{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:28:13Z","timestamp":1761719293437,"version":"build-2065373602"},"reference-count":57,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Endometrial cancer (EC) is a significant cause of cancer-related deaths in women. MicroRNAs (miRs) play a role in cancer development, acting as oncogenes or tumor suppressors. This study evaluated the diagnostic potential of hsa-miR-185-5p and hsa-miR-191-5p in EC and their correlation with clinical and histopathological features. A cross-sectional study analyzed formalin-fixed, paraffin-embedded tissue samples from 59 patients: 18 with EC, 21 with endometrial hyperplasia (EH), 17 with normal endometrium (NE), and 3 with endometrial polyps (EPs). Quantitative reverse transcription-polymerase chain reaction and TaqMan probes were used for miR expression analysis. The Shapiro\u2013Wilk test was used to analyze the normal distribution of the data. Subsequently, parametric or non-parametric tests were used to evaluate the associations between the expression levels of each miR and clinical parameters. Both miRs were underexpressed in some precursor and malignant lesions compared to certain NE subtypes and benign lesions. Specifically, hsa-miR-185-5p showed underexpression in grade 3 EC compared to some NE and EH subtypes (FC: \u221257.9 to \u22128.5, p &lt; 0.05), and hsa-miR-191-5p was underexpressed in EH and EC compared to secretory endometrium and EPs (FC: \u22124.2 to \u221232.8, p &lt; 0.05). SETD1B, TJP1, and MSI1 were common predicted target genes. In conclusion, hsa-miR-185-5p and hsa-miR-191-5p are underexpressed in EC tissues, correlating with histopathological grades, highlighting their potential as diagnostic biomarkers and their role as tumor suppressors in EC.<\/jats:p>","DOI":"10.3390\/cells13131099","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T10:10:07Z","timestamp":1719310207000},"page":"1099","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Assessment of miR-185-5p and miR-191-5p Expression: From Normal Endometrium to High-Grade Endometrial Cancer"],"prefix":"10.3390","volume":"13","author":[{"given":"Sergio Antonio","family":"Oropeza-de Lara","sequence":"first","affiliation":[{"name":"Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km 6 Ejido la Escondida, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-1696","authenticated-orcid":false,"given":"Idalia","family":"Garza-Veloz","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km 6 Ejido la Escondida, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertha","family":"Berthaud-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital General \u201cLuz Gonz\u00e1lez Cos\u00edo\u201d, Circuito el Orito, Cd. Administrativa, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania Guillermina","family":"Tirado-Navarro","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km 6 Ejido la Escondida, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinaldo","family":"Gurrola-Carlos","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km 6 Ejido la Escondida, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8609-0779","authenticated-orcid":false,"given":"Bernardo","family":"Bonilla-Rocha","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km 6 Ejido la Escondida, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9848-862X","authenticated-orcid":false,"given":"Ivan","family":"Delgado-Enciso","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Medicine, University of Colima, Av. Universidad No. 333, Las Viboras, Colima 28040, Mexico"},{"name":"Department of Research, Colima Cancerology State Institute, IMSS-Bienestar Colima, Colima 28085, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-9068","authenticated-orcid":false,"given":"Margarita L.","family":"Martinez-Fierro","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km 6 Ejido la Escondida, Zacatecas 98160, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"ref_1","first-page":"569","article-title":"Obesidad y c\u00e1ncer de endometrio: Las repercusiones de un problema de salud p\u00fablica","volume":"88","year":"2020","journal-title":"Ginecol. Obstet. Mex."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lee, T.S., Jeon, H.W., Kim, Y.B., Kim, Y.A., Kim, M.A., and Kang, S.B. (2013). Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081421"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/ijc.22454","article-title":"MicroRNA and cancer: Current status and prospective","volume":"120","author":"Wu","year":"2007","journal-title":"Int. J. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nature09267","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"Guo","year":"2010","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","article-title":"microRNAs as oncogenes and tumor suppressors","volume":"302","author":"Zhang","year":"2007","journal-title":"Dev. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7495","DOI":"10.1158\/0008-5472.CAN-09-2111","article-title":"Metastamir: The field of metastasis-regulatory microRNA is spreading","volume":"69","author":"Hurst","year":"2009","journal-title":"Cancer Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1002\/jcp.25819","article-title":"Interplay between the miRNome and the epigenetic machinery: Implications in health and disease","volume":"232","author":"Poddar","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ghaffari, S.H., and Bashash, D. (2015). Reciprocal interconnection of miRNome-Epigenome in cancer pathogenesis and its therapeutic potential. Epigenetics Territory and Cancer, Springer.","DOI":"10.1007\/978-94-017-9639-2_4"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Gasparri, M.L., Casorelli, A., Bardhi, E., Besharat, A.R., Savone, D., Ruscito, I., Farooqi, A.A., Papadia, A., Mueller, M.D., and Ferretti, E. (2017). Beyond circulating microRNA biomarkers: Urinary microRNAs in ovarian and breast cancer. Tumour Biol., 39.","DOI":"10.1177\/1010428317695525"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/cgt.2009.88","article-title":"Role of anti-oncomirs miR-143 and -145 in human colorectal tumors","volume":"17","author":"Akao","year":"2010","journal-title":"Cancer Gene Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/IGC.0000000000000913","article-title":"Aberrant MicroRNA Expression in Patients With Endometrial Cancer","volume":"27","author":"Montagnana","year":"2017","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3892\/or.2017.5717","article-title":"Hypoxia- and acidosis-driven aberrations of secreted microRNAs in endometrial cancer in vitro","volume":"38","author":"Eismann","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_15","first-page":"2621","article-title":"miR-185-5p inhibits F-actin polymerization and reverses epithelial mesenchymal transition of human breast cancer cells by modulating RAGE","volume":"18","author":"Yin","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Luo, Y., Ye, J., Deng, Y., Huang, Y., Liu, X., He, Q., Chen, Y., Li, Q., Lin, Y., and Liang, R. (2023). The miRNA-185-5p\/STIM1 Axis Regulates the Invasiveness of Nasopharyngeal Carcinoma Cell Lines by Modulating EGFR Activation-Stimulated Switch from E- to N-Cadherin. Molecules, 28.","DOI":"10.3390\/molecules28020818"},{"key":"ref_17","unstructured":"Pei, K., Zhu, J., Wang, C., Xie, Q., and Guo, J.J.E.R.M.P.S. MicroRNA-185-5p modulates chemosensitivity of human non-small cell lung cancer to cisplatin via targeting ABCC1. 2016, 20, 4697\u20134704."},{"key":"ref_18","first-page":"3689","article-title":"miRNA-191-5p represses cell growth by targeting CDK6 in gastric cancer","volume":"100","author":"Cao","year":"2020","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_19","first-page":"1686","article-title":"MicroRNA-191-5p exerts a tumor suppressive role in renal cell carcinoma","volume":"15","author":"Chen","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2058738418790318","DOI":"10.1177\/2058738418790318","article-title":"Upregulation of PD-L1 predicts poor prognosis and is associated with miR-191-5p dysregulation in colon adenocarcinoma","volume":"32","author":"Chen","year":"2018","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1038\/onc.2010.233","article-title":"MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers","volume":"29","author":"Imam","year":"2010","journal-title":"Oncogene"},{"key":"ref_22","first-page":"4933","article-title":"MiR-191 inhibits TNF-alpha induced apoptosis of ovarian endometriosis and endometrioid carcinoma cells by targeting DAPK1","volume":"8","author":"Tian","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Di Leva, G., Piovan, C., Gasparini, P., Ngankeu, A., Taccioli, C., Briskin, D., Cheung, D.G., Bolon, B., Anderlucci, L., and Alder, H. (2013). Estrogen mediated-activation of miR-191\/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLoS Genet., 9.","DOI":"10.1371\/annotation\/92dfa670-d431-4d68-b70b-706df1f93e46"},{"key":"ref_24","unstructured":"Kurman, R.J., Carcangiu, M.L., and Herrington, C.S. (2014). World Health Organisation Classification of Tumours of the Female Reproductive Organs, International Agency for Research on Cancer."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ygyno.2011.11.008","article-title":"Revision of FIGO surgical staging in 2009 for endometrial cancer validates to improve risk stratification","volume":"125","author":"Werner","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"W147","DOI":"10.1093\/nar\/gkw419","article-title":"Heatmapper: Web-enabled heat mapping for all","volume":"44","author":"Babicki","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_28","unstructured":"Damian Szklarczyk, R.K., Koutrouli, M., Nastou, K., Mehryary, F., Hachilif, R., Gable, A.L., Fang, T., Doncheva, N.T., Pyysalo, S., and Bork, P. (2024, June 21). The STRING Database in 2023: Protein-Protein Association Networks and Functional Enrichment Analyses for Any Sequenced Genome of Interest. Available online: https:\/\/string-db.org\/cgi\/input?sessionId=bVi1ZSVnEWsv&input_page_show_search=on."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gkv403","article-title":"DIANA-miRPath v3.0: Deciphering microRNA function with experimental support","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1158\/1078-0432.CCR-12-3675","article-title":"GKN1-miR-185-DNMT1 axis suppresses gastric carcinogenesis through regulation of epigenetic alteration and cell cycle","volume":"19","author":"Yoon","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1101\/gad.381706","article-title":"Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions","volume":"20","author":"Bracken","year":"2006","journal-title":"Genes Dev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.ejca.2011.02.024","article-title":"DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer","volume":"47","author":"Mutze","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.ajpath.2014.05.004","article-title":"miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1\/PTEN\/Akt pathway","volume":"184","author":"Qadir","year":"2014","journal-title":"Am. J. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1053\/j.gastro.2007.01.034","article-title":"Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein","volume":"132","author":"Park","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng1982","article-title":"Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells","volume":"39","author":"Chen","year":"2007","journal-title":"Nat. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1634\/theoncologist.5-suppl_1-37","article-title":"Prognostic value of vascular endothelial growth factor in breast cancer","volume":"5","author":"Gasparini","year":"2000","journal-title":"Oncologist"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1016\/j.febslet.2014.09.045","article-title":"MiR-185 is involved in human breast carcinogenesis by targeting Vegfa","volume":"588","author":"Wang","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/35025215","article-title":"Vascular-specific growth factors and blood vessel formation","volume":"407","author":"Yancopoulos","year":"2000","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"806682","DOI":"10.3389\/fphar.2022.806682","article-title":"Hypoxia-Induced Upregulation of lncRNA ELFN1-AS1 Promotes Colon Cancer Growth and Metastasis Through Targeting TRIM14 via Sponging miR-191-5p","volume":"13","author":"Jing","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nrc3929","article-title":"Hijacked in cancer: The KMT2 (MLL) family of methyltransferases","volume":"15","author":"Rao","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Boron, D., Zmarzly, N., Wierzbik-Stronska, M., Rosinczuk, J., Mieszczanski, P., and Grabarek, B.O. (2022). Recent Multiomics Approaches in Endometrial Cancer. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031237"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/ijc.30573","article-title":"Chromatin remodelling and DNA repair genes are frequently mutated in endometrioid endometrial carcinoma","volume":"140","author":"Trivino","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12672-022-00466-5","article-title":"The clinicopathological characteristics, prognosis and immune microenvironment mapping in MSI-H\/MMR-D endometrial carcinomas","volume":"13","author":"Guo","year":"2022","journal-title":"Discov. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"29745","DOI":"10.1074\/jbc.273.45.29745","article-title":"The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton","volume":"273","author":"Fanning","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0960-9822(02)00501-8","article-title":"Cell signalling: MAGUK magic","volume":"6","author":"Anderson","year":"1996","journal-title":"Curr. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"C461","DOI":"10.1152\/ajpcell.1992.262.2.C461","article-title":"Detection of the tight junction-associated protein ZO-1 in astrocytes and other nonepithelial cell types","volume":"262","author":"Howarth","year":"1992","journal-title":"Am. J. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"784","DOI":"10.14348\/molcells.2021.0130","article-title":"TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma","volume":"44","author":"Lee","year":"2021","journal-title":"Mol. Cells"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1096\/fj.201600890R","article-title":"Zonula occludens-1\/NF-kappaB\/CXCL8: A new regulatory axis for tumor angiogenesis","volume":"31","author":"Lesage","year":"2017","journal-title":"FASEB J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000101304","article-title":"Beta-catenin and ZO-1: Shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes","volume":"185","author":"Polette","year":"2007","journal-title":"Cells Tissues Organs"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00109-020-01909-8","article-title":"Targeting TJP1 attenuates cell-cell aggregation and modulates chemosensitivity against doxorubicin in leiomyosarcoma","volume":"98","author":"Lee","year":"2020","journal-title":"J. Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s13287-020-01703-w","article-title":"Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells","volume":"11","author":"Forouzanfar","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_53","first-page":"1127","article-title":"Expression of a putative stem cell marker Musashi-1 in endometrium","volume":"26","author":"Lu","year":"2011","journal-title":"Histol. Histopathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/path.2364","article-title":"Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma","volume":"215","author":"Gotte","year":"2008","journal-title":"J. Pathol."},{"key":"ref_55","first-page":"4564","article-title":"Prognostic value of Musashi-1 in endometrioid adenocarcinoma","volume":"8","author":"Ma","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s13287-022-02891-3","article-title":"Knockdown of the stem cell marker Musashi-1 inhibits endometrial cancer growth and sensitizes cells to radiation","volume":"13","author":"Falke","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_57","first-page":"115","article-title":"Research protocol VIII. The ethics of research on human subjects","volume":"66","year":"2019","journal-title":"Rev. Alerg. Mex."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/13\/1099\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:04:08Z","timestamp":1760108648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/13\/1099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":57,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["cells13131099"],"URL":"https:\/\/doi.org\/10.3390\/cells13131099","relation":{},"ISSN":["2073-4409"],"issn-type":[{"type":"electronic","value":"2073-4409"}],"subject":[],"published":{"date-parts":[[2024,6,25]]}}}