{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:31:29Z","timestamp":1788838289480,"version":"build-2803163510"},"reference-count":174,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sistema Nacional de Investigaci\u00f3n de Panam\u00e1","award":["SNI"],"award-info":[{"award-number":["SNI"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Plasmodium parasites need to find red blood cells (RBCs) that, on the one hand, expose receptors for the pathogen ligands and, on the other hand, maintain the right geometry to facilitate merozoite attachment and entry into the red blood cell. Both characteristics change with the maturation of erythrocytes. Some Plasmodia prefer younger vs. older erythrocytes. How does the life evolution of the RBC affect the invasion of the parasite? What happens when the RBC ages? In this review, we present what is known up until now.<\/jats:p>","DOI":"10.3390\/cells13040334","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T06:19:59Z","timestamp":1707718799000},"page":"334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["P. falciparum Invasion and Erythrocyte Aging"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2766-7361","authenticated-orcid":false,"given":"Mar\u00eda Fernanda","family":"Alves-Rosa","sequence":"first","affiliation":[{"name":"Center of Cellular and Molecular Biology of Diseases, Instituto de Investigaciones Cient\u00edficas y Servicio de Alta Tecnolog\u00eda (INDICASAT AIP), City of Knowledge, Panama City 0843-01103, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-6464","authenticated-orcid":false,"given":"Nicole M.","family":"Tayler","sequence":"additional","affiliation":[{"name":"Center of Cellular and Molecular Biology of Diseases, Instituto de Investigaciones Cient\u00edficas y Servicio de Alta Tecnolog\u00eda (INDICASAT AIP), City of Knowledge, Panama City 0843-01103, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9692-466X","authenticated-orcid":false,"given":"Doriana","family":"Dorta","sequence":"additional","affiliation":[{"name":"Center of Cellular and Molecular Biology of Diseases, Instituto de Investigaciones Cient\u00edficas y Servicio de Alta Tecnolog\u00eda (INDICASAT AIP), City of Knowledge, Panama City 0843-01103, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6755-3118","authenticated-orcid":false,"given":"Lorena M.","family":"Coronado","sequence":"additional","affiliation":[{"name":"Center of Cellular and Molecular Biology of Diseases, Instituto de Investigaciones Cient\u00edficas y Servicio de Alta Tecnolog\u00eda (INDICASAT AIP), City of Knowledge, Panama City 0843-01103, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3002-9467","authenticated-orcid":false,"given":"Carmenza","family":"Spadafora","sequence":"additional","affiliation":[{"name":"Center of Cellular and Molecular Biology of Diseases, Instituto de Investigaciones Cient\u00edficas y Servicio de Alta Tecnolog\u00eda (INDICASAT AIP), City of Knowledge, Panama City 0843-01103, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022). World malaria report 2022, World Health Organization. Licence: CC BY-NC-SA 3.0 IGO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12936-023-04682-4","article-title":"Climate change and malaria: Some recent trends of malaria incidence rates and average annual temperature in selected sub-Saharan African countries from 2000 to 2018","volume":"22","author":"May","year":"2023","journal-title":"Malar. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1086\/322858","article-title":"Chloroquine-Resistant Malaria","volume":"184","author":"Wellems","year":"2001","journal-title":"J. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gomez, G.M., D\u2019Arrigo, G., Sanchez, C.P., Berger, F., Wade, R.C., and Lanzer, M. (2023). PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011436"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1038\/s41467-018-05652-0","article-title":"Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine","volume":"9","author":"Ross","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1038\/ncomms11553","article-title":"Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies","volume":"7","author":"Veiga","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1128\/AAC.03494-14","article-title":"Role of Pfmdr1 in in vitro Plasmodium falciparum susceptibility to chloroquine, quinine, monodesethylamodiaquine, mefloquine, lumefantrine, and dihydroartemisinin","volume":"58","author":"Wurtz","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature09107","article-title":"Thousands of chemical starting points for antimalarial lead identification","volume":"465","author":"Alvarez","year":"2010","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/biot.201500055","article-title":"The stage-specific in vitro efficacy of a malaria antigen cocktail provides valuable insights into the development of effective multi-stage vaccines","volume":"10","author":"Spiegel","year":"2015","journal-title":"Biotechnol. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-1-4939-9550-9_15","article-title":"Development of Blood Stage Malaria Vaccines","volume":"2013","author":"Vijayan","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Molina-Franky, J., Patarroyo, M.E., Kalkum, M., and Patarroyo, M.A. (2022). The Cellular and Molecular Interaction Between Erythrocytes and Plasmodium falciparum Merozoites. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.816574"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1242\/jcs.102.3.527","article-title":"Origins of the parasitophorous vacuole membrane of the malaria parasite, Plasmodium falciparum, in human red blood cells","volume":"102","author":"Dluzewski","year":"1992","journal-title":"J. Cell Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.chom.2017.07.003","article-title":"The Molecular Basis of Erythrocyte Invasion by Malaria Parasites","volume":"22","author":"Cowman","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1182\/blood.V67.5.1519.1519","article-title":"Invasion of erythrocytes by Plasmodium falciparum malaria parasites: Evidence for receptor heterogeneity and two receptors","volume":"67","author":"Mitchell","year":"1986","journal-title":"Blood"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1126\/science.8009226","article-title":"Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum","volume":"264","author":"Sim","year":"1994","journal-title":"Science"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molbiopara.2012.01.002","article-title":"Identification of a specific region of Plasmodium falciparum EBL-1 that binds to host receptor glycophorin B and inhibits merozoite invasion in human red blood cells","volume":"183","author":"Li","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"P36830","DOI":"10.1074\/jbc.M112.409276","article-title":"Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion","volume":"287","author":"Lin","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1182\/blood-2002-10-3076","article-title":"Glycophorin C is the receptor for the Plasmodium falciparum erythrocyte binding ligand PfEBP-2 (baebl)","volume":"101","author":"Lobo","year":"2003","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0268-960X(99)90020-6","article-title":"Functional aspects of red cell antigens","volume":"13","author":"Daniels","year":"1999","journal-title":"Blood Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/trf.13450","article-title":"GYP*Kip, a novel GYP(B-A-B) hybrid allele, encoding the MNS48 (KIPP) antigen","volume":"56","author":"Lopez","year":"2016","journal-title":"Transfusion"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00251-022-01280-7","article-title":"Genetic variation of glycophorins and infectious disease","volume":"75","author":"Hollox","year":"2023","journal-title":"Immunogenetics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.146.1.277","article-title":"Evidence for differences in erythrocyte surface receptors for the malarial parasites, Plasmodium falciparum and Plasmodium knowlesi","volume":"146","author":"Miller","year":"1977","journal-title":"J. Exp. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.meegid.2019.02.004","article-title":"Few Plasmodium falciparum merozoite ligand and erythrocyte receptor pairs show evidence of balancing selection","volume":"69","author":"Wamae","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1073\/pnas.0900878106","article-title":"Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1","volume":"106","author":"Mayer","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13071-019-3575-8","article-title":"Erythrocyte glycophorins as receptors for Plasmodium merozoites","volume":"12","author":"Jaskiewicz","year":"2019","journal-title":"Parasit. Vectors"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e00074-17","DOI":"10.1128\/IAI.00074-17","article-title":"Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes","volume":"85","author":"Dankwa","year":"2017","journal-title":"Infect. Immun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1073\/pnas.0730883100","article-title":"Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways","volume":"100","author":"Duraisingh","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1128\/IAI.00048-09","article-title":"Antibodies to reticulocyte binding protein-like homologue 4 inhibit invasion of Plasmodium falciparum into human erythrocytes","volume":"77","author":"Tham","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"17789","DOI":"10.1073\/pnas.0708772104","article-title":"Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasion","volume":"104","author":"Gaur","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1126\/science.1115257","article-title":"Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes","volume":"309","author":"Stubbs","year":"2005","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Spadafora, C., Awandare, G.A., Kopydlowski, K.M., Czege, J., Moch, J.K., Finberg, R.W., Tsokos, G.C., and Stoute, J.A. (2010). Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000968"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molbiopara.2011.01.005","article-title":"Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes","volume":"177","author":"Awandare","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Rodriguez, M., Lustigman, S., Montero, E., Oksov, Y., and Lobo, C.A. (2008). PfRH5: A novel reticulocyte-binding family homolog of Plasmodium falciparum that binds to the erythrocyte, and an investigation of its receptor. PLoS ONE, 3.","DOI":"10.1371\/annotation\/dde6c172-c9c3-43bb-8fc3-db54613d4424"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20735","DOI":"10.1073\/pnas.1320771110","article-title":"RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum","volume":"110","author":"Wanaguru","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e83681","DOI":"10.7554\/eLife.83681","article-title":"Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes","volume":"5","author":"Jamwal","year":"2023","journal-title":"Elife"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1126\/science.aaa3526","article-title":"A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion","volume":"348","author":"Egan","year":"2015","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12936-019-2868-x","article-title":"Temporal changes in Plasmodium falciparum reticulocyte binding protein homolog 2b (PfRh2b) in Senegal and The Gambia","volume":"18","author":"Moussa","year":"2019","journal-title":"Malar. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.pt.2005.03.004","article-title":"Complement-regulatory proteins in severe malaria: Too little or too much of a good thing?","volume":"21","author":"Stoute","year":"2005","journal-title":"Trends Parasitol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1046\/j.1365-2249.2000.01218.x","article-title":"C1q receptors","volume":"120","author":"Eggleton","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/gene.2011.33","article-title":"Evidence for malaria selection of a CR1 haplotype in Sardinia","volume":"12","author":"Kosoy","year":"2011","journal-title":"Genes Immun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"17327","DOI":"10.1073\/pnas.1008151107","article-title":"Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand","volume":"107","author":"Tham","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/jb\/mvv127","article-title":"Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners","volume":"159","author":"Muramatsu","year":"2016","journal-title":"J. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.4049\/jimmunol.1501889","article-title":"Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling","volume":"196","author":"Supper","year":"2016","journal-title":"J. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/infdis\/jit070","article-title":"An ATP2B4 polymorphism protects against malaria in pregnancy","volume":"207","author":"Meese","year":"2013","journal-title":"J. Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fnins.2014.00125","article-title":"Lactate transport and receptor actions in cerebral malaria","volume":"8","author":"Mariga","year":"2014","journal-title":"Front. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e333","DOI":"10.1016\/S2352-3026(18)30107-8","article-title":"MalariaGEN Consortium. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: A case-control association study","volume":"5","author":"Ndila","year":"2018","journal-title":"Lancet Haematol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature13715","article-title":"Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies","volume":"515","author":"Wright","year":"2014","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature10606","article-title":"Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum","volume":"480","author":"Crosnier","year":"2011","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.21307\/immunohematology-2019-210","article-title":"The Cromer blood group system: A review","volume":"26","author":"Storry","year":"2010","journal-title":"Immunohematology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cell.2005.10.035","article-title":"Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions","volume":"124","author":"Coyne","year":"2006","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Sahar, T., Reddy, K.S., Bharadwaj, M., Pandey, A.K., Singh, S., Chitnis, C.E., and Gaur, D. (2011). Plasmodium falciparum reticulocyte binding-like homologue protein 2 (PfRH2) is a key adhesive molecule involved in erythrocyte invasion. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017102"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"25655","DOI":"10.1074\/jbc.M114.586495","article-title":"The merozoite surface protein 1 complex is a platform for binding to human erythrocytes by Plasmodium falciparum","volume":"289","author":"Lin","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/cmi.12118","article-title":"A thrombospondin structural repeat containing rhoptry protein from Plasmodium falciparum mediates erythrocyte invasion","volume":"15","author":"Siddiqui","year":"2013","journal-title":"Cell. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.molbiopara.2012.12.005","article-title":"Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and rats","volume":"187","author":"Hayton","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MOH.0000000000000219","article-title":"Red cell receptors as access points for malaria infection","volume":"23","author":"Salinas","year":"2016","journal-title":"Curr. Opin. Hematol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1537-2995.2010.02926.x","article-title":"Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities","volume":"51","author":"Mock","year":"2011","journal-title":"Transfusion"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"655393","DOI":"10.3389\/fphys.2021.655393","article-title":"How Do Red Blood Cells Die?","volume":"12","author":"Thiagarajan","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_58","first-page":"s39","article-title":"Aging and death signalling in mature red cells: From basic science to transfusion practice","volume":"8","author":"Antonelou","year":"2010","journal-title":"Blood Transfus."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3389\/fphys.2013.00387","article-title":"Mechanisms tagging senescent red blood cells for clearance in healthy humans","volume":"4","author":"Lutz","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1021\/bi00380a041","article-title":"Partial characterization of the copolymerization reaction of erythrocyte membrane band 3 with hemichromes","volume":"26","author":"Waugh","year":"1987","journal-title":"Biochemistry"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Badior, K., and Casey, J.R. (2021). Large conformational dynamics in Band 3 protein: Significance for erythrocyte senescence signalling, Biochim. Biophys. Acta BBA Biomembr., 1863.","DOI":"10.1016\/j.bbamem.2021.183678"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000212706","article-title":"Aging of cell membrane molecules leads to appearance of an aging antigen and removal of senescent cells","volume":"31","author":"Kay","year":"1985","journal-title":"Gerontology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/978-1-4614-3461-0_6","article-title":"Naturally occurring autoantibodies in mediating clearance of senescent red blood cells","volume":"750","author":"Lutz","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1073\/pnas.72.9.3521","article-title":"Mechanism of removal of senescent cells by human macrophages in situ","volume":"72","author":"Kay","year":"1975","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1182\/blood-2012-01-404103","article-title":"Quantitative assessment of sensing and sequestration of spherocytic erythrocytes by the human spleen","volume":"120","author":"Safeukui","year":"2012","journal-title":"Blood"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.3324\/haematol.2021.278643","article-title":"Band 3, an essential red blood cell hub of activity","volume":"106","author":"Satchwell","year":"2021","journal-title":"Haematologica"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1073\/pnas.84.21.7368","article-title":"Naturally occurring anti-band-3 antibodies and complement together mediate phagocytosis of oxidatively stressed human erythrocytes","volume":"84","author":"Lutz","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1182\/blood-2018-07-865451","article-title":"Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid-rich protein","volume":"133","author":"Almukadi","year":"2019","journal-title":"Blood"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Lu, J., Chu, R., Yin, Y., Yu, H., Xu, Q., Yang, B., Sun, Y., Song, J., Wang, Q., and Xu, J. (2022). Glycosylphosphatidylinositol-anchored micronemal antigen (GAMA) interacts with the band 3 receptor to promote erythrocyte invasion by malaria parasites. J. Biol. Chem., 298.","DOI":"10.1016\/j.jbc.2022.101765"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0047-6374(93)90128-E","article-title":"Reduced CR1 expression on aged human erythrocytes: Immuno-electron microscopic and functional analysis","volume":"72","author":"Fishelson","year":"1993","journal-title":"Mech. Ageing Dev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1042\/bj2350815","article-title":"Loss of complement receptor type 1 (CR1) on ageing of erythrocytes. Studies of proteolytic release of the receptor","volume":"235","author":"Ripoche","year":"1986","journal-title":"Biochem. J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4049\/jimmunol.151.1.397","article-title":"Release of vesicles enriched in complement receptor 1 from human erythrocytes","volume":"151","author":"Pascual","year":"1993","journal-title":"J. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bcmd.2005.04.008","article-title":"Exosome release by reticulocytes\u2014An integral part of the red blood cell differentiation system","volume":"35","author":"Blanc","year":"2005","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1365-2141.2008.07055.x","article-title":"Erythrocyte vesiculation: A self-protective mechanism?","volume":"141","author":"Willekens","year":"2008","journal-title":"Br. J. Haematol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Thangaraju, K., Neerukonda, S.N., Katneni, U., and Buehler, P.W. (2020). Extracellular Vesicles from Red Blood Cells and Their Evolving Roles in Health, Coagulopathy and Therapy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010153"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s13071-017-2157-x","article-title":"Volatile organic compounds associated with Plasmodium falciparum infection in vitro","volume":"10","author":"Correa","year":"2017","journal-title":"Parasit. Vectors"},{"key":"ref_77","first-page":"743","article-title":"Disproportional loss of membrane constituents in the course of erythrocyte aging","volume":"40","author":"Trautsch","year":"1981","journal-title":"Acta Biol. Medica Ger."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0003-9861(84)90547-2","article-title":"Nonuniform loss of membrane glycoconjugates during in vivo aging of human erythrocytes: Studies of normal and diabetic red cell saccharides","volume":"232","author":"Miyahara","year":"1984","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.transci.2005.09.006","article-title":"Red blood cell age determines the impact of storage and leukocyte burden on cell adhesion molecules, glycophorin A and the release of annexin V","volume":"34","author":"Sparrow","year":"2006","journal-title":"Transfus. Apher. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s40798-023-00662-9","article-title":"Age-Markers on the Red Blood Cell Surface and Erythrocyte Microparticles may Constitute a Multi-parametric Strategy for Detection of Autologous Blood Transfusion","volume":"9","author":"Biasini","year":"2023","journal-title":"Sports Med. Open"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1182\/blood-2014-12-512772","article-title":"4th. Anatomy of the red cell membrane skeleton: Unanswered questions","volume":"127","author":"Lux","year":"2016","journal-title":"Blood"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1182\/blood.2023022781","article-title":"Parasite hijacks red cell membrane proteins","volume":"142","author":"Mohandas","year":"2023","journal-title":"Blood"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1182\/blood.2023020831","article-title":"Plasmodium falciparum exploits CD44 as a coreceptor for erythrocyte invasion","volume":"142","author":"Baro","year":"2023","journal-title":"Blood"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.immuni.2020.07.008","article-title":"CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis","volume":"53","author":"Morrissey","year":"2020","journal-title":"Immunity"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2009.05.046","article-title":"CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis","volume":"138","author":"Jaiswal","year":"2009","journal-title":"Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/bj1400557","article-title":"Membrane glycopeptides from old and young human erythrocytes","volume":"140","author":"Balduini","year":"1974","journal-title":"Biochem. J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0008-6215(00)85960-1","article-title":"Changes in carbohydrate content of surface membranes of human erythrocytes during aging","volume":"52","author":"Gattegno","year":"1976","journal-title":"Carbohydr. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/jcmm.12721","article-title":"Restoring the youth of aged red blood cells and extending their lifespan in circulation by remodeling membrane sialic acid","volume":"20","author":"Huang","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"297","DOI":"10.5581\/1516-8484.20110080","article-title":"de L. Electrical properties of the red blood cell membrane and immunohematological investigation","volume":"33","author":"Fernandes","year":"2011","journal-title":"Rev. Bras. Hematol. Hemoter."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1128\/IAI.01426-15","article-title":"CD47-SIRP\u03b1 Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria in vivo","volume":"84","author":"Ayi","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.1182\/blood.V97.12.3984","article-title":"Unavailability of CD147 leads to selective erythrocyte trapping in the spleen","volume":"97","author":"Coste","year":"2001","journal-title":"Blood"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s12288-020-01272-1","article-title":"Splenectomy Modulates the Erythrocyte Turnover and Basigin (CD147) Expression in Mice","volume":"36","author":"Bhardwaj","year":"2020","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"13991","DOI":"10.1111\/jcmm.16010","article-title":"Reduction in flippase activity contributes to surface presentation of phosphatidylserine in human senescent erythrocytes","volume":"24","author":"Seki","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3389\/fphys.2019.01629","article-title":"Intracellular Ca2+ Concentration and Phosphatidylserine Exposure in Healthy Human Erythrocytes in Dependence on in vivo Cell Age","volume":"10","author":"Bernhardt","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000089839","article-title":"Band 3\/complement-mediated recognition and removal of normally senescent and pathological human erythrocytes","volume":"16","author":"Arese","year":"2005","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/vox.12014","article-title":"Elevated levels of thrombin-generating microparticles in stored red blood cells","volume":"105","author":"Gao","year":"2013","journal-title":"Vox Sang."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1001\/jama.1987.03390090092032","article-title":"Autologous and aged blood donors","volume":"257","author":"Greenwalt","year":"1987","journal-title":"JAMA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1111\/j.1537-2995.2008.01794.x","article-title":"RBC-derived vesicles during storage: Ultrastructure, protein composition, oxidation, and signaling components","volume":"48","author":"Kriebardis","year":"2008","journal-title":"Transfusion"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Koshiar, R.L., Somajo, S., Norstr\u00f6m, E., and Dahlb\u00e4ck, B. (2014). Erythrocyte-derived microparticles supporting activated protein C-mediated regulation of blood coagulation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104200"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1537-2995.2010.02929.x","article-title":"Susceptibility to hyperosmotic stress-induced phosphatidylserine exposure increases during red blood cell storage","volume":"51","author":"Bosman","year":"2011","journal-title":"Transfusion"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Koshkaryev, A., Livshits, L., Pajic-Lijakovic, I., Gural, A., Barshtein, G., and Yedgar, S. (2020). Non-oxidative band-3 clustering agents cause the externalization of phosphatidylserine on erythrocyte surfaces by a calcium-independent mechanism. Biochim. Biophys. Acta Biomembr., 1862.","DOI":"10.1016\/j.bbamem.2020.183231"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Livshits, L., Barshtein, G., Arbell, D., Gural, A., Levin, C., and Guizouarn, H. (2021). Do We Store Packed Red Blood Cells under \u201cQuasi-Diabetic\u201d Conditions?. Biomolecules, 11.","DOI":"10.3390\/biom11070992"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0006-3495(64)86784-9","article-title":"Mechanical properties of the red cell membrane: II. Viscoelastic breakdown of the membrane","volume":"4","author":"Rand","year":"1964","journal-title":"Biophys. J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3233\/BIR-1988-25605","article-title":"RBC membrane instability for large pipette deformation. A theoretical approach","volume":"25","author":"Kozlov","year":"1988","journal-title":"Biorheology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3233\/BIR-1984-23S145","article-title":"Filtration pressure and red blood cell deformability: Evaluation of a new device: Erythrometre","volume":"1","author":"Gueguen","year":"1984","journal-title":"Biorheol. Suppl."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1039\/C9LC01058K","article-title":"Deformability based sorting of stored red blood cells reveals donor-dependent aging curves","volume":"20","author":"Islamzada","year":"2020","journal-title":"Lab. Chip"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbbm.2005.11.003","article-title":"Stiffness of normal and pathological erythrocytes studied by means of atomic force microscopy","volume":"66","author":"Dulinska","year":"2006","journal-title":"J. Biochem. Biophys. Methods"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3233\/BIR-1996-33607","article-title":"Determination of red blood cell shape recovery time constant in a Couette system by the analysis of light reflectance and ektacytometry","volume":"33","author":"Baskurt","year":"1996","journal-title":"Biorheology"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Sonmez, M., Ince, H.Y., Yalcin, O., Ajd\u017eanovi\u0107, V., Spasojevi\u0107, I., Meiselman, H.J., and Baskurt, O.K. (2013). The effect of alcohols on red blood cell mechanical properties and membrane fluidity depends on their molecular size. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076579"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1034\/j.1600-0609.2003.00027.x","article-title":"Optical tweezers for measuring red blood cell elasticity: Application to the study of drug response in sickle cell disease","volume":"70","author":"Fontes","year":"2003","journal-title":"Eur. J. Haematol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"15873","DOI":"10.1038\/srep15873","article-title":"Assessment of red blood cell deformability in type 2 diabetes mellitus and diabetic retinopathy by dual optical tweezers stretching technique","volume":"6","author":"Agrawal","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3233\/BIR-2012-0616","article-title":"Analysis of light scattering by red blood cells in ektacytometry using global pattern fitting","volume":"49","author":"Rabai","year":"2012","journal-title":"Biorheology"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Barshtein, G., Gural, A., Arbell, D., Barkan, R., Livshits, L., Pajic-Lijakovic, I., and Yedgar, S. (2023). Red Blood Cell Deformability Is Expressed by a Set of Interrelated Membrane Proteins. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612755"},{"key":"ref_114","first-page":"159","article-title":"Erythrocyte aging and malaria","volume":"50","author":"Sherman","year":"2004","journal-title":"Cell. Mol. Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tracli.2015.05.004","article-title":"Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method","volume":"22","author":"Duez","year":"2015","journal-title":"Transfus. Clin. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.actbio.2004.09.001","article-title":"Reprint of: Connections between single-cell biomechanics and human disease states: Gastrointestinal cancer and malaria","volume":"1","author":"Suresh","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1182\/blood-2002-08-2437","article-title":"Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum","volume":"102","author":"Motti","year":"2003","journal-title":"Blood"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e00716-18","DOI":"10.1128\/IAI.00716-18","article-title":"Moderately Neutralizing Epitopes in Nonfunctional Regions Dominate the Antibody Response to Plasmodium falciparum EBA-140","volume":"87","author":"Salinas","year":"2019","journal-title":"Infect. Immun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1007\/s00018-021-03799-6","article-title":"Of membranes and malaria: Phospholipid asymmetry in Plasmodium falciparum-infected red blood cells","volume":"78","author":"Fraser","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Ahiya, A.I., Bhatnagar, S., Morrisey, J.M., Beck, J.R., and Vaidya, A.B. (2022). Dramatic Consequences of Reducing Erythrocyte Membrane Cholesterol on Plasmodium falciparum. Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.00158-22"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"23611","DOI":"10.1016\/S0021-9258(18)54327-1","article-title":"Clustering of integral membrane proteins of the human erythrocyte membrane stimulates autologous IgG binding, complement deposition, and phagocytosis","volume":"266","author":"Turrini","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1182\/blood.V81.11.3146.3146","article-title":"Characterization of the autologous antibodies that opsonize erythrocytes with clustered integral membrane proteins","volume":"81","author":"Turrini","year":"1993","journal-title":"Blood"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0005-2736(94)90087-6","article-title":"Binding of naturally occurring antibodies to oxidatively and nonoxidatively modified erythrocyte band 3","volume":"1190","author":"Turrini","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0169-4758(00)01666-5","article-title":"Abnormal blood flow and red blood cell deformability in severe malaria","volume":"16","author":"Dondorp","year":"2000","journal-title":"Parasitol. Today"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/trstmh\/trt010","article-title":"The bystander effect in optically trapped red blood cells due to Plasmodium falciparum infection","volume":"107","author":"Paul","year":"2013","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1182\/bloodadvances.2017013730","article-title":"Reduced red blood cell deformability in Plasmodium knowlesi malaria","volume":"2","author":"Barber","year":"2018","journal-title":"Blood Adv."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Platt, D. (1988). Blood Cells, Rheology, and Aging, Springer.","DOI":"10.1007\/978-3-642-71790-1"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bpj.2012.05.026","article-title":"How malaria parasites reduce the deformability of infected red blood cells","volume":"103","author":"Hosseini","year":"2012","journal-title":"Biophys. J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/j.1462-5822.2012.01786.x","article-title":"Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum","volume":"14","author":"Aingaran","year":"2012","journal-title":"Cell. Microbiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1182\/blood-2012-03-414557","article-title":"A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages","volume":"119","author":"Tiburcio","year":"2012","journal-title":"Blood"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Neveu, G., and Lavazec, C. (2019). Erythrocyte Membrane Makeover by Plasmodium falciparum Gametocytes. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02652"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1038\/s41598-017-04241-3","article-title":"Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151","volume":"7","author":"Metwally","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3389\/fphys.2019.01613","article-title":"Methods to Investigate the Deformability of RBC During Malaria","volume":"10","author":"Depond","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4161\/viru.25949","article-title":"Contrasting pediatric and adult cerebral malaria: The role of the endothelial barrier","volume":"4","author":"Hawkes","year":"2013","journal-title":"Virulence"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/j.1462-5822.2011.01648.x","article-title":"Complement receptor 1 and malaria","volume":"13","author":"Stoute","year":"2011","journal-title":"Cell. Microbiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1172\/JCI106629","article-title":"Alteration in the rheologic properties of Plasmodium knowlesi-infected red cells. A possible mechanism for capillary obstruction","volume":"50","author":"Miller","year":"1971","journal-title":"J. Clin. Investig."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1126\/science.1204588","article-title":"Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number","volume":"333","author":"Metcalf","year":"2011","journal-title":"Science"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"103666","DOI":"10.1016\/j.mechrescom.2021.103666","article-title":"Mechanics of deformation of malaria-infected red blood cells","volume":"113","year":"2021","journal-title":"Mech. Res. Commun."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0035-9203(71)90036-8","article-title":"Evidence for cyclic development and short-lived maturity in the gametocytes of Plasmodium falciparum","volume":"65","author":"Hawking","year":"1971","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"244re5","DOI":"10.1126\/scitranslmed.3008882","article-title":"Plasmodium falciparum transmission stages accumulate in the human bone marrow","volume":"6","author":"Joice","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Bachmann, A., Esser, C., Petter, M., Predehl, S., von Kalckreuth, V., Schmiedel, S., Bruchhaus, I., and Tannich, E. (2009). Absence of erythrocyte sequestration and lack of multicopy gene family expression in Plasmodium falciparum from a splenectomized malaria patient. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007459"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"a025452","DOI":"10.1101\/cshperspect.a025452","article-title":"Biology of Malaria Transmission","volume":"7","author":"Meibalan","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1182\/blood.V99.3.1060","article-title":"Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells","volume":"99","author":"Glenister","year":"2002","journal-title":"Blood"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"9213","DOI":"10.1073\/pnas.0703433104","article-title":"Effect of plasmodial RESA protein on deformability of human red blood cells harboring Plasmodium falciparum","volume":"104","author":"Mills","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1128\/EC.1.6.926-935.2002","article-title":"Small variant STEVOR antigen is uniquely located within Maurer\u2019s clefts in Plasmodium falciparum-infected red blood cells","volume":"1","author":"Kaviratne","year":"2002","journal-title":"Eukaryot. Cell"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1101\/gr.2126104","article-title":"A Plasmodium gene family encoding Maurer\u2019s cleft membrane proteins: Structural properties and expression profiling","volume":"14","author":"Florens","year":"2004","journal-title":"Genome Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1093\/nar\/gkl942","article-title":"Hypervariability within the Rifin, Stevor and Pfmc-2TM superfamilies in Plasmodium falciparum","volume":"34","author":"Lavazec","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1128\/IAI.01460-07","article-title":"Plasmodium falciparum STEVOR proteins are highly expressed in patient isolates and located in the surface membranes of infected red blood cells and the apical tips of merozoites","volume":"76","author":"Blythe","year":"2008","journal-title":"Infect. Immun."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e4757","DOI":"10.7717\/peerj.4757","article-title":"\u20182TM proteins\u2019: An antigenically diverse superfamily with variable functions and export pathways","volume":"6","author":"Kaur","year":"2018","journal-title":"PeerJ"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1182\/blood-2011-08-370734","article-title":"Plasmodium falciparum STEVOR proteins impact erythrocyte mechanical properties","volume":"119","author":"Sanyal","year":"2012","journal-title":"Blood"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.1128\/IAI.72.11.6597-6602.2004","article-title":"Distinct trafficking and localization of STEVOR proteins in three stages of the Plasmodium falciparum life cycle","volume":"72","author":"McRobert","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1128\/EC.00029-06","article-title":"Programmed transcription of the var gene family, but not of stevor, in Plasmodium falciparum gametocytes","volume":"5","author":"Sharp","year":"2006","journal-title":"Eukaryot. Cell"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.molbiopara.2007.07.011","article-title":"Variant proteins of the Plasmodium falciparum RIFIN family show distinct subcellular localization and developmental expression patterns","volume":"156","author":"Petter","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1086\/428289","article-title":". In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins","volume":"191","author":"Daily","year":"2005","journal-title":"J. Infect. Dis."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1111\/j.1582-4934.2011.01310.x","article-title":"Human red blood cell aging: Correlative changes in surface charge and cell properties","volume":"15","author":"Huang","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Leong, Y.W., Russell, B., Malleret, B., and R\u00e9nia, L. (2022). Erythrocyte tropism of malarial parasites: The reticulocyte appeal. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1022828"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Kerlin, D.H., and Gatton, M.L. (2013). Preferential invasion by Plasmodium merozoites and the self-regulation of parasite burden. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057434"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"24623","DOI":"10.1038\/srep24623","article-title":"Invasion characteristics of a Plasmodium knowlesi line newly isolated from a human","volume":"6","author":"Amir","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1073\/pnas.0308256101","article-title":"Age-structured red blood cell susceptibility and the dynamics of malaria infections","volume":"101","author":"McQueen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"626","DOI":"10.2307\/3285103","article-title":"Plasmodium malariae blood-stage dynamics","volume":"87","author":"McKenzie","year":"2001","journal-title":"J. Parasitol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12936-022-04250-2","article-title":"Vivax malaria in Duffy-negative patients shows invariably low asexual parasitaemia: Implication towards malaria control in Ethiopia","volume":"21","author":"Abate","year":"2022","journal-title":"Malar. J."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12936-022-04165-y","article-title":"Duffy blood system and G6PD genetic variants in vivax malaria patients from Manaus, Amazonas, Brazil","volume":"21","author":"Ferreira","year":"2022","journal-title":"Malar. J."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"15","DOI":"10.21307\/immunohematology-2019-387","article-title":"Expression of Duffy antigen receptor for chemokines during reticulocyte maturation: Using a CD71 flow cytometric technique to identify reticulocytes","volume":"21","author":"Woolley","year":"2005","journal-title":"Immunohematology"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3389\/fphys.2017.01076","article-title":"From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals","volume":"8","author":"Moras","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nri.2017.138","article-title":"Tissue-specific immunopathology during malaria infection","volume":"18","author":"Coban","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/244040a0","article-title":"Mechanism of host specificity in malarial infection","volume":"244","author":"Butcher","year":"1973","journal-title":"Nature"},{"key":"ref_167","first-page":"391","article-title":"The relationship of erythrocyte age and parasitization with Plasmodium gallinaceum in chickens","volume":"38","author":"Swann","year":"1974","journal-title":"Can. J. Comp. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/ddr.20347","article-title":"Targeting the Lipid Metabolic Pathways for the Treatment of Malaria","volume":"71","author":"Prigge","year":"2010","journal-title":"Drug Dev. Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/bj2730701","article-title":"Increased permeability to choline in simian erythrocytes after Plasmodium knowlesi infection","volume":"273","author":"Ancelin","year":"1991","journal-title":"Biochem. J."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e82207","DOI":"10.7554\/eLife.82207","article-title":"A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite","volume":"11","author":"Ramaprasad","year":"2022","journal-title":"eLife"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1042\/bj2830617","article-title":"Effect of cell age on erythrocyte choline transport: Implications for the increased choline permeability of malaria-infected erythrocytes","volume":"283","author":"Kirk","year":"1992","journal-title":"Biochem. J."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1182\/blood-2011-09-376475","article-title":"Maturing reticulocytes internalize plasma membrane in glycophorin A\u2013containing vesicles that fuse with autophagosomes before exocytosis","volume":"119","author":"Griffiths","year":"2012","journal-title":"Blood"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Malleret, B., Xu, F., Mohandas, N., Suwanarusk, R., Chu, C., Leite, J.A., Low, K., Turner, C., Sriprawat, K., and Zhang, R. (2013). Significant biochemical, biophysical and metabolic diversity in circulating human cord blood reticulocytes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076062"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Aniweh, Y., Gao, X., Hao, P., Meng, W., Lai, S.K., Gunalan, K., Chu, T.T., Sinha, A., Lescar, J., and Chandramohanadas, R. (2017). P. falciparum RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC. Cell. Microbiol., 19.","DOI":"10.1111\/cmi.12747"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/4\/334\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:58:55Z","timestamp":1760104735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/4\/334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,12]]},"references-count":174,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["cells13040334"],"URL":"https:\/\/doi.org\/10.3390\/cells13040334","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,12]]}}}