{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:08Z","timestamp":1787027828192,"version":"build-2736575974"},"reference-count":247,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Regenerative medicine (RM) has emerged as a promising and revolutionary solution to address a range of unmet needs in healthcare, including ophthalmology. Moreover, RM takes advantage of the body\u2019s innate ability to repair and replace pathologically affected tissues. On the other hand, despite its immense promise, RM faces challenges such as ethical concerns, host-related immune responses, and the need for additional scientific validation, among others. The primary aim of this review is to present a high-level overview of current strategies in the domain of RM (cell therapy, exosomes, scaffolds, in vivo reprogramming, organoids, and interspecies chimerism), centering around the field of ophthalmology. A search conducted on clinicaltrials.gov unveiled a total of at least 209 interventional trials related to RM within the ophthalmological field. Among these trials, there were numerous early-phase studies, including phase I, I\/II, II, II\/III, and III trials. Many of these studies demonstrate potential in addressing previously challenging and degenerative eye conditions, spanning from posterior segment pathologies like Age-related Macular Degeneration and Retinitis Pigmentosa to anterior structure diseases such as Dry Eye Disease and Limbal Stem Cell Deficiency. Notably, these therapeutic approaches offer tailored solutions specific to the underlying causes of each pathology, thus allowing for the hopeful possibility of bringing forth a treatment for ocular diseases that previously seemed incurable and significantly enhancing patients\u2019 quality of life. As advancements in research and technology continue to unfold, future objectives should focus on ensuring the safety and prolonged viability of transplanted cells, devising efficient delivery techniques, etc.<\/jats:p>","DOI":"10.3390\/cells13020179","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T10:39:47Z","timestamp":1705487987000},"page":"179","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Beyond Vision: An Overview of Regenerative Medicine and Its Current Applications in Ophthalmological Care"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-388X","authenticated-orcid":false,"given":"Francisco J.","family":"Santa Cruz-Pavlovich","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2762-5281","authenticated-orcid":false,"given":"Andres J.","family":"Bola\u00f1os-Chang","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7665-2873","authenticated-orcid":false,"given":"Ximena I.","family":"Del Rio-Murillo","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo A.","family":"Aranda-Preciado","sequence":"additional","affiliation":[{"name":"Instituto de Oftalmologia Guillermo Avalos Urzua, Guadalajara 44260, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmeralda M.","family":"Razura-Ruiz","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4640-7263","authenticated-orcid":false,"given":"Arturo","family":"Santos","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-821X","authenticated-orcid":false,"given":"Jose","family":"Navarro-Partida","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64849, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/cts.12736","article-title":"The Progression of Regenerative Medicine and its Impact on Therapy Translation","volume":"13","author":"Jacques","year":"2020","journal-title":"Clin. Transl. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.reth.2020.01.004","article-title":"Advances in regenerative therapy: A review of the literature and future directions","volume":"14","author":"Ntege","year":"2020","journal-title":"Regen. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jmau.2015.05.002","article-title":"Regenerative medicine: Historical roots and potential strategies in modern medicine","volume":"3","author":"Sampogna","year":"2015","journal-title":"J. Microsc. Ultrastruct."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"14452","DOI":"10.1073\/pnas.1508520112","article-title":"Regenerative medicine: Current therapies and future directions","volume":"112","author":"Mao","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.exer.2018.07.019","article-title":"The current state of stem cell therapy for ocular disease","volume":"177","author":"Bobba","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10384-021-00821-z","article-title":"Systematic review of clinical research on regenerative medicine for the cornea","volume":"65","author":"Oie","year":"2021","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_7","unstructured":"Mahmood, S.C. (2020). Regenerative Medicine, IntechOpen."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"756029","DOI":"10.3389\/fmed.2021.756029","article-title":"Cell Therapy: Types, Regulation, and Clinical Benefits","volume":"8","author":"Rafei","year":"2021","journal-title":"Front. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4274\/tjo.89972","article-title":"Stem Cell Treatment in Retinal Diseases: Recent Developments","volume":"48","author":"Oner","year":"2018","journal-title":"Turk. J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000345615","article-title":"Introduction to stem cells and regenerative medicine","volume":"85","author":"Kolios","year":"2013","journal-title":"Respiration"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.coche.2012.11.002","article-title":"Stem Cell Separation Technologies","volume":"2","author":"Zhu","year":"2013","journal-title":"Curr. Opin. Chem. Eng."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1378\/chest.11-3093","article-title":"Risk of Teratoma Formation After Transplantation of Induced Pluripotent Stem Cells: Response","volume":"141","author":"Yang","year":"2012","journal-title":"Chest"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13287-016-0286-3","article-title":"Attenuation of teratoma formation by p27 overexpression in induced pluripotent stem cells","volume":"7","author":"Sasaki","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E3281","DOI":"10.1073\/pnas.1303669110","article-title":"Inhibition of pluripotent stem cell-derived teratoma formation by small molecules","volume":"110","author":"Lee","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41536-021-00133-3","article-title":"Scaffold-free cell-based tissue engineering therapies: Advances, shortfalls and forecast","volume":"6","author":"Rochev","year":"2021","journal-title":"NPJ Regen. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13287-019-1165-5","article-title":"Stem cells: Past, present, and future","volume":"10","author":"Zakrzewski","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6196","DOI":"10.3390\/molecules17066196","article-title":"Embryonic stem cell markers","volume":"17","author":"Zhao","year":"2012","journal-title":"Molecules"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev-cellbio-100913-013116","article-title":"The nature of embryonic stem cells","volume":"30","author":"Martello","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/stem.2450","article-title":"Concise Review: Human. Embryonic Stem Cells-What Have We Done? What Are We Doing? Where Are We Going?","volume":"35","author":"Ilic","year":"2017","journal-title":"Stem Cells"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/5584_2020_592","article-title":"Embryonic Stem Cells in Clinical Trials: Current Overview of Developments and Challenges","volume":"1312","author":"Golchin","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1055\/s-2006-952149","article-title":"Fetal stem cells: Betwixt and between","volume":"24","author":"Guillot","year":"2006","journal-title":"Semin. Reprod. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4252\/wjsc.v6.i4.404","article-title":"Fetal stem cell transplantation: Past, present, and future","volume":"6","author":"Ishii","year":"2014","journal-title":"World J. Stem Cells"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9978837","DOI":"10.1155\/2021\/9978837","article-title":"Stem Cells: A Historical Review about Biological, Religious, and Ethical Issues","volume":"2021","author":"Charitos","year":"2021","journal-title":"Stem Cells Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-3-319-93485-3_14","article-title":"Human Fetal Neural Stem Cells for Neurodegenerative Disease Treatment","volume":"66","author":"Ferrari","year":"2018","journal-title":"Results Probl. Cell Differ."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.bpobgyn.2004.06.010","article-title":"Fetal stem cells","volume":"18","author":"Fisk","year":"2004","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"11879","DOI":"10.1038\/s41598-021-91272-6","article-title":"In vitro expansion of fetal liver hematopoietic stem cells","volume":"11","author":"Bhardwaj","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Song, I., Rim, J., Lee, J., Jang, I., Jung, B., Kim, K., and Lee, S. (2022). Therapeutic Potential of Human Fetal Mesenchymal Stem Cells in Musculoskeletal Disorders: A Narrative Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031439"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13287-021-02176-1","article-title":"Human fetal liver MSCs are more effective than adult bone marrow MSCs for their immunosuppressive, immunomodulatory, and Foxp3(+) T reg induction capacity","volume":"12","author":"Yu","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_29","first-page":"2757","article-title":"Development of neural stem cells at different sites of fetus brain of different gestational age","volume":"6","author":"Yin","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/jasi.jasi_100_21","article-title":"Proliferative Capacity of Retinal Progenitor Cells in Human Fetal Retina","volume":"70","author":"Mane","year":"2021","journal-title":"J. Anat. Soc. India"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1582-4934.2008.00221.x","article-title":"Fetal stem cells from extra-embryonic tissues: Do not discard","volume":"12","author":"Marcus","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"769","DOI":"10.4252\/wjsc.v7.i4.769","article-title":"Placental-derived stem cells: Culture, differentiation and challenges","volume":"7","author":"Oliveira","year":"2015","journal-title":"World J. Stem Cells"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1634\/stemcells.22-5-649","article-title":"Human placenta-derived cells have mesenchymal stem\/progenitor cell potential","volume":"22","author":"Fukuchi","year":"2004","journal-title":"Stem Cells"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"174328","DOI":"10.1155\/2012\/174328","article-title":"Long-term cultured human term placenta-derived mesenchymal stem cells of maternal origin displays plasticity","volume":"2012","author":"Sabapathy","year":"2012","journal-title":"Stem Cells Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"615508","DOI":"10.3389\/fped.2021.615508","article-title":"A Review of Placenta and Umbilical Cord-Derived Stem Cells and the Immunomodulatory Basis of Their Therapeutic Potential in Bronchopulmonary Dysplasia","volume":"9","author":"Chia","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/stem.2553","article-title":"Concise Review: Amniotic Fluid Stem Cells: The Known, the Unknown, and Potential Regenerative Medicine Applications","volume":"35","author":"Loukogeorgakis","year":"2017","journal-title":"Stem Cells"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s13224-017-1034-z","article-title":"Amniotic Fluid Stem Cells: A New Era in Regenerative Medicine","volume":"68","author":"Srivastava","year":"2018","journal-title":"J. Obstet. Gynaecol. India"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/scd.2018.81001","article-title":"Review: Umbilical Cord Stem Cells","volume":"8","author":"Azzopardi","year":"2018","journal-title":"Stem Cell Discov."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2174\/092986706776872998","article-title":"Human umbilical cord blood biology, transplantation and plasticity","volume":"13","author":"Goldstein","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4252\/wjsc.v6.i2.195","article-title":"Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility","volume":"6","author":"He","year":"2014","journal-title":"World J. Stem Cells"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s12265-009-9155-0","article-title":"Stem cells and ethics: Current issues","volume":"3","author":"McCormick","year":"2010","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.med.54.101601.152334","article-title":"Hematopoietic stem and progenitor cells: Clinical and preclinical regeneration of the hematolymphoid system","volume":"56","author":"Shizuru","year":"2005","journal-title":"Annu. Rev. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s10238-003-0017-9","article-title":"Biology of human bone marrow stem cells","volume":"3","author":"Bonnet","year":"2003","journal-title":"Clin. Exp. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1009160","DOI":"10.3389\/fphys.2022.1009160","article-title":"Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function","volume":"13","author":"Rix","year":"2022","journal-title":"Front. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0076-6879(06)19007-2","article-title":"Hematopoietic stem cells","volume":"419","author":"Hawley","year":"2006","journal-title":"Methods Enzymol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15283\/ijsc19127","article-title":"Hematopoietic Stem Cells and Their Roles in Tissue Regeneration","volume":"13","author":"Lee","year":"2020","journal-title":"Int. J. Stem Cells"},{"key":"ref_47","unstructured":"Lanza, R., Langer, R., and Vacanti, J. (2007). Principles of Tissue Engineering, Academic Press. [3rd ed.]."},{"key":"ref_48","first-page":"315","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells","volume":"8","author":"Dominici","year":"2006","journal-title":"Int. Soc. Cell. Ther. Position Statement. Cytotherapy"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/stem.1649","article-title":"Concise review: Bone marrow-derived mesenchymal stem cells change phenotype following in vitro culture: Implications for basic research and the clinic","volume":"32","author":"Bara","year":"2014","journal-title":"Stem Cells"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.4142\/jvs.2021.22.e74","article-title":"Comparative characteristic study from bone marrow-derived mesenchymal stem cells","volume":"22","author":"Purwaningrum","year":"2021","journal-title":"J. Vet. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1038\/emm.2013.94","article-title":"Mesenchymal stem cells: Environmentally responsive therapeutics for regenerative medicine","volume":"45","author":"Murphy","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4252\/wjsc.v6.i3.288","article-title":"Osteogenic potential: Comparison between bone marrow and adipose-derived mesenchymal stem cells","volume":"6","author":"Liao","year":"2014","journal-title":"World J. Stem Cells"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13287-018-0914-1","article-title":"Adipose-derived and bone marrow mesenchymal stem cells: A donor-matched comparison","volume":"9","author":"Fristad","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"181","DOI":"10.46582\/jsrm.0803011","article-title":"Autologous intravenous mononuclear stem cell therapy in chronic ischemic stroke","volume":"8","author":"Bhasin","year":"2012","journal-title":"J. Stem Cells Regen. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s13287-020-01675-x","article-title":"Autologous bone marrow-derived mononuclear cell therapy in three patients with severe asthma","volume":"11","author":"Aguiar","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1038\/s41598-021-83088-1","article-title":"Expansion and characterization of bone marrow derived human mesenchymal stromal cells in serum-free conditions","volume":"11","author":"Bhat","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jot.2014.07.005","article-title":"An improved protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow","volume":"3","author":"Huang","year":"2015","journal-title":"J. Orthop. Translat."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Abdallah, B.M., Alzahrani, A.M., Abdel-Moneim, A.M., Ditzel, N., and Kassem, M. (2019). A simple and reliable protocol for long-term culture of murine bone marrow stromal (mesenchymal) stem cells that retained their in vitro and in vivo stemness in long-term culture. Biol. Proced. Online, 21.","DOI":"10.1186\/s12575-019-0091-3"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1046\/j.1365-2141.2003.04329.x","article-title":"Bone marrow biopsy morbidity and mortality","volume":"121","author":"Bain","year":"2003","journal-title":"Br. J. Haematol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1046\/j.1365-2141.2003.04799.x","article-title":"Complications of bone marrow biopsy","volume":"124","author":"Marti","year":"2004","journal-title":"Br. J. Haematol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physiol.00021.2019","article-title":"Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential","volume":"35","author":"Bunnell","year":"2020","journal-title":"Physiology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ymeth.2008.03.006","article-title":"Adipose-derived stem cells: Isolation, expansion and differentiation","volume":"45","author":"Bunnell","year":"2008","journal-title":"Methods"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1186\/s40064-015-1509-2","article-title":"Mechanical versus enzymatic isolation of stromal vascular fraction cells from adipose tissue","volume":"4","author":"Aronowitz","year":"2015","journal-title":"Springerplus"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"312","DOI":"10.4252\/wjsc.v6.i3.312","article-title":"Adipose-derived stem cells: Implications in tissue regeneration","volume":"6","author":"Tsuji","year":"2014","journal-title":"World J. Stem Cells"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1F.17.1","DOI":"10.1002\/cpsc.29","article-title":"Isolation of Ready-to-Use Adipose-Derived Stem Cell (ASC) Pellet for Clinical Applications and a Comparative Overview of Alternate Methods for ASC Isolation","volume":"41","author":"Raposio","year":"2017","journal-title":"Curr. Protoc. Stem Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Trzyna, A., and Banas-Zabczyk, A. (2021). Adipose-Derived Stem Cells Secretome and Its Potential Application in \u201cStem Cell-Free Therapy\u201d. Biomolecules, 11.","DOI":"10.3390\/biom11060878"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"37801","DOI":"10.1038\/srep37801","article-title":"Adipose Stem Cells Display Higher Regenerative Capacities and More Adaptable Electro-Kinetic Properties Compared to Bone Marrow-Derived Mesenchymal Stromal Cells","volume":"6","author":"Amer","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/biores.2019.0046","article-title":"Induced Pluripotent Stem Cells: Reprogramming Platforms and Applications in Cell Replacement Therapy","volume":"9","author":"Ngai","year":"2020","journal-title":"Biores Open Access"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/cdd.2014.132","article-title":"Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection","volume":"22","author":"Noguchi","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/stem.700","article-title":"Concise review: Induced pluripotent stem cells versus embryonic stem cells: Close enough or yet too far apart?","volume":"30","author":"Bilic","year":"2012","journal-title":"Stem Cells"},{"key":"ref_74","first-page":"109","article-title":"Generation of clinically relevant \"induced pluripotent stem\" (iPS) cells","volume":"6","author":"Heffernan","year":"2011","journal-title":"J. Stem Cells"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s11739-019-02126-z","article-title":"Regenerative medicine: The red planet for clinicians","volume":"14","author":"Ciccocioppo","year":"2019","journal-title":"Intern. Emerg. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10565-016-9370-9","article-title":"Clinical potential of human-induced pluripotent stem cells: Perspectives of induced pluripotent stem cells","volume":"33","author":"Kumar","year":"2017","journal-title":"Cell Biol. Toxicol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Noguchi, H., Miyagi-Shiohira, C., and Nakashima, Y. (2018). Induced Tissue-Specific Stem Cells and Epigenetic Memory in Induced Pluripotent Stem Cells. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19040930"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Saitoh, I., Sato, M., Kiyokawa, Y., Inada, E., Iwase, Y., Ibano, N., and Noguchi, H. (2021). Induced Tissue-Specific Stem Cells (iTSCs): Their Generation and Possible Use in Regenerative Medicine. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13060780"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/sj.leu.2404171","article-title":"A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1(+)Oct-4+ stem cells identified in adult bone marrow","volume":"20","author":"Kucia","year":"2006","journal-title":"Leukemia"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1161\/CIRCRESAHA.118.314287","article-title":"Very Small Embryonic-Like Stem Cells (VSELs)","volume":"124","author":"Ratajczak","year":"2019","journal-title":"Circ. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jcyt.2013.10.009","article-title":"Recovery of CD45(-)\/Lin(-)\/SSEA-4(+) very small embryonic-like stem cells by cord blood bank standard operating procedures","volume":"16","author":"Chang","year":"2014","journal-title":"Cytotherapy"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1038\/leu.2009.153","article-title":"Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4(+) very small embryonic-like stem cells","volume":"23","author":"Shin","year":"2009","journal-title":"Leukemia"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1182\/blood.V114.22.1484.1484","article-title":"Quiescent Status of Very Small Embryonic Like Stem Cells (VSELs) Points to Pivotal Role of Autocrine Role of Insulin-Like Growth Factor-2 (Igf2)\u2014Ras-Activating Guanine Nucleotide Exchange Factor (Rasgrf1) Axis in Regulating Proliferation of Embryonic Stem Cells","volume":"114","author":"Klich","year":"2009","journal-title":"Blood"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Bhartiya, D., Jha, N., Tripathi, A., and Tripathi, A. (2022). Very small embryonic-like stem cells have the potential to win the three-front war on tissue damage, cancer, and aging. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.1061022"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/leu.2013.255","article-title":"Very small embryonic-like stem cells (VSELs) represent a real challenge in stem cell biology: Recent pros and cons in the midst of a lively debate","volume":"28","author":"Ratajczak","year":"2014","journal-title":"Leukemia"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/CIRCRESAHA.116.309362","article-title":"A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells","volume":"120","author":"Ratajczak","year":"2017","journal-title":"Circ. Res."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Danova-Alt, R., Heider, A., Egger, D., Cross, M., and Alt, R. (2012). Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034899"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.stem.2013.07.003","article-title":"VSELs: Is ideology overtaking science?","volume":"13","author":"Nicholls","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Szade, K., Bukowska-Strakova, K., Nowak, W.N., Szade, A., Kachamakova-Trojanowska, N., Zukowska, M., Jozkowicz, A., and Dulak, J. (2013). Murine bone marrow Lin(-)Sca(-)1(+)CD45(-) very small embryonic-like (VSEL) cells are heterogeneous population lacking Oct-4A expression. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063329"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.stemcr.2013.07.001","article-title":"Do pluripotent stem cells exist in adult mice as very small embryonic stem cells?","volume":"1","author":"Miyanishi","year":"2013","journal-title":"Stem Cell Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/499390a","article-title":"Doubt cast over tiny stem cells","volume":"499","author":"Abbott","year":"2013","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Liu, Y., Liu, H., and Tang, W.H. (2019). Exosomes: Biogenesis, biologic function and clinical potential. Cell Biosci., 9.","DOI":"10.1186\/s13578-019-0282-2"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"293","DOI":"10.15171\/apb.2016.041","article-title":"Mesenchymal Stem Cell-Derived Exosomes: New Opportunity in Cell-Free Therapy","volume":"6","author":"Shamsasenjan","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"7","DOI":"10.21037\/sci-2020-037","article-title":"Exosomal therapy-a new frontier in regenerative medicine","volume":"8","author":"Muthu","year":"2021","journal-title":"Stem Cell Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2018.01.005","article-title":"Exosomes and regenerative medicine: State of the art and perspectives","volume":"196","author":"Jing","year":"2018","journal-title":"Transl. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.gendis.2022.03.021","article-title":"The biogenesis and secretion of exosomes and multivesicular bodies (MVBs): Intercellular shuttles and implications in human diseases","volume":"10","author":"Xu","year":"2023","journal-title":"Genes Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12943-022-01671-0","article-title":"Exosome biogenesis: Machinery, regulation, and therapeutic implications in cancer","volume":"21","author":"Han","year":"2022","journal-title":"Mol. Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ymthe.2016.12.022","article-title":"Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis","volume":"25","author":"Beltrami","year":"2017","journal-title":"Mol. Ther."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Chen, J., Li, P., Zhang, T., Xu, Z., Huang, X., Wang, R., and Du, L. (2021). Review on Strategies and Technologies for Exosome Isolation and Purification. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.811971"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/stem.1129","article-title":"Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth","volume":"30","author":"Xin","year":"2012","journal-title":"Stem Cells"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Takeda, Y.S., and Xu, Q. (2015). Neuronal Differentiation of Human Mesenchymal Stem Cells Using Exosomes Derived from Differentiating Neuronal Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0135111"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuint.2016.08.003","article-title":"Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury","volume":"111","author":"Zhang","year":"2017","journal-title":"Neurochem. Int."},{"key":"ref_103","first-page":"183","article-title":"MALAT1 in Human Adipose Stem Cells Modulates Survival and Alternative Splicing of PKCdeltaII in HT22 Cells","volume":"158","author":"Patel","year":"2017","journal-title":"Endocrinology"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/sctm.16-0428","article-title":"Bone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms","volume":"6","author":"Mead","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Lee, B.C., Kang, I., and Yu, K.R. (2021). Therapeutic Features and Updated Clinical Trials of Mesenchymal Stem Cell (MSC)-Derived Exosomes. J. Clin. Med., 10.","DOI":"10.3390\/jcm10040711"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Han, F., Wang, J., Ding, L., Hu, Y., Li, W., Yuan, Z., Guo, Q., Zhu, C., Yu, L., and Wang, H. (2020). Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00083"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tibtech.2018.01.005","article-title":"The Synergy of Scaffold-Based and Scaffold-Free Tissue Engineering Strategies","volume":"36","author":"Ovsianikov","year":"2018","journal-title":"Trends Biotechnol."},{"key":"ref_108","first-page":"271","article-title":"Recent advances in biomaterials for 3D scaffolds: A review","volume":"4","author":"Nikolova","year":"2019","journal-title":"Bioact. Mater."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00586-008-0745-3","article-title":"Scaffolding in tissue engineering: General approaches and tissue-specific considerations","volume":"17","author":"Chan","year":"2008","journal-title":"Eur. Spine J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3390\/ma2030790","article-title":"Metallic Scaffolds for Bone Regeneration","volume":"2","author":"Alvarez","year":"2009","journal-title":"Materials"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Perez-Puyana, V., Jimenez-Rosado, M., Romero, A., and Guerrero, A. (2020). Polymer-Based Scaffolds for Soft-Tissue Engineering. Polymers, 12.","DOI":"10.3390\/polym12071566"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Wu, D., Zhao, X., Pakvasa, M., Tucker, A.B., Luo, H., Qin, K.H., Hu, D.A., Wang, E.J., and Li, A.J. (2020). Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.598607"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1039\/D1MA01166A","article-title":"Preparation of mesh-like collagen scaffolds for tissue engineering","volume":"3","author":"Xie","year":"2022","journal-title":"Mater. Adv."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ijbiomac.2019.12.127","article-title":"3D bioprinted alginate-gelatin based scaffolds for soft tissue engineering","volume":"144","author":"Chawla","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s41565-020-00813-z","article-title":"DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation","volume":"16","author":"Huang","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Arslan-Yildiz, A., El Assal, R., Chen, P., Guven, S., Inci, F., and Demirci, U. (2016). Towards artificial tissue models: Past, present, and future of 3D bioprinting. Biofabrication, 8.","DOI":"10.1088\/1758-5090\/8\/1\/014103"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/adhm.201700598","article-title":"Freeze-Drying as a Novel Biofabrication Method for Achieving a Controlled Microarchitecture within Large, Complex Natural Biomaterial Scaffolds","volume":"6","author":"Brougham","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Jimenez-Beltran, M.A., Gomez-Calderon, A.J., Quintanar-Zuniga, R.E., Santillan-Cortez, D., Tellez-Gonzalez, M.A., Suarez-Cuenca, J.A., Garcia, S., and Mondragon-Teran, P. (2022). Electrospinning-Generated Nanofiber Scaffolds Suitable for Integration of Primary Human Circulating Endothelial Progenitor Cells. Polymers, 14.","DOI":"10.3390\/polym14122448"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1908996","DOI":"10.1002\/adfm.201908996","article-title":"Designing Scaffolds for Corneal Regeneration","volume":"30","author":"Ahearne","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fcvm.2018.00035","article-title":"Using Acellular Bioactive Extracellular Matrix Scaffolds to Enhance Endogenous Cardiac Repair","volume":"5","author":"Svystonyuk","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e2201680","DOI":"10.1002\/adhm.202201680","article-title":"An Acellular Scaffold Facilitates Endometrial Regeneration and Fertility Restoration via Recruiting Endogenous Mesenchymal Stem Cells","volume":"11","author":"Xin","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1186\/s13287-021-02650-w","article-title":"Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy","volume":"12","author":"Zhao","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Baldari, S., Di Rocco, G., Piccoli, M., Pozzobon, M., Muraca, M., and Toietta, G. (2017). Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18102087"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ceb.2019.06.002","article-title":"Strategies for in vivo reprogramming","volume":"61","author":"Ofenbauer","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1177\/0022034509337480","article-title":"Gene therapy: Design and prospects for craniofacial regeneration","volume":"88","author":"Scheller","year":"2009","journal-title":"J. Dent. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1590\/s1679-45082017rb4024","article-title":"Gene therapy: Advances, challenges and perspectives","volume":"15","author":"Goncalves","year":"2017","journal-title":"Einstein"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.gene.2013.03.137","article-title":"History of gene therapy","volume":"525","author":"Wirth","year":"2013","journal-title":"Gene"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1146\/annurev-med-012017-043332","article-title":"Entering the Modern Era of Gene Therapy","volume":"70","author":"Anguela","year":"2019","journal-title":"Annu. Rev. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11010-020-03834-3","article-title":"Gene therapy: A double-edged sword with great powers","volume":"474","author":"Tang","year":"2020","journal-title":"Mol. Cell Biochem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13023-018-0791-9","article-title":"Gene therapy in rare diseases: The benefits and challenges of developing a patient-centric registry for Strimvelis in ADA-SCID","volume":"13","author":"Kudari","year":"2018","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1080\/10428194.2017.1387905","article-title":"Axicabtagene ciloleucel, a first-in-class CAR T cell therapy for aggressive NHL","volume":"59","author":"Roberts","year":"2018","journal-title":"Leuk. Lymphoma"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3389\/fgene.2019.00868","article-title":"Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders","volume":"10","author":"Shahryari","year":"2019","journal-title":"Front. Genet."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0140-6736(16)30371-3","article-title":"Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: A follow-on phase 1 trial","volume":"388","author":"Bennett","year":"2016","journal-title":"Lancet"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(17)31868-8","article-title":"Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: A randomised, controlled, open-label, phase 3 trial","volume":"390","author":"Russell","year":"2017","journal-title":"Lancet"},{"key":"ref_135","first-page":"S3","article-title":"Gene Therapy for Spinal Muscular Atrophy: An Emerging Treatment Option for a Devastating Disease","volume":"24","author":"Rao","year":"2018","journal-title":"J. Manag. Care Spec. Pharm."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Ma, C.C., Wang, Z.L., Xu, T., He, Z.Y., and Wei, Y.Q. (2020). The approved gene therapy drugs worldwide: From 1998 to 2019. Biotechnol. Adv., 40.","DOI":"10.1016\/j.biotechadv.2019.107502"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13148-021-01131-4","article-title":"Epigenetic reprogramming of cell identity: Lessons from development for regenerative medicine","volume":"13","author":"Basu","year":"2021","journal-title":"Clin. Epigenet."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals","volume":"33","author":"Jaenisch","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1089\/rej.2012.1324","article-title":"The role of DNA methylation in aging, rejuvenation, and age-related disease","volume":"15","author":"Johnson","year":"2012","journal-title":"Rejuvenation Res."},{"key":"ref_140","unstructured":"Lu, Y. (2020). Reversal of Aging via in Vivo Epigenetic Reprogramming. [Ph.D. Thesis, Harvard University]."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.cell.2016.11.052","article-title":"In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming","volume":"167","author":"Ocampo","year":"2016","journal-title":"Cell"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nature08797","article-title":"Direct conversion of fibroblasts to functional neurons by defined factors","volume":"463","author":"Vierbuchen","year":"2010","journal-title":"Nature"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","article-title":"Reprogramming to recover youthful epigenetic information and restore vision","volume":"588","author":"Lu","year":"2020","journal-title":"Nature"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.stem.2011.03.001","article-title":"Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency","volume":"8","author":"Trivedi","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nbt1418","article-title":"Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds","volume":"26","author":"Huangfu","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.stem.2008.10.004","article-title":"Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds","volume":"3","author":"Shi","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nm.3793","article-title":"Therapeutic genome editing: Prospects and challenges","volume":"21","author":"Cox","year":"2015","journal-title":"Nat. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1007\/s11427-019-1684-x","article-title":"Recent developments in regenerative ophthalmology","volume":"63","author":"Shen","year":"2020","journal-title":"Sci. China Life Sci."},{"key":"ref_149","unstructured":"Barh, D. (2022). Biotechnology in Healthcare, Academic Press."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nbt.1733","article-title":"Expression of therapeutic proteins after delivery of chemically modified mRNA in mice","volume":"29","author":"Kormann","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1800087","DOI":"10.1002\/adtp.201800087","article-title":"Organoids for Advanced Therapeutics and Disease Models","volume":"2","author":"Kim","year":"2019","journal-title":"Adv. Ther."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cell.2016.05.082","article-title":"Modeling Development and Disease with Organoids","volume":"165","author":"Clevers","year":"2016","journal-title":"Cell"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.stem.2015.12.005","article-title":"Engineering Stem Cell Organoids","volume":"18","author":"Yin","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1039\/C8IB00116B","article-title":"Towards organogenesis and morphogenesis in vitro: Harnessing engineered microenvironment and autonomous behaviors of pluripotent stem cells","volume":"10","author":"Li","year":"2018","journal-title":"Integr. Biol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s43586-022-00174-y","article-title":"Organoids","volume":"2","author":"Zhao","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"6632160","DOI":"10.1155\/2021\/6632160","article-title":"Clinical Application of Human Induced Pluripotent Stem Cell-Derived Organoids as an Alternative to Organ Transplantation","volume":"2021","author":"Hsia","year":"2021","journal-title":"Stem Cells Int."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40164-018-0122-9","article-title":"Organoid technology in disease modelling, drug development, personalized treatment and regeneration medicine","volume":"7","author":"Xu","year":"2018","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.cell.2021.03.020","article-title":"Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo","volume":"184","author":"Tan","year":"2021","journal-title":"Cell"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"576","DOI":"10.21037\/atm.2019.10.13","article-title":"Human-animal chimeras for autologous organ transplantation: Technological advances and future perspectives","volume":"7","author":"Lu","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.stemcr.2020.12.004","article-title":"Apoptosis, G1 Phase Stall, and Premature Differentiation Account for Low Chimeric Competence of Human and Rhesus Monkey Naive Pluripotent Stem Cells","volume":"16","author":"Aksoy","year":"2021","journal-title":"Stem Cell Rep."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cell.2016.12.036","article-title":"Interspecies Chimerism with Mammalian Pluripotent Stem Cells","volume":"168","author":"Wu","year":"2017","journal-title":"Cell"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Kaminska, A., Pinkas, J., Wrzesniewska-Wal, I., Ostrowski, J., and Jankowski, M. (2023). Awareness of Common Eye Diseases and Their Risk Factors-A Nationwide Cross-Sectional Survey among Adults in Poland. Int. J. Environ. Res. Public. Health, 20.","DOI":"10.3390\/ijerph20043594"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.clindermatol.2014.10.006","article-title":"Human ocular anatomy","volume":"33","author":"Kels","year":"2015","journal-title":"Clin. Dermatol."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Tombran-Tink, J., and Barnstable, C.J. (2008). Ocular Transporters in Ophthalmic Diseases and Drug Delivery: Ophthalmology Research, Humana Press.","DOI":"10.1007\/978-1-59745-375-2"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.stem.2018.05.013","article-title":"Regenerating Eye Tissues to Preserve and Restore Vision","volume":"22","author":"Stern","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_166","unstructured":"(2022, December 19). Holoclar. Available online: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/holoclar."},{"key":"ref_167","first-page":"e29583","article-title":"Age-Related Macular Degeneration: Epidemiology, Pathophysiology, Diagnosis, and Treatment","volume":"14","author":"Vyawahare","year":"2022","journal-title":"Cureus"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ebiom.2016.11.016","article-title":"Phase 2a Randomized Clinical Trial: Safety and Post Hoc Analysis of Subretinal rAAV.sFLT-1 for Wet Age-related Macular Degeneration","volume":"14","author":"Constable","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/S0140-6736(15)00345-1","article-title":"Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial","volume":"386","author":"Rakoczy","year":"2015","journal-title":"Lancet"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ajo.2019.03.006","article-title":"Three-Year Follow-Up of Phase 1 and 2a rAAV.sFLT-1 Subretinal Gene Therapy Trials for Exudative Age-Related Macular Degeneration","volume":"204","author":"Rakoczy","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/eye.2012.106","article-title":"Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients","volume":"26","author":"Nguyen","year":"2012","journal-title":"Eye"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/hum.2016.117","article-title":"Lentiviral Vector Gene Transfer of Endostatin\/Angiostatin for Macular Degeneration (GEM) Study","volume":"28","author":"Campochiaro","year":"2017","journal-title":"Hum. Gene Ther."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4103\/tjo.tjo_47_21","article-title":"Gene therapy for retinitis pigmentosa","volume":"11","author":"Piri","year":"2021","journal-title":"Taiwan. J. Ophthalmol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13287-022-02828-w","article-title":"Human primitive mesenchymal stem cell-derived retinal progenitor cells improved neuroprotection, neurogenesis, and vision in rd12 mouse model of retinitis pigmentosa","volume":"13","author":"Brown","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Liu, W., Liu, S., Li, P., and Yao, K. (2022). Retinitis Pigmentosa: Progress in Molecular Pathology and Biotherapeutical Strategies. Int. J. Mol. Sci.","DOI":"10.3390\/ijms23094883"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"3249064","DOI":"10.1155\/2018\/3249064","article-title":"A Brief Review on the Pathological Role of Decreased Blood Flow Affected in Retinitis Pigmentosa","volume":"2018","author":"Yang","year":"2018","journal-title":"J. Ophthalmol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1089\/scd.2020.0037","article-title":"Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells Maintains and Partially Improves Visual Function in Patients with Advanced Retinitis Pigmentosa","volume":"29","author":"Zhao","year":"2020","journal-title":"Stem Cells Dev."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s13287-017-0661-8","article-title":"Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients","volume":"8","author":"Liu","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s13287-020-01870-w","article-title":"Management of retinitis pigmentosa by Wharton\u2019s jelly-derived mesenchymal stem cells: Prospective analysis of 1-year results","volume":"11","author":"Ozmert","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"101039","DOI":"10.1016\/j.cegh.2022.101039","article-title":"Validity and reliability of the NEI VFQ-25 questionnaire in Indonesian leprosy patients","volume":"15","author":"Rahayu","year":"2022","journal-title":"Clin. Epidemiol. Glob. Health"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13287-020-02122-7","article-title":"Intravitreal autologous mesenchymal stem cell transplantation: A non-randomized phase I clinical trial in patients with retinitis pigmentosa","volume":"12","author":"Tuekprakhon","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Wu, K.Y., Kulbay, M., Toameh, D., Xu, A.Q., Kalevar, A., and Tran, S.D. (2023). Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15020685"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.ophtha.2018.04.037","article-title":"Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration","volume":"125","author":"Mehat","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/bjophthalmol-2020-316225","article-title":"Long-term safety and tolerability of subretinal transplantation of embryonic stem cell-derived retinal pigment epithelium in Asian Stargardt disease patients","volume":"105","author":"Sung","year":"2021","journal-title":"Br. J. Ophthalmol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/IAE.0000000000003655","article-title":"TRANSPLANTATION OF SUBRETINAL STEM CELL-DERIVED RETINAL PIGMENT EPITHELIUM FOR STARGARDT DISEASE: A Phase I Clinical Trial","volume":"43","author":"Lojudice","year":"2023","journal-title":"Retina"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e13100","DOI":"10.1111\/cpr.13100","article-title":"A phase I clinical trial of human embryonic stem cell-derived retinal pigment epithelial cells for early-stage Stargardt macular degeneration: 5-years\u2019 follow-up","volume":"54","author":"Li","year":"2021","journal-title":"Cell Prolif."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ajo.2022.02.013","article-title":"Three-Year Safety Results of SAR422459 (EIAV-ABCA4) Gene Therapy in Patients With ABCA4-Associated Stargardt Disease: An Open-Label Dose-Escalation Phase I\/IIa Clinical Trial, Cohorts 1-5","volume":"240","author":"Parker","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41421-018-0053-y","article-title":"Human embryonic stem cell-derived retinal pigment epithelium transplants as a potential treatment for wet age-related macular degeneration","volume":"4","author":"Liu","year":"2018","journal-title":"Cell Discov."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nbt.4114","article-title":"Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration","volume":"36","author":"Fynes","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"ref_190","first-page":"1862","article-title":"Safety and Efficacy of a Phase 1\/2a Clinical Trial of Transplanted Allogeneic Retinal Pigmented Epithelium (RPE, OpRegen) Cells in Advanced Dry Age-Related Macular Degeneration (AMD)","volume":"63","author":"Ho","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/tvst.10.10.13","article-title":"One-Year Follow-Up in a Phase 1\/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration","volume":"10","author":"Kashani","year":"2021","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"eaao4097","DOI":"10.1126\/scitranslmed.aao4097","article-title":"A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration","volume":"10","author":"Kashani","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II Definition and Classification Report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"eabj9617","DOI":"10.1126\/sciadv.abj9617","article-title":"miR-204-containing exosomes ameliorate GVHD-associated dry eye disease","volume":"8","author":"Zhou","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"9636897221133818","DOI":"10.1177\/09636897221133818","article-title":"Mesenchymal Stromal Cell-Based Therapy for Dry Eye: Current Status and Future Perspectives","volume":"31","author":"Jiang","year":"2022","journal-title":"Cell Transplant."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jtos.2020.11.013","article-title":"Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease","volume":"19","author":"Larsen","year":"2021","journal-title":"Ocul. Surf."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.mayocpiqo.2022.09.007","article-title":"Updates on the Diagnosis and Management of Glaucoma","volume":"6","author":"Wagner","year":"2022","journal-title":"Mayo Clin. Proc. Innov. Qual. Outcomes"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.mcna.2021.01.004","article-title":"Glaucoma","volume":"105","author":"Kang","year":"2021","journal-title":"Med. Clin. N. Am."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.18240\/ijo.2020.09.23","article-title":"Progress in exosomes and their potential use in ocular diseases","volume":"13","author":"Li","year":"2020","journal-title":"Int. J. Ophthalmol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jchemneu.2019.01.006","article-title":"UMSC-derived exosomes promote retinal ganglion cells survival in a rat model of optic nerve crush","volume":"96","author":"Pan","year":"2019","journal-title":"J. Chem. Neuroanat."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1111\/jcmm.13505","article-title":"Extracellular vesicles have variable dose-dependent effects on cultured draining cells in the eye","volume":"22","author":"Tabak","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jtos.2023.05.008","article-title":"Insights into the clinical development of regenerative medical products through a comparison of three cell-based products recently approved for limbal stem cell deficiency","volume":"29","author":"Aketa","year":"2023","journal-title":"Ocul. Surf."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"836009","DOI":"10.3389\/fmed.2022.836009","article-title":"A Review of the Diagnosis and Treatment of Limbal Stem Cell Deficiency","volume":"9","author":"Kate","year":"2022","journal-title":"Front. Med."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Ramirez, B.E., Sanchez, A., Herreras, J.M., Fernandez, I., Garcia-Sancho, J., Nieto-Miguel, T., and Calonge, M. (2015). Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures. Biomed. Res. Int., 2015.","DOI":"10.1155\/2015\/408495"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/sctm.18-0140","article-title":"Allogeneic Ex Vivo Expanded Corneal Epithelial Stem Cell Transplantation: A Randomized Controlled Clinical Trial","volume":"8","author":"Campbell","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/stem.276","article-title":"Successful clinical implementation of corneal epithelial stem cell therapy for treatment of unilateral limbal stem cell deficiency","volume":"28","author":"Kolli","year":"2010","journal-title":"Stem Cells"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1167\/iovs.11-7744","article-title":"Cultured autologous oral mucosal epithelial cell sheet (CAOMECS) transplantation for the treatment of corneal limbal epithelial stem cell deficiency","volume":"53","author":"Burillon","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1056\/NEJMoa040455","article-title":"Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium","volume":"351","author":"Nishida","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1479-5876-12-58","article-title":"Results of a phase I\/II clinical trial: Standardized, non-xenogenic, cultivated limbal stem cell transplantation","volume":"12","author":"Zakaria","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1002\/stem.1694","article-title":"Successful application of ex vivo expanded human autologous oral mucosal epithelium for the treatment of total bilateral limbal stem cell deficiency","volume":"32","author":"Kolli","year":"2014","journal-title":"Stem Cells"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/ICO.0000000000001409","article-title":"Prospective Clinical Trial of Corneal Reconstruction With Biomaterial-Free Cultured Oral Mucosal Epithelial Cell Sheets","volume":"37","author":"Kim","year":"2018","journal-title":"Cornea"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.trsl.2018.11.003","article-title":"A proof-of-concept clinical trial using mesenchymal stem cells for the treatment of corneal epithelial stem cell deficiency","volume":"206","author":"Calonge","year":"2019","journal-title":"Transl. Res."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ajo.2017.10.026","article-title":"Corneal Stroma Enhancement With Decellularized Stromal Laminas With or Without Stem Cell Recellularization for Advanced Keratoconus","volume":"186","author":"Azaar","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1097\/ICO.0000000000001228","article-title":"Cellular Therapy With Human Autologous Adipose-Derived Adult Stem Cells for Advanced Keratoconus","volume":"36","author":"Azaar","year":"2017","journal-title":"Cornea"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1097\/ICO.0000000000002646","article-title":"Corneal Stromal Regeneration Therapy for Advanced Keratoconus: Long-term Outcomes at 3 Years","volume":"40","author":"Alio","year":"2021","journal-title":"Cornea"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/iovs.61.4.22","article-title":"Corneal Stroma Cell Density Evolution in Keratoconus Corneas Following the Implantation of Adipose Mesenchymal Stem Cells and Corneal Laminas: An In Vivo Confocal Microscopy Study","volume":"61","author":"Jawad","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1038\/mt.2012.208","article-title":"Mesenchymal stromal cells treatment attenuates dry eye in patients with chronic graft-versus-host disease","volume":"20","author":"Weng","year":"2012","journal-title":"Mol. Ther."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1056\/NEJMoa1712770","article-title":"Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy","volume":"378","author":"Kinoshita","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"e016487","DOI":"10.1136\/bmjopen-2017-016487","article-title":"A study protocol for a multicentre randomised clinical trial evaluating the safety and feasibility of a bioengineered human allogeneic nanostructured anterior cornea in patients with advanced corneal trophic ulcers refractory to conventional treatment","volume":"7","author":"Mata","year":"2017","journal-title":"BMJ Open"},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Limoli, P.G., Vingolo, E.M., Limoli, C., Scalinci, S.Z., and Nebbioso, M. (2018). Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report. J. Vis. Exp.","DOI":"10.3791\/56469"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Weiss, J.N., and Levy, S. (2020). Stem Cell Ophthalmology Treatment Study (SCOTS): Bone Marrow-Derived Stem Cells in the Treatment of Age-Related Macular Degeneration. Medicines, 7.","DOI":"10.3390\/medicines7040016"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.oret.2020.06.012","article-title":"Effect of Human Central Nervous System Stem Cell Subretinal Transplantation on Progression of Geographic Atrophy Secondary to Nonneovascular Age-Related Macular Degeneration","volume":"5","author":"Nittala","year":"2021","journal-title":"Ophthalmol. Retina"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0140-6736(12)60028-2","article-title":"Embryonic stem cell trials for macular degeneration: A preliminary report","volume":"379","author":"Schwartz","year":"2012","journal-title":"Lancet"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0140-6736(14)61376-3","article-title":"Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt\u2019s macular dystrophy: Follow-up of two open-label phase 1\/2 studies","volume":"385","author":"Schwartz","year":"2015","journal-title":"Lancet"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.stemcr.2015.04.005","article-title":"Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: Preliminary results in Asian patients","volume":"4","author":"Song","year":"2015","journal-title":"Stem Cell Rep."},{"key":"ref_226","first-page":"ORSFc1-9","article-title":"Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years","volume":"57","author":"Schwartz","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1089\/cell.2018.0045","article-title":"Suprachoroidal Adipose Tissue-Derived Mesenchymal Stem Cell Implantation in Patients with Dry-Type Age-Related Macular Degeneration and Stargardt\u2019s Macular Dystrophy: 6-Month Follow-Up Results of a Phase 2 Study","volume":"20","author":"Oner","year":"2018","journal-title":"Cell Reprogram"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Weiss, J.N., and Levy, S. (2021). Stem Cell Ophthalmology Treatment Study (SCOTS): Bone Marrow-Derived Stem Cells in the Treatment of Stargardt Disease. Medicines, 8.","DOI":"10.3390\/medicines8020010"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13287-016-0432-y","article-title":"Subretinal adipose tissue-derived mesenchymal stem cell implantation in advanced stage retinitis pigmentosa: A phase I clinical safety study","volume":"7","author":"Oner","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1167\/iovs.14-15415","article-title":"Intravitreal autologous bone marrow CD34+ cell therapy for ischemic and degenerative retinal disorders: Preliminary phase 1 clinical trial findings","volume":"56","author":"Park","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/APO.0000000000000222","article-title":"Gene Therapy for Age-Related Macular Degeneration","volume":"5","author":"Constable","year":"2016","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41591-020-0763-1","article-title":"Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR","volume":"26","author":"Xue","year":"2020","journal-title":"Nat. Med."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00439-016-1637-y","article-title":"Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: Results of a phase I trial","volume":"135","author":"Ghazi","year":"2016","journal-title":"Hum. Genet."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"eaaz7423","DOI":"10.1126\/scitranslmed.aaz7423","article-title":"Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy","volume":"12","author":"Newman","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ophtha.2020.12.012","article-title":"Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset","volume":"128","author":"Newman","year":"2021","journal-title":"Ophthalmology"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/WNO.0000000000001367","article-title":"Long-Term Follow-Up After Unilateral Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy: The RESTORE Study","volume":"41","author":"Biousse","year":"2021","journal-title":"J. Neuroophthalmol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/IAE.0000000000002360","article-title":"Changes in Retinal Sensitivity after Gene Therapy in Choroideremia","volume":"40","author":"Fischer","year":"2020","journal-title":"Retina"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.ophtha.2022.06.006","article-title":"Adeno-Associated Virus Serotype 2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two-Year Interim Results of an Ongoing Phase I\/II Gene Therapy Trial","volume":"129","author":"Aleman","year":"2022","journal-title":"Ophthalmology"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(13)62117-0","article-title":"Retinal gene therapy in patients with choroideremia: Initial findings from a phase 1\/2 clinical trial","volume":"383","author":"MacLaren","year":"2014","journal-title":"Lancet"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"7666","DOI":"10.1167\/iovs.12-9961","article-title":"Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)","volume":"53","author":"Nguyen","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1056\/NEJMoa0802315","article-title":"Safety and efficacy of gene transfer for Leber\u2019s congenital amaurosis","volume":"358","author":"Maguire","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1001\/jamaophthalmol.2020.1032","article-title":"Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial","volume":"138","author":"Fischer","year":"2020","journal-title":"JAMA Ophthalmol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.2147\/OPTH.S364200","article-title":"Ocular Gene Therapy: A Literature Review with Special Focus on Immune and Inflammatory Responses","volume":"16","author":"Ghoraba","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/sctm.21-0239","article-title":"A stem cell journey in ophthalmology: From the bench to the clinic","volume":"10","author":"Caras","year":"2021","journal-title":"Stem Cells Transl. Med."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"366","DOI":"10.4252\/wjsc.v13.i5.366","article-title":"Stem cell therapy in ocular pathologies in the past 20 years","volume":"13","author":"Miotti","year":"2021","journal-title":"World J. Stem Cells"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/aos.14932","article-title":"Advances in exosome therapies in ophthalmology-From bench to clinical trial","volume":"100","author":"Sanghani","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Tomczak, W., Winkler-Lach, W., Tomczyk-Socha, M., and Misiuk-Hojlo, M. (2023). 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