{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:09:49Z","timestamp":1793340589355,"version":"4.5.0"},"reference-count":63,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7ao de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2019\/18431-4"],"award-info":[{"award-number":["2019\/18431-4"]}]},{"name":"Funda\u00e7ao de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2016\/15603-0"],"award-info":[{"award-number":["2016\/15603-0"]}]},{"name":"Funda\u00e7ao de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2021\/02401-9"],"award-info":[{"award-number":["2021\/02401-9"]}]},{"name":"Funda\u00e7ao de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2019\/25702-4"],"award-info":[{"award-number":["2019\/25702-4"]}]},{"name":"Funda\u00e7ao de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2023\/00995-4"],"award-info":[{"award-number":["2023\/00995-4"]}]},{"name":"Funda\u00e7ao de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["303095\/2021-0"],"award-info":[{"award-number":["303095\/2021-0"]}]},{"name":"Funda\u00e7ao de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["310699\/2022-3"],"award-info":[{"award-number":["310699\/2022-3"]}]},{"name":"Funda\u00e7ao de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["308778\/2021-9"],"award-info":[{"award-number":["308778\/2021-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The association between high-density lipoprotein (HDL) cholesterol and breast cancer (BC) remains controversial due to the high complexity of the HDL particle and its functionality. The HDL proteome was determined in newly diagnosed BC classified according to the molecular type [luminal A or B (LA or LB), HER2, and triple-negative (TN)] and clinical stage of the disease. Women (n = 141) aged between 18 and 80 years with BC, treatment-na\u00efve, and healthy women [n = 103; control group (CT)], matched by age and body mass index, were included. Data-independent acquisition (DIA) proteomics was performed in isolated HDL (D = 1.063\u20131.21 g\/mL). Results: Paraoxonase1, carnosine dipeptidase1, immunoglobulin mMu heavy chain constant region (IGHM), apoA-4, and transthyretin were reduced, and serum amyloid A2 and tetranectin were higher in BC compared to CT. In TNBC, apoA-1, apoA-2, apoC-2, and apoC-4 were reduced compared to LA, LB, and HER2, and apoA-4 compared to LA and HER2. ComplementC3, lambda immunoglobulin2\/3, serpin3, IGHM, complement9, alpha2 lysine rich-glycoprotein1, and complement4B were higher in TNBC in comparison to all other types; complement factor B and vitamin D-binding protein were in contrast to LA and HER2, and plasminogen compared to LA and LB. In grouped stages III + IV, tetranectin and alpha2-macroglobulin were reduced, and haptoglobin-related protein; lecithin cholesterol acyltransferase, serum amyloid A1, and IGHM were increased compared to stages I + II. Conclusions: A differential proteomic profile of HDL in BC based on tumor molecular classification and the clinical stage of the disease may contribute to a better understanding of the association of HDL with BC pathophysiology, treatment, and outcomes.<\/jats:p>","DOI":"10.3390\/cells13161327","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T07:59:07Z","timestamp":1723190347000},"page":"1327","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Proteomic Profiling of HDL in Newly Diagnosed Breast Cancer Based on Tumor Molecular Classification and Clinical Stage of Disease"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-0696","authenticated-orcid":false,"given":"Monique de Fatima Mello","family":"Santana","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de L\u00edpides (LIM10), Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 01246-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2698-4496","authenticated-orcid":false,"given":"Maria Isabela Bloise Alves Caldas","family":"Sawada","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina, Universidade Nove de Julho, Sao Paulo 01525-000, Brazil"},{"name":"Grupo de Sa\u00fade de Curitiba (GSAU-CT), CINDACTA II, Brazilian Air Force, Curitiba 82510-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-5137","authenticated-orcid":false,"given":"Douglas Ricardo Souza","family":"Junior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Prote\u00f4mica Aplicada \u00e0 Processos Inflamat\u00f3rios, Instituto de Qu\u00edmica, Universidade de Sao Paulo, Sao Paulo 05508-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Benacchio","family":"Giacaglia","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina, Universidade Nove de Julho, Sao Paulo 01525-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mozania","family":"Reis","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina, Universidade Nove de Julho, Sao Paulo 01525-000, Brazil"},{"name":"Unidade B\u00e1sica de Sa\u00fade Dra. Ilza Weltman Hutzler, Sao Paulo 02472-180, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacira","family":"Xavier","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina, Universidade Nove de Julho, Sao Paulo 01525-000, Brazil"},{"name":"Unidade B\u00e1sica de Sa\u00fade Dra. Ilza Weltman Hutzler, Sao Paulo 02472-180, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-4446","authenticated-orcid":false,"given":"Maria Lucia","family":"C\u00f4rrea-Giannella","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Carboidratos e Radioimunoensaio (LIM18), Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 01246-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-0135","authenticated-orcid":false,"given":"Francisco Garcia","family":"Soriano","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Emerg\u00eancias Cl\u00ednicas (LIM51), Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 01246-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-9191","authenticated-orcid":false,"given":"Luiz Henrique","family":"Gebrim","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia da Sa\u00fade, Mulher-Hospital P\u00e9rola Byington, Sao Paulo 01215-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2340-6770","authenticated-orcid":false,"given":"Graziella Eliza","family":"Ronsein","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Prote\u00f4mica Aplicada \u00e0 Processos Inflamat\u00f3rios, Instituto de Qu\u00edmica, Universidade de Sao Paulo, Sao Paulo 05508-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9249-4698","authenticated-orcid":false,"given":"Marisa","family":"Passarelli","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de L\u00edpides (LIM10), Hospital das Cl\u00ednicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 01246-000, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina, Universidade Nove de Julho, Sao Paulo 01525-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106535","DOI":"10.1016\/j.intimp.2020.106535","article-title":"Breast cancer: Biology, biomarkers, and treatments","volume":"84","author":"Barzaman","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lofter\u00f8d, T., Mortensen, E.S., Nalwoga, H., Wilsgaard, T., Frydenberg, H., Risberg, T., Eggen, A.E., McTiernan, A., Aziz, S., and Wist, E.A. (2018). Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4568-2"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sawada, M.I.B.A.C., de F\u00e1tima Mello Santana, M., Reis, M., de Assis, S.I.S., Pereira, L.A., Santos, D.R., Nunes, V.S., Correa-Giannella, M.L.C., Gebrim, L.H., and Passarelli, M. (2023). Increased plasma lipids in triple-negative breast cancer and impairment in HDL functionality in advanced stages of tumors. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-35764-7"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5756","DOI":"10.1002\/jcb.27862","article-title":"High-density lipoprotein functionality and breast cancer: A potential therapeutic target","volume":"120","author":"Samadi","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.annepidem.2008.06.006","article-title":"HDL-cholesterol and incidence of breast cancer in the ARIC cohort study","volume":"18","author":"Rosamond","year":"2008","journal-title":"Ann. Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5301\/jbm.5000143","article-title":"Decreased serum HDL at initial diagnosis correlates with worse outcomes for triple-negative breast cancer but not non-TNBCs","volume":"30","author":"Fan","year":"2015","journal-title":"Int. J. Biol. Markers"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/ije\/dyz242","article-title":"A Mendelian randomization analysis of circulating lipid traits and breast cancer risk","volume":"49","author":"Khankari","year":"2020","journal-title":"Int. J. Epidemiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"djv119","DOI":"10.1093\/jnci\/djv119","article-title":"Androgen deprivation with or without radiation therapy for clinically node-positive prostate cancer","volume":"107","author":"Lin","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10552-016-0832-4","article-title":"Associations between serum lipids and breast cancer incidence and survival in the E3N prospective cohort study","volume":"28","author":"His","year":"2017","journal-title":"Cancer Causes Control"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Graham, A. (2023). Modulation of the Cellular microRNA Landscape: Contribution to the Protective Effects of High-Density Lipoproteins (HDL). Biology, 12.","DOI":"10.3390\/biology12091232"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Davidson, W.S., Shah, A.S., Sexmith, H., and Gordon, S.M. (2022). The HDL Proteome Watch: Compilation of studies leads to new insights on HDL function. Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1867.","DOI":"10.1016\/j.bbalip.2021.159072"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Network (2012). Comprehensive molecular portraits of human breast tumors. Nature, 490, 61\u201370.","DOI":"10.1038\/nature11412"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature18003","article-title":"Proteogenomics connects somatic mutations to signalling in breast cancer","volume":"534","author":"Mertins","year":"2016","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.cell.2020.10.036","article-title":"Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy","volume":"183","author":"Krug","year":"2020","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1093\/annonc\/mdr304","article-title":"Strategies for subtypes-dealing with the diversity of breast cancer: Highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011","volume":"22","author":"Goldhirsch","year":"2011","journal-title":"Ann. Oncol."},{"key":"ref_16","unstructured":"Gospodarowicz, M.K., Wittekind, C., and Brierley, J.D. (2016). TNM Classification of Malignant Tumours, Wiley-Blackwell. [8th ed.]."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jprot.2014.10.017","article-title":"Parallel reaction monitoring (PRM) and selected reaction monitoring (SRM) exhibit comparable linearity, dynamic range and precision for targeted quantitative HDL proteomics","volume":"113","author":"Ronsein","year":"2015","journal-title":"J. Proteom."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1021\/acs.jproteome.9b00511","article-title":"Comparing Data-Independent Acquisition and Parallel Reaction Monitoring in Their Abilities To Differentiate High-Density Lipoprotein Subclasses","volume":"19","author":"Silva","year":"2020","journal-title":"J. Proteome Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1038\/nprot.2007.261","article-title":"Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips","volume":"2","author":"Rappsilber","year":"2007","journal-title":"Nat. Protoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100397","DOI":"10.1016\/j.jlr.2023.100397","article-title":"Strategies for consistent and automated quantification of HDL proteome using data-independent acquisition","volume":"64","author":"Silva","year":"2023","journal-title":"J. Lipid Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jacl.2021.10.005","article-title":"HDL proteome remodeling associates with COVID-19 severity","volume":"15","author":"Silva","year":"2021","journal-title":"J. Clin. Lipidol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S362","DOI":"10.4103\/0973-1482.235355","article-title":"Serum paraoxonase and arylesterase can be useful markers to predict neoadjuvant chemotherapy requirement in patients with breast cancer","volume":"14","author":"Okuturlar","year":"2018","journal-title":"J. Cancer Res. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Arenas, M., Garc\u00eda-Heredia, A., Cabr\u00e9, N., Luciano-Mateo, F., Hern\u00e1ndez-Aguilera, A., Sabater, S., Bonet, M., Gasc\u00f3n, M., Fern\u00e1ndez-Arroyo, S., and Fort-Gallifa, I. (2017). Effect of radiotherapy on activity and concentration of serum paraoxonase-1 in breast cancer patients. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188633"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Prakash, M.D., Fraser, S., Boer, J.C., Plebanski, M., de Courten, B., and Apostolopoulos, V. (2021). Anti-Cancer Effects of Carnosine\u2014A Dipeptide Molecule. Molecules, 26.","DOI":"10.3390\/molecules26061644"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1172\/JCI200421233","article-title":"Apolipoprotein A-IV inhibits experimental colitis","volume":"114","author":"Vowinkel","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1016\/S0021-9258(19)39557-2","article-title":"Lipoprotein apoC-II activation of lipoprotein lipase. Molulation by apolipoprotein A-IV","volume":"265","author":"Goldberg","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.1016\/S0021-9258(19)39010-6","article-title":"Human apolipoprotein A-IV binds to apolipoprotein A-I\/A-II receptor sites and promotes cholesterp\u00e7 efflux from adipose cells","volume":"265","author":"Steinmetz","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00432-012-1161-y","article-title":"Changes in the expression of plasma proteins associated with thrombosis in BRCA1 mutation carriers","volume":"138","author":"Custodio","year":"2012","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4137\/BIC.S10502","article-title":"Potential biomarkers in the sera of breast cancer patients from bahawalpur, pakistan","volume":"4","author":"Nasim","year":"2012","journal-title":"Biomark. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1593\/neo.06805","article-title":"Posttranslational modifications of transthyretin are serum markers in patients with mycosis fungoides","volume":"9","author":"Escher","year":"2007","journal-title":"Neoplasia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1007\/s12094-023-03082-z","article-title":"Metabolic heterogeneity in early-stage lung adenocarcinoma revealed by RNA-seq and scRNA-seq","volume":"25","author":"Zhang","year":"2023","journal-title":"Clin. Transl. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Li, P., Lin, Z., Liu, Q., Chen, S., Gao, X., Guo, W., Gong, F., Wei, J., and Lin, H. (2021). Enhancer RNA SLIT2 Inhibits Bone Metastasis of Breast Cancer Through Regulating P38 MAPK\/c-Fos Signaling Pathway. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.743840"},{"key":"ref_33","first-page":"6190","article-title":"Tetranektin, et plasma- og vaevsprotein--en prognostisk mark\u00f8r for mamma- og ovariekarcinom [Tetranectin, a plasma and tissue protein--a prognostic marker of breast and ovarian cancer]","volume":"156","author":"Christensen","year":"1994","journal-title":"Ugeskr. Laeger"},{"key":"ref_34","first-page":"3903","article-title":"Serum tetranectin and CA125 in endometrial adenocarcinoma","volume":"20","author":"Nielsen","year":"2000","journal-title":"Anticancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1006\/gyno.2000.5996","article-title":"The prognostic value of pretherapeutic tetranectin and CA-125 in patients with relapse of ovarian cancer","volume":"79","author":"Deng","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1006\/gyno.1995.1004","article-title":"The role of serum tetranectin, CA 125, and a combined index as tumor markers in women with pelvic tumors","volume":"56","author":"Mogensen","year":"1995","journal-title":"Gynecol. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3109\/02841869309092443","article-title":"Prognostic value of serum tetranectin in patients with metastatic breast cancer","volume":"32","author":"Nielsen","year":"1993","journal-title":"Acta Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"511","DOI":"10.18632\/oncotarget.26566","article-title":"Serum amyloid A predisposes inflammatory tumor microenvironment in triple negative breast cancer","volume":"10","author":"Ignacio","year":"2019","journal-title":"Oncotarget"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Zhang, G., Liu, J., Wu, L., Fan, Y., Sun, L., Qian, F., Chen, D., and Ye, R.D. (2018). Elevated Expression of Serum Amyloid A 3 Protects Colon Epithelium Against Acute Injury Through TLR2-Dependent Induction of Neutrophil IL-22 Expression in a Mouse Model of Colitis. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01503"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tem.2010.10.001","article-title":"High density lipoprotein: It\u2019s not just about lipid transport anymore","volume":"22","author":"Gordon","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1126\/science.1193494","article-title":"The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes","volume":"330","author":"Levine","year":"2010","journal-title":"Science"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zamanian-Daryoush, M., and DiDonato, J.A. (2015). Apolipoprotein A-I and Cancer. Front. Pharmacol., 6.","DOI":"10.3389\/fphar.2015.00265"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/sj.onc.1209131","article-title":"Postoperative serum proteomic profiles may predict metastatic relapse in high-risk primary breast cancer patients receiving adjuvant chemotherapy","volume":"25","author":"Esterni","year":"2006","journal-title":"Oncogene"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.2147\/CMAR.S191352","article-title":"Apolipoprotein A1 and B as risk factors for development of intraocular metastasis in patients with breast cancer","volume":"11","author":"Liu","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Torres-Romero, J.C., Lara-Riegos, J.C., Parra, E.A.E., S\u00e1nchez, V.F., Arana-Arg\u00e1ez, V.E., and Uc-Colli, S. (2021). Lipoproteomics: Methodologies and Analysis of Lipoprotein-Associated Proteins along with the Drug Intervention. Drug Design-Novel Advances in the Omics Field and Applications, IntechOpen.","DOI":"10.5772\/intechopen.93634"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Bobin-Dubigeon, C., Nazih, H., Blanchard, V., Croyal, M., and Bard, J.M. (2022). Circulating HDL and Non-HDL Associated Apolipoproteins and Breast Cancer Severity. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051345"},{"key":"ref_47","first-page":"616","article-title":"IGHG1 promotes malignant progression in breast cancer cells through the regulation of AKT and VEGF signaling","volume":"23","author":"Zhang","year":"2023","journal-title":"Biomol. Biomed."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1194\/jlr.M800362-JLR200","article-title":"Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux","volume":"50","author":"Sankaranarayanan","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Avena, P., Casaburi, I., Zavaglia, L., Nocito, M.C., La Padula, D., Rago, V., Dong, J., Thomas, P., Mineo, C., and Sirianni, R. (2022). 27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer. Cancers, 14.","DOI":"10.3390\/cancers14061521"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Campos, A.L., Sawada, M.I.B.A.C., Santana, M.F.M., Iborra, R.T., de Assis, S.I.S., Reis, M., de Carvalho, J.X., Gebrim, L.H., and Passarelli, M. (2023). The increased antioxidant action of HDL is independent of HDL cholesterol plasma levels in triple-negative breast cancer. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1111094"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Santana, M.F.M., Sawada, M.I.B.A.C., Santos, A.S., Reis, M., Xavier, J., C\u00f4rrea-Giannella, M.L., Hirata, A.H.L., Gebrim, L.H., Soriano, F.G., and Camacho, C.P. (2023). Increased Expression of miR-223-3p and miR-375-3p and Anti-Inflammatory Activity in HDL of Newly Diagnosed Women in Advanced Stages of Breast Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612762"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1021\/pr060125o","article-title":"Quantification of membrane and membrane-bound proteins in normal and malignant breast cancer cells isolated from the same patient with primary breast carcinoma","volume":"5","author":"Liang","year":"2006","journal-title":"J. Proteome Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jprot.2016.07.033","article-title":"Quantitative proteomics revealed novel proteins associated with molecular subtypes of breast cancer","volume":"148","author":"Suman","year":"2016","journal-title":"J. Proteom."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"35843","DOI":"10.18632\/oncotarget.8561","article-title":"Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/onc.2013.568","article-title":"A link between inflammation and metastasis: Serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4","volume":"34","author":"Hansen","year":"2015","journal-title":"Oncogene"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/978-3-030-41769-7_17","article-title":"Serum amyloid A (SAA) proteins","volume":"94","author":"Sack","year":"2020","journal-title":"Subcell. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1002\/ijc.34859","article-title":"SAA1-dependent reprogramming of adipocytes by tumor cells is associated with triple negative breast cancer aggressiveness","volume":"154","author":"Rybinska","year":"2024","journal-title":"Int. J. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1056\/NEJM198909073211003","article-title":"Haptoglobin-related protein (Hpr) epitopes in breast cancer as a predictor of recurrence of the disease","volume":"321","author":"Kuhajda","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/s41467-022-28524-0","article-title":"Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes","volume":"13","author":"Asleh","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Jeanmard, N., Bissanum, R., Sriplung, H., Charoenlappanit, S., Roytrakul, S., and Navakanitworakul, R. (2023). Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0291574"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Xu, G., Huang, R., Wumaier, R., Lyu, J., Huang, M., Zhang, Y., Chen, Q., Liu, W., Tao, M., and Li, J. (2024). Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer. Cancer Res.","DOI":"10.1158\/0008-5472.CAN-23-3998"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1161\/CIRCULATIONAHA.117.031276","article-title":"High-Density Lipoprotein Subspecies Defined by Presence of Apolipoprotein C-III and Incident Coronary Heart Disease in Four Cohorts","volume":"137","author":"Jensen","year":"2018","journal-title":"Circulation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"7314","DOI":"10.1021\/bi100359f","article-title":"Phospholipid transfer protein in human plasma associates with proteins linked to immunity and inflammation","volume":"49","author":"Cheung","year":"2010","journal-title":"Biochemistry"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/16\/1327\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:32:39Z","timestamp":1760110359000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/16\/1327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":63,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["cells13161327"],"URL":"https:\/\/doi.org\/10.3390\/cells13161327","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]}}}