{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:34:10Z","timestamp":1774053250154,"version":"3.50.1"},"reference-count":61,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Industry-Academia-Research Institute (IAR) Collabo R&amp;D Fund Grant funded by Korea Government","award":["1425178959"],"award-info":[{"award-number":["1425178959"]}]},{"name":"PLABiologics Co., Ltd.","award":["1425178959"],"award-info":[{"award-number":["1425178959"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Age-related ocular diseases such as age-related macular degeneration, glaucoma, and diabetic retinopathy are major causes of irreversible vision impairment in the elderly. Conventional treatments focus on symptom relief and disease slowdown, often involving surgery, but fall short of providing a cure, leading to substantial vision loss. Regenerative medicine, particularly mesenchymal stem cells (MSCs), holds promise for ocular disease treatment. This study investigates the synergistic potential of combining placenta-derived MSCs (PD-MSCs) with Achyranthis radix extract (ARE) from Achyranthes japonica to enhance therapeutic outcomes. In a 24-h treatment, ARE significantly increased the proliferative capacity of PD-MSCs and delayed their senescence (* p &lt; 0.05). ARE also enhanced antioxidant capabilities and increased the expression of regeneration-associated genes in an in vitro injured model using chemical damages on human retinal pigment epithelial cell line (ARPE-19) (* p &lt; 0.05). These results suggest that ARE-primed PD-MSC have the capability to enhance the activation of genes associated with regeneration in the injured eye via increasing antioxidant properties. Taken together, these findings support the conclusion that ARE-primed PD-MSC may serve as an enhanced source for stem cell-based therapy in ocular diseases.<\/jats:p>","DOI":"10.3390\/cells13141229","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T08:24:59Z","timestamp":1721636699000},"page":"1229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Achyranthis radix Extract Enhances Antioxidant Effect of Placenta-Derived Mesenchymal Stem Cell on Injured Human Ocular Cells"],"prefix":"10.3390","volume":"13","author":[{"given":"Dae-Hyun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam 13488, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Woong","family":"Han","sequence":"additional","affiliation":[{"name":"Advanced PLAB, PLABiologics Co., Ltd., Seongnam 13522, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeri","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam 13488, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Jin","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam 13488, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7610-9887","authenticated-orcid":false,"given":"Chan-Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-402X","authenticated-orcid":false,"given":"Young Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-7646","authenticated-orcid":false,"given":"Ik Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2320-7157","authenticated-orcid":false,"given":"Gi Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Seongnam 13488, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.1016\/S2214-109X(20)30488-5","article-title":"The Lancet Global Health Commission on Global Eye Health: Vision beyond 2020","volume":"9","author":"Burton","year":"2021","journal-title":"Lancet Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jconrel.2023.07.055","article-title":"Challenges and strategies for ocular posterior diseases therapy via non-invasive advanced drug delivery","volume":"361","author":"Qi","year":"2023","journal-title":"J. Control Release"},{"key":"ref_3","first-page":"e29583","article-title":"Age-Related Macular Degeneration: Epidemiology, Pathophysiology, Diagnosis, and Treatment","volume":"14","author":"Vyawahare","year":"2022","journal-title":"Cureus"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.2337\/db05-1635","article-title":"Diabetic retinopathy: Seeing beyond glucose-induced microvascular disease","volume":"55","author":"Antonetti","year":"2006","journal-title":"Diabetes"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"106516","DOI":"10.1016\/j.phrs.2022.106516","article-title":"Morpho-functional analysis of the early changes induced in retinal ganglion cells by the onset of diabetic retinopathy: The effects of a neuroprotective strategy","volume":"185","author":"Amato","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bohm, E.W., Buonfiglio, F., Voigt, A.M., Bachmann, P., Safi, T., Pfeiffer, N., and Gericke, A. (2023). Oxidative stress in the eye and its role in the pathophysiology of ocular diseases. Redox Biol., 68.","DOI":"10.1016\/j.redox.2023.102967"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7836828","DOI":"10.1155\/2022\/7836828","article-title":"Role of Oxidative Stress in Retinal Disease and the Early Intervention Strategies: A Review","volume":"2022","author":"Wang","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Hsueh, Y.J., Chen, Y.N., Tsao, Y.T., Cheng, C.M., Wu, W.C., and Chen, H.C. (2022). The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031255"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jep.2012.08.037","article-title":"Achyranthes japonica exhibits anti-inflammatory effect via NF-kappaB suppression and HO-1 induction in macrophages","volume":"144","author":"Bang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Choi, B.R., Kang, S.J., Kim, J.L., Lee, Y.J., and Ku, S.K. (2020). Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis radix 5:4:1 (g\/g) in a Surgically Induced Osteoarthritic Rabbit Model. Nutrients, 12.","DOI":"10.3390\/nu12030852"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"113944","DOI":"10.1016\/j.jep.2021.113944","article-title":"Evaluation of oral toxicity and genotoxicity of Achyranthis radix extract","volume":"274","author":"Hyun","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jep.2014.12.073","article-title":"Preclinical evaluations on the efficacy of a topical Chinese herbal formula for swelling control and pain relief","volume":"162","author":"Siu","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Salari, V., Mengoni, F., Del Gallo, F., Bertini, G., and Fabene, P.F. (2020). The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249683"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jtos.2022.10.003","article-title":"Trends in using mesenchymal stromal\/stem cells (MSCs) in treating corneal diseases","volume":"26","author":"Venkatakrishnan","year":"2022","journal-title":"Ocul. Surf."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/164_2016_78","article-title":"Anti-angiogenic Therapy for Retinal Disease","volume":"242","author":"Paulus","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"9201374","DOI":"10.1155\/2018\/9201374","article-title":"Notch Signaling Activation Enhances Human Adipose-Derived Stem Cell Retinal Differentiation","volume":"2018","author":"Huang","year":"2018","journal-title":"Stem Cells Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.aanat.2018.08.002","article-title":"Differentiation of eye field neuroectoderm from human adipose-derived stem cells by using small-molecules and hADSC-conditioned medium","volume":"221","author":"Amirpour","year":"2019","journal-title":"Ann. Anat."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4142\/jvs.2017.18.1.59","article-title":"Inhibition by miR-410 facilitates direct retinal pigment epithelium differentiation of umbilical cord blood-derived mesenchymal stem cells","volume":"18","author":"Choi","year":"2017","journal-title":"J. Vet. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.stemcr.2015.04.005","article-title":"Treatment of macular degeneration using embryonic stem cell-derived retinal pigment epithelium: Preliminary results in Asian patients","volume":"4","author":"Song","year":"2015","journal-title":"Stem Cell Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0140-6736(14)61376-3","article-title":"Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt\u2019s macular dystrophy: Follow-up of two open-label phase 1\/2 studies","volume":"385","author":"Schwartz","year":"2015","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJMoa1608368","article-title":"Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration","volume":"376","author":"Mandai","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ding, S.L.S., Kumar, S., and Mok, P.L. (2017). Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081406"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.4103\/1673-5374.165525","article-title":"Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: A case report of improvement in relapsing auto-immune optic neuropathy","volume":"10","author":"Weiss","year":"2015","journal-title":"Neural Regen. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/2008-322X.200164","article-title":"Intravitreal Injection of Bone Marrow Mesenchymal Stem Cells in Patients with Advanced Retinitis Pigmentosa; a Safety Study","volume":"12","author":"Satarian","year":"2017","journal-title":"J. Ophthalmic Vis. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13287-016-0432-y","article-title":"Subretinal adipose tissue-derived mesenchymal stem cell implantation in advanced stage retinitis pigmentosa: A phase I clinical safety study","volume":"7","author":"Oner","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/aos.15739","article-title":"Mesenchymal stem cell therapy in aqueous deficient dry eye disease","volume":"101","year":"2023","journal-title":"Acta Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/aos.15629","article-title":"Role of stem cells in regenerative treatment of dry eye disease caused by lacrimal gland dysfunction","volume":"101","author":"Jackson","year":"2023","journal-title":"Acta Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00441-011-1249-8","article-title":"Human chorionic-plate-derived mesenchymal stem cells and Wharton\u2019s jelly-derived mesenchymal stem cells: A comparative analysis of their potential as placenta-derived stem cells","volume":"346","author":"Kim","year":"2011","journal-title":"Cell Tissue Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.intimp.2012.03.024","article-title":"Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cells","volume":"13","author":"Lee","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41374-020-0470-z","article-title":"Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells","volume":"101","author":"Kim","year":"2021","journal-title":"Lab. Investig."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kim, J.Y., Park, S., Park, H.J., Kim, S.H., Lew, H., and Kim, G.J. (2021). PEDF-Mediated Mitophagy Triggers the Visual Cycle by Enhancing Mitochondrial Functions in a H2O2-Injured Rat Model. Cells, 10.","DOI":"10.3390\/cells10051117"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/s13287-020-01982-3","article-title":"Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves\u2019 ophthalmopathy","volume":"11","author":"Kim","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ding, S.S.L., Subbiah, S.K., Khan, M.S.A., Farhana, A., and Mok, P.L. (2019). Empowering Mesenchymal Stem Cells for Ocular Degenerative Disorders. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071784"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12015-023-10658-3","article-title":"Regulation Mechanisms and Maintenance Strategies of Stemness in Mesenchymal Stem Cells","volume":"20","author":"Jiang","year":"2023","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13287-019-1224-y","article-title":"Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies","volume":"10","author":"Noronha","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Baldari, S., Di Rocco, G., Piccoli, M., Pozzobon, M., Muraca, M., and Toietta, G. (2017). Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18102087"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lee, T.G., Hyun, S.W., Jo, K., Park, B., Lee, I.S., Song, S.J., and Kim, C.S. (2019). Achyranthis radix Extract Improves Urban Particulate Matter-Induced Dry Eye Disease. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16183229"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/jcb.22873","article-title":"Anti-fibrotic effect of chorionic plate-derived mesenchymal stem cells isolated from human placenta in a rat model of CCl4-injured liver: Potential application to the treatment of hepatic diseases","volume":"111","author":"Lee","year":"2010","journal-title":"J. Cell Biochem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hung, Y.W., Ouyang, C., Ping, X., Qi, Y., Wang, Y.C., Kung, H.J., and Ann, D.K. (2023). Extracellular arginine availability modulates eIF2alpha O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis. J. Biomed. Sci., 30.","DOI":"10.1186\/s12929-023-00924-4"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"164","DOI":"10.26502\/jesph.96120197","article-title":"PFOS Impairs Mitochondrial Biogenesis and Dynamics and Reduces Oxygen Consumption in Human Trophoblasts","volume":"7","author":"Hofmann","year":"2023","journal-title":"J. Environ. Sci. Public Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.3892\/ol.2017.5700","article-title":"Treatment with the herbal formula Songyou Yin inhibits epithelial-mesenchymal transition in hepatocellular carcinoma through downregulation of TGF-beta1 expression and inhibition of the SMAD2\/3 signaling pathway","volume":"13","author":"Zheng","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4049\/jimmunol.181.1.680","article-title":"The transcription factor Nrf2 is a therapeutic target against brain inflammation","volume":"181","author":"Innamorato","year":"2008","journal-title":"J. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3892\/mmr.2021.12028","article-title":"Connective tissue growth factor promotes retinal pigment epithelium mesenchymal transition via the PI3K\/AKT signaling pathway","volume":"23","author":"Wang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0002-9440(10)62298-5","article-title":"Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors","volume":"166","author":"Suomalainen","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"30935","DOI":"10.1074\/jbc.M201919200","article-title":"Phosphatidylinositol 3-kinase\/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation","volume":"277","author":"Sharma","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1038\/srep04923","article-title":"Dissecting the cell to nucleus, perinucleus and cytosol","volume":"4","author":"Shaiken","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Park, S., Kim, J.Y., Myung, S., Jung, N., Choi, Y., and Jung, S.C. (2019). Differentiation of Motor Neuron-Like Cells from Tonsil-Derived Mesenchymal Stem Cells and Their Possible Application to Neuromuscular Junction Formation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112702"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.bbamcr.2008.03.011","article-title":"Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alpha1","volume":"1783","author":"Zhang","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_50","first-page":"1809","article-title":"Effects of FSS on the expression and localization of the core proteins in two Wnt signaling pathways, and their association with ciliogenesis","volume":"42","author":"Sheng","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s12272-012-0815-2","article-title":"High performance liquid chromatography used for quality control of Achyranthis radix","volume":"35","author":"Zhao","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1007\/s10571-023-01383-z","article-title":"Oxidative Stress-Involved Mitophagy of Retinal Pigment Epithelium and Retinal Degenerative Diseases","volume":"43","author":"Zhang","year":"2023","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"101013","DOI":"10.1016\/j.preteyeres.2021.101013","article-title":"Retinal pigment epithelium 65 kDa protein (RPE65): An update","volume":"88","author":"Kiser","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"28909","DOI":"10.1074\/jbc.M202588200","article-title":"Evidence that the human gene for prostate short-chain dehydrogenase\/reductase (PSDR1) encodes a novel retinal reductase (RalR1)","volume":"277","author":"Kedishvili","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1076\/ceyr.26.1.55.14254","article-title":"Intrinsic activation of PI3K\/Akt signaling pathway and its neuroprotective effect against retinal injury","volume":"26","author":"Nakazawa","year":"2003","journal-title":"Curr. Eye Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Shu, D.Y., Chaudhary, S., Cho, K.S., Lennikov, A., Miller, W.P., Thorn, D.C., Yang, M., and McKay, T.B. (2023). Role of Oxidative Stress in Ocular Diseases: A Balancing Act. Metabolites, 13.","DOI":"10.3390\/metabo13020187"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1186\/s13287-020-02029-3","article-title":"Enhanced PRL-1 expression in placenta-derived mesenchymal stem cells accelerates hepatic function via mitochondrial dynamics in a cirrhotic rat model","volume":"11","author":"Kim","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13287-022-02747-w","article-title":"Enhancement strategies for mesenchymal stem cells and related therapies","volume":"13","author":"Alagesan","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.pharmtox.43.100901.140223","article-title":"Hormesis: The dose-response revolution","volume":"43","author":"Calabrese","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Gavanji, S., Bakhtari, A., Famurewa, A.C., and Othman, E.M. (2023). Cytotoxic Activity of Herbal Medicines as Assessed in Vitro: A Review. Chem. Biodivers., 20.","DOI":"10.1002\/cbdv.202201098"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0960-9822(95)00151-5","article-title":"Transcriptional control by protein phosphorylation: Signal transmission from the cell surface to the nucleus","volume":"5","author":"Karin","year":"1995","journal-title":"Curr. Biol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/14\/1229\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:20:41Z","timestamp":1760109641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/14\/1229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,21]]},"references-count":61,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["cells13141229"],"URL":"https:\/\/doi.org\/10.3390\/cells13141229","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,21]]}}}