{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:43:56Z","timestamp":1769604236861,"version":"3.49.0"},"reference-count":53,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","doi-asserted-by":"publisher","award":["F30AA030472"],"award-info":[{"award-number":["F30AA030472"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","doi-asserted-by":"publisher","award":["R21AA029747"],"award-info":[{"award-number":["R21AA029747"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","doi-asserted-by":"publisher","award":["VA Merit I01 BX005845"],"award-info":[{"award-number":["VA Merit I01 BX005845"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","doi-asserted-by":"publisher","award":["VA RCS BX004016"],"award-info":[{"award-number":["VA RCS BX004016"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans Affairs","award":["F30AA030472"],"award-info":[{"award-number":["F30AA030472"]}]},{"name":"Veterans Affairs","award":["R21AA029747"],"award-info":[{"award-number":["R21AA029747"]}]},{"name":"Veterans Affairs","award":["VA Merit I01 BX005845"],"award-info":[{"award-number":["VA Merit I01 BX005845"]}]},{"name":"Veterans Affairs","award":["VA RCS BX004016"],"award-info":[{"award-number":["VA RCS BX004016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Alcohol-induced cardiomyopathy (ACM) has a poor prognosis with up to a 50% chance of death within four years of diagnosis. There are limited studies investigating the potential of abstinence for promoting repair after alcohol-induced cardiac damage, particularly in a controlled preclinical study design. Here, we developed an exposure protocol that led to significant decreases in cardiac function in C57BL6\/J mice within 30 days; dP\/dt max decreased in the mice fed alcohol for 30 days (8054 \u00b1 664.5 mmHg\/s compared to control mice: 11,188 \u00b1 724.2 mmHg\/s, p &lt; 0.01), and the dP\/dt min decreased, as well (\u22127711 \u00b1 561 mmHg\/s compared to control mice: \u221210,147 \u00b1 448.2 mmHg\/s, p &lt; 0.01). Quantitative PCR was used to investigate inflammatory and fibrotic biomarkers, while histology was used to depict overt changes in cardiac fibrosis. We observed a complete recovery of function after abstinence (dP\/dt max increased from 8054 \u00b1 664 mmHg\/s at 30 days to 11,967 \u00b1 449 mmHg\/s after abstinence, p &lt; 0.01); further, both inflammatory and fibrotic biomarkers decreased after abstinence. These results lay the groundwork for future investigation of the molecular mechanisms underlying recovery from alcohol-induced damage in the heart.<\/jats:p>","DOI":"10.3390\/cells12242783","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T03:35:31Z","timestamp":1701920131000},"page":"2783","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Abstinence Restores Cardiac Function in Mice with Established Alcohol-Induced Cardiomyopathy"],"prefix":"10.3390","volume":"12","author":[{"given":"Joshua M.","family":"Edavettal","sequence":"first","affiliation":[{"name":"Department of Physiology, LSU Health Sciences Center\u2014New Orleans, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas R.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Physiology, LSU Health Sciences Center\u2014New Orleans, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Physiology, LSU Health Sciences Center\u2014New Orleans, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7691-4138","authenticated-orcid":false,"given":"Janos","family":"Paloczi","sequence":"additional","affiliation":[{"name":"Department of Physiology, LSU Health Sciences Center\u2014New Orleans, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bysani","family":"Chandrasekar","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA"},{"name":"Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Research Center, and Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65212, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Physiology, LSU Health Sciences Center\u2014New Orleans, New Orleans, LA 70112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0140-6736(09)60009-X","article-title":"Alcohol-Use Disorders","volume":"373","author":"Schuckit","year":"2009","journal-title":"Lancet"},{"key":"ref_2","unstructured":"National Institute on Alcohol Abuse and Alcoholism (NIAAA) (2023, September 28). 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