{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:13:20Z","timestamp":1760112800294,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Hodgkin lymphoma (HL) is a rare lymphoid neoplasm in which Hodgkin\/Reed\u2013Stenberg (HRS) cells are admixed with a population of non-neoplastic inflammatory cells and fibrosis. Dysregulated expressions of cell cycle regulators and transcription factors have been proven as one of the hallmarks of HL. In that context, SATB1 and p16 have been reported as potential regulators of HL progression and survival. However, to date, no studies have assessed the expression levels of SATB1 and p16 in HL in Croatian patients or their prognostic values. Therefore, we investigated the expression pattern of SATB1 and p16 in paraffin-embedded lymph node biopsies using standard immunohistochemistry. We found that 21% of the patients stained positive for SATB1, while 15% of the patients displayed positive staining for p16. Furthermore, we aimed to understand the prognostic value of each protein through the analysis of the overall survival (OS) and progression-free survival (PFS). SATB1 showed a significantly positive correlation with better OS and PFS, while p16 expression had no impact. Interestingly, when patients were stratified by a combination of the two studied markers, we found that patients in the SATB1+\/p16- group tended to have the best prognosis in HL, according to statistical significance. In conclusion, SATB1 and p16 might be potentially useful as diagnostic and prognostic markers for HL.<\/jats:p>","DOI":"10.3390\/cells13161323","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T12:13:14Z","timestamp":1723119194000},"page":"1323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SATB1 and p16 Expression and Prognostic Value in Croatian Hodgkin Lymphoma Patients: A Unicentric Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Lu\u010dana","family":"Viceli\u0107 \u010cutura","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Haematology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Vuj\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Haematology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-8529","authenticated-orcid":false,"given":"Davor","family":"Galu\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Haematology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Blaslov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Haematology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Petri\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Haematology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonija","family":"Miljak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Haematology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-4768","authenticated-orcid":false,"given":"Mirela","family":"Lozi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry, University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3681-8499","authenticated-orcid":false,"given":"Benjamin","family":"Benzon","sequence":"additional","affiliation":[{"name":"Department of Anatomy Histology and Embryology, University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2182-2890","authenticated-orcid":false,"given":"Katarina","family":"Vukojevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Anatomy Histology and Embryology, University of Split School of Medicine, 21000 Split, Croatia"},{"name":"Laboratory of Morphology, Department of Histology and Embryology, School of Medicine, University of Mostar, 8800 Mostar, Bosnia and Herzegovina"},{"name":"Faculty of Health Studies, University of Mostar, 88000 Mostar, Bosnia and Herzegovina"},{"name":"Department of Anatomy, University of Mostar, 88000 Mostar, Bosnia and Herzegovina"},{"name":"Center for Translational Research in Biomedicine, University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toni","family":"Bubi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathology, Judicial Medicine, and Cytology, Division of Pathology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nenad","family":"Kunac","sequence":"additional","affiliation":[{"name":"Department of Pathology, Judicial Medicine, and Cytology, Division of Pathology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4257-8417","authenticated-orcid":false,"given":"Danijela","family":"Zja\u010di\u0107 Puljiz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology and Haemodialysis, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana Kristina","family":"Deli\u0107 Juki\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology and Haemodialysis, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinela","family":"Kri\u017eanac","sequence":"additional","affiliation":[{"name":"Department of Pediatric Disease, Division of Haematology, Oncology, Clinical Immunology and Genetics, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8242-0388","authenticated-orcid":false,"given":"Bernarda","family":"Lozi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pediatric Disease, Division of Haematology, Oncology, Clinical Immunology and Genetics, University Hospital of Split, 21000 Split, Croatia"},{"name":"University of Split School of Medicine, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Liu, Y., van den Berg, A., Veenstra, R., Rutgers, B., Nolte, I., van Imhoff, G., Visser, L., and Diepstra, A. 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