{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:02:33Z","timestamp":1788631353187,"version":"build-2803163510"},"reference-count":102,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["RS-2023-00209312"],"award-info":[{"award-number":["RS-2023-00209312"]}]},{"name":"Research Fund of Seoul St. Mary\u2019s Hospital, The catholic University of Korea","award":["RS-2023-00209312"],"award-info":[{"award-number":["RS-2023-00209312"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Genetic or hereditary kidney disease stands as a pivotal cause of chronic kidney disease (CKD). The proliferation and widespread utilization of DNA testing in clinical settings have notably eased the diagnosis of genetic kidney diseases, which were once elusive but are now increasingly identified in cases previously deemed CKD of unknown etiology. However, despite these diagnostic strides, research into disease pathogenesis and novel drug development faces significant hurdles, chiefly due to the dearth of appropriate animal models and the challenges posed by limited patient cohorts in clinical studies. Conversely, the advent and utilization of human-induced pluripotent stem cells (hiPSCs) offer a promising avenue for genetic kidney disease research. Particularly, the development of hiPSC-derived kidney organoid systems presents a novel platform for investigating various forms of genetic kidney diseases. Moreover, the integration of the CRISPR\/Cas9 technique into this system holds immense potential for efficient research on genetic kidney diseases. This review aims to explore the applications of in vitro kidney organoids generated from hiPSCs in the study of diverse genetic kidney diseases. Additionally, it will delve into the limitations of this research platform and outline future perspectives for advancing research in this crucial area.<\/jats:p>","DOI":"10.3390\/cells13141190","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T08:35:17Z","timestamp":1721032517000},"page":"1190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Advancements in Research on Genetic Kidney Diseases Using Human-Induced Pluripotent Stem Cell-Derived Kidney Organoids"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-8651","authenticated-orcid":false,"given":"Do Hyun","family":"Na","sequence":"first","affiliation":[{"name":"Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Division of Nephrology, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, The College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0114-1767","authenticated-orcid":false,"given":"Sheng","family":"Cui","sequence":"additional","affiliation":[{"name":"Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianying","family":"Fang","sequence":"additional","affiliation":[{"name":"Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbi","family":"Lee","sequence":"additional","affiliation":[{"name":"Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Division of Nephrology, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, The College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hun","family":"Eum","sequence":"additional","affiliation":[{"name":"Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Division of Nephrology, Department of Internal Medicine, Incheon St. Mary\u2019s Hospital, The College of Medicine, The Catholic University of Korea, Incheon 21431, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-9369","authenticated-orcid":false,"given":"Yoo Jin","family":"Shin","sequence":"additional","affiliation":[{"name":"Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-6819","authenticated-orcid":false,"given":"Sun Woo","family":"Lim","sequence":"additional","affiliation":[{"name":"Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-636X","authenticated-orcid":false,"given":"Chul Woo","family":"Yang","sequence":"additional","affiliation":[{"name":"Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Division of Nephrology, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, The College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0048-5717","authenticated-orcid":false,"given":"Byung Ha","family":"Chung","sequence":"additional","affiliation":[{"name":"Transplantation Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Division of Nephrology, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, The College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","article-title":"Chronic kidney disease: Global dimension and perspectives","volume":"382","author":"Jha","year":"2013","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: An update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int. 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