{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:35:47Z","timestamp":1789763747258,"version":"4.0.1"},"reference-count":61,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>IBD is an uncontrolled inflammatory condition of the gastrointestinal tract, which mainly manifests in two forms: ulcerative colitis (UC) and Crohn\u2019s disease (CD). The pathogenesis of IBD appears to be associated with an abnormal response of innate and adaptive immune cells. Innate immunity cells, such as macrophages, mast cells, and granulocytes, can produce proinflammatory (e.g., TNF-\u03b1) and oxidative stress (ROS) mediators promoting intestinal damage, and their abnormal responses can induce an imbalance in adaptive immunity, leading to the production of inflammatory cytokines that increase innate immune damage, abate intestinal barrier functions, and aggravate inflammation. Considering that Ca2+ signalling plays a key role in a plethora of cellular functions, this review has the purpose of deepening the potential Ca2+ involvement in IBD pathogenesis.<\/jats:p>","DOI":"10.3390\/cells13131079","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T11:10:28Z","timestamp":1718968228000},"page":"1079","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ca2+-Dependent Processes of Innate Immunity in IBD"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-7475","authenticated-orcid":false,"given":"Francesco","family":"Palestra","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy"},{"name":"World Allergy Organization (WAO), Center of Excellence, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Memoli","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy"},{"name":"World Allergy Organization (WAO), Center of Excellence, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annagioia","family":"Ventrici","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy"},{"name":"World Allergy Organization (WAO), Center of Excellence, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Trocchia","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy"},{"name":"World Allergy Organization (WAO), Center of Excellence, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-9130","authenticated-orcid":false,"given":"Mariarosaria","family":"Galdiero","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy"},{"name":"World Allergy Organization (WAO), Center of Excellence, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-4657","authenticated-orcid":false,"given":"Gilda","family":"Varricchi","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy"},{"name":"World Allergy Organization (WAO), Center of Excellence, 80131 Naples, Italy"},{"name":"Institute of Experimental Endocrinology and Oncology, National Research Council (CNR), 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-1898","authenticated-orcid":false,"given":"Stefania","family":"Loffredo","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy"},{"name":"World Allergy Organization (WAO), Center of Excellence, 80131 Naples, Italy"},{"name":"Institute of Experimental Endocrinology and Oncology, National Research Council (CNR), 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"ref_1","unstructured":"GBD Inflammatory Bowel Disease Collaborators (2020). 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