{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:56:32Z","timestamp":1792443392299,"version":"4.5.0"},"reference-count":103,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["CB-2015-01-258043"],"award-info":[{"award-number":["CB-2015-01-258043"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["CB A1-S-15759"],"award-info":[{"award-number":["CB A1-S-15759"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["PAPIIT IN204722"],"award-info":[{"award-number":["PAPIIT IN204722"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DGAPA-UNAM","award":["CB-2015-01-258043"],"award-info":[{"award-number":["CB-2015-01-258043"]}]},{"name":"DGAPA-UNAM","award":["CB A1-S-15759"],"award-info":[{"award-number":["CB A1-S-15759"]}]},{"name":"DGAPA-UNAM","award":["PAPIIT IN204722"],"award-info":[{"award-number":["PAPIIT IN204722"]}]},{"name":"Research Direction of Tecnologico de Monterrey","award":["CB-2015-01-258043"],"award-info":[{"award-number":["CB-2015-01-258043"]}]},{"name":"Research Direction of Tecnologico de Monterrey","award":["CB A1-S-15759"],"award-info":[{"award-number":["CB A1-S-15759"]}]},{"name":"Research Direction of Tecnologico de Monterrey","award":["PAPIIT IN204722"],"award-info":[{"award-number":["PAPIIT IN204722"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant inherited disease characterized by progressive ataxia and retinal degeneration. SCA7 belongs to a group of neurodegenerative diseases caused by an expanded CAG repeat in the disease-causing gene, resulting in aberrant polyglutamine (polyQ) protein synthesis. PolyQ ataxin-7 is prone to aggregate in intracellular inclusions, perturbing cellular processes leading to neuronal death in specific regions of the central nervous system (CNS). Currently, there is no treatment for SCA7; however, a promising approach successfully applied to other polyQ diseases involves the clearance of polyQ protein aggregates through pharmacological activation of autophagy. Nonetheless, the blood\u2013brain barrier (BBB) poses a challenge for delivering drugs to the CNS, limiting treatment effectiveness. This study aimed to develop a polymeric nanocarrier system to deliver therapeutic agents across the BBB into the CNS. We prepared poly(lactic-co-glycolic acid) nanoparticles (NPs) modified with Poloxamer188 and loaded with rapamycin to enable NPs to activate autophagy. We demonstrated that these rapamycin-loaded NPs were successfully taken up by neuronal and glial cells, demonstrating high biocompatibility without adverse effects. Remarkably, rapamycin-loaded NPs effectively cleared mutant ataxin-7 aggregates in a SCA7 glial cell model, highlighting their potential as a therapeutic approach to fight SCA7 and other polyQ diseases.<\/jats:p>","DOI":"10.3390\/cells12232735","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:34:10Z","timestamp":1701304450000},"page":"2735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of a Polymeric Pharmacological Nanocarrier System as a Potential Therapy for Spinocerebellar Ataxia Type 7"],"prefix":"10.3390","volume":"12","author":[{"given":"Fabiola V.","family":"Borbolla-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica, Departamento de Gen\u00e9tica (CENIAQ), Instituto Nacional de Rehabilitaci\u00f3n-Luis Guillermo Ibarra Ibarra (INR-LGII), Ciudad de M\u00e9xico 14389, Mexico"},{"name":"Programa de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Garc\u00eda-Aguirre","sequence":"additional","affiliation":[{"name":"Departamento de Bioingenier\u00eda, Escuela de Ingenier\u00eda y Ciencias, Tecnologico de Monterrey, Ciudad de M\u00e9xico 14380, Mexico"},{"name":"Departamento de Gen\u00e9tica y Biolog\u00eda Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados (CINVESTAV-IPN), Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Del Prado-Audelo","sequence":"additional","affiliation":[{"name":"Departamento de Bioingenier\u00eda, Escuela de Ingenier\u00eda y Ciencias, Tecnologico de Monterrey, Ciudad de M\u00e9xico 14380, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Hern\u00e1ndez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica, Departamento de Gen\u00e9tica (CENIAQ), Instituto Nacional de Rehabilitaci\u00f3n-Luis Guillermo Ibarra Ibarra (INR-LGII), Ciudad de M\u00e9xico 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulmaro","family":"Cisneros","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica y Biolog\u00eda Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados (CINVESTAV-IPN), Ciudad de M\u00e9xico 07360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7940-1100","authenticated-orcid":false,"given":"Gerardo","family":"Leyva-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad Universitaria, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica, Departamento de Gen\u00e9tica (CENIAQ), Instituto Nacional de Rehabilitaci\u00f3n-Luis Guillermo Ibarra Ibarra (INR-LGII), Ciudad de M\u00e9xico 14389, Mexico"},{"name":"Programa de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"},{"name":"Departamento de Bioingenier\u00eda, Escuela de Ingenier\u00eda y Ciencias, Tecnologico de Monterrey, Ciudad de M\u00e9xico 14380, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jns.2015.04.040","article-title":"Infantile Spinocerebellar Ataxia Type 7: Case Report and a Review of the Literature","volume":"354","year":"2015","journal-title":"J. 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