{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:47:06Z","timestamp":1790128026820,"version":"4.0.1"},"reference-count":66,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"state assignment of the Ministry of Health, \u201cThe role of energy metabolism and immune defense disorders in the development of various forms of endometriosis, the development of personalized therapy and the forecast of its effectiveness in the early reproductive period (from menarche to 18 years)\u201d","award":["18-A21"],"award-info":[{"award-number":["18-A21"]}]},{"name":"state assignment of the Ministry of Health, \u201cThe role of energy metabolism and immune defense disorders in the development of various forms of endometriosis, the development of personalized therapy and the forecast of its effectiveness in the early reproductive period (from menarche to 18 years)\u201d","award":["22-15-00241"],"award-info":[{"award-number":["22-15-00241"]}]},{"name":"state assignment of the Ministry of Health, \u201cThe role of energy metabolism and immune defense disorders in the development of various forms of endometriosis, the development of personalized therapy and the forecast of its effectiveness in the early reproductive period (from menarche to 18 years)\u201d","award":["075-15-2022-294"],"award-info":[{"award-number":["075-15-2022-294"]}]},{"name":"Russian Science Foundation","award":["18-A21"],"award-info":[{"award-number":["18-A21"]}]},{"name":"Russian Science Foundation","award":["22-15-00241"],"award-info":[{"award-number":["22-15-00241"]}]},{"name":"Russian Science Foundation","award":["075-15-2022-294"],"award-info":[{"award-number":["075-15-2022-294"]}]},{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["18-A21"],"award-info":[{"award-number":["18-A21"]}]},{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["22-15-00241"],"award-info":[{"award-number":["22-15-00241"]}]},{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["075-15-2022-294"],"award-info":[{"award-number":["075-15-2022-294"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Background: Immunological imbalances characteristic of endometriosis may develop as early as the primary manifestations of the disease in adolescence. Objective: To evaluate subpopulation dynamics of monocytes and lymphocytes in peripheral blood and peritoneal fluid of adolescents with peritoneal endometriosis at diagnosis and after 1-year progestogen therapy. Methods: This study included 70 girls, 13\u201317 years old, diagnosed laparoscopically with peritoneal endometriosis (n = 50, main group) or paramesonephric cysts (n = 20, comparison group). Phenotypes of monocytes and lymphocytes of the blood and macrophages of the peritoneal fluid were analyzed by flow cytometry at diagnosis and during progestogen therapy. Results: Differential blood counts of CD16+ (p &lt; 0.001) and CD86+ (p = 0.017) monocytes were identified as independent risk factors for peritoneal endometriosis in adolescents. During the treatment, cytotoxic lymphocytes CD56dimCD16bright (p = 0.049) and CD206+ monocytes (p &lt; 0.001) significantly increased while CD163+ monocytes decreased in number (p = 0.017). The CD56dimCD16bright blood counts before (p &lt; 0.001) and during progestogen therapy (p = 0.006), as well as CD206+ blood counts during the treatment (p = 0.038), were associated with the efficacy of pain relief after 1-year progestogen therapy. Conclusions: Adolescents with peritoneal endometriosis have altered counts of pro- and anti-inflammatory monocytes and lymphocytes both before and after 1-year progestogen therapy, correlating with treatment efficacy and justifying long-term hormonal therapy.<\/jats:p>","DOI":"10.3390\/cells13141187","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T14:04:35Z","timestamp":1720793075000},"page":"1187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Altered Monocyte and Lymphocyte Phenotypes Associated with Pathogenesis and Clinical Efficacy of Progestogen Therapy for Peritoneal Endometriosis in Adolescents"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-307X","authenticated-orcid":false,"given":"Elena P.","family":"Khashchenko","sequence":"first","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-3476","authenticated-orcid":false,"given":"Lyubov V.","family":"Krechetova","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina A.","family":"Vishnyakova","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Research Institute of Molecular and Cellular Medicine, Peoples\u2019 Friendship University of Russia (RUDN University), 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur Kh.","family":"Fatkhudinov","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Research Institute of Molecular and Cellular Medicine, Peoples\u2019 Friendship University of Russia (RUDN University), 117997 Moscow, Russia"},{"name":"Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d, 117418 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeniya V.","family":"Inviyaeva","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina V.","family":"Vtorushina","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena A.","family":"Gantsova","sequence":"additional","affiliation":[{"name":"Research Institute of Molecular and Cellular Medicine, Peoples\u2019 Friendship University of Russia (RUDN University), 117997 Moscow, Russia"},{"name":"Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d, 117418 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriia V.","family":"Kiseleva","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Research Institute of Molecular and Cellular Medicine, Peoples\u2019 Friendship University of Russia (RUDN University), 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya S.","family":"Poltavets","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-4439","authenticated-orcid":false,"given":"Andrey V.","family":"Elchaninov","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Research Institute of Molecular and Cellular Medicine, Peoples\u2019 Friendship University of Russia (RUDN University), 117997 Moscow, Russia"},{"name":"Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution \u201cPetrovsky National Research Centre of Surgery\u201d, 117418 Moscow, Russia"},{"name":"Department of Histology, Embryology and Cytology, Pirogov Russian National Research Medical University (Pirogov Medical University), 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Uvarova","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Department of Obstetrics and Gynecology, Sechenov First Moscow State Medical University, Trubetskaya str. 8, bld. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir D.","family":"Chuprynin","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennady T.","family":"Sukhikh","sequence":"additional","affiliation":[{"name":"FSBI \u201cNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov\u201d Ministry of Healthcare of the Russian Federation, 4, Oparina Street, 117997 Moscow, Russia"},{"name":"Department of Obstetrics and Gynecology, Sechenov First Moscow State Medical University, Trubetskaya str. 8, bld. 2, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"324.e1","DOI":"10.1016\/j.ajog.2017.12.007","article-title":"Spectrum of symptoms in women diagnosed with endometriosis during adolescence vs adulthood","volume":"218","author":"DiVasta","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jpag.2020.07.011","article-title":"The Prevalence of Endometriosis in Adolescents with Pelvic Pain: A Systematic Review","volume":"33","author":"Hirsch","year":"2020","journal-title":"J. Pediatr. Adolesc. 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