{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:59:05Z","timestamp":1791644345031,"version":"4.3.4"},"reference-count":163,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The NLRP3 inflammasome is a critical component of the innate immune response. NLRP3 activation is a tightly controlled process involving an initial priming to express NLRP3, pro-IL-1 \u03b2, and pro-IL-18, followed by an activation signal. The precise mechanism of activation is not fully understood due to the diverse range of activators, yet it effectively orchestrates the activation of caspase-1, which subsequently triggers the release of proinflammatory cytokines IL-1\u03b2 and IL-18. NLRP3 dysregulation can lead to a variety of inflammatory diseases, highlighting its significant role in immune response and disease pathogenesis. NLRP3 is divided into three domains: the PYD, the NACHT, and the LRR domains. This review focuses on the LRR domain of NLRP3, detailing its structural characteristics, its function in pathogen sensing, its role in the degradation process, and its involvement in inflammasome auto-inhibition and activation. Additionally, we discuss the impact of mutations within the LRR domain found in atypical Cryopyrin-Associated Periodic Syndromes (CAPS), highlighting the clinical relevance of this domain.<\/jats:p>","DOI":"10.3390\/cells13161365","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T06:23:20Z","timestamp":1723789400000},"page":"1365","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Implication of the LRR Domain in the Regulation and Activation of the NLRP3 Inflammasome"],"prefix":"10.3390","volume":"13","author":[{"given":"Margaux","family":"Cescato","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacological and Toxicological Chemistry and Biochemistry, CNRS, Paris Cit\u00e9 University, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiang Y J","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacological and Toxicological Chemistry and Biochemistry, CNRS, Paris Cit\u00e9 University, 75006 Paris, France"},{"name":"National Reference Center for Autoinflammatory Diseases and AA Amyloidosis, Department of Internal Medicine, Tenon Hospital, Sorbonne University, Assistance Publique\u2014H\u00f4pitaux de Paris (APHP), 75020 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Le Corre","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacological and Toxicological Chemistry and Biochemistry, CNRS, Paris Cit\u00e9 University, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte F","family":"Py","sequence":"additional","affiliation":[{"name":"CIRI, International Center for Research in Infectiology, Inserm, University Claude Bernard Lyon 1, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Georgin-Lavialle","sequence":"additional","affiliation":[{"name":"National Reference Center for Autoinflammatory Diseases and AA Amyloidosis, Department of Internal Medicine, Tenon Hospital, Sorbonne University, Assistance Publique\u2014H\u00f4pitaux de Paris (APHP), 75020 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu P","family":"Rodero","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacological and Toxicological Chemistry and Biochemistry, CNRS, Paris Cit\u00e9 University, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen Recognition by the Innate Immune System","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. 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