{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:34:25Z","timestamp":1776753265108,"version":"3.51.2"},"reference-count":50,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["11-2314-B-038-138-"],"award-info":[{"award-number":["11-2314-B-038-138-"]}]},{"name":"National Science and Technology Council","award":["NHRI-EX112-11132HT"],"award-info":[{"award-number":["NHRI-EX112-11132HT"]}]},{"name":"National Health Research Institutes","award":["11-2314-B-038-138-"],"award-info":[{"award-number":["11-2314-B-038-138-"]}]},{"name":"National Health Research Institutes","award":["NHRI-EX112-11132HT"],"award-info":[{"award-number":["NHRI-EX112-11132HT"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Increased medical attention is needed as the prevalence of autism spectrum disorder (ASD) rises. Both cardiovascular disorder (CVD) and hyperlipidemia are closely associated with adult ASD. Shank3 plays a key genetic role in ASD. We hypothesized that Shank3 contributes to CVD development in young adults with ASD. In this study, we investigated whether Shank3 facilitates the development of atherosclerosis. Using Gene Set Enrichment Analysis software (Version No.: GSEA-4.0.3), we analyzed the data obtained from Shank3 knockout mice (Gene Expression Omnibus database), a human population-based study cohort (from Taiwan\u2019s National Health Insurance Research Database), and a Shank3 knockdown cellular model. Shank3 knockout upregulated the expression of genes of cholesterol homeostasis and fatty acid metabolism but downregulated the expression of genes associated with inflammatory responses. Individuals with autism had higher risks of hyperlipidemia (adjusted hazard ratio (aHR): 1.39; p &lt; 0.001), major adverse cardiac events (aHR: 2.67; p &lt; 0.001), and stroke (aHR: 3.55; p &lt; 0.001) than age- and sex-matched individuals without autism did. Shank3 downregulation suppressed tumor necrosis factor-\u03b1-induced fatty acid synthase expression; vascular cell adhesion molecule 1 expression; and downstream signaling pathways involving p38, Jun N-terminal kinase, and nuclear factor-\u03baB. Thus, Shank3 may influence the development of early-onset atherosclerosis and CVD in ASD. Furthermore, regulating Shank3 expression may reduce inflammation-related disorders, such as atherosclerosis, by inhibiting tumor necrosis factor-alpha-mediated inflammatory cascades.<\/jats:p>","DOI":"10.3390\/cells12212546","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T12:50:42Z","timestamp":1698670242000},"page":"2546","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of the Autism Risk Gene Shank3 in the Development of Atherosclerosis: Insights from Big Data and Mechanistic Analyses"],"prefix":"10.3390","volume":"12","author":[{"given":"Hsiu-Wen","family":"Chang","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Neurology, Sijhih Cathay General Hospital, New Taipei City 22174, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Jen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Nien","family":"Chien","sequence":"additional","affiliation":[{"name":"Institute of Health and Welfare Policy, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2204-4923","authenticated-orcid":false,"given":"Nai-Fang","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 11267, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Chieh","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-0766","authenticated-orcid":false,"given":"Yuan-Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-5967","authenticated-orcid":false,"given":"Chaur-Jong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan"},{"name":"Taipei Neuroscience Institute, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11154-017-9409-0","article-title":"Vitamin D and Autism, What\u2019s New?","volume":"18","author":"Cannell","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1352\/1934-9556-49.3.172","article-title":"Sowing the Seeds of the Autism Field: Leo Kanner (1943)","volume":"49","author":"Blacher","year":"2011","journal-title":"Intellect Dev. Disabil."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/aur.2080","article-title":"Autism Prevalence and Outcomes in Older Adults","volume":"12","author":"Robison","year":"2019","journal-title":"Autism Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1007\/s10803-020-04494-4","article-title":"National and State Estimates of Adults with Autism Spectrum Disorder","volume":"50","author":"Dietz","year":"2020","journal-title":"J. Autism Dev. Disord."},{"key":"ref_5","first-page":"1","article-title":"Changes in Prevalence of Parent-Reported Autism Spectrum Disorder in School-Aged U.S. Children: 2007 to 2011\u20132012","volume":"65","author":"Blumberg","year":"2013","journal-title":"Natl. Health Stat. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1177\/1362361320953652","article-title":"Increased Prevalence of Non-Communicable Physical Health Conditions among Autistic Adults","volume":"25","author":"Weir","year":"2021","journal-title":"Autism"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/s41591-020-1007-0","article-title":"A Multidimensional Precision Medicine Approach Identifies an Autism Subtype Characterized by Dyslipidemia","volume":"26","author":"Luo","year":"2020","journal-title":"Nat. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1192\/bjp.bp.114.160192","article-title":"Premature Mortality in Autism Spectrum Disorder","volume":"208","author":"Hirvikoski","year":"2016","journal-title":"Br. J. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1001\/jamapediatrics.2022.5629","article-title":"Association between Autism Spectrum Disorders and Cardiometabolic Diseases: A Systematic Review and Meta-Analysis","volume":"177","author":"Dhanasekara","year":"2023","journal-title":"JAMA Pediatr."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mehu, M., Narasimhulu, C.A., and Singla, D.K. (2022). Inflammatory Cells in Atherosclerosis. Antioxidants, 11.","DOI":"10.3390\/antiox11020233"},{"key":"ref_11","first-page":"413","article-title":"Impact of Eating Habits and Nutritional Status on Children with Autism Spectrum Disorder","volume":"16","author":"Cebeci","year":"2021","journal-title":"J. Taibah Univ. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Liu, T., Kelly, J., Davis, L., and Zamora, K. (2019). Nutrition, BMI and Motor Competence in Children with Autism Spectrum Disorder. Medicina, 55.","DOI":"10.3390\/medicina55050135"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1002\/eat.23631","article-title":"Food Selectivity, Nutritional Inadequacies, and Mealtime Behavioral Problems in Children with Autism Spectrum Disorder Compared to Neurotypical Children","volume":"54","author":"Planells","year":"2021","journal-title":"Int. J. Eat. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/1362361319861579","article-title":"Obesity, Physical Activity, and Sedentary Behaviors in Adolescents with Autism Spectrum Disorder Compared with Typically Developing Peers","volume":"24","author":"McCoy","year":"2020","journal-title":"Autism"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jones, R.A., Downing, K., Rinehart, N.J., Barnett, L.M., May, T., McGillivray, J.A., Papadopoulos, N.V., Skouteris, H., Timperio, A., and Hinkley, T. (2017). Physical Activity, Sedentary Behavior and Their Correlates in Children with Autism Spectrum Disorder: A Systematic Review. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0172482"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1177\/1362361313479039","article-title":"Comparison of Sedentary Behaviors between Children with Autism Spectrum Disorders and Typically Developing Children","volume":"18","author":"Must","year":"2014","journal-title":"Autism"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/2047487319869400","article-title":"Lifestyle Factors and High-Risk Atherosclerosis: Pathways and Mechanisms beyond Traditional Risk Factors","volume":"27","author":"Lechner","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Acosta, S., Johansson, A., and Drake, I. (2021). Diet and Lifestyle Factors and Risk of Atherosclerotic Cardiovascular Disease\u2014A Prospective Cohort Study. Nutrients, 13.","DOI":"10.3390\/nu13113822"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wei, T., Liu, J., Zhang, D., Wang, X., Li, G., Ma, R., Chen, G., Lin, X., and Guo, X. (2021). The Relationship Between Nutrition and Atherosclerosis. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.635504"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/eurheartj\/ehq141","article-title":"Life-Time Risk Factors and Progression of Carotid Atherosclerosis in Young Adults: The Cardiovascular Risk in Young Finns Study","volume":"31","author":"Juonala","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.200404108","article-title":"The Neuronal Scaffold Protein Shank3 Mediates Signaling and Biological Function of the Receptor Tyrosine Kinase Ret in Epithelial Cells","volume":"167","author":"Schuetz","year":"2004","journal-title":"J. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/jmg.40.8.575","article-title":"Molecular Characterisation of the 22q13 Deletion Syndrome Supports the Role of Haploinsufficiency of SHANK3\/PROSAP2 in the Major Neurological Symptoms","volume":"40","author":"Wilson","year":"2003","journal-title":"J. Med. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/j.1471-4159.2006.03831.x","article-title":"Direct Interaction of Post-Synaptic Density-95\/Dlg\/ZO-1 Domain-Containing Synaptic Molecule Shank3 with GluR1 \u03b1-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid Receptor","volume":"97","author":"Uchino","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"13805","DOI":"10.1074\/jbc.M601101200","article-title":"ProSAP-Interacting Protein 1 (ProSAPiP1), a Novel Protein of the Postsynaptic Density That Links the Spine-Associated Rap-Gap (SPAR) to the Scaffolding Protein ProSAP2\/Shank3","volume":"281","author":"Wendholt","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7596","DOI":"10.1038\/s41380-021-01230-x","article-title":"Restoring Glutamate Receptosome Dynamics at Synapses Rescues Autism-like Deficits in Shank3-Deficient Mice","volume":"26","author":"Moutin","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.braindev.2012.05.013","article-title":"SHANK3 as an Autism Spectrum Disorder-Associated Gene","volume":"35","author":"Uchino","year":"2013","journal-title":"Brain Dev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ejhg.2012.175","article-title":"Prevalence of SHANK3 Variants in Patients with Different Subtypes of Autism Spectrum Disorders","volume":"21","author":"Boccuto","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1017512","DOI":"10.3389\/fnmol.2022.1017512","article-title":"Age, Brain Region, and Gene Dosage-Differential Transcriptomic Changes in Shank3-Mutant Mice","volume":"15","author":"Yoo","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng1933","article-title":"Mutations in the Gene Encoding the Synaptic Scaffolding Protein SHANK3 Are Associated with Autism Spectrum Disorders","volume":"39","author":"Durand","year":"2007","journal-title":"Nat. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/2040-2392-5-30","article-title":"Transcriptional and Functional Complexity of Shank3 Provides a Molecular Framework to Understand the Phenotypic Heterogeneity of SHANK3 Causing Autism and Shank3 Mutant Mice","volume":"5","author":"Wang","year":"2014","journal-title":"Mol. Autism"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/s41386-021-01212-1","article-title":"Rescue of Histone Hypoacetylation and Social Deficits by Ketogenic Diet in a Shank3 Mouse Model of Autism","volume":"47","author":"Qin","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature12618","article-title":"SHANK3 and IGF1 Restore Synaptic Deficits in Neurons from 22q13 Deletion Syndrome Patients","volume":"503","author":"Shcheglovitov","year":"2013","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.18632\/oncotarget.2765","article-title":"WMJ-S-001, a Novel Aliphatic Hydroxamate Derivative, Exhibits Anti-Angiogenic Activities via Src-Homology-2-Domain-Containing Protein Tyrosine Phosphatase 1","volume":"6","author":"Chang","year":"2015","journal-title":"Oncotarget"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"531518","DOI":"10.1155\/2015\/531518","article-title":"Inflammatory Cytokines: Potential Biomarkers of Immunologic Dysfunction in Autism Spectrum Disorders","volume":"2015","author":"Xu","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"788","DOI":"10.2337\/dc15-1807","article-title":"Risk of Developing Type 2 Diabetes in Adolescents and Young Adults with Autism Spectrum Disorder: A Nationwide Longitudinal Study","volume":"39","author":"Chen","year":"2016","journal-title":"Diabetes Care"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9737","DOI":"10.1038\/s41598-022-13365-0","article-title":"Prevalence and Factors Associated with Overweight, Obesity, and Hypertension in a Large Clinical Sample of Adults with Autism Spectrum Disorder","volume":"12","author":"Thom","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1542\/peds.2015-1437","article-title":"Obesity and Autism","volume":"136","author":"Hill","year":"2015","journal-title":"Pediatrics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1017\/S0033291718002283","article-title":"Anxiety and Depression in Adults with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis","volume":"49","author":"Hollocks","year":"2019","journal-title":"Psychol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hasheminasabgorji, E., and Jha, J.C. (2021). Dyslipidemia, Diabetes and Atherosclerosis: Role of Inflammation and Ros-Redox-Sensitive Factors. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111602"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1352\/1944-7558-116.5.371","article-title":"Chronic Disease Risks in Young Adults with Autism Spectrum Disorder: Forewarned Is Forearmed","volume":"116","author":"Tyler","year":"2011","journal-title":"Am. J. Intellect. Dev. Disabil."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wang, Y., Xu, Y., Guo, W., Fang, Y., Hu, L., Wang, R., Zhao, R., Guo, D., Qi, B., and Ren, G. (2022). Ablation of Shank3 Alleviates Cardiac Dysfunction in Aging Mice by Promoting CaMKII Activation and Parkin-Mediated Mitophagy. Redox Biol., 58.","DOI":"10.1016\/j.redox.2022.102537"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/CS20080196","article-title":"Role of TNF-Alpha in Vascular Dysfunction","volume":"116","author":"Zhang","year":"2009","journal-title":"Clin. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Troncoso, M.F., Ortiz-Quintero, J., Garrido-Moreno, V., Sanhueza-Olivares, F., Guerrero-Moncayo, A., Chiong, M., Castro, P.F., Garc\u00eda, L., Gabrielli, L., and Corbal\u00e1n, R. (2021). VCAM-1 as a Predictor Biomarker in Cardiovascular Disease. Biochim. Biophys. Acta (BBA) Mol. Basis Dis., 1867.","DOI":"10.1016\/j.bbadis.2021.166170"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1172\/JCI11871","article-title":"A Major Role for VCAM-1, but Not ICAM-1, in Early Atherosclerosis","volume":"107","author":"Cybulsky","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1876390101103010027","article-title":"Dual Philosophy in Death Receptor Signalling","volume":"3","author":"Kantari","year":"2011","journal-title":"Open Cell Signal. J."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Reustle, A., and Torzewski, M. (2018). Role of P38 MAPK in Atherosclerosis and Aortic Valve Sclerosis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19123761"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.atherosclerosis.2014.05.950","article-title":"Requirement of JNK1 for Endothelial Cell Injury in Atherogenesis","volume":"235","author":"Amini","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1042\/CS20160465","article-title":"Adipose-Specific Inactivation of JNK Alleviates Atherosclerosis in ApoE-Deficient Mice","volume":"130","author":"Kwok","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_49","first-page":"322","article-title":"LncRNA H19 Promotes Atherosclerosis by Regulating MAPK and NF-KB Signaling Pathway","volume":"21","author":"Pan","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Yang, S., Mei, S., Jin, H., Zhu, B., Tian, Y., Huo, J., Cui, X., Guo, A., and Zhao, Z. (2017). Identification of Two Immortalized Cell Lines, ECV304 and BEnd3, for in Vitro Permeability Studies of Blood-Brain Barrier. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187017"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/21\/2546\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:14:02Z","timestamp":1760130842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/21\/2546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,30]]},"references-count":50,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["cells12212546"],"URL":"https:\/\/doi.org\/10.3390\/cells12212546","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,30]]}}}