{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:40:33Z","timestamp":1778636433430,"version":"3.51.4"},"reference-count":41,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Duchenne Parent Project","award":["#22.013"],"award-info":[{"award-number":["#22.013"]}]},{"name":"Duchenne Parent Project","award":["#847507"],"award-info":[{"award-number":["#847507"]}]},{"name":"Duchenne Parent Project","award":["24762"],"award-info":[{"award-number":["24762"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program funding","award":["#22.013"],"award-info":[{"award-number":["#22.013"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program funding","award":["#847507"],"award-info":[{"award-number":["#847507"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program funding","award":["24762"],"award-info":[{"award-number":["24762"]}]},{"name":"Fondazione Veronesi fellowship","award":["#22.013"],"award-info":[{"award-number":["#22.013"]}]},{"name":"Fondazione Veronesi fellowship","award":["#847507"],"award-info":[{"award-number":["#847507"]}]},{"name":"Fondazione Veronesi fellowship","award":["24762"],"award-info":[{"award-number":["24762"]}]},{"DOI":"10.13039\/501100007076","name":"AIRC","doi-asserted-by":"publisher","award":["#22.013"],"award-info":[{"award-number":["#22.013"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"AIRC","doi-asserted-by":"publisher","award":["#847507"],"award-info":[{"award-number":["#847507"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"AIRC","doi-asserted-by":"publisher","award":["24762"],"award-info":[{"award-number":["24762"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The Sertoli cells (SeCs) of the seminiferous tubules secrete a multitude of immunoregulatory and trophic factors to provide immune protection and assist in the orderly development of germ cells. Grafts of naked or encapsulated SeCs have been proved to represent an interesting therapeutic option in a plethora of experimental models of diseases. However, whether SeCs have immunosuppressive or immunomodulatory effects, which is imperative for their clinical translatability, has not been demonstrated. We directly assessed the immunopotential of intraperitoneally grafted microencapsulated porcine SeCs (MC-SeCs) in murine models of fungal infection (Aspergillus fumigatus or Candida albicans) or cancer (Lewis lung carcinoma\/LLC or B16 melanoma cells). We found that MC-SeCs (i) provide antifungal resistance with minimum inflammatory pathology through the activation of the tolerogenic aryl hydrocarbon receptor\/indoleamine 2,3-dioxygenase pathway; (ii) do not affect tumor growth in vivo; and (iii) reduce the LLC cell metastatic cancer spread associated with restricted Vegfr2 expression in primary tumors. Our results point to the fine immunoregulation of SeCs in the relative absence of overt immunosuppression in both infection and cancer conditions, providing additional support for the potential therapeutic use of SeC grafts in human patients.<\/jats:p>","DOI":"10.3390\/cells13060544","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T05:56:07Z","timestamp":1710914167000},"page":"544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Grafted Sertoli Cells Exert Immunomodulatory Non-Immunosuppressive Effects in Preclinical Models of Infection and Cancer"],"prefix":"10.3390","volume":"13","author":[{"given":"Sara","family":"Chiappalupi","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"},{"name":"Interuniversity Institute of Myology (IIM), 06132 Perugia, Italy"},{"name":"Consorzio Interuniversitario Biotecnologie (CIB), 34127 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Salvadori","sequence":"additional","affiliation":[{"name":"Interuniversity Institute of Myology (IIM), 06132 Perugia, Italy"},{"name":"Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6337-5999","authenticated-orcid":false,"given":"Monica","family":"Borghi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilena","family":"Pariano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-3379","authenticated-orcid":false,"given":"Francesca","family":"Riuzzi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"},{"name":"Interuniversity Institute of Myology (IIM), 06132 Perugia, Italy"},{"name":"Consorzio Interuniversitario Biotecnologie (CIB), 34127 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Luca","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"},{"name":"Centro Biotecnologico Internazionale di Ricerca Traslazionale ad indirizzo Endocrino, Metabolico ed Embrio-Riproduttivo (CIRTEMER), 06132 Perugia, Italy"},{"name":"Centro Universitario di Ricerca sulla Genomica Funzionale (CURGeF), 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigina","family":"Romani","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Arato","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1973-9679","authenticated-orcid":false,"given":"Guglielmo","family":"Sorci","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"},{"name":"Interuniversity Institute of Myology (IIM), 06132 Perugia, Italy"},{"name":"Consorzio Interuniversitario Biotecnologie (CIB), 34127 Trieste, Italy"},{"name":"Centro Biotecnologico Internazionale di Ricerca Traslazionale ad indirizzo Endocrino, Metabolico ed Embrio-Riproduttivo (CIRTEMER), 06132 Perugia, Italy"},{"name":"Centro Universitario di Ricerca sulla Genomica Funzionale (CURGeF), 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1530\/REP-09-0384","article-title":"Immunoprotective Sertoli cells: Making allogeneic and xenogeneic trasplatantion feasible","volume":"139","author":"Mital","year":"2010","journal-title":"Reproduction"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.semcdb.2014.02.011","article-title":"Sertoli cells-immunological sentinels of spermatogenesis","volume":"30","author":"Kaur","year":"2014","journal-title":"Semin. 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