{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:06:03Z","timestamp":1782450363848,"version":"3.54.5"},"reference-count":71,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Higher Education and Scientific Research","award":["LR16IPT\/05"],"award-info":[{"award-number":["LR16IPT\/05"]}]},{"name":"Ministry of Higher Education and Scientific Research","award":["PCI33_Ageing"],"award-info":[{"award-number":["PCI33_Ageing"]}]},{"name":"Projet Collaboratif Interne","award":["LR16IPT\/05"],"award-info":[{"award-number":["LR16IPT\/05"]}]},{"name":"Projet Collaboratif Interne","award":["PCI33_Ageing"],"award-info":[{"award-number":["PCI33_Ageing"]}]},{"name":"MOBIDOC-753","award":["LR16IPT\/05"],"award-info":[{"award-number":["LR16IPT\/05"]}]},{"name":"MOBIDOC-753","award":["PCI33_Ageing"],"award-info":[{"award-number":["PCI33_Ageing"]}]},{"name":"PTR111-17","award":["LR16IPT\/05"],"award-info":[{"award-number":["LR16IPT\/05"]}]},{"name":"PTR111-17","award":["PCI33_Ageing"],"award-info":[{"award-number":["PCI33_Ageing"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Cockayne syndrome (CS) is a rare autosomal recessive disorder that affects the DNA repair process. It is a progeroid syndrome predisposing patients to accelerated aging and to increased susceptibility to respiratory infections. Here, we studied the immune status of CS patients to determine potential biomarkers associated with pathological aging. CS patients, as well as elderly and young, healthy donors, were enrolled in this study. Complete blood counts for patients and donors were assessed, immune cell subsets were analyzed using flow cytometry, and candidate cytokines were analyzed via multi-analyte ELISArray kits. In CS patients, we noticed a high percentage of lymphocytes, an increased rate of intermediate and non-classical monocytes, and a high level of pro-inflammatory cytokine IL-8. In addition, we identified an increased rate of particular subtypes of T Lymphocyte CD8+ CD28\u2212 CD27\u2212, which are senescent T cells. Thus, an inflammatory state was found in CS patients that is similar to that observed in the elderly donors and is associated with an immunosenescence status in both groups. This could explain the CS patients\u2019 increased susceptibility to infections, which is partly due to an aging-associated inflammation process.<\/jats:p>","DOI":"10.3390\/cells13050402","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T07:51:39Z","timestamp":1708933899000},"page":"402","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Immunity in the Progeroid Model of Cockayne Syndrome: Biomarkers of Pathological Aging"],"prefix":"10.3390","volume":"13","author":[{"given":"Khouloud","family":"Zayoud","sequence":"first","affiliation":[{"name":"Laboratory of Biomedical Genomics and Oncogenetics (LR16IPT05), Institut Pasteur de Tunis, Universit\u00e9 Tunis El Manar, El Manar I, Tunis 1002, Tunisia"},{"name":"Faculty of Sciences of Bizerte, Bizerte 7021, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Chikhaoui","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Genomics and Oncogenetics (LR16IPT05), Institut Pasteur de Tunis, Universit\u00e9 Tunis El Manar, El Manar I, Tunis 1002, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichraf","family":"Kraoua","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics, National Institute of Neurology Mongi Ben Hamida, Tunis 1007, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anis","family":"Tebourbi","sequence":"additional","affiliation":[{"name":"Orthopedic and Trauma Surgery Department, Mongi Slim Hospital, La Marsa 2070, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorra","family":"Najjar","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Genomics and Oncogenetics (LR16IPT05), Institut Pasteur de Tunis, Universit\u00e9 Tunis El Manar, El Manar I, Tunis 1002, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saker","family":"Ayari","sequence":"additional","affiliation":[{"name":"Orthopedic and Trauma Surgery Department, Mongi Slim Hospital, La Marsa 2070, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Safra","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Hematology (LR16IPT07), Institut Pasteur de Tunis, Universit\u00e9 Tunis El Manar, El Manar I, Tunis 1002, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Kraiem","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Hematology (LR16IPT07), Institut Pasteur de Tunis, Universit\u00e9 Tunis El Manar, El Manar I, Tunis 1002, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhem","family":"Turki","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics, National Institute of Neurology Mongi Ben Hamida, Tunis 1007, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Menif","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Hematology (LR16IPT07), Institut Pasteur de Tunis, Universit\u00e9 Tunis El Manar, El Manar I, Tunis 1002, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-4775","authenticated-orcid":false,"given":"Houda","family":"Yacoub-Youssef","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Genomics and Oncogenetics (LR16IPT05), Institut Pasteur de Tunis, Universit\u00e9 Tunis El Manar, El Manar I, Tunis 1002, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101410","DOI":"10.1016\/j.arr.2021.101410","article-title":"Targeting immune dysfunction in aging","volume":"70","author":"Borgoni","year":"2021","journal-title":"Ageing Res. 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