{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:58:28Z","timestamp":1792789108734,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation of Hubei Hongshan Laboratory","award":["2021hskf014"],"award-info":[{"award-number":["2021hskf014"]}]},{"name":"Foundation of Hubei Hongshan Laboratory","award":["2023ZD0405402"],"award-info":[{"award-number":["2023ZD0405402"]}]},{"name":"Foundation of Hubei Hongshan Laboratory","award":["2023ZD0405405"],"award-info":[{"award-number":["2023ZD0405405"]}]},{"name":"Foundation of Hubei Hongshan Laboratory","award":["2022YFF1000301-01"],"award-info":[{"award-number":["2022YFF1000301-01"]}]},{"name":"Foundation of Hubei Hongshan Laboratory","award":["2020TD36"],"award-info":[{"award-number":["2020TD36"]}]},{"name":"Science and Technology Innovation 2030-Major Project","award":["2021hskf014"],"award-info":[{"award-number":["2021hskf014"]}]},{"name":"Science and Technology Innovation 2030-Major Project","award":["2023ZD0405402"],"award-info":[{"award-number":["2023ZD0405402"]}]},{"name":"Science and Technology Innovation 2030-Major Project","award":["2023ZD0405405"],"award-info":[{"award-number":["2023ZD0405405"]}]},{"name":"Science and Technology Innovation 2030-Major Project","award":["2022YFF1000301-01"],"award-info":[{"award-number":["2022YFF1000301-01"]}]},{"name":"Science and Technology Innovation 2030-Major Project","award":["2020TD36"],"award-info":[{"award-number":["2020TD36"]}]},{"name":"National Key R&amp;D Program of China","award":["2021hskf014"],"award-info":[{"award-number":["2021hskf014"]}]},{"name":"National Key R&amp;D Program of China","award":["2023ZD0405402"],"award-info":[{"award-number":["2023ZD0405402"]}]},{"name":"National Key R&amp;D Program of China","award":["2023ZD0405405"],"award-info":[{"award-number":["2023ZD0405405"]}]},{"name":"National Key R&amp;D Program of China","award":["2022YFF1000301-01"],"award-info":[{"award-number":["2022YFF1000301-01"]}]},{"name":"National Key R&amp;D Program of China","award":["2020TD36"],"award-info":[{"award-number":["2020TD36"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund","award":["2021hskf014"],"award-info":[{"award-number":["2021hskf014"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund","award":["2023ZD0405402"],"award-info":[{"award-number":["2023ZD0405402"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund","award":["2023ZD0405405"],"award-info":[{"award-number":["2023ZD0405405"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund","award":["2022YFF1000301-01"],"award-info":[{"award-number":["2022YFF1000301-01"]}]},{"name":"Central Public-interest Scientific Institution Basal Research Fund","award":["2020TD36"],"award-info":[{"award-number":["2020TD36"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Corticotropin-releasing hormone (CRH) is known for its crucial role in the stress response system, which could induce pituitary adrenocorticotropic hormone (ACTH) secretion to promote glucocorticoid release in the adrenal gland. However, little is known about other pituitary actions of CRH in teleosts. Somatolactin is a fish-specific hormone released from the neurointermediate lobe (NIL) of the posterior pituitary. A previous study has reported that ACTH was also located in the pituitary NIL region. Interestingly, our present study found that CRH could significantly induce two somatolactin isoforms\u2019 (SL\u03b1 and SL\u03b2) secretion and synthesis in primary cultured grass carp pituitary cells. Pharmacological analysis further demonstrated that CRH-induced pituitary somatolactin expression was mediated by the AC\/cAMP\/PKA, PLC\/IP3\/PKC, and Ca2+\/CaM\/CaMK-II pathways. Finally, transcriptomic analysis showed that both SL\u03b1 and SL\u03b2 should play an important role in the regulation of lipid metabolism in primary cultured hepatocytes. These results indicate that CRH is a novel stimulator of somatolactins in teleost pituitary cells, and somatolactins may participate in the stress response by regulating energy metabolism.<\/jats:p>","DOI":"10.3390\/cells12242770","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T08:09:17Z","timestamp":1701763757000},"page":"2770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Corticotropin-Releasing Hormone: A Novel Stimulator of Somatolactin in Teleost Pituitary Cells"],"prefix":"10.3390","volume":"12","author":[{"given":"Ruixin","family":"Du","sequence":"first","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Shi","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Liang","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Key Lab of Freshwater Biodiversity Conservation Ministry of Agriculture, Yangtze River Fisheries Research Institute, The Chinese Academy of Fisheries Sciences, Wuhan 430223, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-1920","authenticated-orcid":false,"given":"Guangfu","family":"Hu","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7570","DOI":"10.1073\/pnas.121165198","article-title":"Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor","volume":"98","author":"Lewis","year":"2001","journal-title":"Proc. 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