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In this sense, the Wnt\/\u03b2-Catenin pathway has a vital part in tooth development, maintenance, repair, and regeneration by controlling physiological activities such as growth, differentiation, and migration. This pathway consists of a network of proteins, such as Wnt signaling molecules, which interact with receptors of targeted cells and play a role in development and adult tissue homeostasis. The Wnt signals are specific spatiotemporally, suggesting its intricate mechanism in development, regulation, repair, and regeneration by the formation of tertiary dentin. This review provides an overview of the recent advances in the Wnt\/\u03b2-Catenin signaling pathway in dentin and pulp regeneration, how different proteins, molecules, and ligands influence this pathway, either upregulating or silencing it, and how it may be used in the future for clinical dentistry, in vital pulp therapy as an effective treatment for dental caries, as an alternative approach for root canal therapy, and to provide a path for therapeutic and regenerative dentistry.<\/jats:p>","DOI":"10.3390\/cells13131153","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T04:52:49Z","timestamp":1720414369000},"page":"1153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Advances in Regenerative Dentistry: A Systematic Review of Harnessing Wnt\/\u03b2-Catenin in Dentin-Pulp Regeneration"],"prefix":"10.3390","volume":"13","author":[{"given":"Mariam","family":"Amir","sequence":"first","affiliation":[{"name":"Department of Oral Biology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Jeevithan","sequence":"additional","affiliation":[{"name":"Department of Marine Biopharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maham","family":"Barkat","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda Habib","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malalai","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Israr","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Naseer","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-2149","authenticated-orcid":false,"given":"Sarmad","family":"Fayyaz","sequence":"additional","affiliation":[{"name":"Department of Dental Materials Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4115-9918","authenticated-orcid":false,"given":"Jeevithan","family":"Elango","sequence":"additional","affiliation":[{"name":"Department of Marine Biopharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China"},{"name":"Center of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, India"},{"name":"Department of Biomaterials Engineering, Faculty of Health Sciences, UCAM\u2014Universidad Cat\u00f3lica San Antonio de Murcia, Guadalupe, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-8582","authenticated-orcid":false,"given":"Wenhui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Marine Biopharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4216-421X","authenticated-orcid":false,"given":"Jos\u00e9 Eduardo","family":"Mat\u00e9 S\u00e1nchez de Val","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Engineering, Faculty of Health Sciences, UCAM\u2014Universidad Cat\u00f3lica San Antonio de Murcia, Guadalupe, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2234-2274","authenticated-orcid":false,"given":"Saeed Ur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s40496-018-0196-9","article-title":"Tooth Repair and Regeneration","volume":"5","author":"Zaugg","year":"2018","journal-title":"Curr. 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