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Recently, the use of mesenchymal stem cells (MSCs) as a possible kind of cell therapy against glioblastoma is gaining great interest due to their immunomodulatory properties, tumor tropism, and differentiation into other cell types. However, MSCs seem to present both antitumor and pro-tumor properties depending on the tissue from which they come. In this work, the possibility of using MSCs to deliver therapeutic genes, oncolytic viruses, and miRNA is presented, as well as strategies that can improve their therapeutic efficacy against glioblastoma, such as CAR-T cells, nanoparticles, and exosomes.<\/jats:p>","DOI":"10.3390\/cells13070617","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:58:38Z","timestamp":1712105918000},"page":"617","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mesenchymal-Stem-Cell-Based Therapy against Gliomas"],"prefix":"10.3390","volume":"13","author":[{"given":"Sisa M.","family":"Santill\u00e1n-Guaj\u00e1n","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Genetics, University of Navarra School of Sciences, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9589-4382","authenticated-orcid":false,"given":"Mehdi H.","family":"Shahi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim University, Aligarh 202002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2373-482X","authenticated-orcid":false,"given":"Javier S.","family":"Castresana","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics, University of Navarra School of Sciences, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1053\/j.seminoncol.2004.07.005","article-title":"Current management of glioblastoma multiforme","volume":"31","author":"Grossman","year":"2004","journal-title":"Semin. 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