{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:47:47Z","timestamp":1792532867398,"version":"4.5.0"},"reference-count":386,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>This review on acne transcriptomics allows for deeper insights into the pathogenesis of acne and isotretinoin\u2019s mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin and androgen signaling activate the kinase AKT and mechanistic target of rapamycin complex 1 (mTORC1). A Western diet (hyperglycemic carbohydrates and milk\/dairy products) also co-stimulates AKT\/mTORC1 signaling. The AKT-mediated phosphorylation of nuclear FoxO1 and FoxO3 results in their extrusion into the cytoplasm, a critical switch which enhances the transactivation of lipogenic and proinflammatory transcription factors, including androgen receptor (AR), sterol regulatory element-binding transcription factor 1 (SREBF1), peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) and signal transducer and activator of transcription 3 (STAT3), but reduces the FoxO1-dependent expression of GATA binding protein 6 (GATA6), the key transcription factor for infundibular keratinocyte homeostasis. The AKT-mediated phosphorylation of the p53-binding protein MDM2 promotes the degradation of p53. In contrast, isotretinoin enhances the expression of p53, FoxO1 and FoxO3 in the sebaceous glands of acne patients. The overexpression of these proapoptotic transcription factors explains isotretinoin\u2019s desirable sebum-suppressive effect via the induction of sebocyte apoptosis and the depletion of BLIMP1(+) sebocyte progenitor cells; it also explains its adverse effects, including teratogenicity (neural crest cell apoptosis), a reduced ovarian reserve (granulosa cell apoptosis), the risk of depression (the apoptosis of hypothalamic neurons), VLDL hyperlipidemia, intracranial hypertension and dry skin.<\/jats:p>","DOI":"10.3390\/cells12222600","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T05:04:56Z","timestamp":1699592696000},"page":"2600","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-1809","authenticated-orcid":false,"given":"Bodo C.","family":"Melnik","sequence":"first","affiliation":[{"name":"Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabr\u00fcck, 49069 Osnabr\u00fcck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00403-019-01908-x","article-title":"From pathogenesis of acne vulgaris to anti-acne agents","volume":"311","author":"Cong","year":"2019","journal-title":"Arch. Dermatol. Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Plewig, G., Melnik, B., and Chen, W. (2019). Plewig and Kligman\u2019s Acne and Rosacea, Springer.","DOI":"10.1007\/978-3-319-49274-2"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/1357-2725(95)00168-9","article-title":"IGF-I: A mitogen also involved in differentiation processes in mammalian cells","volume":"28","author":"Benito","year":"1996","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"T69","DOI":"10.1530\/JME-17-0311","article-title":"IGF1 receptor signaling pathways","volume":"61","author":"Hakuno","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"ref_5","first-page":"5","article-title":"Growth hormone\/insulin-like growth factor-1 axis during puberty","volume":"3","author":"Christoforidis","year":"2005","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41390-020-01215-6","article-title":"Does height and IGF-I determine pubertal timing in girls?","volume":"90","author":"Upners","year":"2021","journal-title":"Pediatr. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s11914-020-00570-x","article-title":"The actions of IGF-1 in the growth plate and its role in postnatal bone elongation","volume":"18","author":"Racine","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1017\/S0021932000013651","article-title":"Is acne a sign of normal puberty? A longitudinal study","volume":"13","author":"Fellowes","year":"1981","journal-title":"J. Biosoc. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1210\/edrv.21.4.0404","article-title":"Role of hormones in pilosebaceous unit development","volume":"21","author":"Deplewski","year":"2000","journal-title":"Endocr. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1001\/archderm.141.3.333","article-title":"Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women","volume":"143","author":"Cappel","year":"2005","journal-title":"Arch. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1365-2133.2008.08764.x","article-title":"Correlation of facial sebum to serum insulin-like growth factor-1 in patients with acne","volume":"159","author":"Vora","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"ref_12","first-page":"267","article-title":"Body mass index, selected dietary factors, and acne severity: Are they related to in situ expression of insulin-like growth factor-1?","volume":"36","author":"Seleit","year":"2014","journal-title":"Anal. Quant. Cytopathol. Histpathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.jand.2018.02.009","article-title":"A low glycemic index and glycemic load diet decreases insulin-like growth factor-1 among adults with moderate and severe acne: A short-duration, 2-week randomized controlled trial","volume":"118","author":"Burris","year":"2018","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1080\/09637480903150114","article-title":"Milk consumption and circulating insulin-like growth factor-I level: A systematic literature review","volume":"60","author":"Qin","year":"2009","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1016\/j.clnu.2021.04.021","article-title":"Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients","volume":"40","author":"Watling","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1600-0625.2009.00924.x","article-title":"Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris","volume":"18","author":"Melnik","year":"2009","journal-title":"Exp. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jdin.2022.02.012","article-title":"Diet and acne: A systematic review","volume":"7","author":"Meixiong","year":"2022","journal-title":"JAAD Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/j.1468-3083.2010.03896.x","article-title":"Effect of insulin-like growth factor-1 deficiency or administration on the occurrence of acne","volume":"25","author":"Laron","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2265.1998.00356.x","article-title":"Development of hyperandrogenism during treatment with insulin-like growth factor-I (IGF-I) in female patients with Laron syndrome","volume":"48","author":"Klinger","year":"1998","journal-title":"Clin. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: Navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"key":"ref_21","first-page":"105","article-title":"FoxO1\u2014The key for the pathogenesis and therapy of acne?","volume":"8","author":"Melnik","year":"2010","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2015.08.001","article-title":"Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase\/Akt\/FoxO1 pathway in SZ95 sebocytes in vitro","volume":"415","author":"Mirdamadi","year":"2015","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7329","DOI":"10.1074\/jbc.M610447200","article-title":"Insulin-like growth factor 1\/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor","volume":"282","author":"Fan","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"20132","DOI":"10.1074\/jbc.M112.347211","article-title":"FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c","volume":"287","author":"Deng","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"12188","DOI":"10.1074\/jbc.M808915200","article-title":"FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes","volume":"284","author":"Fan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1074\/jbc.M804965200","article-title":"FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1","volume":"284","author":"Yang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/bjd.13229","article-title":"Leptin promotes a proinflammatory lipid profile and induces inflammatory pathways in human SZ95 sebocytes","volume":"171","author":"Camera","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4161\/derm.1.2.8354","article-title":"Hormones and the pilosebaceous unit","volume":"1","author":"Chen","year":"2009","journal-title":"Dermatoendocrinology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/sj.jid.5701155","article-title":"IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase\/Akt pathway","volume":"128","author":"Smith","year":"2008","journal-title":"J. Investig. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bcp.2017.04.030","article-title":"Pharmacological PPAR\u03b3 modulation regulates sebogenesis and inflammation in SZ95 human sebocytes","volume":"138","author":"Mastrofrancesco","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2340\/00015555-1346","article-title":"Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients: A randomized, controlled trial","volume":"92","author":"Kwon","year":"2012","journal-title":"Acta Derm. Venereol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11598","DOI":"10.1073\/pnas.181181198","article-title":"A phosphatidylinositol 3-kinase\/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus","volume":"98","author":"Mayo","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/387296a0","article-title":"Mdm2 promotes the rapid degradation of p53","volume":"387","author":"Haupt","year":"1997","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"21843","DOI":"10.1074\/jbc.M109745200","article-title":"Akt enhances Mdm2-mediated ubiquitination and degradation of p53","volume":"277","author":"Ogawara","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12967-017-1297-2","article-title":"p53: Key conductor of all anti-acne therapies","volume":"15","author":"Melnik","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ncb2763","article-title":"Signal integration by mTORC1 coordinates nutrient input with biosynthetic output","volume":"15","author":"Dibble","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ceb.2017.02.012","article-title":"mTORC1 signaling and the metabolic control of cell growth","volume":"45","author":"Manning","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20080281","article-title":"The TSC1-TSC2 complex: A molecular switchboard controlling cell growth","volume":"412","author":"Huang","year":"2008","journal-title":"Biochem. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4161\/derm.19828","article-title":"Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet","volume":"4","author":"Melnik","year":"2012","journal-title":"Dermatoendocrinology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/exd.12142","article-title":"Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne","volume":"22","author":"Melnik","year":"2013","journal-title":"Exp. Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/exd.12885","article-title":"Mechanistic target of rapamycin (mTOR) expression is increased in acne patients\u2019 skin","volume":"25","author":"Monfrecola","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/bjd.14409","article-title":"Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin-like growth factor-1 in patients with acne vulgaris and their relationship with diet","volume":"174","author":"Agamia","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00403-019-01959-0","article-title":"The increase of mTOR expression is consistent with FoxO1 decrease at gene level in acne but not in psoriasis","volume":"312","author":"Lembo","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1743-7075-8-41","article-title":"Over-stimulation of insulin\/IGF-1 signaling by western diet may promote diseases of civilization: Lessons learnt from Laron syndrome","volume":"8","author":"Melnik","year":"2011","journal-title":"Nutr. Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"17048","DOI":"10.3390\/ijms160817048","article-title":"Milk\u2014A nutrient system of mammalian evolution promoting mTORC1-dependent translation","volume":"16","author":"Melnik","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_47","first-page":"1713","article-title":"Regulation of mTORC1 and its impact on gene expression at a glance","volume":"126","author":"Laplante","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1210\/me.2008-0148","article-title":"The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: The role of the 5\u2032-untranslated region in the expression of leptin messenger ribonucleic acid","volume":"22","author":"Chakrabarti","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1468-3083.2010.03937.x","article-title":"Acne-associated syndromes: Models for better understanding of acne pathogenesis","volume":"25","author":"Chen","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"S262","DOI":"10.2337\/dc08-s264","article-title":"Insulin resistance and hyperinsulinemia: Is hyperinsulinemia the cart or the horse?","volume":"31","author":"Shanik","year":"2008","journal-title":"Diabetes Care"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"14892","DOI":"10.1038\/ncomms14892","article-title":"Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression","volume":"8","author":"Cai","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1079\/BJN20041304","article-title":"Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk","volume":"93","author":"Hoyt","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.ejcn.1602086","article-title":"High intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year-old boys","volume":"59","author":"Hoppe","year":"2005","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.diabres.2017.06.011","article-title":"Insulin and the polycystic ovary syndrome","volume":"130","author":"Macut","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_55","first-page":"321","article-title":"Analysis of phenotypic features and FGFR2 mutations in Apert syndrome","volume":"57","author":"Park","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41392-020-00222-7","article-title":"FGF\/FGFR signaling in health and disease","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1001\/archderm.1970.04000100029007","article-title":"Pilosebaceous abnormalities in Apert\u2019s syndrome","volume":"102","author":"Solomon","year":"1970","journal-title":"Arch. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0094-1298(20)30832-4","article-title":"Acne in Apert syndrome","volume":"18","author":"Krafchik","year":"1991","journal-title":"Clin. Plast. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0140-6736(05)60820-3","article-title":"Epidermal mosaicism producing localised acne: Somatic mutation in FGFR2","volume":"352","author":"Munro","year":"1998","journal-title":"Lancet"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.1365-2133.2008.08559.x","article-title":"Unilateral segmental acneiform naevus: A model disorder towards understanding fibroblast growth factor receptor 2 function in acne?","volume":"158","author":"Melnik","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.abd.2021.09.021","article-title":"Segmental hypopigmented acneiform nevus with FGFR2 gene mutation","volume":"98","author":"Xie","year":"2023","journal-title":"An. Bras. Dermatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1610-0387.2008.06822.x","article-title":"FGFR2 signaling and the pathogenesis of acne","volume":"6","author":"Melnik","year":"2008","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4161\/derm.1.3.8474","article-title":"Role of FGFR2-signaling in the pathogenesis of acne","volume":"1","author":"Melnik","year":"2009","journal-title":"Dermatoendocrinology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1038\/jid.2009.8","article-title":"Anti-acne agents attenuate FGFR2 signal transduction in acne","volume":"129","author":"Melnik","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_65","first-page":"509","article-title":"Sex hormones and acne: State of the art","volume":"19","author":"Hu","year":"2021","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11154-008-9105-1","article-title":"Expression of the IGF and the aromatase\/estrogen receptor systems in human adrenal tissues from early infancy to late puberty: Implications for the development of adrenarche","volume":"10","author":"Belgorosky","year":"2009","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_67","first-page":"483","article-title":"Short-term exposure to insulin-like growth factors stimulates testosterone production by testicular interstitial cells","volume":"115","author":"Handelsman","year":"1987","journal-title":"Acta Endocrinol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/0006-291X(86)90317-7","article-title":"Direct stimulatory effects of insulin-like growth factor-I on Leydig cell steroidogenesis in primary culture","volume":"137","author":"Lin","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0303-7207(87)90093-1","article-title":"Insulin-like growth factor-I augments gonadotropin-stimulated androgen biosynthesis by cultured rat testicular cells","volume":"52","author":"Kasson","year":"1987","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1210\/endo-123-2-733","article-title":"Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells","volume":"123","author":"Cara","year":"1988","journal-title":"Endocrinology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000184145","article-title":"Insulin-like growth factors, insulin-like growth factor binding proteins and ovarian androgen production","volume":"42","author":"Cara","year":"1994","journal-title":"Horm. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1210\/endo.133.2.8344190","article-title":"Androgen induction of steroid 5 alpha-reductase may be mediated via insulin-like growth factor-I","volume":"133","author":"Horton","year":"1993","journal-title":"Endocrinology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1210\/endo-126-2-1165","article-title":"Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone","volume":"126","author":"Grino","year":"1990","journal-title":"Endocrinology"},{"key":"ref_74","first-page":"3","article-title":"Androgen receptor structure, function and biology: From bench to bedside","volume":"37","author":"Davey","year":"2016","journal-title":"Clin. Biochem. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jsbmb.2015.04.005","article-title":"Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor","volume":"152","author":"Barrault","year":"2015","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1210\/en.2006-1653","article-title":"Identification of androgen response elements in the insulin-like growth factor I upstream promoter","volume":"148","author":"Wu","year":"2007","journal-title":"Endocrinology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1158\/0008-5472.CAN-04-1837","article-title":"Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells","volume":"65","author":"Pandini","year":"2005","journal-title":"Cancer Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1074\/jbc.M111.323303","article-title":"Androgen receptor enhances p27 degradation in prostate cancer cells through rapid and selective TORC2 activation","volume":"287","author":"Fang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"T131","DOI":"10.1530\/ERC-13-0472","article-title":"Androgen receptor phosphorylation: Biological context and functional consequences","volume":"21","author":"Koryakina","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1593\/neo.07769","article-title":"Expression of androgen receptor is negatively regulated by p53","volume":"9","author":"Alimirah","year":"2007","journal-title":"Neoplasia"},{"key":"ref_81","first-page":"524","article-title":"The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity","volume":"76","author":"Gautier","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jaad.2013.11.029","article-title":"Ductal hypoxia in acne: Is it the missing link between comedogenesis and inflammation?","volume":"70","author":"Danby","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/exd.12917","article-title":"Is sebocyte-derived leptin the missing link between hyperseborrhea, ductal hypoxia, inflammation and comedogenesis in acne vulgaris?","volume":"25","author":"Melnik","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1172\/JCI84431","article-title":"HIF1\u03b1 and metabolic reprogramming in inflammation","volume":"126","author":"Corcoran","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"42953","DOI":"10.1074\/jbc.M206775200","article-title":"Hypoxia-inducible factor 1 transactivates the human leptin gene promoter","volume":"277","author":"Grosfeld","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1172\/JCI9148","article-title":"Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair","volume":"106","author":"Frank","year":"2000","journal-title":"J. Clin. Investig."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/jid.2014.283","article-title":"Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function","volume":"135","author":"Wong","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/1523-1747.ep12477026","article-title":"Monoclonal antibody labeling for cytokeratins and filaggrin in the human pilosebaceous unit of normal, seborrhoeic and acne skin","volume":"91","author":"Kurokawa","year":"1988","journal-title":"J. Investig. Dermatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00403-018-1821-0","article-title":"Leptin regulates the pro-inflammatory response in human epidermal keratinocytes","volume":"310","author":"Lee","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): Implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J. Physiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","article-title":"Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation","volume":"27","author":"Lunt","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"121201","DOI":"10.1016\/j.lfs.2022.121201","article-title":"LPA\/LPAR1 signaling induces PGAM1 expression via AKT\/mTOR\/HIF-1\u03b1 pathway and increases aerobic glycolysis, contributing to keratinocyte proliferation","volume":"311","author":"Kim","year":"2022","journal-title":"Life Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1188745","DOI":"10.3389\/fimmu.2023.1188745","article-title":"A prediction model identifying glycolysis signature as therapeutic target for psoriasis","volume":"14","author":"Shou","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2133.2004.06004.x","article-title":"Human sebaceous glands engage in aerobic glycolysis and glutaminolysis","volume":"151","author":"Downie","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1111\/febs.15327","article-title":"Glycolysis\u2014A key player in the inflammatory response","volume":"287","author":"Oller","year":"2020","journal-title":"FEBS J."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Kelh\u00e4l\u00e4, H.L., Palatsi, R., Fyhrquist, N., Lehtim\u00e4ki, S., V\u00e4yrynen, J.P., Kallioinen, M., Kubin, M.E., Greco, D., Tasanen, K., and Alenius, H. (2014). IL-17\/Th17 pathway is activated in acne lesions. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105238"},{"key":"ref_99","first-page":"E61","article-title":"Acne lesion extraction versus oral doxycycline for moderate acne vulgaris: A randomized clinical trial","volume":"14","author":"Sitohang","year":"2021","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000505537","article-title":"Increased lipid accumulation under hypoxia in SZ95 human sebocytes","volume":"237","author":"Choi","year":"2021","journal-title":"Dermatology"},{"key":"ref_101","first-page":"659","article-title":"Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits hypoxia-induced neovasculogenesis through prolyl hydroxylase, von Hippel-Lindau-dependent pathway","volume":"88","author":"Li","year":"2014","journal-title":"Arch. Toxicol."},{"key":"ref_102","first-page":"s6","article-title":"Oral tetracyclines and acne: A systematic review for dermatologists","volume":"19","author":"Armstrong","year":"2020","journal-title":"J. Drugs Dermatol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1001\/jama.2021.17633","article-title":"Management of acne vulgaris: A review","volume":"326","author":"Eichenfield","year":"2021","journal-title":"JAMA"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0190-9622(87)70294-1","article-title":"Azelaic acid","volume":"17","year":"1987","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1476-4598-12-93","article-title":"Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses","volume":"12","author":"Obacz","year":"2013","journal-title":"Mol. Cancer"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.1128\/MCB.24.13.5757-5766.2004","article-title":"DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX","volume":"24","author":"Kaluz","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/jcp.21980","article-title":"PKB\/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2","volume":"222","author":"Choy","year":"2010","journal-title":"J. Cell Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"22785","DOI":"10.1074\/jbc.M114.587493","article-title":"MDM2 regulates hypoxic hypoxia-inducible factor 1\u03b1 stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner","volume":"289","author":"Joshi","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1007\/s00403-023-02594-6","article-title":"Overexpression of hypoxia-inducible factor-1\u03b1 in hidradenitis suppurativa: The link between deviated immunity and metabolism","volume":"315","author":"Agamia","year":"2023","journal-title":"Arch. Dermatol. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/ncb3532","article-title":"Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties","volume":"19","author":"Donati","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/exd.13757","article-title":"Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct","volume":"28","author":"Swanson","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1038\/s41467-020-18784-z","article-title":"Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis","volume":"11","author":"Philippeos","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.cell.2014.04.016","article-title":"Tissue-specific signals control reversible program of localization and functional polarization of macrophages","volume":"157","author":"Okabe","year":"2014","journal-title":"Cell"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.celrep.2017.08.046","article-title":"mTORC2 signaling selectively regulates the generation and function of tissue-resident peritoneal macrophages","volume":"20","author":"Oh","year":"2017","journal-title":"Cell Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"ra44","DOI":"10.1126\/scisignal.2005482","article-title":"Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition","volume":"8","author":"Xie","year":"2015","journal-title":"Sci. Signal."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/sj.jid.5700289","article-title":"13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes","volume":"126","author":"Nelson","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41418-022-00988-z","article-title":"Cell cycle regulation: p53-p21-RB signaling","volume":"29","author":"Engeland","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"13713","DOI":"10.1074\/jbc.273.22.13713","article-title":"GATA-6 induces p21(Cip1) expression and G1 cell cycle arrest","volume":"273","author":"Perlman","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.3892\/or.2015.3900","article-title":"Hypoxia-induced miR-181b enhances angiogenesis of retinoblastoma cells by targeting PDCD10 and GATA6","volume":"33","author":"Xu","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1038\/ncomms5020","article-title":"Genome-wide association study identifies three novel susceptibility loci for severe acne vulgaris","volume":"5","author":"Navarini","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41467-022-28252-5","article-title":"Genome-wide association meta-analysis identifies 29 new acne susceptibility loci","volume":"13","author":"Mitchell","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"McNairn, A.J., Doucet, Y., Demaude, J., Brusadelli, M., Gordon, C.B., Uribe-Rivera, A., Lambert, P.F., Bouez, C., Breton, L., and Guasch, G. (2013). TGF\u03b2 signaling regulates lipogenesis in human sebaceous glands cells. BMC Dermatol., 13.","DOI":"10.1186\/1471-5945-13-2"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"30488","DOI":"10.1073\/pnas.2017056117","article-title":"FoxO1 is a crucial mediator of TGF-\u03b2\/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis","volume":"117","author":"Wang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Huang, C., Zhuo, F., Han, B., Li, W., Jiang, B., Zhang, K., Jian, X., Chen, Z., Li, H., and Huang, H. (2023). The updates and implications of cutaneous microbiota in acne. Cell Biosci., 13.","DOI":"10.1186\/s13578-023-01072-w"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/jid.2014.290","article-title":"Propionibacterium acnes promotes Th17 and Th17\/Th1 responses in acne patients","volume":"135","author":"Kistowska","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1029818","DOI":"10.3389\/fimmu.2022.1029818","article-title":"Sebaceous immunobiology\u2014Skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations","volume":"13","author":"Zouboulis","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/jid.2010.281","article-title":"Propionibacterium acnes activates the IGF-1\/IGF-1R system in the epidermis and induces keratinocyte proliferation","volume":"131","author":"Isard","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/j.1365-2133.2005.06933.x","article-title":"Induction of toll-like receptors by Propionibacterium acnes","volume":"153","author":"Jugeau","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"109303","DOI":"10.1016\/j.celrep.2021.109303","article-title":"Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration","volume":"35","author":"Marks","year":"2021","journal-title":"Cell Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.anaerobe.2016.10.001","article-title":"Transcriptomic analysis of Propionibacterium acnes biofilms in vitro","volume":"42","author":"Jahns","year":"2016","journal-title":"Anaerobe"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Mayslich, C., Grange, P.A., and Dupin, N. (2021). Cutibacterium acnes as an opportunistic pathogen: An update of its virulence-associated factors. Microorganisms, 9.","DOI":"10.3390\/microorganisms9020303"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.resmic.2007.02.001","article-title":"Biofilm formation by Propionibacterium acnes is associated with increased resistance to antimicrobial agents and increased production of putative virulence factors","volume":"158","author":"Coenye","year":"2007","journal-title":"Res. Microbiol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Coenye, T., Spittaels, K.J., and Achermann, Y. (2021). The role of biofilm formation in the pathogenesis and antimicrobial susceptibility of Cutibacterium acnes. Biofilm, 4.","DOI":"10.1016\/j.bioflm.2021.100063"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1194\/jlr.D029546","article-title":"Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways","volume":"53","author":"Huang","year":"2012","journal-title":"J. Lipid Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.lfs.2015.07.028","article-title":"Cell-free extracts of Propionibacterium acnes stimulate cytokine production through activation of p38 MAPK and Toll-like receptor in SZ95 sebocytes","volume":"139","author":"Huang","year":"2015","journal-title":"Life Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"530429","DOI":"10.1155\/2013\/530429","article-title":"Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleukin-1\u03b2, and tumor necrosis factor-\u03b1 via a NF-\u03baB-dependent mechanism in HaCaT keratinocytes","volume":"2013","author":"Zhou","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1006\/abbi.1993.1104","article-title":"Expression, purification, and binding properties of human cellular retinoic acid-binding protein type I and type II","volume":"300","author":"Fogh","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1073\/pnas.90.1.30","article-title":"Retinoic acid receptors and retinoid X receptors: Interactions with endogenous retinoic acids","volume":"90","author":"Allenby","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_139","first-page":"181","article-title":"13-cis retinoic acid does not bind to retinoic acid receptors alpha, beta and gamma","volume":"12","author":"Levin","year":"1992","journal-title":"Toxicologist"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000246226","article-title":"Oral 9-cis-retinoic acid versus 13-cis-retinoic acid in acne therapy","volume":"193","author":"Ott","year":"1996","journal-title":"Dermatology"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1021\/bi00285a032","article-title":"13-cis-retinoic acid metabolism in vivo. The major tissue metabolites in the rat have the all-trans configuration","volume":"22","author":"McCormick","year":"1983","journal-title":"Biochemistry"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/tcm.1770110104","article-title":"Isotretinoin (13-cis-retinoic acid) metabolism, cis-trans isomerization, glucuronidation, and transfer to the mouse embryo: Consequences for teratogenicity","volume":"11","author":"Eckhoff","year":"1991","journal-title":"Teratog. Carcinog. Mutagen."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s002040050044","article-title":"The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-retinoic acid","volume":"68","author":"Tzimas","year":"1994","journal-title":"Arch. Toxicol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1067\/mjd.2001.113714","article-title":"Cellular metabolism and actions of 13-cis-retinoic acid","volume":"45","author":"Blaner","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1067\/mjd.2001.113720","article-title":"Teratogenicity of isotretinoin revisited: Species variation and the role of all-trans-retinoic acid","volume":"45","author":"Nau","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4161\/derm.1.3.9364","article-title":"The use of isotretinoin in acne","volume":"1","author":"Layton","year":"2009","journal-title":"Dermatoendocrinology"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1523-1747.2000.00066.x","article-title":"13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors","volume":"115","author":"Tsukada","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/jid.2008.338","article-title":"Isotretinoin temporally regulates distinct sets of genes in patient skin","volume":"129","author":"Nelson","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/bjd.18562","article-title":"Isotretinoin is indirectly effective in sebocytes","volume":"182","author":"Hegyi","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2133.1995.tb02622.x","article-title":"In situ hybridization analysis of CRABP II expression in sebaceous follicles from 13-cis retinoic acid-treated acne patients","volume":"133","author":"Sitzmann","year":"1995","journal-title":"Br. J. Dermatol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0092-8674(92)90267-G","article-title":"All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs","volume":"71","author":"Durand","year":"1992","journal-title":"Cell"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"22334","DOI":"10.1016\/S0021-9258(17)31794-5","article-title":"Retinoic acid induction of human cellular retinoic acid-binding protein-II gene transcription is mediated by retinoic acid receptor-retinoid X receptor heterodimers bound to one far upstream retinoic acid-responsive element with 5-base pair spacing","volume":"269","author":"Pettersson","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/1523-1747.ep12343887","article-title":"Retinoid induction of CRABP II mRNA in human dermal fibroblasts: Use as a retinoid bioassay","volume":"106","author":"Elder","year":"1996","journal-title":"J. Investig. Dermatol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.cell.2007.02.050","article-title":"Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors","volume":"129","author":"Schug","year":"2007","journal-title":"Cell"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1172\/JCI33869","article-title":"Neutrophil gelatinase-associated lipocalin mediates 13-cis retinoic acid-induced apoptosis of human sebaceous gland cells","volume":"118","author":"Nelson","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jcp.22417","article-title":"Retinoids regulate stem cell differentiation","volume":"226","author":"Gudas","year":"2011","journal-title":"J. Cell Physiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/exd.14303","article-title":"Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies","volume":"30","author":"Geueke","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Hou, X., Wei, Z., Zouboulis, C.C., and Ju, Q. (2022). Aging in the sebaceous gland. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.909694"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"113121","DOI":"10.1016\/j.celrep.2023.113121","article-title":"Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury","volume":"42","author":"Veniaminova","year":"2023","journal-title":"Cell Rep."},{"key":"ref_160","first-page":"701","article-title":"Retinoids induce stem cell differentiation via epigenetic changes. Semin","volume":"24","author":"Gudas","year":"2013","journal-title":"Cell Dev. Biol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"T37","DOI":"10.1530\/JME-22-0082","article-title":"Retinoid metabolism: New insights","volume":"69","author":"Gudas","year":"2022","journal-title":"J. Mol. Endocrinol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cell.2006.06.048","article-title":"Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland","volume":"126","author":"Horsley","year":"2006","journal-title":"Cell"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1038\/s41467-019-10261-6","article-title":"Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro","volume":"10","author":"Feldman","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e1141","DOI":"10.1038\/cddis.2014.87","article-title":"p53 Induces skin aging by depleting Blimp1+ sebaceous gland cells","volume":"5","author":"Kim","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.celrep.2013.01.013","article-title":"c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor\/p53 axis","volume":"3","author":"Cottle","year":"2013","journal-title":"Cell Rep."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1634\/stemcells.2007-0651","article-title":"Characterization of bipotential epidermal progenitors derived from human sebaceous gland: Contrasting roles of c-Myc and beta-catenin","volume":"26","author":"Berta","year":"2008","journal-title":"Stem Cells"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1073\/pnas.0605562104","article-title":"BLIMP1 regulates cell growth through repression of p53 transcription","volume":"104","author":"Yan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41385-022-00504-z","article-title":"FoxO1 suppresses IL-10 producing B cell differentiation via negatively regulating Blimp-1 expression and contributes to allergic asthma progression","volume":"15","author":"Wang","year":"2022","journal-title":"Mucosal Immunol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/bjd.15668","article-title":"Efficacy and adverse events of oral isotretinoin for acne: A systematic review","volume":"178","author":"Vallerand","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/17512433.2020.1796637","article-title":"The use of isotretinoin for acne\u2014An update on optimal dosing, surveillance, and adverse effects","volume":"13","author":"Bagatin","year":"2020","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4161\/derm.15331","article-title":"Isotretinoin and FoxO1: A scientific hypothesis","volume":"3","author":"Melnik","year":"2011","journal-title":"Dermatoendocrinology"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/j.1365-2133.2010.09754.x","article-title":"Is nuclear deficiency of FoxO1 due to increased growth factor\/PI3K\/Akt-signalling in acne vulgaris reversed by isotretinoin treatment?","volume":"162","author":"Melnik","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_173","first-page":"559","article-title":"The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action","volume":"145","author":"Melnik","year":"2010","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/exd.13775","article-title":"FoxO1 enhances differentiation and apoptosis in human primary keratinocytes","volume":"27","author":"Shi","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jdermsci.2020.04.001","article-title":"Autophagy regulates lipid production and contributes to the sebosuppressive effect of retinoic acid in human SZ95 sebocytes","volume":"98","author":"Seo","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/exd.13787","article-title":"Effect of oral isotretinoin on the nucleo-cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris","volume":"27","author":"Agamia","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1158\/1541-7786.MCR-17-0089","article-title":"p53 maintains baseline expression of multiple tumor suppressor genes","volume":"15","author":"Pappas","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1038\/onc.2011.35","article-title":"The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor","volume":"30","author":"Renault","year":"2011","journal-title":"Oncogene"},{"key":"ref_179","first-page":"1355","article-title":"Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris","volume":"315","author":"Agamia","year":"2023","journal-title":"Arch. Dermatol. Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.bbamcr.2011.03.010","article-title":"Akt, FoxO and regulation of apoptosis","volume":"1813","author":"Zhang","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1159\/000487576","article-title":"FOXO1, a potential therapeutic target, regulates autophagic flux, oxidative stress, mitochondrial dysfunction, and apoptosis in human cholangiocarcinoma QBC939 cells","volume":"45","author":"He","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1080\/15384101.2022.2155443","article-title":"The role of FOXO1-mediated autophagy in the regulation of bone formation","volume":"22","author":"Jiang","year":"2023","journal-title":"Cell Cycle"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ceb.2009.12.001","article-title":"Autophagy regulation by p53","volume":"22","author":"Maiuri","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1042\/bst0290684","article-title":"Mechanisms of p53-dependent apoptosis","volume":"29","author":"Schuler","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.canlet.2015.04.014","article-title":"p53-mediated autophagic regulation: A prospective strategy for cancer therapy","volume":"363","author":"Tang","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/cdd.2017.169","article-title":"How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?","volume":"25","author":"Aubrey","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"664","DOI":"10.21037\/tcr.2016.09.16","article-title":"The IGF-1R\/AKT pathway determines cell fate in response to p53","volume":"5","author":"Duan","year":"2016","journal-title":"Transl. Cancer Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1073\/pnas.0502857102","article-title":"The coordinate regulation of the p53 and mTOR pathways in cells","volume":"102","author":"Feng","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tcb.2010.03.004","article-title":"The regulation of energy metabolism and the IGF-1\/mTOR pathways by the p53 protein","volume":"20","author":"Feng","year":"2010","journal-title":"Trends Cell Biol."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Feng, Z. (2010). p53 regulation of the IGF-1\/AKT\/mTOR pathways and the endosomal compartment. Cold Spring Harb. Perspect. Biol., 2.","DOI":"10.1101\/cshperspect.a001057"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1038\/onc.2011.92","article-title":"ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability","volume":"30","author":"Goetz","year":"2011","journal-title":"Oncogene"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1365-2133.2009.09618.x","article-title":"Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: Does isotretinoin affect growth hormone physiology?","volume":"162","author":"Karadag","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"8318","DOI":"10.1073\/pnas.93.16.8318","article-title":"Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene","volume":"93","author":"Werner","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.18632\/oncotarget.27645","article-title":"Tumor suppressor p53 regulates insulin receptor (INSR) gene expression via direct binding to the INSR promoter","volume":"11","author":"Sarfstein","year":"2020","journal-title":"Oncotarget"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1158\/0008-5472.CAN-06-4149","article-title":"The regulation of AMPK beta1, TSC2, and PTEN expression by p53: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways","volume":"67","author":"Feng","year":"2007","journal-title":"Cancer Res."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Cui, D., Qu, R., Liu, D., Xiong, X., Liang, T., and Zhao, Y. (2021). The cross talk between p53 and mTOR pathways in response to physiological and genotoxic stresses. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.775507"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/s41419-020-03185-3","article-title":"DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity","volume":"11","author":"Cui","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"553","DOI":"10.4161\/cbt.19605","article-title":"P53 and the proteasome regulate androgen receptor activity","volume":"13","author":"Guseva","year":"2012","journal-title":"Cancer Biol Ther."},{"key":"ref_199","first-page":"1158","article-title":"Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients","volume":"80","author":"Boudou","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clindermatol.2017.09.006","article-title":"Acne vulgaris: The metabolic syndrome of the pilosebaceous follicle","volume":"36","author":"Melnik","year":"2018","journal-title":"Clin. Dermatol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1021\/cr400161b","article-title":"Retinoic acid actions through mammalian nuclear receptors","volume":"114","author":"Huang","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"jcs259501","DOI":"10.1242\/jcs.259501","article-title":"Perilipins at a glance","volume":"135","author":"Najt","year":"2022","journal-title":"J. Cell Sci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.yexcr.2014.12.004","article-title":"Characterization of the sebocyte lipid droplet proteome reveals novel potential regulators of sebaceous lipogenesis","volume":"332","author":"Dahlhoff","year":"2015","journal-title":"Exp. Cell Res."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.yexcr.2015.11.008","article-title":"Lipid droplets and associated proteins in sebocytes","volume":"340","author":"Schneider","year":"2016","journal-title":"Exp. Cell Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1016\/j.bbagen.2013.05.016","article-title":"PLIN2, the major perilipin regulated during sebocyte differentiation, controls sebaceous lipid accumulation in vitro and sebaceous gland size in vivo","volume":"1830","author":"Dahlhoff","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.2337\/db07-1383","article-title":"Consequences of lipid droplet coat protein downregulation in liver cells: Abnormal lipid droplet metabolism and induction of insulin resistance","volume":"57","author":"Bell","year":"2008","journal-title":"Diabetes"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1194\/jlr.R700014-JLR200","article-title":"Thematic review series: Adipocyte biology. The perilipin family of structural lipid droplet proteins: Stabilization of lipid droplets and control of lipolysis","volume":"48","author":"Brasaemle","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.bbalip.2017.07.009","article-title":"The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis","volume":"1862","author":"Sztalryd","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"100057","DOI":"10.1016\/j.xjidi.2021.100057","article-title":"Lipid droplet proteins in acne skin: A sound target for the maintenance of low comedogenic sebum and acne-prone skin health","volume":"1","author":"Sorg","year":"2021","journal-title":"JID Innov."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1158\/1535-7163.207.4.2","article-title":"Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2\/Bax, cytochrome c release, and caspase activation","volume":"4","author":"Katiyar","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3109\/10715762.2012.655244","article-title":"P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK","volume":"46","author":"Fan","year":"2012","journal-title":"Free Radic. Res."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3109\/10715762.2012.688964","article-title":"P53-mediated GSH depletion enhanced the cytotoxicity of NO in silibinin-treated human cervical carcinoma HeLa cells","volume":"46","author":"Fan","year":"2012","journal-title":"Free Radic. Res."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Conte, M., Vasuri, F., Trisolino, G., Bellavista, E., Santoro, A., Degiovanni, A., Martucci, E., D\u2019Errico-Grigioni, A., Caporossi, D., and Capri, M. (2013). Increased Plin2 expression in human skeletal muscle is associated with sarcopenia and muscle weakness. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073709"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10522-014-9549-5","article-title":"Differential expression of perilipin 2 and 5 in human skeletal muscle during aging and their association with atrophy-related genes","volume":"16","author":"Conte","year":"2015","journal-title":"Biogerontology"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2340\/00015555-2535","article-title":"Apoptosis may explain the pharmacological mode of action and adverse effects of isotretinoin, including teratogenicity","volume":"97","author":"Melnik","year":"2017","journal-title":"Acta Derm. Venereol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1365-2133.2011.10392.x","article-title":"TRAIL contributes to the apoptotic effect of 13-cis retinoic acid in human sebaceous gland cells","volume":"165","author":"Nelson","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.4161\/cbt.7.12.7460","article-title":"TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death","volume":"7","author":"Kuribayashi","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"7040312","DOI":"10.1155\/2016\/7040312","article-title":"Survivin as a novel biomarker in the pathogenesis of acne vulgaris and its correlation to insulin-like growth factor-I","volume":"2016","author":"Assaf","year":"2016","journal-title":"Dis. Markers"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1111\/jocd.14742","article-title":"Elevated survivin levels in patients with acne vulgaris","volume":"21","author":"Kader","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1038\/sj.onc.1205353","article-title":"Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway","volume":"21","author":"Mirza","year":"2002","journal-title":"Oncogene"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Karadag, A.S., Aksoy, B., and Parish, L.C. (2020). Retinoids in Dermatology, CRC Press. [1st ed.]. Chapter 4.","DOI":"10.1201\/9780429456732"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"18128","DOI":"10.1074\/jbc.274.25.18128","article-title":"Retinoic acid confers resistance to p53-dependent apoptosis in SH-SY5Y neuroblastoma cells by modulating nuclear import of p53","volume":"274","author":"Ronca","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000041036","article-title":"p53 pathway in apoptosis induced by all-trans-retinoic acid in acute myeloblastic leukaemia cells","volume":"103","author":"Zheng","year":"2000","journal-title":"Acta Haematol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1038\/sj.onc.1204370","article-title":"Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function","volume":"20","author":"Curtin","year":"2001","journal-title":"Oncogene"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1158\/0008-5472.CAN-04-1129","article-title":"Retinoic acid increases the expression of p53 and proapoptotic caspases and sensitizes keratinocytes to apoptosis: A possible explanation for tumor preventive action of retinoids","volume":"64","author":"Mrass","year":"2004","journal-title":"Cancer Res."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.3892\/or.2013.2391","article-title":"All-trans retinoic acid upregulates the expression of p53 via Axin and inhibits the proliferation of glioma cells","volume":"29","author":"Lu","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Blanco-Luquin, I., L\u00e1zcoz, P., Celay, J., Castresana, J.S., and Enc\u00edo, I.J. (2021). In vitro assessment of the role of p53 on chemotherapy treatments in neuroblastoma cell lines. Pharmaceuticals, 14.","DOI":"10.3390\/ph14111184"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1615\/JEnvironPatholToxicolOncol.v27.i3.40","article-title":"13-cis-retinoic acid induces apoptosis by modulating caspase-3, bcl-2, and p53 gene expression and regulates the activation of transcription factors in B16F-10 melanoma cells","volume":"27","author":"Guruvayoorappan","year":"2008","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/bjd.16837","article-title":"Short-term exposure of human sebocytes to 13-cis-retinoic acid induces acnegenic changes","volume":"179","author":"Burney","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1126\/science.1218395","article-title":"Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress","volume":"336","author":"Lee","year":"2012","journal-title":"Science"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1101\/gad.212282.112","article-title":"Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses","volume":"27","author":"Bieging","year":"2013","journal-title":"Genes Dev."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"a026120","DOI":"10.1101\/cshperspect.a026120","article-title":"Autophagy and p53","volume":"6","author":"White","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/292063a0","article-title":"SV40 T antigen binds specifically to a cellular 53 K protein in vitro","volume":"292","author":"McCormick","year":"1981","journal-title":"Nature"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1099\/0022-1317-79-12-3079","article-title":"The large T antigen of simian virus 40 binds and inactivates p53 but not p73","volume":"79","author":"Dobbelstein","year":"1998","journal-title":"J. Gen. Virol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/archderm.1982.01650200023009","article-title":"Isotretinoin in the treatment of acne: Histologic changes, sebum production, and clinical observations","volume":"118","author":"Goldstein","year":"1982","journal-title":"Arch. Dermatol."},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Morriss-Kay, G. (1991). Retinoids in Normal Development and Teratogenesis, Oxford University Press.","DOI":"10.1093\/oso\/9780198547709.001.0001"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3892\/etm.2021.9966","article-title":"Teratogenic effect of isotretinoin in both fertile females and males (Review)","volume":"21","author":"Draghici","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/sj.cdd.4401879","article-title":"Neural precursor cells possess multiple p53-dependent apoptotic pathways","volume":"13","author":"Akhtar","year":"2006","journal-title":"Cell Death Differ."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/exd.13420","article-title":"Overexpression of p53 explains isotretinoin\u2019s teratogenicity","volume":"27","author":"Melnik","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1242\/dev.053645","article-title":"p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition\/delamination processes","volume":"138","author":"Rinon","year":"2011","journal-title":"Development"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nm1725","article-title":"Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function","volume":"14","author":"Jones","year":"2008","journal-title":"Nat. Med."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"17492","DOI":"10.1038\/s41598-018-35681-0","article-title":"Prenatal retinoic acid exposure reveals candidate genes for craniofacial disorders","volume":"8","author":"Berenguer","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/hmg\/ddab051","article-title":"Mutation in Eftud2 causes craniofacial defects in mice via mis-splicing of Mdm2 and increased p53","volume":"30","author":"Beauchamp","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.cub.2004.09.046","article-title":"Blimp-1 specifies neural crest and sensory neuron progenitors in the zebrafish embryo","volume":"14","author":"Roy","year":"2004","journal-title":"Curr. Biol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5498\/wjp.v5.i2.222","article-title":"Inter-relationships between isotretinoin treatment and psychiatric disorders: Depression, bipolar disorder, anxiety, psychosis and suicide risks","volume":"5","author":"Ludot","year":"2015","journal-title":"World J. Psychiatry"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/1203475417719052","article-title":"Association of isotretinoin with depression and suicide: A review of current literature","volume":"22","author":"Oliveira","year":"2018","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"e12795","DOI":"10.1111\/dth.12795","article-title":"Does isotretinoin cause depression and anxiety in acne patients?","volume":"32","author":"Metekoglu","year":"2019","journal-title":"Dermatol. Ther."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"e021549","DOI":"10.1136\/bmjopen-2018-021549","article-title":"Use of isotretinoin and risk of depression in patients with acne: A systematic review and meta-analysis","volume":"9","author":"Li","year":"2019","journal-title":"BMJ Open"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"100230","DOI":"10.1016\/j.jadr.2021.100230","article-title":"Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed","volume":"6","author":"Bremner","year":"2021","journal-title":"J. Affect. Disord. Rep."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jaad.2022.10.031","article-title":"Isotretinoin and the risk of psychiatric disturbances: A global study shedding new light on a debatable story","volume":"88","author":"Kridin","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.biopsych.2004.02.033","article-title":"Depression: A case of neuronal life and death?","volume":"56","author":"Duman","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1073\/pnas.231475998","article-title":"Depression, antidepressants, and the shrinking hippocampus","volume":"98","author":"Sapolsky","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1586\/14737175.7.7.853","article-title":"Regulation of adult hippocampal neurogenesis: Relevance to depression","volume":"7","author":"Vaidya","year":"2007","journal-title":"Expert Rev. Neurother."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.brainres.2016.01.023","article-title":"The role of adult neurogenesis in psychiatric and cognitive disorders","volume":"1655","author":"Apple","year":"2017","journal-title":"Brain Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"594448","DOI":"10.3389\/fnins.2021.594448","article-title":"Adult hippocampal neurogenesis and affective disorders: New neurons for psychic well-being","volume":"15","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1046\/j.1471-4159.2000.0751729.x","article-title":"Enhancement of hippocampal neurogenesis by lithium","volume":"75","author":"Chen","year":"2000","journal-title":"J. Neurochem."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1046\/j.1471-4159.2004.02329.x","article-title":"Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo","volume":"89","author":"Kim","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41398-021-01695-y","article-title":"Lithium treatment and human hippocampal neurogenesis","volume":"11","author":"Palmos","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/00001756-199904060-00040","article-title":"Lithium attenuates p53 levels in human neuroblastoma SH-SY5Y cells","volume":"10","author":"Lu","year":"1999","journal-title":"Neuroreport"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.1074\/jbc.274.10.6039","article-title":"Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity","volume":"274","author":"Chen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.biopsych.2007.01.006","article-title":"Lithium reduces FoxO3a transcriptional activity by decreasing its intracellular content","volume":"62","author":"Mao","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000251073","article-title":"Lithium acne","volume":"154","author":"Okrasinski","year":"1977","journal-title":"Dermatologica"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1345\/aph.10323","article-title":"Severe acne with lithium","volume":"35","author":"Oztas","year":"2001","journal-title":"Ann. Pharmacother."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1503\/cmaj.130009","article-title":"Lithium acne","volume":"85","author":"Scarfi","year":"2013","journal-title":"CMAJ"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1073\/pnas.0306336101","article-title":"13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice","volume":"101","author":"Crandall","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neures.2010.08.003","article-title":"13-Cis-retinoic acid decreases hypothalamic cell number in vitro","volume":"68","author":"Griffin","year":"2010","journal-title":"Neurosci. Res."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/hipo.22574","article-title":"Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior","volume":"26","author":"Hu","year":"2016","journal-title":"Hippocampus"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2147\/NDT.S72536","article-title":"Increased expression of retinoic acid-induced gene 1 in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression","volume":"11","author":"Haybaeck","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cellsig.2015.10.015","article-title":"Gene expression profiling reveals the role of RIG1 like receptor signaling in p53 dependent apoptosis induced by PUVA in keratinocytes","volume":"28","author":"Chowdhari","year":"2016","journal-title":"Cell Signal."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1523\/JNEUROSCI.16-21-06753.1996","article-title":"Evidence for p53-mediated modulation of neuronal viability","volume":"16","author":"Xiang","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/sj.cdd.4400741","article-title":"The role of p53 in neuronal cell death","volume":"7","author":"Morrison","year":"2000","journal-title":"Cell Death Differ."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1021687810103","article-title":"p53-dependent cell death signaling in neurons","volume":"28","author":"Morrison","year":"2003","journal-title":"Neurochem. Res."},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Liu, W., Huang, Z., Xia, J., Cui, Z., Li, L., Qi, Z., and Liu, W. (2022). Gene expression profile associated with Asmt knockout-induced depression-like behaviors and exercise effects in mouse hypothalamus. Biosci. Rep., 42.","DOI":"10.1042\/BSR20220800"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1523\/JNEUROSCI.18-04-01363.1998","article-title":"Bax involvement in p53-mediated neuronal cell death","volume":"18","author":"Xiang","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuropharm.2015.08.020","article-title":"Forkhead box O transcription factors as possible mediators in the development of major depression","volume":"99","author":"Wang","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1007\/s11064-021-03364-4","article-title":"Elucidating the possible role of FoxO in depression","volume":"46","author":"Rana","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.stem.2009.09.013","article-title":"FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis","volume":"5","author":"Paik","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1254\/jphs.FMJ05001X3","article-title":"Transcriptional regulation of neuronal genes and its effect on neural functions: Expression and function of forkhead transcription factors in neurons","volume":"98","author":"Fukunaga","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","article-title":"Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1128\/MCB.21.3.952-965.2001","article-title":"Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)","volume":"21","author":"Brunet","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"10334","DOI":"10.1074\/jbc.M808848200","article-title":"The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors","volume":"284","author":"Essaghir","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"39152","DOI":"10.1074\/jbc.M002417200","article-title":"Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells","volume":"275","author":"Zheng","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.biopsych.2008.08.005","article-title":"Forkhead box, class O transcription factors in brain: Regulation and behavioral manifestation","volume":"65","author":"Polter","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1124\/mol.62.2.225","article-title":"Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase\/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons","volume":"62","author":"Zheng","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1038\/cdd.2015.123","article-title":"Functional regulation of FoxO1 in neural stem cell differentiation","volume":"22","author":"Kim","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2340\/00015555-1013","article-title":"Isotretinoin influences pituitary hormone levels in acne patients","volume":"91","author":"Karadag","year":"2011","journal-title":"Acta Derm. Venereol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1159\/000375370","article-title":"The effect of different doses of isotretinoin on pituitary hormones","volume":"230","author":"Karadag","year":"2015","journal-title":"Dermatology"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1210\/mend.16.3.0806","article-title":"Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: Evidence for regulation by IGF-I, estrogen, and the gonadotropins","volume":"16","author":"Richards","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1210\/me.2013-1185","article-title":"Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes","volume":"27","author":"Skarra","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"33424","DOI":"10.1074\/jbc.M112.362103","article-title":"FOXO1 transcription factor inhibits luteinizing hormone \u03b2 gene expression in pituitary gonadotrope cells","volume":"287","author":"Arriola","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mce.2013.09.034","article-title":"Fox tales: Regulation of gonadotropin gene expression by forkhead transcription factors","volume":"385","author":"Thackray","year":"2014","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.rbmo.2013.04.010","article-title":"Decreased ovarian reserve in female Sprague-Dawley rats induced by isotretinoin (retinoic acid) exposure","volume":"27","author":"Abali","year":"2013","journal-title":"Reprod. Biomed. Online"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000371551","article-title":"The effect of isotretinoin on ovarian reserve based on hormonal parameters, ovarian volume, and antral follicle count in women with acne","volume":"79","author":"Aksoy","year":"2015","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1210\/me.2012-1296","article-title":"FOXO1\/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH","volume":"27","author":"Liu","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"e1475","DOI":"10.1038\/cddis.2014.400","article-title":"Involvement of FoxO1 in the effects of follicle-stimulating hormone on inhibition of apoptosis in mouse granulosa cells","volume":"5","author":"Shen","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1080\/15548627.2017.1327941","article-title":"Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy","volume":"13","author":"Shen","year":"2017","journal-title":"Autophagy"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"6147345","DOI":"10.1155\/2016\/6147345","article-title":"Critical role of FoxO1 in granulosa cell apoptosis caused by oxidative stress and protective effects of grape seed procyanidin B2","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Cui, C., Han, S., Yin, H., Luo, B., Shen, X., Yang, F., Liu, Z., Zhu, Q., Li, D., and Wang, Y. (2019). FOXO3 is expressed in ovarian tissues and acts as an apoptosis initiator in granulosa cells of chickens. Biomed. Res. Int., 2019.","DOI":"10.1155\/2019\/6902906"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1210\/me.2008-0412","article-title":"FSH and FOXO1 regulate genes in the sterol\/steroid and lipid biosynthetic pathways in granulosa cells","volume":"23","author":"Liu","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1530\/REP-08-0229","article-title":"Transcription factor p53 can regulate proliferation, apoptosis and secretory activity of luteinizing porcine ovarian granulosa cell cultured with and without ghrelin and FSH","volume":"136","author":"Sirotkin","year":"2008","journal-title":"Reproduction"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.reprotox.2021.06.017","article-title":"The impact of isotretinoin on the pituitary-ovarian axis: An interpretative review of the literature","volume":"104","author":"Abdelhamed","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2133.1986.tb02842.x","article-title":"Hyperlipidaemia due to isotretinoin and etretinate: Possible mechanisms and consequences","volume":"114","author":"Marsden","year":"1986","journal-title":"Br. J. Dermatol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000248880","article-title":"Characterization of apoprotein metabolism and atherogenic lipoproteins during oral isotretinoin treatment","volume":"175","author":"Melnik","year":"1987","journal-title":"Dermatologica"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-2275(20)43204-3","article-title":"Metabolism of very low density lipoproteins in rats with isotretinoin (13-cis retinoic acid)-induced hyperlipidemia","volume":"31","author":"Gustafson","year":"1990","journal-title":"J. Lipid Res."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1194\/jlr.M800240-JLR200","article-title":"ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob\/ob mice","volume":"49","author":"Chen","year":"2008","journal-title":"J. Lipid Res."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1161\/ATVBAHA.112.251116","article-title":"Apolipoprotein B secretory regulation by degradation","volume":"32","author":"Olofsson","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_307","first-page":"3761","article-title":"apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53","volume":"9","author":"Shaish","year":"2010","journal-title":"Cell Cycle"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.4161\/cc.7.20.6882","article-title":"FoxO1 integrates insulin signaling to VLDL production","volume":"7","author":"Kamagate","year":"2008","journal-title":"Cell Cycle"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1172\/JCI200419992","article-title":"Foxo1 mediates insulin action on apoC-III and triglyceride metabolism","volume":"114","author":"Altomonte","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Peng, S., Li, W., Hou, N., and Huang, N. (2020). A Review of FoxO1-regulated metabolic diseases and related drug discoveries. Cells, 9.","DOI":"10.3390\/cells9010184"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI1581","article-title":"Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids","volume":"102","author":"Gervois","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1161\/ATVBAHA.109.197830","article-title":"Metabolism of very-low-density lipoprotein and low-density lipoprotein containing apolipoprotein C-III and not other small apolipoproteins","volume":"30","author":"Mendivil","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"33997","DOI":"10.1074\/jbc.M113.495366","article-title":"Apolipoproteins C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets","volume":"288","author":"Larsson","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1194\/jlr.M078220","article-title":"Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL","volume":"58","author":"Larsson","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3906\/sag-1507-31","article-title":"The effect of systemic isotretinoin treatment on skin biophysical parameters among patients with acne vulgaris","volume":"46","year":"2016","journal-title":"Turk. J. Med. Sci."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"15016951","DOI":"10.4238\/gmr.15016951","article-title":"Effect of retinoic acid on aquaporin 3 expression in keratinocytes","volume":"15","author":"Xing","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"C1144","DOI":"10.1152\/ajpcell.00075.2020","article-title":"Aquaporin-3 in the epidermis: More than skin deep","volume":"318","author":"Bollag","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/j.jid.2017.04.031","article-title":"Regulation of the glycerol transporter, aquaporin-3, by histone deacetylase-3 and p53 in keratinocytes","volume":"137","author":"Choudhary","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.ophtha.2003.09.044","article-title":"Isotretinoin-associated intracranial hypertension","volume":"111","author":"Fraunfelder","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_320","doi-asserted-by":"crossref","unstructured":"Reifenrath, J., Rupprecht, C., Gmeiner, V., and Haslinger, B. (2023). Intracranial hypertension after rosacea treatment with isotretinoin. Neurol. Sci., Epub ahead of print.","DOI":"10.1007\/s10072-023-07039-6"},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/ijo.2017.83","article-title":"Choroid plexus aquaporin 1 and intracranial pressure are increased in obese rats: Towards an idiopathic intracranial hypertension model?","volume":"41","author":"Uldall","year":"2017","journal-title":"Int. J. Obes."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.addr.2010.07.003","article-title":"Retinoid pathway and cancer therapeutics","volume":"62","author":"Bushue","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_323","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Marrero, I., Hern\u00e1ndez-Abad, G., Gonz\u00e1lez-G\u00f3mez, M., Soto-Viera, M., Carmona-Calero, E.M., Casta\u00f1eyra-Ruiz, L., and Casta\u00f1eyra-Perdomo, A. (2022). Altered expression of AQP1 and AQP4 in brain barriers and cerebrospinal fluid may affect cerebral water balance during chronic hypertension. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232012277"},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.mehy.2013.10.002","article-title":"The role of aquaporin-1 in idiopathic and drug-induced intracranial hypertension","volume":"81","author":"Eyal","year":"2013","journal-title":"Med. Hypotheses"},{"key":"ref_325","doi-asserted-by":"crossref","unstructured":"Lv, W., Xue, L., Liang, L., Liu, D., Li, C., Liao, J., and Jin, Y. (2023). Endotoxin induced acute kidney injury modulates expression of AQP1, P53 and P21 in rat kidney, heart, lung and small intestine. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0288507"},{"key":"ref_326","doi-asserted-by":"crossref","unstructured":"Abreu-Rodr\u00edguez, I., S\u00e1nchez Silva, R., Martins, A.P., Soveral, G., Toledo-Aral, J.J., L\u00f3pez-Barneo, J., and Echevarr\u00eda, M. (2011). Functional and transcriptional induction of aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1\u03b1. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028385"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/jid.2013.438","article-title":"IL-1\u03b2 drives inflammatory responses to propionibacterium acnes in vitro and in vivo","volume":"134","author":"Kistowska","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1111\/jocd.14852","article-title":"Study of interleukin-1 beta expression in acne vulgaris and acne scars","volume":"21","author":"ElAttar","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"9444","DOI":"10.4081\/dr.2022.9444","article-title":"Immunohistochemical expression of interleukin 1 beta in papule biopsies from patients with acne vulgaris","volume":"14","author":"Thanh","year":"2022","journal-title":"Dermatol. Reports"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1038\/cddis.2012.86","article-title":"Caspase-1: Is IL-1 just the tip of the ICEberg?","volume":"3","author":"Denes","year":"2012","journal-title":"Cell Death Dis."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.immuni.2006.02.004","article-title":"Critical role for NALP3\/CIAS1\/cryopyrin in innate and adaptive immunity through its regulation of caspase-1","volume":"24","author":"Sutterwala","year":"2006","journal-title":"Immunity"},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"10585","DOI":"10.1074\/jbc.C100025200","article-title":"Direct transcriptional activation of human caspase-1 by tumor suppressor p53","volume":"276","author":"Gupta","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000182270","article-title":"Acute acne flare following isotretinoin administration: Potential protective role of low starting dose","volume":"218","author":"Borghi","year":"2009","journal-title":"Dermatology"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"13030\/qt14h2419w","DOI":"10.5070\/D32612051358","article-title":"Acne fulminans induced by a low dose isotretinoin: Case report and review of the literature","volume":"26","author":"Fakih","year":"2020","journal-title":"Dermatol. Online J."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1177\/12034754211045379","article-title":"Isotretinoin-induced acne fulminans","volume":"26","author":"Yorulmaz","year":"2022","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_336","doi-asserted-by":"crossref","unstructured":"Lee, K.H., and Kang, T.B. (2019). The molecular links between cell death and inflammasome. Cells, 8.","DOI":"10.3390\/cells8091057"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/278261a0","article-title":"T antigen is bound to a host protein in SV40-transformed cells","volume":"278","author":"Lane","year":"1979","journal-title":"Nature"},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0092-8674(79)90293-9","article-title":"Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells","volume":"17","author":"Linzer","year":"1979","journal-title":"Cell"},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1128\/jvi.31.2.472-483.1979","article-title":"Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum","volume":"31","author":"Kress","year":"1979","journal-title":"J. Virol."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1073\/pnas.76.5.2420","article-title":"Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse","volume":"76","author":"DeLeo","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1046\/j.1523-1747.1999.00771.x","article-title":"Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)","volume":"113","author":"Zouboulis","year":"1999","journal-title":"J. Investig. Dermatol."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1046\/j.1523-1747.2003.12244.x","article-title":"Human skin is a steroidogenic tissue: Steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1)","volume":"120","author":"Thiboutot","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1101\/gad.6.10.1886","article-title":"Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53","volume":"6","author":"Bargonetti","year":"1992","journal-title":"Genes Dev."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/358015a0","article-title":"Cancer. p53, guardian of the genome","volume":"358","author":"Lane","year":"1992","journal-title":"Nature"},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrc2715","article-title":"p53 and metabolism","volume":"9","author":"Vousden","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jhep.2011.08.022","article-title":"p53, a novel regulator of lipid metabolism pathways","volume":"56","author":"Goldstein","year":"2012","journal-title":"J. Hepatol."},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1038\/s41467-021-27307-3","article-title":"The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes","volume":"12","author":"Lacroix","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/jmcb\/mjy070","article-title":"Tumor suppressor p53 and metabolism","volume":"11","author":"Liu","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molmet.2019.10.002","article-title":"Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer","volume":"33","author":"Lacroix","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"25395","DOI":"10.1074\/jbc.M302364200","article-title":"p53 Activation in adipocytes of obese mice","volume":"278","author":"Yahagi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/sj.cdd.4401183","article-title":"Decision making by p53: Life, death and cancer","volume":"10","author":"Oren","year":"2003","journal-title":"Cell Death Differ."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/cdd.2017.172","article-title":"Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM","volume":"25","author":"Engeland","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0065-230X(01)82002-9","article-title":"p53-dependent apoptosis pathways","volume":"82","author":"Shen","year":"2001","journal-title":"Adv. Cancer Res."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.bbrc.2005.04.013","article-title":"p53 in apoptosis control: An introduction","volume":"331","author":"Zamzami","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/156800908783769337","article-title":"p53: A guide to apoptosis","volume":"8","author":"Meulmeester","year":"2008","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1046\/j.1523-1747.2003.12029.x","article-title":"Differentiation and apoptosis in human immortalized sebocytes","volume":"120","author":"Seltmann","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1158\/0008-5472.CAN-07-5203","article-title":"The SV40 large T antigen-p53 complexes bind and activate the insulin-like growth factor-I promoter stimulating cell growth","volume":"68","author":"Bocchetta","year":"2008","journal-title":"Cancer Res."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/bjd.17579","article-title":"Isotretinoin\u2019s paradoxical effects in immortalized sebocytes","volume":"180","author":"Melnik","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1038\/s41467-018-05805-1","article-title":"Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers","volume":"9","author":"Kumar","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/1523-1747.ep12259161","article-title":"Suppression of sebum secretion with 13-cis-retinoic acid: Effect on individual skin surface lipids and implications for their anatomic origin","volume":"82","author":"Stewart","year":"1984","journal-title":"J. Investig. Dermatol."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF00406424","article-title":"Inhibitory effects of 13-cis-retinoic acid on human sebaceous glands","volume":"269","author":"Landthaler","year":"1980","journal-title":"Arch. Dermatol. Res."},{"key":"ref_362","unstructured":"Hoover, E., Aslam, S., and Krishnamurthy, K. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jid.2016.10.017","article-title":"Holocrine secretion of sebum is a unique DNase2-dependent mode of programmed cell death","volume":"137","author":"Fischer","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1038\/s41467-021-22622-1","article-title":"DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells","volume":"12","author":"Maurice","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/s41418-023-01125-0","article-title":"Cuproptosis: p53-regulated metabolic cell death?","volume":"30","author":"Xiong","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1038\/sj.cdd.4401965","article-title":"Regulation of AIF expression by p53","volume":"13","author":"Stambolsky","year":"2006","journal-title":"Cell Death Differ."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/exd.13169","article-title":"The TRAIL to acne pathogenesis: Let\u2019s focus on death pathways","volume":"26","author":"Melnik","year":"2017","journal-title":"Exp. Dermatol."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1001\/archderm.138.12.1584","article-title":"Acne vulgaris: A disease of Western civilization","volume":"138","author":"Cordain","year":"2002","journal-title":"Arch. Dermatol."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bjd.13462","article-title":"A global perspective on the epidemiology of acne","volume":"172","author":"Tan","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"15029","DOI":"10.1038\/nrdp.2015.29","article-title":"Acne vulgaris","volume":"1","author":"Makrantonaki","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/jdv.14820","article-title":"The influence of exposome on acne","volume":"32","author":"Bettoli","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2340\/00015555-1358","article-title":"Diet in acne: Further evidence for the role of nutrient signalling in acne pathogenesis","volume":"92","author":"Melnik","year":"2012","journal-title":"Acta Derm. Venereol."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2147\/CCID.S69135","article-title":"Linking diet to acne metabolomics, inflammation, and comedogenesis: An update","volume":"8","author":"Melnik","year":"2015","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJM197902153000701","article-title":"Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid","volume":"300","author":"Peck","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1128\/MCB.25.17.7432-7440.2005","article-title":"Role of Stat3 in regulating p53 expression and function","volume":"25","author":"Niu","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"ref_376","first-page":"1","article-title":"The endocrine and epigenetic impact of persistent cow milk consumption on prostate carcinogenesis","volume":"6","author":"Melnik","year":"2022","journal-title":"J. Transl. Genet. Genom."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s13668-023-00457-0","article-title":"The role of cow\u2019s milk consumption in breast cancer initiation and progression","volume":"12","author":"Melnik","year":"2023","journal-title":"Curr. Nutr. Rep."},{"key":"ref_378","doi-asserted-by":"crossref","unstructured":"Melnik, B.C. (2021). Lifetime impact of cow\u2019s milk on overactivation of mTORC1: From fetal to childhood overgrowth, acne, diabetes, cancers, and neurodegeneration. Biomolecules, 11.","DOI":"10.3390\/biom11030404"},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1002\/ijc.23032","article-title":"Acne and risk of prostate cancer","volume":"121","author":"Sutcliffe","year":"2007","journal-title":"Int. J. Cancer"},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/ijc.31192","article-title":"Acne in late adolescence and risk of prostate cancer","volume":"142","author":"Ugge","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10549-019-05302-z","article-title":"Severe acne and risk of breast cancer","volume":"177","author":"Murphy","year":"2019","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0190-9622(82)70071-4","article-title":"Chemoprevention of basal cell carcinoma with isotretinoin","volume":"6","author":"Peck","year":"1982","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/oxfordjournals.annonc.a058252","article-title":"Retinoids in cancer prevention and therapy","volume":"3","author":"Bollag","year":"1992","journal-title":"Ann. Oncol."},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/09546634.2012.746634","article-title":"Retinoids in the chemoprevention of non-melanoma skin cancers: Why, when and how","volume":"24","author":"Bettoli","year":"2013","journal-title":"J. Dermatolog. Treat."},{"key":"ref_385","doi-asserted-by":"crossref","unstructured":"Veal, G.J., Tweddle, D.A., Visser, J., Errington, J., Buck, H., Marange, J., Moss, J., Joseph, S., and Mulla, H. (2021). Pharmacokinetics and safety of a novel oral liquid formulation of 13-cis retinoic acid in children with neuroblastoma: A randomized crossover clinical trial. Cancers, 13.","DOI":"10.3390\/cancers13081868"},{"key":"ref_386","unstructured":"Pile, H.D., and Sadiq, N.M. (2023). StatPearls, StatPearls Publishing."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/22\/2600\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:21:01Z","timestamp":1760131261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/22\/2600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,10]]},"references-count":386,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["cells12222600"],"URL":"https:\/\/doi.org\/10.3390\/cells12222600","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,10]]}}}