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As down-time is often unknown, this technique needs to be investigated over a range of scenarios. As this tool limits reperfusion injury, there may be limited benefit or even harm after short arrest and limited ischemia-reperfusion injury. Methods: Eighteen male Wistar rats underwent 7 min of asphyxial arrest. Animals randomized to IPoC received a 20 s pause followed by 20 s of compressions, repeated four times, initiated 40 s into cardiopulmonary resuscitation. If return of spontaneous circulation (ROSC) was achieved, epinephrine was titrated to mean arterial pressure (MAP) of 70 mmHg. Data were analyzed using t-test or Mann\u2013Whitney test. Significance set at p \u2264 0.05. Results: The rate of ROSC was equivalent in both groups, 88%. There was no statistically significant difference in time to ROSC, epinephrine required post ROSC, carotid flow, or peak lactate at any timepoint. There was a significantly elevated MAP with IPoC, 90.7 mmHg (SD 13.9), as compared to standard CPR, 76.7 mmHg (8.5), 2 h after ROSC, p = 0.03. Conclusions: IPoC demonstrated no harm in a model of short arrest using a new arrest etiology for CPR based IPoC intervention in a rat model.<\/jats:p>","DOI":"10.3390\/cells13121047","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T08:48:31Z","timestamp":1718614111000},"page":"1047","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ischemic Post-Conditioning in a Rat Model of Asphyxial Cardiac Arrest"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3313-3112","authenticated-orcid":false,"given":"Matthew B.","family":"Barajas","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Tennessee Valley Healthcare System, Veterans Affairs Medical Center, Nashville, TN 37212, USA"},{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Shiota","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37212, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6228-8845","authenticated-orcid":false,"given":"Zhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximillian","family":"Zaum","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA"},{"name":"Department of Anesthesiology, University Medicine Greifswald, 17489 Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilija","family":"Zecevic","sequence":"additional","affiliation":[{"name":"School of Medicine, Meharry Medical College, Nashville, TN 37212, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-5757","authenticated-orcid":false,"given":"Matthias L.","family":"Riess","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tennessee Valley Healthcare System, Veterans Affairs Medical Center, Nashville, TN 37212, USA"},{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA"},{"name":"Department of Pharmacology, Vanderbilt University, Nashville, TN 37212, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e645","DOI":"10.1161\/CIR.0000000000000557","article-title":"Out-of-hospital cardiac arrest resuscitation systems of care: A scientific statement from the American Heart Association","volume":"137","author":"McCarthy","year":"2018","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.ajem.2012.02.015","article-title":"Cardiopulmonary resuscitation for cardiac arrest: The importance of uninterrupted chest compressions in cardiac arrest resuscitation","volume":"30","author":"Cunningham","year":"2012","journal-title":"Am. 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