{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:00:00Z","timestamp":1770775200237,"version":"3.50.0"},"reference-count":72,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Allergy and Infectious Diseases","award":["R01AI125111"],"award-info":[{"award-number":["R01AI125111"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["R01AI178128"],"award-info":[{"award-number":["R01AI178128"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["R21AR082631"],"award-info":[{"award-number":["R21AR082631"]}]},{"name":"National Institute of Allergy and Infectious Diseases","award":["P30 CA006927"],"award-info":[{"award-number":["P30 CA006927"]}]},{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["R01AI125111"],"award-info":[{"award-number":["R01AI125111"]}]},{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["R01AI178128"],"award-info":[{"award-number":["R01AI178128"]}]},{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["R21AR082631"],"award-info":[{"award-number":["R21AR082631"]}]},{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["P30 CA006927"],"award-info":[{"award-number":["P30 CA006927"]}]},{"name":"National Cancer Institute","award":["R01AI125111"],"award-info":[{"award-number":["R01AI125111"]}]},{"name":"National Cancer Institute","award":["R01AI178128"],"award-info":[{"award-number":["R01AI178128"]}]},{"name":"National Cancer Institute","award":["R21AR082631"],"award-info":[{"award-number":["R21AR082631"]}]},{"name":"National Cancer Institute","award":["P30 CA006927"],"award-info":[{"award-number":["P30 CA006927"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>IL-36 cytokines are emerging as beneficial in immunity against pathogens and cancers but can also be detrimental when dysregulated in autoimmune and autoinflammatory conditions. Interest in targeting IL-36 activity for therapeutic purposes is rapidly growing, yet many unknowns about the functions of these cytokines remain. Thus, the availability of robust research tools is essential for both fundamental basic science and pre-clinical studies to fully access outcomes of any manipulation of the system. For this purpose, a floxed Il1rl2, the gene encoding the IL-36 receptor, mouse strain was developed to facilitate the generation of conditional knockout mice. The targeted locus was engineered to contain an inverted mCherry reporter sequence that upon Cre-mediated recombination will be flipped and expressed under the control of the endogenous Il1rl2 promoter. This feature can be used to confirm knockout in individual cells but also as a reporter to determine which cells express the IL-36 receptor IL-1RL2. The locus was confirmed to function as intended and further used to demonstrate the expression of IL-1RL2 in barrier tissues. Il1rl2 expression was detected in leukocytes in all barrier tissues. Interestingly, strong expression was observed in epithelial cells at locations in direct contact with the environment such as the skin, oral mucosa, the esophagus, and the upper airways, but almost absent from epithelial cells at more inward facing sites, including lung alveoli, the small intestine, and the colon. These findings suggest specialized functions of IL-1RL2 in outward facing epithelial tissues and cells. The generated mouse model should prove valuable in defining such functions and may also facilitate basic and translational research.<\/jats:p>","DOI":"10.3390\/cells13090787","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T15:09:36Z","timestamp":1715008176000},"page":"787","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues"],"prefix":"10.3390","volume":"13","author":[{"given":"Nopprarat","family":"Tongmuang","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA"},{"name":"Center for Inflammation and Lung Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy Q.","family":"Cai","sequence":"additional","affiliation":[{"name":"Histopathology Facility, Fox Chase Cancer Center, Temple Health, Philadelphia, PA 19111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"An","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA"},{"name":"Center for Inflammation and Lung Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariah","family":"Novy","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA"},{"name":"Center for Inflammation and Lung Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-8312","authenticated-orcid":false,"given":"Liselotte E.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA"},{"name":"Center for Inflammation and Lung Research, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA"},{"name":"Cancer Signaling and Microenvironment, Fox Chase Cancer Center, Temple Health, Philadelphia, PA 19111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s40265-022-01801-4","article-title":"Spesolimab: First Approval","volume":"82","author":"Blair","year":"2022","journal-title":"Drugs"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/exd.13841","article-title":"IL-36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis","volume":"28","author":"Su","year":"2019","journal-title":"Exp. 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