-023-00462-x","article-title":"LINC00659 exacerbates endothelial progenitor cell dysfunction in deep vein thrombosis of the lower extremities by activating DNMT3A-mediated FGF1 promoter methylation","volume":"21","author":"Zhang","year":"2023","journal-title":"Thromb. J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.jid.2020.10.023","article-title":"Transient High Glucose Causes Persistent Vascular Dysfunction and Delayed Wound Healing by the DNMT1-Mediated Ang-1\/NF-kappaB Pathway","volume":"141","author":"Zhao","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1093\/nar\/gki836","article-title":"NF-\u03baB controls the global pro-inflammatory response in endothelial cells: Evidence for the regulation of a pro-atherogenic program","volume":"33","author":"Kempe","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1073\/pnas.0610467104","article-title":"The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted","volume":"104","author":"Bonnet","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ebiom.2019.10.004","article-title":"Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI","volume":"49","author":"Zhu","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s40620-018-0482-6","article-title":"Defective activation of the MAPK\/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schonlein purpura","volume":"31","author":"Milillo","year":"2018","journal-title":"J. Nephrol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1289\/EHP181","article-title":"Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children\u2019s Health Study","volume":"124","author":"Breton","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1251343","DOI":"10.1126\/science.1251343","article-title":"Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes","volume":"345","author":"Tubio","year":"2014","journal-title":"Science"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/10641963.2018.1425420","article-title":"Polymorphism of the DNA methyltransferase 1 gene is associated with the susceptibility to essential hypertension in male","volume":"40","author":"Chen","year":"2018","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1161\/JAHA.117.007673","article-title":"DNA Methyltransferase 1-Dependent DNA Hypermethylation Constrains Arteriogenesis by Augmenting Shear Stress Set Point","volume":"6","author":"Heuslein","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/s41374-022-00740-8","article-title":"DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p\/ETS1\/RhoH axis","volume":"102","author":"Deng","year":"2022","journal-title":"Lab. Investig."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"H183","DOI":"10.1152\/ajpheart.00708.2014","article-title":"Mending a broken heart: The role of mitophagy in cardioprotection","volume":"308","author":"Moyzis","year":"2015","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"119552","DOI":"10.1016\/j.lfs.2021.119552","article-title":"Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure","volume":"292","author":"Wang","year":"2022","journal-title":"Life Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2013.02.031","article-title":"Anti-apoptotic cardioprotective effects of SHP-1 gene silencing against ischemia\u2013reperfusion injury: Use of deoxycholic acid-modified low molecular weight polyethyleneimine as a cardiac siRNA-carrier","volume":"168","author":"Kim","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/s41374-020-0402-y","article-title":"Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin","volume":"100","author":"Wu","year":"2020","journal-title":"Lab. Investig."},{"key":"ref_110","first-page":"5402997","article-title":"Selenium Supplementation Improved Cardiac Functions by Suppressing DNMT2-Mediated GPX1 Promoter DNA Methylation in AGE-Induced Heart Failure","volume":"2022","author":"Zhu","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.yjmcc.2015.03.007","article-title":"Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B","volume":"82","author":"Vujic","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.18632\/aging.203965","article-title":"piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure","volume":"14","author":"Zhong","year":"2022","journal-title":"Aging"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCRESAHA.120.317104","article-title":"Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure","volume":"128","author":"Abplanalp","year":"2021","journal-title":"Circ. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.jacc.2021.02.028","article-title":"Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction","volume":"77","author":"Vazquez","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/eurheartj\/ehaa845","article-title":"Clonal haematopoiesis in chronic ischaemic heart failure: Prognostic role of clone size for DNMT3A-and TET2-driver gene mutations","volume":"42","author":"Assmus","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/s12012-021-09690-x","article-title":"DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in Cardiac Fibrosis","volume":"21","author":"Xu","year":"2021","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tox.2018.08.004","article-title":"Epigenetic aberrations of miR-369-5p and DNMT3A control Patched1 signal pathway in cardiac fibrosis","volume":"410","author":"Tao","year":"2018","journal-title":"Toxicology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s10753-020-01191-3","article-title":"DNMT1 Methylation of LncRNA GAS5 Leads to Cardiac Fibroblast Pyroptosis via Affecting NLRP3 Axis","volume":"43","author":"She","year":"2020","journal-title":"Inflammation"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1002\/jcp.30078","article-title":"DNMT1 deregulation of SOCS3 axis drives cardiac fibroblast activation in diabetic cardiac fibrosis","volume":"236","author":"Tao","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Tao, H., Shi, P., Xuan, H.Y., and Ding, X.S. (2020). DNA methyltransferase-1 inactivation of androgen receptor axis triggers homocysteine induced cardiac fibroblast autophagy in diabetic cardiac fibrosis. Arch. Biochem. Biophys., 692.","DOI":"10.1016\/j.abb.2020.108521"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1002\/jcp.27471","article-title":"DNA methylation regulates alpha-smooth muscle actin expression during cardiac fibroblast differentiation","volume":"234","author":"He","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00011-018-1159-2","article-title":"DNMT3A controls miR-200b in cardiac fibroblast autophagy and cardiac fibrosis","volume":"67","author":"Zhao","year":"2018","journal-title":"Inflamm. Res."},{"key":"ref_123","first-page":"1465","article-title":"Down-regulation of DNMT3A expression by microRNA-200b inhibits myocardial fibrosis in SD rats. [Chinese]","volume":"34","author":"Qin","year":"2018","journal-title":"Chin. Pharmacol. Bull."},{"key":"ref_124","first-page":"198","article-title":"microRNA-29a inhibits cardiac fibrosis in Sprague-Dawley rats by downregulating the expression of DNMT3A","volume":"20","author":"Qin","year":"2021","journal-title":"Anatol. J. Cardiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tox.2014.06.006","article-title":"DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1\/2","volume":"323","author":"Tao","year":"2014","journal-title":"Toxicology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/1440-1681.13562","article-title":"Low-intensity pulsed ultrasound prevents prolonged hypoxia-induced cardiac fibrosis through HIF-1alpha\/DNMT3a pathway via a TRAAK-dependent manner","volume":"48","author":"Zhao","year":"2021","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1093\/hmg\/ddt614","article-title":"Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype","volume":"23","author":"Watson","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1002\/ehf2.14115","article-title":"Clonal haematopoiesis of indeterminate potential-related mutations and outcome in dilated and ischaemic cardiomyopathy","volume":"9","author":"Wu","year":"2022","journal-title":"ESC Heart Fail."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.bbamcr.2016.03.002","article-title":"Epigenetic response to environmental stress: Assembly of BRG1-G9a\/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts","volume":"1863","author":"Han","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1161\/CIRCULATIONAHA.119.044444","article-title":"An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility","volume":"142","author":"Madsen","year":"2020","journal-title":"Circulation"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yjmcc.2021.02.002","article-title":"Hypertrophic signaling compensates for contractile and metabolic consequences of DNA methyltransferase 3A loss in human cardiomyocytes","volume":"154","author":"Madsen","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Nuhrenberg, T.G., Hammann, N., Schnick, T., Preisl, S., Witten, A., Stoll, M., Gilsbach, R., Neumann, F.J., and Hein, L. (2015). Cardiac Myocyte De Novo DNA Methyltransferases 3a\/3b Are Dispensable for Cardiac Function and Remodeling after Chronic Pressure Overload in Mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131019"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1111\/jcmm.17358","article-title":"LncRNA SNHG1 promotes sepsis-induced myocardial injury by inhibiting Bcl-2 expression via DNMT1","volume":"26","author":"Zhang","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1002\/2211-5463.13252","article-title":"Knockdown of DNA methyltransferase 1 reduces DNA methylation and alters expression patterns of cardiac genes in embryonic cardiomyocytes","volume":"11","author":"Fang","year":"2021","journal-title":"FEBS Open Bio"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Kakoki, M., Ramanathan, P.V., Hagaman, J.R., Grant, R., Wilder, J.C., Taylor, J.M., Charles Jennette, J., Smithies, O., and Maeda-Smithies, N. (2021). Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1\/3-IGF-1 signaling. Commun. Biol., 4.","DOI":"10.1038\/s42003-021-02291-y"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.yjmcc.2018.05.012","article-title":"Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats","volume":"120","author":"Stenzig","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_137","first-page":"1468","article-title":"Abnormal expressions of plasma dnmt3a in elderly patients with recurrent atrial fibrillation","volume":"14","author":"Zeng","year":"2021","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jacc.2023.01.036","article-title":"Hematopoietic somatic mosaicism is associated with an increased risk of postoperative atrial fibrillation","volume":"81","author":"Ninni","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1001\/jamacardio.2020.2468","article-title":"Association of clonal hematopoiesis of indeterminate potential with inflammatory gene expression in patients with severe degenerative aortic valve stenosis or chronic postischemic heart failure","volume":"5","author":"Abplanalp","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/jdi.12988","article-title":"Genetic variants in DNMT1 and the risk of cardiac autonomic neuropathy in women with type 1 diabetes","volume":"10","author":"Admoni","year":"2019","journal-title":"J. Diabetes Investig."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1080\/21655979.2021.1971482","article-title":"Coordination of PRKCA\/PRKCA-AS1 interplay facilitates DNA methyltransferase 1 recruitment on DNA methylation to affect protein kinase C alpha transcription in mitral valve of rheumatic heart disease","volume":"12","author":"Xie","year":"2021","journal-title":"Bioengineered"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/ajmg.a.36867","article-title":"Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation","volume":"167","author":"Tang","year":"2015","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00439-014-1453-1","article-title":"A genetic association study detects haplotypes associated with obstructive heart defects","volume":"133","author":"Li","year":"2014","journal-title":"Hum. Genet."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/bdr2.1988","article-title":"The study of expression levels of DNA methylation regulators in patients affected with congenital heart defects (CHDs)","volume":"114","author":"Joshi","year":"2022","journal-title":"Birth Defects Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3892\/ijmm.2013.1427","article-title":"Association between mRNA levels of DNMT1, DNMT3A, DNMT3B, MBD2 and LINE-1 methylation status in infants with tetralogy of Fallot","volume":"32","author":"Sheng","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"e005796","DOI":"10.1161\/JAHA.117.005796","article-title":"In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood","volume":"6","author":"Tanwar","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e1010","DOI":"10.1002\/mgg3.1010","article-title":"Gene-by-gene interactions associated with the risk of conotruncal heart defects","volume":"8","author":"Lyu","year":"2020","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"100768","DOI":"10.1016\/j.mgene.2020.100768","article-title":"Rs4841587 in GATA4 and rs6999593 in DNMT1 gene associated with congenital heart diseases in the southeast of Iran","volume":"26","author":"Noori","year":"2020","journal-title":"Meta Gene"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.gene.2017.03.012","article-title":"DNA methyltransferase 1 rs16999593 genetic polymorphism decreases risk in patients with transposition of great arteries","volume":"615","author":"Lei","year":"2017","journal-title":"Gene"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Majstorovi\u0107, D., Bari\u0161i\u0107, A., Bo\u017eovi\u0107, I.B., \u010ca\u010de, I.B., \u010ca\u010de, N., \u0160tifani\u0107, M., and Vranekovi\u0107, J. (2023). DNMT3B rs2424913 as a Risk Factor for Congenital Heart Defects in Down Syndrome. Genes, 14.","DOI":"10.3390\/genes14030576"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"576","DOI":"10.7150\/ijms.32773","article-title":"Decreased DNA methyltransferases expression is associated with coronary artery lesion formation in Kawasaki disease","volume":"16","author":"Huang","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1080\/15384101.2021.1919820","article-title":"MiR-206 promotes extracellular matrix accumulation and relieves infantile hemangioma through targeted inhibition of DNMT3A","volume":"20","author":"Wu","year":"2021","journal-title":"Cell Cycle"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/mrd.23137","article-title":"Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice","volume":"86","author":"Sasaki","year":"2019","journal-title":"Mol. Reprod. Dev."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ng.2917","article-title":"Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability","volume":"46","author":"Seal","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_155","unstructured":"Ostrowski, P.J., and Tatton-Brown, K. (2022). Tatton-Brown-Rahman Syndrome, GeneReviews\u00ae."},{"key":"ref_156","unstructured":"Kiernan, J. (2023, September 09). Tatton Brown Rahman Syndrome. Available online: https:\/\/tbrsyndrome.org\/about-tbrs\/."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1038\/s41467-021-24800-7","article-title":"Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome","volume":"12","author":"Smith","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_158","first-page":"461","article-title":"DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults","volume":"139","author":"Ferris","year":"2022","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1136\/jmedgenet-2017-104574","article-title":"Acute myeloid leukaemia in a case with Tatton-Brown-Rahman syndrome: The peculiar DNMT3A R882 mutation","volume":"54","author":"Hollink","year":"2017","journal-title":"J. Med. Genet."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/21\/2528\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:12:14Z","timestamp":1760130734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/21\/2528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,26]]},"references-count":159,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["cells12212528"],"URL":"https:\/\/doi.org\/10.3390\/cells12212528","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,26]]}}}