{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:36:54Z","timestamp":1768786614023,"version":"3.49.0"},"reference-count":60,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Colombia\u2019s General Royalties System (SGR by its Spanish acronym) through the project \u201cFortalecimiento del manejo y cuidado integral de pacientes con los c\u00e1nceres de mayor incidencia en la regi\u00f3n pac\u00edfico y evaluaci\u00f3n de dos prote\u00ednas recombinantes para uso potencial como tratamiento farmacol\u00f3gico en el Valle del Cauca\u201d","award":["BPIN 2020000100053"],"award-info":[{"award-number":["BPIN 2020000100053"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Despite advances in chemotherapeutic drugs used against cervical cancer, available chemotherapy treatments adversely affect the patient\u2019s quality of life. For this reason, new molecules from natural sources with antitumor potential and few side effects are required. In previous research, Pllans\u2212II, a phospholipase A2 type-Asp49 from Porthidium lansbergii lansbergii snake venom, has shown selective attack against the HeLa and Ca Ski cervical cancer cell lines. This work suggests that the cytotoxic effect generated by Pllans\u2212II on HeLa cells is triggered without affecting the integrity of the cytoplasmic membrane or depolarizing the mitochondrial membranes. The results allow us to establish that cell death in HeLa is related to the junction blockage between \u03b15\u03b21 integrins and fibronectin of the extracellular matrix. Pllans\u2212II reduces the cells\u2019 ability of adhesion and affects survival and proliferation pathways mediated by intracellular communication with the external environment. Our findings confirmed Pllans\u2212II as a potential prototype for developing a selective chemotherapeutic drug against cervical cancer.<\/jats:p>","DOI":"10.3390\/cells12232715","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T07:56:10Z","timestamp":1701071770000},"page":"2715","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pllans\u2212II: Unveiling the Action Mechanism of a Promising Chemotherapeutic Agent Targeting Cervical Cancer Cell Adhesion and Survival Pathways"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-4207","authenticated-orcid":false,"given":"Alejandro","family":"Montoya-G\u00f3mez","sequence":"first","affiliation":[{"name":"Grupo de Nutrici\u00f3n, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-8938","authenticated-orcid":false,"given":"Fiorella","family":"Tonello","sequence":"additional","affiliation":[{"name":"Istituto di Neuroscienze, CNR, Via Ugo Bassi 58\/B, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-8560","authenticated-orcid":false,"given":"Barbara","family":"Spolaore","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 di Padova, Via F. Marzolo 5, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Lina","family":"Massimino","sequence":"additional","affiliation":[{"name":"Istituto di Neuroscienze, CNR, Via Ugo Bassi 58\/B, 35131 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-717X","authenticated-orcid":false,"given":"Leonel","family":"Montealegre-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Grupo de Nutrici\u00f3n, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia"},{"name":"Grupo de Investigaci\u00f3n en Ingenier\u00eda Biom\u00e9dica-GBIO, Universidad Aut\u00f3noma de Occidente, Cali 760030, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9006-6721","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Castillo","sequence":"additional","affiliation":[{"name":"TAO-Lab, Centre for Bioinformatics and Photonics-CIBioFi, Department of Biology, Universidad del Valle, Cali 760032, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4733-5452","authenticated-orcid":false,"given":"Nelson","family":"Rivera Franco","sequence":"additional","affiliation":[{"name":"TAO-Lab, Centre for Bioinformatics and Photonics-CIBioFi, Department of Biology, Universidad del Valle, Cali 760032, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-3736","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Sevilla-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Grupo de Nutrici\u00f3n, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Manuel","family":"Solano-Redondo","sequence":"additional","affiliation":[{"name":"Grupo de Nutrici\u00f3n, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0783-5839","authenticated-orcid":false,"given":"Mildrey","family":"Mosquera-Escudero","sequence":"additional","affiliation":[{"name":"Grupo de Nutrici\u00f3n, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-1521","authenticated-orcid":false,"given":"Eli\u00e9cer","family":"Jim\u00e9nez-Charris","sequence":"additional","affiliation":[{"name":"Grupo de Nutrici\u00f3n, Facultad de Salud, Universidad del Valle, Cali 760043, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","article-title":"Estimates of Incidence and Mortality of Cervical Cancer in 2018: A Worldwide Analysis","volume":"8","author":"Arbyn","year":"2020","journal-title":"Lancet Glob. 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