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The progression of sarcopenia is correlated with the onset of physical disability, the inability to live independently, and increased mortality. Due to global increases in lifespan and demographic aging in developed countries, sarcopenia has become a major socioeconomic burden. Clinical therapies for sarcopenia are based on physical therapy and nutritional support, although these may suffer from low adherence and variable outcomes. There are currently no clinically approved drugs for sarcopenia. Consequently, there is a large amount of pre-clinical research focusing on discovering new candidate drugs and novel targets. In this review, recent progress in this research will be discussed, along with the challenges that may preclude successful translational research in the clinic. The types of drugs examined include mitochondria-targeting compounds, anti-diabetes agents, small molecules that target non-coding RNAs, protein therapeutics, natural products, and repositioning candidates. In light of the large number of drugs and targets being reported, it can be envisioned that clinically approved pharmaceuticals to prevent the progression or even mitigate sarcopenia may be within reach.<\/jats:p>","DOI":"10.3390\/cells12222608","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:10:43Z","timestamp":1699841443000},"page":"2608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Age Is Just a Number: Progress and Obstacles in the Discovery of New Candidate Drugs for Sarcopenia"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-2335","authenticated-orcid":false,"given":"Hyun-Jun","family":"Kim","sequence":"first","affiliation":[{"name":"New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Woon","family":"Jung","sequence":"additional","affiliation":[{"name":"New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2555-3069","authenticated-orcid":false,"given":"Darren Reece","family":"Williams","sequence":"additional","affiliation":[{"name":"New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3904\/kjim.2016.015","article-title":"Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia","volume":"31","author":"Kim","year":"2016","journal-title":"Korean J. Intern. Med."},{"key":"ref_2","unstructured":"McCuller, C., Jessu, R., and Callahan, A.L. (2022). Physiology, Skeletal Muscle, StatPearls."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/07853890600888413","article-title":"The metabolic syndrome: Role of skeletal muscle metabolism","volume":"38","author":"Stump","year":"2006","journal-title":"Ann. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jamda.2016.04.019","article-title":"Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease","volume":"17","author":"Argiles","year":"2016","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1146\/annurev-physiol-021115-105305","article-title":"Systemic Nutrient and Stress Signaling via Myokines and Myometabolites","volume":"78","author":"Rai","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10254-002-0004-7","article-title":"Molecular basis of skeletal muscle plasticity--from gene to form and function","volume":"146","author":"Fluck","year":"2003","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"a029785","DOI":"10.1101\/cshperspect.a029785","article-title":"Effects of Exercise and Aging on Skeletal Muscle","volume":"8","author":"Distefano","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/01.mco.0000134362.76653.b2","article-title":"Muscle tissue changes with aging","volume":"7","author":"Volpi","year":"2004","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0025-6196(19)30634-2","article-title":"The biology of aging","volume":"75","author":"Holloszy","year":"2000","journal-title":"Mayo Clin. Proc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1532-5415.2000.tb04719.x","article-title":"Epidemiology of sarcopenia","volume":"48","author":"Melton","year":"2000","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10522-018-9775-3","article-title":"Age-related changes in skeletal muscle: Changes to life-style as a therapy","volume":"19","author":"McCormick","year":"2018","journal-title":"Biogerontology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-981-13-1435-3_3","article-title":"Muscle Mass, Quality, and Composition Changes During Atrophy and Sarcopenia","volume":"1088","author":"Yamada","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/gerona\/glr046","article-title":"Of Greek heroes, wiggling worms, mighty mice, and old body builders","volume":"67","author":"Ferrucci","year":"2012","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"20428","DOI":"10.18632\/oncotarget.14670","article-title":"Skeletal muscle aging: Influence of oxidative stress and physical exercise","volume":"8","author":"Gomes","year":"2017","journal-title":"Oncotarget"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-0838.1995.tb00026.x","article-title":"Aging of human muscle: Structure, function and adaptability","volume":"5","author":"Porter","year":"1995","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jamda.2011.01.003","article-title":"Sarcopenia: An undiagnosed condition in older adults. Current consensus definition: Prevalence, etiology, and consequences. International working group on sarcopenia","volume":"12","author":"Fielding","year":"2011","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1113\/JP270561","article-title":"Innervation and neuromuscular control in ageing skeletal muscle","volume":"594","author":"Hepple","year":"2016","journal-title":"J. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11556-006-0011-9","article-title":"Ceasing of muscle function with aging: Is it the consequence of intrinsic muscle degeneration or a secondary effect of neuronal impairments?","volume":"3","author":"Figueiredo","year":"2006","journal-title":"Eur. Rev. Aging Phys. Act."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bellanti, F., Buglio, A.L., and Vendemiale, G. (2021). Mitochondrial Impairment in Sarcopenia. Biology, 10.","DOI":"10.3390\/biology10010031"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1474-9726.2012.00844.x","article-title":"The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals","volume":"11","author":"Joseph","year":"2012","journal-title":"Aging Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10522-008-9131-0","article-title":"Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness","volume":"9","author":"Ryall","year":"2008","journal-title":"Biogerontology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11005\/jbm.2013.20.1.1","article-title":"Sarcopenia: Definition, epidemiology, and pathophysiology","volume":"20","author":"Kim","year":"2013","journal-title":"J. Bone Metab."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Baeyens","year":"2010","journal-title":"Age Ageing"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jcsm.12147","article-title":"Welcome to the ICD-10 code for sarcopenia","volume":"7","author":"Anker","year":"2016","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"892749","DOI":"10.3389\/fphys.2022.892749","article-title":"Contribution of muscle satellite cells to sarcopenia","volume":"13","author":"Huo","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_27","unstructured":"Yannis, D. (2017). Frailty and Sarcopenia, IntechOpen."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1152\/japplphysiol.00246.2003","article-title":"Age-associated changes in skeletal muscles and their effect on mobility: An operational diagnosis of sarcopenia","volume":"95","author":"Lauretani","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jamda.2013.11.025","article-title":"Sarcopenia in Asia: Consensus report of the Asian Working Group for Sarcopenia","volume":"15","author":"Chen","year":"2014","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/ageing\/afs197","article-title":"Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) definition: Findings from the Hertfordshire Cohort Study (HCS)","volume":"42","author":"Patel","year":"2013","journal-title":"Age Ageing"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/ageing\/afu115","article-title":"Prevalence of and interventions for sarcopenia in ageing adults: A systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)","volume":"43","author":"Landi","year":"2014","journal-title":"Age Ageing"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jcsm.12783","article-title":"Global prevalence of sarcopenia and severe sarcopenia: A systematic review and meta-analysis","volume":"13","author":"Balntzi","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2147\/CIA.S149232","article-title":"Sarcopenia: Assessment of disease burden and strategies to improve outcomes","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"155533","DOI":"10.1016\/j.metabol.2023.155533","article-title":"Epidemiology of sarcopenia: Prevalence, risk factors, and consequences","volume":"144","author":"Yuan","year":"2023","journal-title":"Metabolism"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.7861\/clinmedicine.14-2-183","article-title":"Sarcopenia","volume":"14","author":"Landi","year":"2014","journal-title":"Clin. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.physio.2019.08.005","article-title":"Exercise as a treatment for sarcopenia: An umbrella review of systematic review evidence","volume":"107","author":"Moore","year":"2020","journal-title":"Physiotherapy"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"afac003","DOI":"10.1093\/ageing\/afac003","article-title":"Resistance exercise as a treatment for sarcopenia: Prescription and delivery","volume":"51","author":"Hurst","year":"2022","journal-title":"Age Ageing"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/JES.0b013e318292f3d5","article-title":"Anabolic resistance of muscle protein synthesis with aging","volume":"41","author":"Burd","year":"2013","journal-title":"Exerc. Sport. Sci. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.clnu.2016.04.002","article-title":"Per meal dose and frequency of protein consumption is associated with lean mass and muscle performance","volume":"35","author":"Loenneke","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S315","DOI":"10.1017\/S0007114512002371","article-title":"Impact of antinutritional factors in food proteins on the digestibility of protein and the bioavailability of amino acids and on protein quality","volume":"108","author":"Xiao","year":"2012","journal-title":"Br. J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Monirujjaman, M., and Ferdouse, A. (2014). Metabolic and Physiological Roles of Branched-Chain Amino Acids. Adv. Mol. Biol., 2014.","DOI":"10.1155\/2014\/364976"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00394-021-02710-0","article-title":"Effects of branched-chain amino acid-rich supplementation on EWGSOP2 criteria for sarcopenia in older adults: A systematic review and meta-analysis","volume":"61","author":"Bai","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s40266-017-0496-0","article-title":"The Potential of beta-Hydroxy-beta-Methylbutyrate as a New Strategy for the Management of Sarcopenia and Sarcopenic Obesity","volume":"34","author":"Rossi","year":"2017","journal-title":"Drugs Aging"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Uchitomi, R., Oyabu, M., and Kamei, Y. (2020). Vitamin D and Sarcopenia: Potential of Vitamin D Supplementation in Sarcopenia Prevention and Treatment. Nutrients, 12.","DOI":"10.3390\/nu12103189"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Cacciatore, S., Calvani, R., Marzetti, E., Picca, A., Coelho-Junior, H.J., Martone, A.M., Massaro, C., Tosato, M., and Landi, F. (2023). Low Adherence to Mediterranean Diet Is Associated with Probable Sarcopenia in Community-Dwelling Older Adults: Results from the Longevity Check-Up (Lookup) 7+ Project. Nutrients, 15.","DOI":"10.3390\/nu15041026"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1051\/sm\/2019018","article-title":"Are masters athletic performances predictive of human aging in men and women?","volume":"104","author":"Senefeld","year":"2019","journal-title":"Mov. Sport Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1939\u20131945.e3","DOI":"10.1016\/j.jamda.2021.04.001","article-title":"Response and Adherence of Nursing Home Residents to a Nutrition\/Exercise Intervention","volume":"22","author":"Karlsson","year":"2021","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s13539-012-0068-4","article-title":"Role and potential mechanisms of anabolic resistance in sarcopenia","volume":"3","author":"Haran","year":"2012","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.2147\/IJGM.S301141","article-title":"A Narrative Review of Gut-Muscle Axis and Sarcopenia: The Potential Role of Gut Microbiota","volume":"14","author":"Zhao","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref_50","unstructured":"Witham, M.D., Adamson, S., Avenell, A., Band, M.M., Bashir, T., Donnan, P.T., George, J., Hapca, A., Hume, C., and Kemp, P. (2022). Efficacy and Mechanism Evaluation, National Institute for Health and Care Research."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Kim, Y. (2021). Emerging Treatment Options for Sarcopenia in Chronic Liver Disease. Life, 11.","DOI":"10.3390\/life11030250"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e30773","DOI":"10.1097\/MD.0000000000030773","article-title":"The efficacy and safety of Codonopsis lanceolata water extract for sarcopenia: A study protocol for randomized, double-blind, placebo-controlled clinical trial","volume":"101","author":"Park","year":"2022","journal-title":"Medicine"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e2020836","DOI":"10.1001\/jamanetworkopen.2020.20836","article-title":"Bimagrumab vs Optimized Standard of Care for Treatment of Sarcopenia in Community-Dwelling Older Adults: A Randomized Clinical Trial","volume":"3","author":"Rooks","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1037200","DOI":"10.3389\/fnut.2023.1037200","article-title":"Sarcopenia: Molecular regulatory network for loss of muscle mass and function","volume":"10","author":"Wu","year":"2023","journal-title":"Front. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nature14614","article-title":"Mitochondrial reticulum for cellular energy distribution in muscle","volume":"523","author":"Glancy","year":"2015","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1083\/jcb.201511036","article-title":"Metabolic regulation of mitochondrial dynamics","volume":"212","author":"Mishra","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.molmed.2021.07.013","article-title":"Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging","volume":"27","author":"Fealy","year":"2021","journal-title":"Trends Mol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Hu, C., Huang, Y., and Li, L. (2017). Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010144"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Chen, G., Kroemer, G., and Kepp, O. (2020). Mitophagy: An Emerging Role in Aging and Age-Associated Diseases. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.00200"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Chistiakov, D.A., Sobenin, I.A., Revin, V.V., Orekhov, A.N., and Bobryshev, Y.V. (2014). Mitochondrial aging and age-related dysfunction of mitochondria. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/238463"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Romanello, V. (2020). The Interplay between Mitochondrial Morphology and Myomitokines in Aging Sarcopenia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010091"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bbrc.2010.11.122","article-title":"Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells","volume":"404","author":"Li","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/1841229a0","article-title":"A cardiolipin-like compound in rat liver mitochondria","volume":"184","author":"Getz","year":"1959","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.lfs.2015.10.025","article-title":"Men and mice: Relating their ages","volume":"152","author":"Dutta","year":"2016","journal-title":"Life Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.freeradbiomed.2018.12.031","article-title":"Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice","volume":"134","author":"Campbell","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e12088","DOI":"10.15252\/emmm.202012088","article-title":"BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control","volume":"12","author":"Axelrod","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1002\/jcsm.12982","article-title":"Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control","volume":"13","author":"Dantas","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-4939-1875-1_4","article-title":"NAD+ content and its role in mitochondria","volume":"1241","author":"Li","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.cmet.2014.04.002","article-title":"Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle","volume":"19","author":"Pirinen","year":"2014","journal-title":"Cell Metab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1749-6632.2002.tb02098.x","article-title":"Prevention of mitochondrial oxidative damage using targeted antioxidants","volume":"959","author":"Kelso","year":"2002","journal-title":"Ann. N. Y Acad. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Pin, F., Huot, J.R., and Bonetto, A. (2022). The Mitochondria-Targeting Agent MitoQ Improves Muscle Atrophy, Weakness and Oxidative Metabolism in C26 Tumor-Bearing Mice. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.861622"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2011.06.033","article-title":"Cross talk between mitochondria and NADPH oxidases","volume":"51","author":"Dikalov","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"L228","DOI":"10.1152\/ajplung.00473.2019","article-title":"MitoTEMPOL, a mitochondrial targeted antioxidant, prevents sepsis-induced diaphragm dysfunction","volume":"319","author":"Supinski","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"559789","DOI":"10.3389\/fmed.2020.559789","article-title":"Intensive Care Unit-Acquired Weakness: A Review of Recent Progress with a Look Toward the Future","volume":"7","author":"Wang","year":"2020","journal-title":"Front. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s11255-020-02508-9","article-title":"Potential mechanisms of uremic muscle wasting and the protective role of the mitochondria-targeted antioxidant Mito-TEMPO","volume":"52","author":"Liu","year":"2020","journal-title":"Int. Urol. Nephrol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/jcsm.13026","article-title":"Combined fibre atrophy and decreased muscle regeneration capacity driven by mitochondrial DNA alterations underlie the development of sarcopenia","volume":"13","author":"Kimoloi","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1038\/s41467-022-30056-6","article-title":"Enhancement of anaerobic glycolysis\u2014A role of PGC-1alpha4 in resistance exercise","volume":"13","author":"Koh","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s40279-015-0323-x","article-title":"Impact of Dietary Antioxidants on Sport Performance: A Review","volume":"45","author":"Braakhuis","year":"2015","journal-title":"Sports Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/mus.20385","article-title":"Effects of N-acetylcysteine on glutathione oxidation and fatigue during handgrip exercise","volume":"32","author":"Matuszczak","year":"2005","journal-title":"Muscle Nerve"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1123\/ijsnem.21.6.451","article-title":"N-Acetylcysteine\u2019s attenuation of fatigue after repeated bouts of intermittent exercise: Practical implications for tournament situations","volume":"21","author":"Cobley","year":"2011","journal-title":"Int. J. Sport. Nutr. Exerc. Metab."},{"key":"ref_83","first-page":"167","article-title":"Free fatty acid metabolism in the forearm at rest: Muscle uptake and adipose tissue release of free fatty acids","volume":"138","author":"Tancredi","year":"1976","journal-title":"Johns. Hopkins Med. J."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Sobczak, I.S., Blindauer, A., and Stewart, J. (2019). Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes. Nutrients, 11.","DOI":"10.3390\/nu11092022"},{"key":"ref_85","first-page":"94","article-title":"Muscle atrophy in patients with Type 2 Diabetes Mellitus: Roles of inflammatory pathways, physical activity and exercise","volume":"22","author":"Perry","year":"2016","journal-title":"Exerc. Immunol. Rev."},{"key":"ref_86","first-page":"289","article-title":"The effect of age on insulin resistance and secretion: A review","volume":"16","author":"Muller","year":"1996","journal-title":"Semin. Nephrol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/apha.12644","article-title":"Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium","volume":"219","author":"Triggle","year":"2017","journal-title":"Acta Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.tips.2018.07.006","article-title":"Metformin as an Anticancer Agent","volume":"39","author":"Vancura","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1113\/jphysiol.2006.109942","article-title":"Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise","volume":"574","author":"Jorgensen","year":"2006","journal-title":"J. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/jcsm.12838","article-title":"Anti-diabetic drugs and sarcopenia: Emerging links, mechanistic insights, and clinical implications","volume":"12","author":"Zhang","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2337\/diabetes.51.7.2074","article-title":"Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes","volume":"51","author":"Musi","year":"2002","journal-title":"Diabetes"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.curtheres.2013.10.002","article-title":"The effects of gliclazide, metformin, and acarbose on body composition in patients with newly diagnosed type 2 diabetes mellitus","volume":"75","author":"Wang","year":"2013","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1463-1326.2004.00385.x","article-title":"Effects of metformin on the body composition in subjects with risk factors for type 2 diabetes","volume":"7","year":"2005","journal-title":"Diabetes Obes. Metab."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1124\/mol.111.073874","article-title":"Rosiglitazone and metformin have opposite effects on intestinal absorption of oligopeptides via the proton-dependent PepT1 transporter","volume":"81","author":"Hindlet","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/jcsm.12833","article-title":"Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a","volume":"13","author":"Kang","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Chawla, G., Pradhan, T., and Gupta, O. (2023). An insight into the combat strategies for the treatment of type 2 diabetes mellitus. Mini Rev. Med. Chem, online ahead of print.","DOI":"10.2174\/1389557523666230517113936"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1113\/jphysiol.2009.185835","article-title":"The KATP channel is a molecular sensor of atrophy in skeletal muscle","volume":"588","author":"Tricarico","year":"2010","journal-title":"J. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.phrs.2012.07.007","article-title":"Opening\/blocking actions of pyruvate kinase antibodies on neuronal and muscular KATP channels","volume":"66","author":"Mele","year":"2012","journal-title":"Pharmacol. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e00028","DOI":"10.1002\/prp2.28","article-title":"Database search of spontaneous reports and pharmacological investigations on the sulfonylureas and glinides-induced atrophy in skeletal muscle","volume":"2","author":"Mele","year":"2014","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/dom.12099","article-title":"Effect of pioglitazone on body composition and bone density in subjects with prediabetes in the ACT NOW trial","volume":"15","author":"Bray","year":"2013","journal-title":"Diabetes Obes. Metab."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.2337\/dc09-0593","article-title":"Pioglitazone-induced acute rhabdomyolysis","volume":"32","author":"Slim","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2337\/diacare.23.3.421","article-title":"Acute rhabdomyolysis associated with troglitazone","volume":"23","author":"Yokoyama","year":"2000","journal-title":"Diabetes Care"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"9368583","DOI":"10.1155\/2020\/9368583","article-title":"The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature Review","volume":"2020","author":"Wu","year":"2020","journal-title":"J. Diabetes Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/1753-0407.12402","article-title":"Increased grip strength with sodium-glucose cotransporter 2","volume":"8","author":"Sano","year":"2016","journal-title":"J. Diabetes"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Pan, R., Zhang, Y., Wang, R., Xu, Y., Ji, H., and Zhao, Y. (2022). Effect of SGLT-2 inhibitors on body composition in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0279889"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.2337\/db07-0697","article-title":"Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice","volume":"56","author":"Flock","year":"2007","journal-title":"Diabetes"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1177\/0192623316672944","article-title":"Acute Toxicity of Vildagliptin","volume":"45","author":"Hoffmann","year":"2017","journal-title":"Toxicol. Pathol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1475-2840-13-36","article-title":"Changes in liraglutide-induced body composition are related to modifications in plasma cardiac natriuretic peptides levels in obese type 2 diabetic patients","volume":"13","author":"Li","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/1573399816666200705210006","article-title":"Effects of Antidiabetic Drugs on Muscle Mass in Type 2 Diabetes Mellitus","volume":"17","author":"Ida","year":"2021","journal-title":"Curr. Diabetes Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.2147\/DDDT.S381546","article-title":"An Effective Glucagon-Like Peptide-1 Receptor Agonists, Semaglutide, Improves Sarcopenic Obesity in Obese Mice by Modulating Skeletal Muscle Metabolism","volume":"16","author":"Ren","year":"2022","journal-title":"Drug Des. Devel Ther."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"21962","DOI":"10.18632\/aging.203546","article-title":"Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice","volume":"13","author":"Khin","year":"2021","journal-title":"Aging"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"9926462","DOI":"10.1155\/2023\/9926462","article-title":"Dulaglutide Protects Mice against Diabetic Sarcopenia-Mediated Muscle Injury by Inhibiting Inflammation and Regulating the Differentiation of Myoblasts","volume":"2023","author":"Deng","year":"2023","journal-title":"Int. J. Endocrinol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fgene.2015.00002","article-title":"Non-coding RNA: What is functional and what is junk?","volume":"6","author":"Palazzo","year":"2015","journal-title":"Front. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41573-021-00219-z","article-title":"Noncoding RNA therapeutics\u2014Challenges and potential solutions","volume":"20","author":"Winkle","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Lee, J., and Kang, H. (2022). Role of MicroRNAs and Long Non-Coding RNAs in Sarcopenia. Cells, 11.","DOI":"10.3390\/cells11020187"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1002\/jcsm.13106","article-title":"Atrophic skeletal muscle fibre-derived small extracellular vesicle miR-690 inhibits satellite cell differentiation during ageing","volume":"13","author":"Shao","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_117","unstructured":"Willis, M.S., Homeister, J.W., and Stone, J.R. (2014). Cellular and Molecular Pathobiology of Cardiovascular Disease, Academic Press."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"E9802","DOI":"10.1073\/pnas.1801471115","article-title":"Long noncoding RNA SYISL regulates myogenesis by interacting with polycomb repressive complex 2","volume":"115","author":"Jin","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1002\/jcsm.13012","article-title":"Conservative analysis of Synaptopodin-2 intron sense-overlapping lncRNA reveals its novel function in promoting muscle atrophy","volume":"13","author":"Jin","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Wada, S., Kato, Y., Okutsu, M., Miyaki, S., Suzuki, K., Yan, Z., Asahara, H., Ushida, T., and Akimoto, T. (2008). Stress responsive miR-23a attenuates skeletal muscle atrophy by targeting MAFbx\/atrogin-1. Nat. Preced.","DOI":"10.1038\/npre.2008.2175.1"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.ajpath.2022.09.003","article-title":"Forkhead Box O Signaling Pathway in Skeletal Muscle Atrophy","volume":"192","author":"Chen","year":"2022","journal-title":"Am. J. Pathol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"15201","DOI":"10.1038\/ncomms15201","article-title":"miR-29b contributes to multiple types of muscle atrophy","volume":"8","author":"Li","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.omtn.2023.02.003","article-title":"Identification of a novel small-molecule inhibitor of miR-29b attenuates muscle atrophy","volume":"31","author":"Liu","year":"2023","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-61779-921-1_1","article-title":"Therapeutic proteins","volume":"899","author":"Dimitrov","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s42255-020-0184-y","article-title":"Meteorin-like facilitates skeletal muscle repair through a Stat3\/IGF-1 mechanism","volume":"2","author":"Baht","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"7613","DOI":"10.1038\/s41467-022-35390-3","article-title":"Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro\/adipogenic progenitor signaling","volume":"13","author":"Lee","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"72","DOI":"10.31491\/APT.2023.06.116","article-title":"Role of fibro-adipogenic progenitors in skeletal muscle aging","volume":"5","author":"Wan","year":"2023","journal-title":"Aging Pathobiol. Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pharmthera.2017.02.032","article-title":"The versatility and paradox of GDF 11","volume":"175","author":"Jamaiyar","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"C1248","DOI":"10.1152\/ajpcell.00104.2009","article-title":"Smad2 and 3 transcription factors control muscle mass in adulthood","volume":"296","author":"Sartori","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Harper, S.C., Brack, A., MacDonnell, S., Franti, M., Olwin, B.B., Bailey, B.A., Rudnicki, M.A., and Houser, S.R. (2016). Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?. Circ. Res., 118.","DOI":"10.1161\/CIRCRESAHA.116.307962"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13395-019-0197-y","article-title":"A GDF11\/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice","volume":"9","author":"Jin","year":"2019","journal-title":"Skelet. Muscle"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3389\/fonc.2019.01039","article-title":"GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies","volume":"9","author":"Bucio","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_133","unstructured":"Williams, D.A., Foye, W.O., and Lemke, T.L. (2002). Foye\u2019s Principles of Medicinal Chemistry, Lippincott Williams & Wilkins."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4236\/pp.2013.43A003","article-title":"The Success of Natural Products in Drug Discovery","volume":"4","author":"Lahlou","year":"2013","journal-title":"Pharmacol. Pharm."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.trac.2019.05.037","article-title":"Green extraction of natural products. Origins, current status, and future challenges","volume":"118","author":"Chemat","year":"2019","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Jia, Q., Zhang, H., Zhao, A., Qu, L., Xiong, W., Alam, M.A., Miao, J., Wang, W., Li, F., and Xu, J. (2023). Produce D-allulose from non-food biomass by integrating corn stalk hydrolysis with whole-cell catalysis. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1156953"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.crphys.2022.11.001","article-title":"Metabolic dysfunctions promoted by AIN-93G standard diet compared with three obesity-inducing diets in C57BL\/6J mice","volume":"5","author":"Aguiar","year":"2022","journal-title":"Curr. Res. Physiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e2100549","DOI":"10.1002\/mnfr.202100549","article-title":"Allulose Attenuated Age-Associated Sarcopenia via Regulating IGF-1 and Myostatin in Aged Mice","volume":"66","author":"Kim","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ncb1101-1009","article-title":"Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K\/Akt\/mTOR and PI(3)K\/Akt\/GSK3 pathways","volume":"3","author":"Rommel","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/14786410500518545","article-title":"The effect of citrus flavonoids on the redox state of alimentary-induced fatty liver in rats","volume":"21","author":"Rapavi","year":"2007","journal-title":"Nat. Prod. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ptr.5256","article-title":"Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: An updated review of their molecular mechanisms and experimental models","volume":"29","author":"Parhiz","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Oh, H.J., Jin, H., and Lee, B.Y. (2023). Hesperidin Ameliorates Sarcopenia through the Regulation of Inflammaging and the AKT\/mTOR\/FoxO3a Signaling Pathway in 22-26-Month-Old Mice. Cells, 12.","DOI":"10.3390\/cells12152015"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/138955709787001712","article-title":"Distribution and biological activities of the flavonoid luteolin","volume":"9","year":"2009","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.2337\/db14-0631","article-title":"Luteolin attenuates hepatic steatosis and insulin resistance through the interplay between the liver and adipose tissue in mice with diet-induced obesity","volume":"64","author":"Kwon","year":"2015","journal-title":"Diabetes"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e2200729","DOI":"10.1002\/mnfr.202200729","article-title":"Luteolin Protects Against Obese Sarcopenia in Mice with High-Fat Diet-Induced Obesity by Ameliorating Inflammation and Protein Degradation in Muscles","volume":"67","author":"Kim","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ebiom.2018.09.015","article-title":"Fisetin is a senotherapeutic that extends health and lifespan","volume":"36","author":"Yousefzadeh","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1002\/jcsm.13101","article-title":"Reduction of senescent fibro-adipogenic progenitors in progeria-aged muscle by senolytics rescues the function of muscle stem cells","volume":"13","author":"Liu","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Molina, T., Fabre, P., and Dumont, N.A. (2021). Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases. Open Biol., 11.","DOI":"10.1098\/rsob.210110"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Scoditti, E., Tumolo, M.R., and Garbarino, S. (2022). Mediterranean Diet on Sleep: A Health Alliance. Nutrients, 14.","DOI":"10.3390\/nu14142998"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Papadopoulou, S.K., Detopoulou, P., Voulgaridou, G., Tsoumana, D., Spanoudaki, M., Sadikou, F., Papadopoulou, V.G., Zidrou, C., Chatziprodromidou, I.P., and Giaginis, C. (2023). Mediterranean Diet and Sarcopenia Features in Apparently Healthy Adults over 65 Years: A Systematic Review. Nutrients, 15.","DOI":"10.3390\/nu15051104"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Gonzalez-Hedstrom, D., Priego, T., Amor, S., de la Fuente-Fernandez, M., Martin, A.I., Lopez-Calderon, A., Inarejos-Garcia, A.M., Garcia-Villalon, A.L., and Granado, M. (2021). Olive Leaf Extract Supplementation to Old Wistar Rats Attenuates Aging-Induced Sarcopenia and Increases Insulin Sensitivity in Adipose Tissue and Skeletal Muscle. Antioxidants, 10.","DOI":"10.3390\/antiox10050737"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Iriondo-DeHond, A., Martorell, P., Genoves, S., Ramon, D., Stamatakis, K., Fresno, M., Molina, A., and Del Castillo, M.D. (2016). Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents. Molecules, 21.","DOI":"10.3390\/molecules21060721"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Juan-Garcia, A., Caprioli, G., Sagratini, G., Manes, J., and Juan, C. (2021). Coffee Silverskin and Spent Coffee Suitable as Neuroprotectors against Cell Death by Beauvericin and alpha-Zearalenol: Evaluating Strategies of Treatment. Toxins, 13.","DOI":"10.3390\/toxins13020132"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Kim, J.H., Kim, J.H., Jang, J.P., Jang, J.H., Jin, D.H., Kim, Y.S., and Jin, H.J. (2021). Identification of Molecules from Coffee Silverskin That Suppresses Myostatin Activity and Improves Muscle Mass and Strength in Mice. Molecules, 26.","DOI":"10.3390\/molecules26092676"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1002\/jcsm.13076","article-title":"Brazilian green propolis improves gut microbiota dysbiosis and protects against sarcopenic obesity","volume":"13","author":"Okamura","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1248\/bpb.27.1797","article-title":"Strong antihyperglycemic effects of water-soluble fraction of Brazilian propolis and its bioactive constituent, 3,4,5-tri-O-caffeoylquinic acid","volume":"27","author":"Matsui","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/jcsm.12784","article-title":"Understanding the gut microbiota and sarcopenia: A systematic review","volume":"12","author":"Liu","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.2174\/1568026619666181210124159","article-title":"Chemistry and Biology of Farnesol and its Derivatives: Quorum Sensing Molecules with Immense Therapeutic Potential","volume":"18","author":"Gupta","year":"2018","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"eabh3489","DOI":"10.1126\/scitranslmed.abh3489","article-title":"Farnesol prevents aging-related muscle weakness in mice through enhanced farnesylation of Parkin-interacting substrate","volume":"15","author":"Bae","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Ali, S., Ahmad, K., Shaikh, S., Lim, J.H., Chun, H.J., Ahmad, S.S., Lee, E.J., and Choi, I. (2022). Identification and Evaluation of Traditional Chinese Medicine Natural Compounds as Potential Myostatin Inhibitors: An In Silico Approach. Molecules, 27.","DOI":"10.3390\/molecules27134303"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Ahmad, S.S., Ahmad, K., Lee, E.J., Shaikh, S., and Choi, I. (2021). Computational Identification of Dithymoquinone as a Potential Inhibitor of Myostatin and Regulator of Muscle Mass. Molecules, 26.","DOI":"10.3390\/molecules26175407"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: Progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/jphp.13273","article-title":"Drug repositioning: A brief overview","volume":"72","author":"Jourdan","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nbt.3557","article-title":"No longer going to waste","volume":"34","author":"Garber","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/01.CIR.98.17.1742","article-title":"Improved Exercise Tolerance After Losartan and Enalapril in Heart Failure","volume":"98","author":"Vescovo","year":"1998","journal-title":"Circulation"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.21873\/invivo.13010","article-title":"Study of Therapeutic Effects of Losartan for Sarcopenia Based on the F344xBN Rat Aging Model","volume":"36","author":"Kang","year":"2022","journal-title":"In Vivo"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1128\/MCB.01071-14","article-title":"Muscle-derived extracellular signal-regulated kinases 1 and 2 are required for the maintenance of adult myofibers and their neuromuscular junctions","volume":"35","author":"Seaberg","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e821","DOI":"10.1038\/cddis.2013.342","article-title":"Lithium chloride attenuates cell death in oculopharyngeal muscular dystrophy by perturbing Wnt\/beta-catenin pathway","volume":"4","author":"Laganiere","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40345-016-0068-y","article-title":"Lithium side effects and toxicity: Prevalence and management strategies","volume":"4","author":"Gitlin","year":"2016","journal-title":"Int. J. Bipolar Disord."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e251","DOI":"10.1002\/ctm2.251","article-title":"Inhibited inositol monophosphatase and decreased myo-inositol concentration improve wasting in skeletal muscles","volume":"10","author":"Lee","year":"2020","journal-title":"Clin. Transl. Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.bbrc.2010.05.021","article-title":"Mouse model of skeletal muscle adiposity: A glycerol treatment approach","volume":"396","author":"Pisani","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Lee, J.H., Kim, S.W., Kim, J.H., Kim, H.J., Um, J., Jung, D.W., and Williams, D.R. (2021). Lithium Chloride Protects against Sepsis-Induced Skeletal Muscle Atrophy and Cancer Cachexia. Cells, 10.","DOI":"10.3390\/cells10051017"},{"key":"ref_173","first-page":"121","article-title":"Malotilate: The new hope for a clinically effective agent for the treatment of liver disease","volume":"22","author":"Ryle","year":"1987","journal-title":"Alcohol. Alcohol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(89)90160-X","article-title":"Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells","volume":"159","author":"Zijlstra","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1002\/jcsm.13092","article-title":"Inhibiting 5-lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signalling and insulin-like growth factor-1","volume":"13","author":"Kim","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S1470-2045(12)70269-3","article-title":"Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: A phase 1 dose-escalation trial","volume":"13","author":"Falchook","year":"2012","journal-title":"Lancet Oncol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/jb\/mvab116","article-title":"DA-Raf and the MEK inhibitor trametinib reverse skeletal myocyte differentiation inhibition or muscle atrophy caused by myostatin and GDF11 through the non-Smad Ras-ERK pathway","volume":"171","author":"Masuzawa","year":"2022","journal-title":"J. Biochem."},{"key":"ref_178","unstructured":"Pan, A., and Gerriets, V. (2023). Etanercept, StatPearls."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"23497","DOI":"10.18632\/aging.202200","article-title":"Pharmacological blockade of TNFalpha prevents sarcopenia and prolongs survival in aging mice","volume":"12","author":"Sciorati","year":"2020","journal-title":"Aging"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Liang, S., Liu, D., Xiao, Z., Greenbaum, J., Shen, H., Xiao, H., and Deng, H. (2023). Repurposing Approved Drugs for Sarcopenia Based on Transcriptomics Data in Humans. Pharmaceuticals, 16.","DOI":"10.3390\/ph16040607"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1358\/dot.2007.43.9.1112980","article-title":"Vorinostat in cutaneous T-cell lymphoma","volume":"43","author":"Duvic","year":"2007","journal-title":"Drugs Today"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1002\/jcsm.13003","article-title":"Upregulation of cluster of differentiation 36 mRNA expression in peripheral blood mononuclear cells correlates with frailty severity in older adults","volume":"13","author":"Lee","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jcsm.12855","article-title":"Alterations of the endocannabinoid system and circulating and peripheral tissue levels of endocannabinoids in sarcopenic rats","volume":"13","author":"Salles","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"7792","DOI":"10.1038\/s41467-022-35547-0","article-title":"Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice","volume":"13","author":"Ang","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1002\/jcsm.13091","article-title":"Single-cell RNA-seq reveals interferon-induced guanylate-binding proteins are linked with sarcopenia","volume":"13","author":"Peng","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/s41467-021-21738-8","article-title":"Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging","volume":"12","author":"Hunt","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"eabc8059","DOI":"10.1126\/science.abc8059","article-title":"Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength","volume":"371","author":"Palla","year":"2021","journal-title":"Science"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"afad024","DOI":"10.1093\/ageing\/afad024","article-title":"Potential therapeutic targets for sarcopenia identified by Mendelian randomisation","volume":"52","author":"Jiang","year":"2023","journal-title":"Age Ageing"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ajpath.2023.01.009","article-title":"Circulating alpha-Klotho Counteracts Transforming Growth Factor-beta-Induced Sarcopenia","volume":"193","author":"Ohsawa","year":"2023","journal-title":"Am. J. Pathol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"923429","DOI":"10.3389\/fgene.2022.923429","article-title":"Putative Candidate Drug Targets for Sarcopenia-Related Traits Identified Through Mendelian Randomization Analysis of the Blood Proteome","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Genet."},{"key":"ref_191","unstructured":"(2023, September 06). Stratview Research: Sarcopenia Treatment Market Report. Available online: https:\/\/www.stratviewresearch.com\/3438\/sarcopenia-treatment-market.html#:~:text=The%20sarcopenia%20treatment%20market%20was,US%24%203.9%20billion%20in%202028."},{"key":"ref_192","first-page":"135","article-title":"Challenges in the Development of Drugs for Sarcopenia and Frailty\u2014Report from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force","volume":"11","author":"Cesari","year":"2022","journal-title":"J. Frailty Aging"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.technovation.2018.06.009","article-title":"The technology transfer ecosystem in academia. An organizational design perspective","volume":"82\u201383","author":"Good","year":"2019","journal-title":"Technovation"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"109971","DOI":"10.1016\/j.celrep.2021.109971","article-title":"Integrated genomic and proteomic analyses identify stimulus-dependent molecular changes associated with distinct modes of skeletal muscle atrophy","volume":"37","author":"Hunt","year":"2021","journal-title":"Cell Rep."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.18632\/aging.102176","article-title":"Rapamycin protects aging muscle","volume":"11","author":"Tang","year":"2019","journal-title":"Aging"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/gerona\/glac142","article-title":"MyMD-1 Improves Health Span and Prolongs Life Span in Old Mice: A Noninferiority Study to Rapamycin","volume":"78","author":"Sabini","year":"2023","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1093\/gerona\/glaa214","article-title":"Antioxidant Apigenin Relieves Age-Related Muscle Atrophy by Inhibiting Oxidative Stress and Hyperactive Mitophagy and Apoptosis in Skeletal Muscle of Mice","volume":"75","author":"Wang","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/gerona\/glt136","article-title":"A clinical frailty index in aging mice: Comparisons with frailty index data in humans","volume":"69","author":"Whitehead","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/jcsm.12558","article-title":"Indoprofen prevents muscle wasting in aged mice through activation of PDK1\/AKT pathway","volume":"11","author":"Kim","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1021\/acsmedchemlett.1c00705","article-title":"Development of Myostatin Inhibitory d-Peptides to Enhance the Potency, Increasing Skeletal Muscle Mass in Mice","volume":"13","author":"Takayama","year":"2022","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jcsm.12709","article-title":"Mouse models of sarcopenia: Classification and evaluation","volume":"12","author":"Xie","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-981-13-1435-3_1","article-title":"An Overview of Muscle Atrophy","volume":"1088","author":"Ding","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1538\/expanim.15-0025","article-title":"Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)","volume":"64","author":"Guo","year":"2015","journal-title":"Exp. Anim."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Bellanti, F., Buglio, A.L., and Vendemiale, G. (2022). Muscle Delivery of Mitochondria-Targeted Drugs for the Treatment of Sarcopenia: Rationale and Perspectives. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14122588"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Buchke, S., Sharma, M., Bora, A., Relekar, M., Bhanu, P., and Kumar, J. (2022). Mitochondria-Targeted, Nanoparticle-Based Drug-Delivery Systems: Therapeutics for Mitochondrial Disorders. Life, 12.","DOI":"10.3390\/life12050657"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/22\/2608\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:21:38Z","timestamp":1760131298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/12\/22\/2608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,11]]},"references-count":205,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["cells12222608"],"URL":"https:\/\/doi.org\/10.3390\/cells12222608","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,11]]}}}