{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:18:07Z","timestamp":1785266287447,"version":"3.55.0"},"reference-count":53,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AIPROSAB","award":["Prot. 3\/2021 \u201cTARGETS\u201d"],"award-info":[{"award-number":["Prot. 3\/2021 \u201cTARGETS\u201d"]}]},{"name":"AIPROSAB","award":["Prot. 3\/2022 \u201cPRE-RECEPTORS\u201d"],"award-info":[{"award-number":["Prot. 3\/2022 \u201cPRE-RECEPTORS\u201d"]}]},{"name":"AIPROSAB","award":["Prot. 20223WFJJ3"],"award-info":[{"award-number":["Prot. 20223WFJJ3"]}]},{"name":"Italian MUR PRIN","award":["Prot. 3\/2021 \u201cTARGETS\u201d"],"award-info":[{"award-number":["Prot. 3\/2021 \u201cTARGETS\u201d"]}]},{"name":"Italian MUR PRIN","award":["Prot. 3\/2022 \u201cPRE-RECEPTORS\u201d"],"award-info":[{"award-number":["Prot. 3\/2022 \u201cPRE-RECEPTORS\u201d"]}]},{"name":"Italian MUR PRIN","award":["Prot. 20223WFJJ3"],"award-info":[{"award-number":["Prot. 20223WFJJ3"]}]},{"name":"IRCCS San Raffaele Institutional","award":["Prot. 3\/2021 \u201cTARGETS\u201d"],"award-info":[{"award-number":["Prot. 3\/2021 \u201cTARGETS\u201d"]}]},{"name":"IRCCS San Raffaele Institutional","award":["Prot. 3\/2022 \u201cPRE-RECEPTORS\u201d"],"award-info":[{"award-number":["Prot. 3\/2022 \u201cPRE-RECEPTORS\u201d"]}]},{"name":"IRCCS San Raffaele Institutional","award":["Prot. 20223WFJJ3"],"award-info":[{"award-number":["Prot. 20223WFJJ3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Type-2 Familial Partial Lipodystrophy (FPLD2), a rare lipodystrophy caused by LMNA mutations, is characterized by a loss of subcutaneous fat from the trunk and limbs and excess accumulation of adipose tissue in the neck and face. Several studies have reported that the mineralocorticoid receptor (MR) plays an essential role in adipose tissue differentiation and functionality. We previously showed that brown preadipocytes isolated from a FPLD2 patient\u2019s neck aberrantly differentiate towards the white lineage. As this condition may be related to MR activation, we suspected altered MR dynamics in FPLD2. Despite cytoplasmic MR localization in control brown adipocytes, retention of MR was observed in FPLD2 brown adipocyte nuclei. Moreover, overexpression of wild-type or mutated prelamin A caused GFP-MR recruitment to the nuclear envelope in HEK293 cells, while drug-induced prelamin A co-localized with endogenous MR in human preadipocytes. Based on in silico analysis and in situ protein ligation assays, we could suggest an interaction between prelamin A and MR, which appears to be inhibited by mineralocorticoid receptor antagonism. Importantly, the MR antagonist spironolactone redirected FPLD2 preadipocyte differentiation towards the brown lineage, avoiding the formation of enlarged and dysmorphic lipid droplets. Finally, beneficial effects on brown adipose tissue activity were observed in an FPLD2 patient undergoing spironolactone treatment. These findings identify MR as a new lamin A interactor and a new player in lamin A-linked lipodystrophies.<\/jats:p>","DOI":"10.3390\/cells12222586","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T11:23:39Z","timestamp":1699356219000},"page":"2586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mineralocorticoid Receptor Antagonism Prevents Type 2 Familial Partial Lipodystrophy Brown Adipocyte Dysfunction"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5960-4157","authenticated-orcid":false,"given":"Elisa","family":"Schena","sequence":"first","affiliation":[{"name":"Unit of Bologna, CNR\u2014National Research Council of Italy, Institute of Molecular Genetics \u201cLuigi Luca Cavalli-Sforza\u201d, 40136 Bologna, Italy"},{"name":"IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Unit of Bologna, CNR\u2014National Research Council of Italy, Institute of Molecular Genetics \u201cLuigi Luca Cavalli-Sforza\u201d, 40136 Bologna, Italy"},{"name":"IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0740-2013","authenticated-orcid":false,"given":"Chiara","family":"Peres","sequence":"additional","affiliation":[{"name":"Unit of Bologna, CNR\u2014National Research Council of Italy, Institute of Molecular Genetics \u201cLuigi Luca Cavalli-Sforza\u201d, 40136 Bologna, Italy"},{"name":"IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zanotti","sequence":"additional","affiliation":[{"name":"Unit of Gynecology and Obstetrics, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Morselli","sequence":"additional","affiliation":[{"name":"Plastic Surgery Unit, Department of Specialised, Experimental and Diagnostic Medicine, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6443-7074","authenticated-orcid":false,"given":"Patricia","family":"Iozzo","sequence":"additional","affiliation":[{"name":"CNR\u2014National Research Council of Italy, Institute of Clinical Physiology, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angela","family":"Guzzardi","sequence":"additional","affiliation":[{"name":"CNR\u2014National Research Council of Italy, Institute of Clinical Physiology, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-0244","authenticated-orcid":false,"given":"Chiara","family":"Bernardini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-6202","authenticated-orcid":false,"given":"Monica","family":"Forni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8569-7158","authenticated-orcid":false,"given":"Salvatore","family":"Nesci","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0722-7163","authenticated-orcid":false,"given":"Massimiliano","family":"Caprio","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele, 00163 Rome, Italy"},{"name":"Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Cecchetti","sequence":"additional","affiliation":[{"name":"Unit of Gynecology and Obstetrics, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-3110","authenticated-orcid":false,"given":"Uberto","family":"Pagotto","sequence":"additional","affiliation":[{"name":"Unit of Gynecology and Obstetrics, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gabusi","sequence":"additional","affiliation":[{"name":"SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cattini","sequence":"additional","affiliation":[{"name":"SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-9967","authenticated-orcid":false,"given":"Gina","family":"Lisignoli","sequence":"additional","affiliation":[{"name":"SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7103-8722","authenticated-orcid":false,"given":"Giovanna","family":"Lattanzi","sequence":"additional","affiliation":[{"name":"Unit of Bologna, CNR\u2014National Research Council of Italy, Institute of Molecular Genetics \u201cLuigi Luca Cavalli-Sforza\u201d, 40136 Bologna, Italy"},{"name":"IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0289-0","article-title":"Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: An in vitro and in vivo study of adipose tissue browning","volume":"51","author":"Pellegrini","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/72807","article-title":"LMNA, encoding lamin A\/C, is mutated in partial lipodystrophy","volume":"24","author":"Shackleton","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Fernandez-Pombo, A., Diaz-Lopez, E.J., Castro, A.I., Sanchez-Iglesias, S., Cobelo-Gomez, S., Prado-Morana, T., and Araujo-Vilar, D. (2023). Clinical Spectrum of LMNA-Associated Type 2 Familial Partial Lipodystrophy: A Systematic Review. Cells, 12.","DOI":"10.3390\/cells12050725"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13023-020-1295-y","article-title":"European lipodystrophy registry: Background and structure","volume":"15","author":"Adams","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Araujo-Vilar, D., Fernandez-Pombo, A., Victoria, B., Mosquera-Orgueira, A., Cobelo-Gomez, S., Castro-Pais, A., Hermida-Ameijeiras, A., Loidi, L., and Sanchez-Iglesias, S. (2021). Variable Expressivity and Allelic Heterogeneity in Type 2 Familial Partial Lipodystrophy: The p.(Thr528Met) LMNA Variant. J. Clin. Med., 10.","DOI":"10.3390\/jcm10071497"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2265.2007.03146.x","article-title":"A novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy","volume":"69","author":"Lattanzi","year":"2008","journal-title":"Clin. Endocrinol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1530\/EJE-08-0272","article-title":"Monogenic polycystic ovary syndrome due to a mutation in the lamin A\/C gene is sensitive to thiazolidinediones but not to metformin","volume":"159","author":"Gambineri","year":"2008","journal-title":"Eur. J. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s13023-022-02308-7","article-title":"Dunnigan lipodystrophy syndrome: French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins)","volume":"17","author":"Mosbah","year":"2022","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s40618-018-0887-z","article-title":"Diagnosis and treatment of lipodystrophy: A step-by-step approach","volume":"42","author":"Santini","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"ref_10","first-page":"40","article-title":"Site-dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissue of patients with type 2 familial partial lipodystrophy","volume":"46","author":"Lattanzi","year":"2009","journal-title":"J. Med. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/hmg\/ddi158","article-title":"Altered pre-lamin A processing is a common mechanism leading to lipodystrophy","volume":"14","author":"Capanni","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.atherosclerosis.2015.12.012","article-title":"LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation","volume":"245","author":"Afonso","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"264","DOI":"10.18632\/aging.100651","article-title":"Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell","volume":"6","author":"Infante","year":"2014","journal-title":"Aging"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41467-021-27869-2","article-title":"Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy","volume":"13","author":"Czapiewski","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/hmg\/ddt509","article-title":"Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A p.R482W mutation elicits a myogenic gene expression program in preadipocytes","volume":"23","author":"Oldenburg","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1083\/jcb.201701043","article-title":"A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus","volume":"216","author":"Oldenburg","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hartinger, R., Lederer, E.M., Schena, E., Lattanzi, G., and Djabali, K. (2023). Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson\u2013Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies. Cells, 12.","DOI":"10.3390\/cells12101350"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1038\/emm.2016.5","article-title":"Heterogeneity of white adipose tissue: Molecular basis and clinical implications","volume":"48","author":"Kwok","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1530\/EJE-13-0945","article-title":"White, brown and pink adipocytes: The extraordinary plasticity of the adipose organ","volume":"170","author":"Giordano","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/cphy.c170042","article-title":"Adipose Organ Development and Remodeling","volume":"8","author":"Cinti","year":"2018","journal-title":"Compr. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1161\/HYPERTENSIONAHA.115.05148","article-title":"What Is the Role of the Adipocyte Mineralocorticoid Receptor in the Metabolic Syndrome?","volume":"66","year":"2015","journal-title":"Hypertension"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JME-15-0122","article-title":"Cellular mechanisms of MR regulation of adipose tissue physiology and pathophysiology","volume":"55","author":"Armani","year":"2015","journal-title":"J. Mol. Endocrinol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1096\/fj.13-245415","article-title":"Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice","volume":"28","author":"Armani","year":"2014","journal-title":"FASEB J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/cvr\/cvp191","article-title":"Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice","volume":"84","author":"Hirata","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.tem.2019.11.006","article-title":"Mineralocorticoid Receptors in Metabolic Syndrome: From Physiology to Disease","volume":"31","author":"Feraco","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/cphy.c160037","article-title":"Impact of Adrenal Steroids on Regulation of Adipose Tissue","volume":"7","author":"Infante","year":"2017","journal-title":"Compr. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1055\/s-2007-993156","article-title":"Effects of spironolactone on glucose transport and interleukin-6 secretion in adipose cells of women","volume":"39","author":"Corbould","year":"2007","journal-title":"Horm. Metab. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s40618-021-01635-z","article-title":"Class-specific responses of brown adipose tissue to steroidal and nonsteroidal mineralocorticoid receptor antagonists","volume":"45","author":"Marzolla","year":"2022","journal-title":"J. Endocrinol. Investig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cdd.2012.63","article-title":"Regulation of lipid stores and metabolism by lipophagy","volume":"20","author":"Liu","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.ajpath.2011.07.049","article-title":"LMNA mutations induce a non-inflammatory fibrosis and a brown fat-like dystrophy of enlarged cervical adipose tissue","volume":"179","author":"Bereziat","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.yexcr.2007.11.012","article-title":"Drugs affecting prelamin A processing: Effects on heterochromatin organization","volume":"314","author":"Mattioli","year":"2008","journal-title":"Exp. Cell Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Capanni, C., Schena, E., Di Giampietro, M.L., Montecucco, A., Mattioli, E., and Lattanzi, G. (2022). The role of prelamin A post-translational maturation in stress response and 53BP1 recruitment. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.1018102"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Santi, S., Cenni, V., Capanni, C., Lattanzi, G., and Mattioli, E. (2020). PCAF Involvement in Lamin A\/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation. Cells, 9.","DOI":"10.3390\/cells9071735"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1038\/sj.cdd.4402197","article-title":"Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence","volume":"14","author":"Caron","year":"2007","journal-title":"Cell Death Differ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4081\/ejh.2009.e6","article-title":"Different prelamin A forms accumulate in human fibroblasts: A study in experimental models and progeria","volume":"53","author":"Dominici","year":"2009","journal-title":"Eur. J. Histochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"E856","DOI":"10.1210\/jc.2010-2234","article-title":"A homozygous mutation of prelamin-A preventing its farnesylation and maturation leads to a severe lipodystrophic phenotype: New insights into the pathogenicity of nonfarnesylated prelamin-A","volume":"96","author":"Schneebeli","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ahj.2014.12.021","article-title":"Metabolic and cardiac phenotype characterization in 37 atypical Dunnigan patients with nonfarnesylated mutated prelamin A","volume":"169","author":"Andre","year":"2015","journal-title":"Am. Heart J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00418-012-0977-5","article-title":"Altered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment","volume":"138","author":"Camozzi","year":"2012","journal-title":"Histochem. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sawada, T., Miyoshi, H., Shimada, K., Suzuki, A., Okamatsu-Ogura, Y., Perfield, J.W., Kondo, T., Nagai, S., Shimizu, C., and Yoshioka, N. (2010). Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype. PLoS ONE, 5.","DOI":"10.1371\/annotation\/45438cdc-913a-4009-b2c1-5c1bc437c926"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1194\/jlr.M700047-JLR200","article-title":"Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue","volume":"48","author":"Souza","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1161\/CIRCULATIONAHA.107.748640","article-title":"Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines","volume":"117","author":"Guo","year":"2008","journal-title":"Circulation"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Martinez-Sanchez, N. (2020). There and Back Again: Leptin Actions in White Adipose Tissue. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176039"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1210\/en.2015-2055","article-title":"Histone Deacetylase 6-Controlled Hsp90 Acetylation Significantly Alters Mineralocorticoid Receptor Subcellular Dynamics But Not its Transcriptional Activity","volume":"157","author":"Jaisser","year":"2016","journal-title":"Endocrinology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/s41419-021-04074-z","article-title":"Lamin-A interacting protein Hsp90 is required for DNA damage repair and chemoresistance of ovarian cancer cells","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41420-018-0053-6","article-title":"Molecular functional analyses revealed essential roles of HSP90 and lamin A\/C in growth, migration, and self-aggregation of dermal papilla cells","volume":"4","author":"Thanomkitti","year":"2018","journal-title":"Cell Death Discov."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e9736","DOI":"10.15252\/emmm.201809736","article-title":"Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells","volume":"11","author":"Hamczyk","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1128\/MCB.01190-09","article-title":"The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events","volume":"30","author":"Galigniana","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e2121816119","DOI":"10.1073\/pnas.2121816119","article-title":"Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics","volume":"119","author":"Vahabikashi","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00418-011-0792-4","article-title":"Reorganization of the nuclear lamina and cytoskeleton in adipogenesis","volume":"135","author":"Verstraeten","year":"2011","journal-title":"Histochem. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1530\/JME-15-0318","article-title":"Mineralocorticoid regulation of cell function: The role of rapid signalling and gene transcription pathways","volume":"58","author":"Ong","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"101073","DOI":"10.1016\/j.arr.2020.101073","article-title":"Lamin A involvement in ageing processes","volume":"62","author":"Cenni","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e13285","DOI":"10.1111\/acel.13285","article-title":"Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice","volume":"20","author":"Squarzoni","year":"2021","journal-title":"Aging Cell"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/22\/2586\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:18:44Z","timestamp":1760131124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/22\/2586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":53,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["cells12222586"],"URL":"https:\/\/doi.org\/10.3390\/cells12222586","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]}}}