{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T05:28:58Z","timestamp":1794115738346,"version":"4.8.0"},"reference-count":142,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T00:00:00Z","timestamp":1705795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["EY031697"],"award-info":[{"award-number":["EY031697"]}]},{"name":"National Institutes of Health","award":["EY034116"],"award-info":[{"award-number":["EY034116"]}]},{"name":"National Institutes of Health","award":["AG081004"],"award-info":[{"award-number":["AG081004"]}]},{"name":"National Institutes of Health","award":["NS129684"],"award-info":[{"award-number":["NS129684"]}]},{"name":"National Institutes of Health","award":["AG081037"],"award-info":[{"award-number":["AG081037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Glaucoma is a group of ocular diseases that cause irreversible blindness. It is characterized by multifactorial degeneration of the optic nerve axons and retinal ganglion cells (RGCs), resulting in the loss of vision. Major components of glaucoma pathogenesis include glia-driven neuroinflammation and impairment of mitochondrial dynamics and bioenergetics, leading to retinal neurodegeneration. In this review article, we summarize current evidence for the emerging role of apolipoprotein A-I binding protein (AIBP) as an important anti-inflammatory and neuroprotective factor in the retina. Due to its association with toll-like receptor 4 (TLR4), extracellular AIBP selectively removes excess cholesterol from the plasma membrane of inflammatory and activated cells. This results in the reduced expression of TLR4-associated, cholesterol-rich lipid rafts and the inhibition of downstream inflammatory signaling. Intracellular AIBP is localized to mitochondria and modulates mitophagy through the ubiquitination of mitofusins 1 and 2. Importantly, elevated intraocular pressure induces AIBP deficiency in mouse models and in human glaucomatous retina. AIBP deficiency leads to the activation of TLR4 in M\u00fcller glia, triggering mitochondrial dysfunction in both RGCs and M\u00fcller glia, and compromising visual function in a mouse model. Conversely, restoring AIBP expression in the retina reduces neuroinflammation, prevents RGCs death, and protects visual function. These results provide new insight into the mechanism of AIBP function in the retina and suggest a therapeutic potential for restoring retinal AIBP expression in the treatment of glaucoma.<\/jats:p>","DOI":"10.3390\/cells13020198","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T05:42:31Z","timestamp":1705902151000},"page":"198","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["AIBP: A New Safeguard against Glaucomatous Neuroinflammation"],"prefix":"10.3390","volume":"13","author":[{"given":"Seunghwan","family":"Choi","sequence":"first","affiliation":[{"name":"Hamilton Glaucoma Center and Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1152-1509","authenticated-orcid":false,"given":"Soo-Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3779-7178","authenticated-orcid":false,"given":"Tonking","family":"Bastola","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younggun","family":"Park","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093, USA"},{"name":"Department of Ophthalmology and Visual Science, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonghyun","family":"Oh","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093, USA"},{"name":"Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang 10326, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"National Center for Microscopy and Imaging Research, Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-1097","authenticated-orcid":false,"given":"Sinwoo","family":"Hwang","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury I.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1117-4834","authenticated-orcid":false,"given":"Won-Kyu","family":"Ju","sequence":"additional","affiliation":[{"name":"Hamilton Glaucoma Center and Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: A review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101136","DOI":"10.1016\/j.preteyeres.2022.101136","article-title":"Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells","volume":"95","author":"Ju","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Tezel, G. (2021). Multifactorial Pathogenic Processes of Retinal Ganglion Cell Degeneration in Glaucoma towards Multi-Target Strategies for Broader Treatment Effects. Cells, 10.","DOI":"10.3390\/cells10061372"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.ophtha.2007.04.003","article-title":"Incident open-angle glaucoma and intraocular pressure","volume":"114","author":"Nemesure","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","article-title":"Primary open-angle glaucoma","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41420-018-0077-y","article-title":"Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA\/2J spontaneous glaucoma mouse model","volume":"4","author":"Hirt","year":"2018","journal-title":"Cell Death Discov."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.exer.2010.04.002","article-title":"Mechanisms of retinal ganglion cell injury and defense in glaucoma","volume":"91","author":"Qu","year":"2010","journal-title":"Exp. Eye Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3129\/can j ophthalmol.i07-036","article-title":"From ocular hypertension to ganglion cell death: A theoretical sequence of events leading to glaucoma","volume":"42","author":"Nickells","year":"2007","journal-title":"Can. J. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Choi, S.H., Kim, K.Y., Perkins, G.A., Phan, S., Edwards, G., Xia, Y., Kim, J., Skowronska-Krawczyk, D., Weinreb, R.N., and Ellisman, M.H. (2020). AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration. Redox Biol., 37.","DOI":"10.1016\/j.redox.2020.101703"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ju, W.K., Ha, Y., Choi, S., Kim, K.Y., Bastola, T., Kim, J., Weinreb, R.N., Zhang, W., Miller, Y.I., and Choi, S.H. (2023). Restoring AIBP deficiency in the retina provides neuroprotection in glaucoma. bioRxiv.","DOI":"10.1101\/2023.10.16.562633"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1006\/geno.2002.6761","article-title":"Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I","volume":"79","author":"Ritter","year":"2002","journal-title":"Genomics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature12166","article-title":"Control of angiogenesis by AIBP-mediated cholesterol efflux","volume":"498","author":"Fang","year":"2013","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1194\/jlr.M083618","article-title":"AIBP protects against metabolic abnormalities and atherosclerosis","volume":"59","author":"Schneider","year":"2018","journal-title":"J. Lipid Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1016\/j.celrep.2018.04.110","article-title":"Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States","volume":"23","author":"Woller","year":"2018","journal-title":"Cell Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e120519","DOI":"10.1172\/jci.insight.120519","article-title":"AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation","volume":"3","author":"Choi","year":"2018","journal-title":"JCI Insight"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e20202059","DOI":"10.1084\/jem.20202059","article-title":"Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain","volume":"218","author":"Choi","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1161\/ATVBAHA.120.315485","article-title":"Intracellular AIBP (Apolipoprotein A-I Binding Protein) Regulates Oxidized LDL (Low-Density Lipoprotein)-Induced Mitophagy in Macrophages","volume":"41","author":"Choi","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1253\/circj.CJ-17-0877","article-title":"Apolipoprotein A-1 Binding Protein Inhibits Inflammatory Signaling Pathways by Binding to Apolipoprotein A-1 in THP-1 Macrophages","volume":"82","author":"Zhang","year":"2018","journal-title":"Circ. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e274","DOI":"10.1097\/j.pain.0000000000002834","article-title":"AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons","volume":"164","author":"Gonzalez","year":"2023","journal-title":"Pain"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nri3793","article-title":"Cholesterol, inflammation and innate immunity","volume":"15","author":"Tall","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"690372","DOI":"10.3389\/fnagi.2021.690372","article-title":"Cholesterol and Alzheimer\u2019s Disease; From Risk Genes to Pathological Effects","volume":"13","author":"Feringa","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/aos.15226","article-title":"Lipid metabolism and retinal diseases","volume":"100","author":"Gabrielle","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1194\/jlr.TR119000468","article-title":"Lipid rafts in glial cells: Role in neuroinflammation and pain processing","volume":"61","author":"Miller","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1194\/jlr.M006486","article-title":"Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol","volume":"51","author":"Zhu","year":"2010","journal-title":"J. Lipid Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fphar.2018.00278","article-title":"Taraxasterol Inhibits LPS-Induced Inflammatory Response in BV2 Microglia Cells by Activating LXRalpha","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/ng.3078","article-title":"Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma","volume":"46","author":"Chen","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng.3482","article-title":"Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma","volume":"48","author":"Bailey","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"van Koolwijk, L.M., Ramdas, W.D., Ikram, M.K., Jansonius, N.M., Pasutto, F., Hysi, P.G., Macgregor, S., Janssen, S.F., Hewitt, A.W., and Viswanathan, A.C. (2012). Common genetic determinants of intraocular pressure and primary open-angle glaucoma. PLoS Genet., 8.","DOI":"10.1371\/journal.pgen.1002611"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1093\/hmg\/ddx184","article-title":"Genetics of glaucoma","volume":"26","author":"Wiggs","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/ng.3079","article-title":"Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma","volume":"46","author":"Gharahkhani","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/ng.3087","article-title":"Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma","volume":"46","author":"Hysi","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1093\/hmg\/ddy053","article-title":"Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma","volume":"27","author":"Shiga","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"eabq1081","DOI":"10.1126\/sciadv.abq1081","article-title":"Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy","volume":"8","author":"Shinozaki","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.omtm.2021.01.012","article-title":"Ad- and AAV8-mediated ABCA1 gene therapy in a murine model with retinal ischemia\/reperfusion injuries","volume":"20","author":"Luo","year":"2021","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.atherosclerosis.2018.03.010","article-title":"AIBP reduces atherosclerosis by promoting reverse cholesterol transport and ameliorating inflammation in apoE\u2212\/\u2212 mice","volume":"273","author":"Zhang","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Zhu, L., Parker, M., Enemchukwu, N., Shen, M., Zhang, G., Yan, Q., Handa, J.T., Fang, L., and Fu, Y. (2020). Combination of apolipoprotein-A-I\/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice. Commun. Biol., 3.","DOI":"10.1038\/s42003-020-1113-z"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12967-019-1910-7","article-title":"AIBP and APOA-I synergistically inhibit intestinal tumor growth and metastasis by promoting cholesterol efflux","volume":"17","author":"Zhang","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1111\/cas.14925","article-title":"NAD(P)HX epimerase downregulation promotes tumor progression through ROS\/HIF-1alpha signaling in hepatocellular carcinoma","volume":"112","author":"Sun","year":"2021","journal-title":"Cancer Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00041433-200104000-00003","article-title":"Cholesterol metabolism in the brain","volume":"12","author":"Dietschy","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1021\/cr200021m","article-title":"Biosynthesis of cholesterol and other sterols","volume":"111","author":"Nes","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2217\/clp.10.37","article-title":"Apolipoproteins in the brain: Implications for neurological and psychiatric disorders","volume":"51","author":"Elliott","year":"2010","journal-title":"Clin. Lipidol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e001156","DOI":"10.1161\/JAHA.114.001156","article-title":"Intravenously injected human apolipoprotein A-I rapidly enters the central nervous system via the choroid plexus","volume":"3","author":"Stukas","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/MOL.0000000000000291","article-title":"Relation between plasma and brain lipids","volume":"27","author":"Wellington","year":"2016","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.preteyeres.2018.10.003","article-title":"Immune regulation in the aging retina","volume":"69","author":"Chen","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1006\/bbrc.2002.6756","article-title":"Human retinal pigment epithelial cells express scavenger receptors BI and BII","volume":"292","author":"Duncan","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1136\/bjo.2008.144006","article-title":"Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium","volume":"93","author":"Duncan","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1194\/jlr.R010538","article-title":"The ins and outs of cholesterol in the vertebrate retina","volume":"51","author":"Fliesler","year":"2010","journal-title":"J. Lipid Res."},{"key":"ref_51","first-page":"1319","article-title":"Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors","volume":"12","author":"Tserentsoodol","year":"2006","journal-title":"Mol. Vis."},{"key":"ref_52","first-page":"1306","article-title":"Uptake of cholesterol by the retina occurs primarily via a low density lipoprotein receptor-mediated process","volume":"12","author":"Tserentsoodol","year":"2006","journal-title":"Mol. Vis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/aos.14769","article-title":"Cholesterol and glaucoma: A systematic review and meta-analysis","volume":"100","author":"Michelitsch","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/CIRCULATIONAHA.108.793869","article-title":"Increased inflammatory gene expression in ABC transporter-deficient macrophages: Free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions","volume":"118","author":"Welch","year":"2008","journal-title":"Circulation"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1161\/CIRCRESAHA.108.182568","article-title":"Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K","volume":"104","author":"Sun","year":"2009","journal-title":"Circ. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/ATVBAHA.108.179283","article-title":"Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses","volume":"30","author":"Wang","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"22930","DOI":"10.1074\/jbc.M801408200","article-title":"Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages","volume":"283","author":"Zhu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1161\/ATVBAHA.108.168690","article-title":"High-density lipoprotein reduces the human monocyte inflammatory response","volume":"28","author":"Murphy","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/liv.15448","article-title":"Apolipoprotein A-1 protected hepatic ischaemia-reperfusion injury through suppressing macrophage pyroptosis via TLR4-NF-kappaB pathway","volume":"43","author":"Chen","year":"2023","journal-title":"Liver Int."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1194\/jlr.R039479","article-title":"Regulation of signal transduction by HDL","volume":"54","author":"Mineo","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by Toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2006.0015","DOI":"10.1038\/msb4100057","article-title":"A comprehensive map of the toll-like receptor signaling network","volume":"2","author":"Oda","year":"2006","journal-title":"Mol. Syst. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: Mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.3233\/JAD-171160","article-title":"TLR4 Gene Expression and Pro-Inflammatory Cytokines in Alzheimer\u2019s Disease and in Response to Hippocampal Deafferentation in Rodents","volume":"63","author":"Miron","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1159\/000110455","article-title":"Role of the toll-like receptor 4 in neuroinflammation in Alzheimer\u2019s disease","volume":"20","author":"Walter","year":"2007","journal-title":"Cell Physiol. Biochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40035-021-00271-0","article-title":"TLR2 and TLR4 in Parkinson\u2019s disease pathogenesis: The environment takes a toll on the gut","volume":"10","author":"Gorecki","year":"2021","journal-title":"Transl. Neurodegener."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.imlet.2020.02.004","article-title":"The roles played by TLR4 in the pathogenesis of multiple sclerosis; A systematic review article","volume":"220","year":"2020","journal-title":"Immunol. Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2014.01.014","article-title":"Biological role of Toll-like receptor-4 in the brain","volume":"268","author":"Trotta","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1161\/01.STR.0000143450.04438.ae","article-title":"Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice","volume":"35","author":"Rosenzweig","year":"2004","journal-title":"Stroke"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1167\/iovs.08-2054","article-title":"Effect of bacterial lipopolysaccharide on ischemic damage in the rat retina","volume":"49","author":"Franco","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Yi, H., Patel, A.K., Sodhi, C.P., Hackam, D.J., and Hackam, A.S. (2012). Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036560"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"15326","DOI":"10.1074\/jbc.M112.448712","article-title":"Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal","volume":"288","author":"Kohno","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/cdd.2017.141","article-title":"Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation","volume":"25","author":"Huang","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/labinvest.2015.156","article-title":"The pro-inflammatory role of high-mobility group box 1 protein (HMGB-1) in photoreceptors and retinal explants exposed to elevated pressure","volume":"96","author":"Bohm","year":"2016","journal-title":"Lab. Investig."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Han, X., Chen, X., Chen, S., Luo, Q., Liu, X., He, A., He, S., Qiu, J., Chen, P., and Wu, Y. (2020). Tetramethylpyrazine attenuates endotoxin-induced retinal inflammation by inhibiting microglial activation via the TLR4\/NF-kappaB signalling pathway. Biomed. Pharmacother., 128.","DOI":"10.1016\/j.biopha.2020.110273"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11181","DOI":"10.1073\/pnas.1402819111","article-title":"Caspase-8 promotes NLRP1\/NLRP3 inflammasome activation and IL-1beta production in acute glaucoma","volume":"111","author":"Chi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1167\/iovs.10-5407","article-title":"Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling","volume":"51","author":"Luo","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00417-017-3610-4","article-title":"Association of Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile with the risk of primary open angle glaucoma","volume":"255","year":"2017","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1167\/iovs.07-1575","article-title":"Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma","volume":"49","author":"Shibuya","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e1839","DOI":"10.1038\/cddis.2015.180","article-title":"DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma","volume":"6","author":"Kim","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/glia.22781","article-title":"Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes","volume":"63","author":"Ju","year":"2015","journal-title":"Glia"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1167\/iovs.07-1337","article-title":"Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA\/2J mouse model of glaucoma","volume":"49","author":"Bosco","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1742-2094-11-133","article-title":"Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers","volume":"11","author":"Rojas","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Bosco, A., Crish, S.D., Steele, M.R., Romero, C.O., Inman, D.M., Horner, P.J., Calkins, D.J., and Vetter, M.L. (2012). Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043602"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cne.22516","article-title":"Early microglia activation in a mouse model of chronic glaucoma","volume":"519","author":"Bosco","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"100998","DOI":"10.1016\/j.preteyeres.2021.100998","article-title":"Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets","volume":"87","author":"Tezel","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_87","first-page":"951","article-title":"Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice","volume":"39","author":"John","year":"1998","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/ng794","article-title":"Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA\/2J mice","volume":"30","author":"Anderson","year":"2002","journal-title":"Nat. Genet."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1242\/dmm.018788","article-title":"Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma","volume":"8","author":"Bosco","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1002\/glia.22715","article-title":"Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model","volume":"62","author":"Wang","year":"2014","journal-title":"Glia"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Roh, M., Zhang, Y., Murakami, Y., Thanos, A., Lee, S.C., Vavvas, D.G., Benowitz, L.I., and Miller, J.W. (2012). Etanercept, a widely used inhibitor of tumor necrosis factor-alpha (TNF-alpha), prevents retinal ganglion cell loss in a rat model of glaucoma. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040065"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"12633","DOI":"10.1523\/JNEUROSCI.2801-06.2006","article-title":"Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma","volume":"26","author":"Nakazawa","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12974-016-0509-7","article-title":"Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat","volume":"13","author":"Sapienza","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_94","first-page":"2962","article-title":"Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma","volume":"43","author":"Naskar","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1167\/iovs.06-1282","article-title":"Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model","volume":"48","author":"Johnson","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1167\/iovs.18-25700","article-title":"Early Optic Nerve Head Glial Proliferation and Jak-Stat Pathway Activation in Chronic Experimental Glaucoma","volume":"60","author":"Lozano","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1007\/s12035-020-01910-9","article-title":"Sub-region-Specific Optic Nerve Head Glial Activation in Glaucoma","volume":"57","author":"Oikawa","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1080\/00207454.2016.1212854","article-title":"Neuroinflammation pathways: A general review","volume":"127","author":"Shabab","year":"2017","journal-title":"Int. J. Neurosci."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Niwa, M., Aoki, H., Hirata, A., Tomita, H., Green, P.G., and Hara, A. (2016). Retinal Cell Degeneration in Animal Models. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17010110"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1742-2094-9-39","article-title":"Microglial TIR-domain-containing adapter-inducing interferon-beta (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-kappaB","volume":"9","author":"Lin","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/jnc.13356","article-title":"Prothymosin-alpha preconditioning activates TLR4-TRIF signaling to induce protection of ischemic retina","volume":"135","author":"Halder","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"72503","DOI":"10.18632\/oncotarget.12700","article-title":"Wogonin prevents TLR4-NF-kappaB-medicated neuro-inflammation and improves retinal ganglion cells survival in retina after optic nerve crush","volume":"7","author":"Xu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jphs.2017.02.012","article-title":"Toll-like receptor 4 inhibitor protects against retinal ganglion cell damage induced by optic nerve crush in mice","volume":"133","author":"Nakano","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12974-019-1576-3","article-title":"A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma","volume":"16","author":"Krishnan","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Astafurov, K., Elhawy, E., Ren, L., Dong, C.Q., Igboin, C., Hyman, L., Griffen, A., Mittag, T., and Danias, J. (2014). Oral microbiome link to neurodegeneration in glaucoma. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104416"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Bohush, A., Niewiadomska, G., and Filipek, A. (2018). Role of Mitogen Activated Protein Kinase Signaling in Parkinson\u2019s Disease. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19102973"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1002\/jnr.21604","article-title":"Dual roles of the MAPK\/ERK1\/2 cell signaling pathway after stroke","volume":"86","author":"Sawe","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3233\/JAD-170283","article-title":"Mitochondrial Dysfunction Triggers Synaptic Deficits via Activation of p38 MAP Kinase Signaling in Differentiated Alzheimer\u2019s Disease Trans-Mitochondrial Cybrid Cells","volume":"59","author":"Yu","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41419-018-0722-7","article-title":"Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T alpha-synuclein model of Parkinson\u2019s disease","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.4049\/jimmunol.180.7.5075","article-title":"Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation","volume":"180","author":"Kang","year":"2008","journal-title":"J. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1053\/j.gastro.2010.01.005","article-title":"Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease","volume":"138","author":"Otsuka","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/MOL.0000000000000596","article-title":"Regulation of lipid rafts, angiogenesis and inflammation by AIBP","volume":"30","author":"Fang","year":"2019","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/440600a","article-title":"Mitochondrial disease: Powerhouse of disease","volume":"440","author":"Lane","year":"2006","journal-title":"Nature"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/iovs.62.3.22","article-title":"Mitophagy: An Emerging Target in Ocular Pathology","volume":"62","author":"Skeie","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1167\/iovs.07-1661","article-title":"Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve","volume":"49","author":"Ju","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/BJ20131482","article-title":"Occurrence and subcellular distribution of the NADPHX repair system in mammals","volume":"460","author":"Marbaix","year":"2014","journal-title":"Biochem. J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12964-022-00858-8","article-title":"Mitochondrial apolipoprotein A-I binding protein alleviates atherosclerosis by regulating mitophagy and macrophage polarization","volume":"20","author":"Duan","year":"2022","journal-title":"Cell Commun. Signal"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Solsona-Vilarrasa, E., Fucho, R., Torres, S., Nunez, S., Nuno-Lambarri, N., Enrich, C., Garcia-Ruiz, C., and Fernandez-Checa, J.C. (2019). Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes. Redox Biol., 24.","DOI":"10.1016\/j.redox.2019.101214"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3389\/fneur.2019.01168","article-title":"Mitochondrial Cholesterol in Alzheimer\u2019s Disease and Niemann-Pick Type C Disease","volume":"10","author":"Torres","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00441-022-03640-x","article-title":"Hydrogen sulfide supplement preserves mitochondrial function of retinal ganglion cell in a rat glaucoma model","volume":"389","author":"Huang","year":"2022","journal-title":"Cell Tissue Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3109\/10799893.2014.910812","article-title":"Elevated hydrostatic pressures induce apoptosis and oxidative stress through mitochondrial membrane depolarization in PC12 neuronal cells: A cell culture model of glaucoma","volume":"34","author":"Tok","year":"2014","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/s12974-018-1346-7","article-title":"Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma","volume":"15","author":"Inman","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s13167-023-00336-2","article-title":"The correlation between primary open-angle glaucoma (POAG) and gut microbiota: A pilot study towards predictive, preventive, and personalized medicine","volume":"14","author":"Chen","year":"2023","journal-title":"EPMA J."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41419-023-06140-0","article-title":"Inhibition of cGAS-STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia\/reperfusion injury","volume":"14","author":"Wu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"100916","DOI":"10.1016\/j.preteyeres.2020.100916","article-title":"Inflammation in Glaucoma: From the back to the front of the eye, and beyond","volume":"83","author":"Baudouin","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.coph.2012.09.008","article-title":"Oxidative stress and mitochondrial dysfunction in glaucoma","volume":"13","author":"Chrysostomou","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nchembio.1141","article-title":"Metabolite damage and its repair or pre-emption","volume":"9","author":"Linster","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD(+) metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ymgme.2022.04.003","article-title":"NAXE deficiency: A neurometabolic disorder of NAD(P)HX repair amenable for metabolic correction","volume":"136","author":"Manor","year":"2022","journal-title":"Mol. Genet. Metab."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"41246","DOI":"10.1074\/jbc.C111.310847","article-title":"Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair","volume":"286","author":"Marbaix","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.str.2012.07.016","article-title":"Identification of unknown protein function using metabolite cocktail screening","volume":"20","author":"Shumilin","year":"2012","journal-title":"Structure"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0021-9258(18)65605-4","article-title":"The action of glyceraldehyde-3-phosphate dehydrogenase on reduced diphosphopyridine nucleotide","volume":"208","author":"Rafter","year":"1954","journal-title":"J. Biol. Chem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0003-9861(75)90344-6","article-title":"Inhibition of NADP-dependent dehydrogenases by modified products of NADPH","volume":"169","author":"Yoshida","year":"1975","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1161\/CIRCRESAHA.116.309754","article-title":"AIBP Limits Angiogenesis Through gamma-Secretase-Mediated Upregulation of Notch Signaling","volume":"120","author":"Mao","year":"2017","journal-title":"Circ. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B(3) modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/ceo.13818","article-title":"Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial","volume":"48","author":"Hui","year":"2020","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1167\/iovs.19-27099","article-title":"Nicotinamide Deficiency in Primary Open-Angle Glaucoma","volume":"60","author":"Guehlouz","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cmet.2018.03.018","article-title":"Quantitative Analysis of NAD Synthesis-Breakdown Fluxes","volume":"27","author":"Liu","year":"2018","journal-title":"Cell Metab."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Kim, J.D., Zhu, L., Sun, Q., and Fang, L. (2021). Systemic metabolite profiling reveals sexual dimorphism of AIBP control of metabolism in mice. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0248964"},{"key":"ref_142","first-page":"1343","article-title":"The role of Toll-like receptors in retinal ischemic diseases","volume":"9","author":"Xu","year":"2016","journal-title":"Int. J. Ophthalmol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/2\/198\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:46:43Z","timestamp":1760104003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/2\/198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,21]]},"references-count":142,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["cells13020198"],"URL":"https:\/\/doi.org\/10.3390\/cells13020198","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,21]]}}}