{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:52:32Z","timestamp":1787316752225,"version":"build-2736575974"},"reference-count":149,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondazione Regionale per la Ricerca Biomedica (Regione Lombardia)","award":["ERAPERMED2022-258, GA 779282"],"award-info":[{"award-number":["ERAPERMED2022-258, GA 779282"]}]},{"name":"Fondazione Regionale per la Ricerca Biomedica (Regione Lombardia)","award":["RF-2016-02364384"],"award-info":[{"award-number":["RF-2016-02364384"]}]},{"name":"Italian Ministry of Health","award":["ERAPERMED2022-258, GA 779282"],"award-info":[{"award-number":["ERAPERMED2022-258, GA 779282"]}]},{"name":"Italian Ministry of Health","award":["RF-2016-02364384"],"award-info":[{"award-number":["RF-2016-02364384"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Myasthenia gravis (MG) is an antibody-mediated autoimmune disorder characterized by altered neuromuscular transmission, which causes weakness and fatigability in the skeletal muscles. The etiology of MG is complex, being associated with multiple genetic and environmental factors. Over recent years, progress has been made in understanding the immunological alterations implicated in the disease, but the exact pathogenesis still needs to be elucidated. A pathogenic interplay between innate immunity and autoimmunity contributes to the intra-thymic MG development. Epigenetic changes are critically involved in both innate and adaptive immune response regulation. They can act as (i) pathological factors besides genetic predisposition and (ii) co-factors contributing to disease phenotypes or patient-specific disease course\/outcomes. This article reviews the role of non-coding RNAs (ncRNAs) as epigenetic factors implicated in MG. Particular attention is dedicated to microRNAs (miRNAs), whose expression is altered in MG patients\u2019 thymuses and circulating blood. The long ncRNA (lncRNA) contribution to MG, although not fully characterized yet, is also discussed. By summarizing the most recent and fast-growing findings on ncRNAs in MG, we highlight the therapeutic potential of these molecules for achieving immune regulation and their value as biomarkers for the development of personalized medicine approaches to improve disease care.<\/jats:p>","DOI":"10.3390\/cells13181550","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T04:14:07Z","timestamp":1726460047000},"page":"1550","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Non-Coding RNAs in Myasthenia Gravis: From Immune Regulation to Personalized Medicine"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1032-9120","authenticated-orcid":false,"given":"Nicola","family":"Iacomino","sequence":"first","affiliation":[{"name":"Neurology 4\u2013Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-3503","authenticated-orcid":false,"given":"Maria Cristina","family":"Tarasco","sequence":"additional","affiliation":[{"name":"Neurology 4\u2013Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy"},{"name":"Ph.D. Program in Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9634-0526","authenticated-orcid":false,"given":"Alessia","family":"Berni","sequence":"additional","affiliation":[{"name":"Neurology 4\u2013Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-4631","authenticated-orcid":false,"given":"Jacopo","family":"Ronchi","sequence":"additional","affiliation":[{"name":"Ph.D. Program in Neuroscience, University of Milano-Bicocca, 20900 Monza, Italy"},{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"},{"name":"BicOMICs, University of Milano-Bicocca, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-5737","authenticated-orcid":false,"given":"Renato","family":"Mantegazza","sequence":"additional","affiliation":[{"name":"Neurology 4\u2013Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1497-1524","authenticated-orcid":false,"given":"Paola","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Neurology 4\u2013Neuroimmunology and Neuromuscolar Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Foti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"},{"name":"BicOMICs, University of Milano-Bicocca, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lazaridis, K., and Tzartos, S.J. (2020). Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00212"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41572-019-0079-y","article-title":"Myasthenia Gravis","volume":"5","author":"Gilhus","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.autrev.2013.03.010","article-title":"Etiology of myasthenia gravis: Innate immunity signature in pathological thymus","volume":"12","author":"Cavalcante","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-981-15-3449-2_1","article-title":"Epigenetics in Health and Disease","volume":"1253","author":"Zhang","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nri.2016.40","article-title":"MicroRNAs as regulatory elements in immune system logic","volume":"16","author":"Mehta","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/ni.3771","article-title":"Gene regulation in the immune system by long noncoding RNAs","volume":"18","author":"Chen","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"102982","DOI":"10.1016\/j.jaut.2022.102982","article-title":"Non-coding RNAs in immunoregulation and autoimmunity: Technological advances and critical limitations","volume":"134","author":"Kumar","year":"2023","journal-title":"J. Autoimmun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102948","DOI":"10.1016\/j.jaut.2022.102948","article-title":"Evolving understandings for the roles of non-coding RNAs in autoimmunity and autoimmune disease","volume":"137","author":"Cheng","year":"2023","journal-title":"J. Autoimmun."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ghafouri-Fard, S., Azimi, T., Hussen, B.M., Taheri, M., and Khoshnoud, R.J. (2021). A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312964"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/BOR.0000000000000647","article-title":"Diagnosis and treatment of myasthenia gravis","volume":"31","author":"Mantegazza","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1172\/JCI29894","article-title":"Myasthenia gravis: Past, present, and future","volume":"116","author":"Milani","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/mus.23882","article-title":"Do acetylcholine receptor and striated muscle antibodies predict the presence of thymoma in patients with myasthenia gravis?","volume":"49","author":"Decroos","year":"2014","journal-title":"Muscle Nerve"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ncl.2018.01.002","article-title":"Generalized myasthenia gravis: Classification, clinical presentation, natural history, and epidemiology","volume":"36","author":"Hehir","year":"2018","journal-title":"Neurol. Clin."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Payet, C.A., You, A., Fayet, O.-M., Dragin, N., Berrih-Aknin, S., and Le Panse, R. (2022). Myasthenia Gravis: An Acquired Interferonopathy?. Cells, 11.","DOI":"10.3390\/cells11071218"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.autrev.2013.03.011","article-title":"Ectopic germinal centers, BAFF and anti-B-cell therapy in myasthenia gravis","volume":"12","author":"Ragheb","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jaut.2013.12.015","article-title":"Both Treg cells and Tconv cells are defective in the Myasthenia gravis thymus: Roles of IL-17 and TNF-\u03b1","volume":"52","author":"Gradolatto","year":"2014","journal-title":"J. Autoimmun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.expneurol.2015.02.010","article-title":"Thymoma related myasthenia gravis in humans and potential animal models","volume":"270","author":"Marx","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.clim.2017.03.003","article-title":"CD4+ FoxP3+ T regulatory cell subsets in myasthenia gravis patients","volume":"179","author":"Kohler","year":"2017","journal-title":"Clin. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Iacomino, N., Scandiffio, L., Conforti, F., Salvi, E., Tarasco, M.C., Bortone, F., Marcuzzo, S., Simoncini, O., Andreetta, F., and Pistillo, D. (2023). Muscle and Muscle-like Autoantigen Expression in Myasthenia Gravis Thymus: Possible Molecular Hint for Autosensitization. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030732"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"Wightman","year":"1993","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/15476286.2020.1845505","article-title":"The role of lncRNAs in innate immunity and inflammation","volume":"18","author":"Walther","year":"2021","journal-title":"RNA Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nri2252","article-title":"Micromanagement of the immune system by microRNAs","volume":"8","author":"Lodish","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1101\/gad.1522907","article-title":"Dynamic regulation of miRNA expression in ordered stages of cellular development","volume":"21","author":"Neilson","year":"2007","journal-title":"Genes Dev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.molmed.2017.11.003","article-title":"Noncoding RNAs: Master Regulators of Inflammatory Signaling","volume":"24","author":"Chew","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"Chen","year":"2008","journal-title":"Cell Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cmet.2019.07.011","article-title":"Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease","volume":"30","author":"Mori","year":"2019","journal-title":"Cell Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12367","article-title":"Immuno-miRs: Critical regulators of T-cell development, function and ageing","volume":"144","author":"Kroesen","year":"2015","journal-title":"Immunology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.canlet.2018.05.020","article-title":"MiRNAs: Dynamic regulators of immune cell functions in inflammation and cancer","volume":"431","author":"Hirschberger","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Boshtam, M., Rahimmanesh, I., Shariati, L., Najaflu, M., Khanahmad, H., Mirian, M., Zarepour, A., Zarrabi, A., and Kouhpayeh, S. (2023). Crosstalk of Transcriptional Regulators of Adaptive Immune System and microRNAs: An Insight into Differentiation and Development. Cells, 12.","DOI":"10.3390\/cells12040635"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Saba, R., Sorensen, D.L., and Booth, S.A. (2014). MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response. Front. Immunol., 21.","DOI":"10.3389\/fimmu.2014.00578"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","article-title":"Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses","volume":"142","author":"Lu","year":"2010","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6436","DOI":"10.1038\/ncomms7436","article-title":"MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres","volume":"6","author":"Pratama","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1038\/s41467-018-05196-3","article-title":"Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b","volume":"9","author":"Cho","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1182\/blood-2012-08-452425","article-title":"Forced miR-146a expression causes autoimmune lymphoproliferative syndrome in mice via downregulation of Fas in germinal center B cells","volume":"121","author":"Guo","year":"2013","journal-title":"Blood"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"7080","DOI":"10.1073\/pnas.0702409104","article-title":"miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely","volume":"104","author":"Zhou","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.1182\/blood-2010-12-326629","article-title":"Modulation of microRNA expression in human T-cell development: Targeting of NOTCH3 by miR-150","volume":"117","author":"Ghisi","year":"2011","journal-title":"Blood"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cell.2007.07.021","article-title":"MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb","volume":"131","author":"Xiao","year":"2007","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1111\/jcmm.13201","article-title":"miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1\/c-Fos pathway","volume":"21","author":"Zhu","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1073\/pnas.0500613102","article-title":"Accumulation of miR-155 and BIC RNA in human B cell lymphomas","volume":"102","author":"Eis","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","article-title":"A mammalian microRNA expression atlas based on small RNA library sequencing","volume":"129","author":"Landgraf","year":"2007","journal-title":"Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.immuni.2010.09.009","article-title":"MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development","volume":"33","author":"Kahn","year":"2010","journal-title":"Immunity"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.1141229","article-title":"Regulation of the germinal center response by microRNA-155","volume":"316","author":"Thai","year":"2007","journal-title":"Science"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.ymthe.2019.07.003","article-title":"Peripheral Circulating Exosome-Mediated Delivery of miR-155 as a Novel Mechanism for Acute Lung Inflammation","volume":"27","author":"Jiang","year":"2019","journal-title":"Mol. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/imm.12468","article-title":"Physiological roles of miR-155","volume":"145","author":"Mashima","year":"2015","journal-title":"Immunology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/gene.2011.84","article-title":"Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene","volume":"13","author":"Truedsson","year":"2012","journal-title":"Genes Immun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1186\/ar2493","article-title":"Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients","volume":"10","author":"Pauley","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7150\/ijms.8647","article-title":"Expression, regulation and function of microRNAs in multiple sclerosis","volume":"11","author":"Ma","year":"2014","journal-title":"Int. J. Med. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Hu, Y.Z., Li, Q., Wang, P.F., Li, X.P., and Hu, Z.L. (2023). Multiple functions and regulatory network of miR-150 in B lymphocyte-related diseases. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1140813"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s00011-022-01643-6","article-title":"Role of miR-155 in inflammatory autoimmune diseases: A comprehensive review","volume":"12","author":"Xu","year":"2022","journal-title":"Inflamm. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Tsai, C.Y., Shen, C.Y., Liu, C.W., Hsieh, S.C., Liao, H.T., Li, K.J., Lu, C.S., Lee, H.T., Lin, C.S., and Wu, C.H. (2020). Aberrant Non-Coding RNA Expression in Patients with Systemic Lupus Erythematosus: Consequences for Immune Dysfunctions and Tissue Damage. Biomolecules, 10.","DOI":"10.3390\/biom10121641"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Cipriano, G.L., Schepici, G., Mazzon, E., and Anchesi, I. (2024). Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042255"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Shaikh, F.S., Siegel, R.J., Srivastava, A., Fox, D.A., and Ahmed, S. (2024). Challenges and promise of targeting miRNA in rheumatic diseases: A computational approach to identify miRNA association with cell types, cytokines, and disease mechanisms. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1322806"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00018-016-2174-5","article-title":"Mechanisms of long noncoding RNA function in development and disease","volume":"73","author":"Schmitz","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Xie, Y., and Wei, Y. (2021). A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179535"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"155041","DOI":"10.1016\/j.prp.2023.155041","article-title":"Bridging autoimmunity and epigenetics: The influence of lncRNA MALAT1","volume":"254","author":"Mohan","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2174\/1570161118666200317153124","article-title":"LncRNA MALAT1 Enhances ox-LDL-Induced Autophagy through the SIRT1\/MAPK\/NF-\u03baB Pathway in Macrophages","volume":"18","author":"Yang","year":"2020","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneuroim.2018.11.013","article-title":"Malat1 long noncoding RNA regulates inflammation and leukocyte differentiation in experimental autoimmune encephalomyelitis","volume":"328","author":"Masoumi","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Wu, J., Zhang, H., Zheng, Y., Jin, X., Liu, M., Li, S., Zhao, Q., Liu, X., Wang, Y., and Shi, M. (2018). The Long Noncoding RNA MALAT1 Induces Tolerogenic Dendritic Cells and Regulatory T Cells via miR155\/Dendritic Cell-Specific Intercellular Adhesion Molecule-3 Grabbing Nonintegrin\/IL10 Axis. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01847"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ahmad, I., Naqvi, R.A., Valverde, A., and Naqvi, A.R. (2023). LncRNA MALAT1\/microRNA-30b axis regulates macrophage polarization and function. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1214810"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"RP87900","DOI":"10.7554\/eLife.87900","article-title":"The lncRNA Malat1 inhibits miR-15\/16 to enhance cytotoxic T cell activation and memory cell formation","volume":"12","author":"Wheeler","year":"2023","journal-title":"eLife"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1080\/13880209.2023.2244004","article-title":"Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1\/miR-124-3p axis","volume":"61","author":"Zhao","year":"2023","journal-title":"Pharm. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1242\/jcs.024646","article-title":"Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5)","volume":"121","author":"Hedge","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s10528-021-10179-z","article-title":"Long Non-coding RNA GAS5\/miR-520-3p\/SOCS3 Axis Regulates Inflammatory Response in Lipopolysaccharide-Induced Macrophages","volume":"60","author":"Du","year":"2022","journal-title":"Biochem. Genet."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"106127","DOI":"10.1016\/j.intimp.2019.106127","article-title":"LncRNA GAS5 inhibits Th17 differentiation and alleviates immune thrombocytopenia via promoting the ubiquitination of STAT3","volume":"80","author":"Li","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature19346","article-title":"The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan","volume":"537","author":"Kotzin","year":"2016","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cell.2013.01.015","article-title":"The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-\u03b3 locus","volume":"152","author":"Gomez","year":"2013","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.isci.2018.12.034","article-title":"IFNG-AS1 Enhances Interferon Gamma Production in Human Natural Killer Cells","volume":"11","author":"Stein","year":"2019","journal-title":"iScience"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/ni.2712","article-title":"Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation","volume":"14","author":"Hu","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"11381","DOI":"10.1073\/pnas.1019711108","article-title":"Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex","volume":"108","author":"Sharma","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nri1632","article-title":"NFAT proteins: Key regulators of T-cell development and function","volume":"5","author":"Macian","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"156585","DOI":"10.1016\/j.cyto.2024.156585","article-title":"LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review","volume":"179","author":"Khalilollah","year":"2024","journal-title":"Cytokine"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"120965","DOI":"10.1016\/j.lfs.2022.120965","article-title":"LncRNA MEG3 regulates the interplay between Th17 and treg cells in beh\u00e7et\u2019s disease and systemic lupus erythematosus","volume":"309","author":"Mehana","year":"2022","journal-title":"Life Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s13075-021-02682-w","article-title":"Involvement of lncRNA IL21-AS1 in interleukin-2 and T follicular regulatory cell activation in systemic lupus erythematosus","volume":"23","author":"Hao","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"77400","DOI":"10.18632\/oncotarget.20490","article-title":"Long noncoding RNA MALAT-1 is a novel inflammatory regulator in human systemic lupus erythematosus","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Nappi, F. (2024). Non-Coding RNA-Targeted Therapy: A State-of-the-Art Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073630"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3389\/fimmu.2019.00539","article-title":"Causes and Consequences of miR-150-5p Dysregulation in Myasthenia Gravis","volume":"10","author":"Cron","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/acn3.24","article-title":"Circulating miRNAs in myasthenia gravis: miR-150-5p as a new potential biomarker","volume":"1","author":"Punga","year":"2014","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jns.2015.06.019","article-title":"Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients","volume":"356","author":"Punga","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1212\/NXI.0000000000000450","article-title":"Thymectomy lowers the myasthenia gravis biomarker miR-150-5p","volume":"5","author":"Molin","year":"2018","journal-title":"Neurol Neuroimmunol. Neuroinflamm."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jneuroim.2018.05.003","article-title":"Circulating microRNA miR-21-5p, miR-150-5p and miR-30e-5p correlate with clinical status in late onset myasthenia gravis","volume":"321","author":"Sabre","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/acn3.692","article-title":"miR-30e-5p as predictor of generalization in ocular myasthenia gravis","volume":"6","author":"Sabre","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.autrev.2018.01.008","article-title":"Analysis of microRNA expression in the thymus of Myasthenia Gravis patients opens new research avenues","volume":"17","author":"Cron","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.imlet.2016.02.005","article-title":"Altered expression of miR-125a-5p in thymoma-associated myasthenia gravis and its down-regulation of foxp3 expression in Jurkat cells","volume":"172","author":"Li","year":"2016","journal-title":"Immunol. Lett."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jneuroim.2018.03.021","article-title":"miR-548k regulates CXCL13 expression in myasthenia gravis patients with thymic hyperplasia and in Jurkat cells","volume":"320","author":"Li","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Bortone, F., Scandiffio, L., Marcuzzo, S., Bonanno, S., Frangiamore, R., Motta, T., Antozzi, C., Mantegazza, R., Cavalcante, P., and Bernasconi, P. (2020). miR-146a in Myasthenia Gravis Thymus Bridges Innate Immunity With Autoimmunity and Is Linked to Therapeutic Effects of Corticosteroids. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00142"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.imbio.2012.06.013","article-title":"Autoimmune regulator (Aire) controls the expression of microRNAs in medullary thymic epithelial cells","volume":"218","author":"Macedo","year":"2013","journal-title":"Immunobiology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jneuroim.2015.08.013","article-title":"Aberrant decrease of microRNA19b regulates TSLP expression and contributes to Th17 cells development in myasthenia gravis related thymomas","volume":"288","author":"Wang","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Xin, Y., Cai, H., Lu, T., Zhang, Y., Yang, Y., and Cui, Y. (2016). miR-20b Inhibits T Cell Proliferation and Activation via NFAT Signaling Pathway in Thymoma-Associated Myasthenia Gravis. BioMed Res. Int., 2016.","DOI":"10.1155\/2016\/9595718"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Nogales-Gadea, G., Ramos-Fransi, A., Su\u00e1rez-Calvet, X., Navas, M., Rojas-Garc\u00eda, R., Mosquera, J.L., D\u00edaz-Manera, J., Querol, L., Gallardo, E., and Illa, I. (2014). Analysis of serum miRNA profiles of myasthenia gravis patients. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0091927"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1684\/ecn.2015.0367","article-title":"Disease-specific signature of serum miR-20b and its targets IL-8 and IL-25, in myasthenia gravis patients","volume":"26","author":"Nie","year":"2015","journal-title":"Eur. Cytokine Netw."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.intimp.2012.07.003","article-title":"Altered let-7 expression in Myasthenia gravis and let-7c mediated regulation of IL-10 by directly targeting IL-10 in Jurkat cells","volume":"14","author":"Jiang","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10875-012-9834-5","article-title":"MiR-320a is downregulated in patients with myasthenia gravis and modulates inflammatory cytokines production by targeting mitogen-activated protein kinase 1","volume":"33","author":"Cheng","year":"2013","journal-title":"J. Clin. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s11481-013-9498-9","article-title":"Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: Down-regulated miR-145 promotes pathogenetic Th17 cell response","volume":"8","author":"Wang","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.imbio.2016.06.012","article-title":"A novel infection- and inflammation-associated molecular signature in peripheral blood of myasthenia gravis patients","volume":"221","author":"Barzago","year":"2016","journal-title":"Immunobiology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10238-015-0358-1","article-title":"Decreased microRNA miR-181c expression in peripheral blood mononuclear cells correlates with elevated serum levels of IL-7 and IL-17 in patients with myasthenia gravis","volume":"16","author":"Zhang","year":"2016","journal-title":"Clin. Exp. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.clim.2015.12.009","article-title":"MiR-15a contributes abnormal immune response in myasthenia gravis by targeting CXCL10","volume":"164","author":"Liu","year":"2016","journal-title":"Clin. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevEukaryotGeneExpr.2021037369","article-title":"Differential Expression of miRNA in the Peripheral Blood Mononuclear Cells in Myasthenia Gravis with Muscle-Specific Receptor Tyrosine Kinase Antibodies","volume":"31","author":"Tan","year":"2021","journal-title":"Crit. Rev.\u2122 Eukaryot. Gene Expr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jneuroim.2016.01.003","article-title":"Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis","volume":"292","author":"Punga","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Taheri, M., Barth, D.A., Kargl, J., Rezaei, O., Ghafouri-Fard, S., and Pichler, M. (2021). Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.756042"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/mus.27233","article-title":"Short-term effect of low-dose rituximab on myasthenia gravis with muscle-specific tyrosine kinase antibody","volume":"63","author":"Zhou","year":"2021","journal-title":"Muscle Nerve"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneuroim.2018.10.003","article-title":"Circulating microRNA plasma profile in MuSK+ myasthenia gravis","volume":"325","author":"Sabre","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ana.21628","article-title":"CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia","volume":"66","author":"Ruhlmann","year":"2009","journal-title":"Ann. Neurol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1474-4422(18)30392-2","article-title":"Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial","volume":"18","author":"Wolfe","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1084\/jem.20142384","article-title":"Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1beta","volume":"212","author":"Kim","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Sengupta, M., Wang, B.D., Lee, N.H., Marx, A., Kusner, L.L., and Kaminski, H.J. (2018). MicroRNA and mRNA expression associated with ectopic germinal centers in thymus of myasthenia gravis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0205464"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1182\/blood-2005-06-2383","article-title":"The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis","volume":"108","author":"Meraouna","year":"2006","journal-title":"Blood"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/ejcts\/ezs663","article-title":"Thymoma and the increased risk of developing extrathymic malignancies: A multicentre study","volume":"44","author":"Filosso","year":"2013","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.autrev.2015.09.005","article-title":"Thymoma associated with autoimmune diseases: 85 cases and literature review","volume":"15","author":"Bernard","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Rosai, J., and Sobin, L.H. (1999). Histological Typing of Tumors of the Thymus, World Health Organization, International Histological Classification of Tumors, Springer. [2nd ed.].","DOI":"10.1007\/978-3-642-60157-6"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11748-007-0185-8","article-title":"Immunological function of thymoma and pathogenesis of paraneoplastic myasthenia gravis","volume":"56","author":"Okumura","year":"2008","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.4049\/jimmunol.1303488","article-title":"miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting ROR\u03b3t and STAT3","volume":"192","author":"Zhu","year":"2014","journal-title":"J. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0165-5728(96)00152-X","article-title":"Tumor necrosis factor-alpha, lymphotoxin, interleukin (IL)-6, IL-10, IL-12 and perforin mRNA expression in mononuclear cells in response to acetylcholine receptor is augmented in Myasthenia gravis","volume":"71","author":"Matusevicius","year":"1996","journal-title":"J. Neuroimmunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1365-2249.1999.01062.x","article-title":"Increased levels of circulating acetylcholine receptor (AChR)-reactive IL-10-secreting cells are characteristic for Myasthenia gravis (MG)","volume":"118","author":"Huang","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/postmj\/qgae015","article-title":"Small extracellular vesicle microRNAs in pediatric myasthenia gravis plasma and skeletal muscle","volume":"100","author":"Zhu","year":"2024","journal-title":"Postgrad. Med. J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1038\/onc.2014.274","article-title":"MiR-181 family: Regulators of myeloid differentiation and acute myeloid leukemia as well as potential therapeutic targets","volume":"34","author":"Su","year":"2015","journal-title":"Oncogene"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12979-021-00240-1","article-title":"miR-181a-regulated pathways in T-cell differentiation and aging","volume":"18","author":"Kim","year":"2021","journal-title":"Immun. Ageing"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5507\/bp.2019.009","article-title":"Upregulation of miR150-5p in generalized myasthenia gravis patients is associated with decreased serum levels of IL-17 and increased serum levels of IL-10","volume":"164","author":"Ao","year":"2020","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/WNO.0000000000000350","article-title":"Ocular Myasthenia Gravis: Toward a Risk of Generalization Score and Sample Size Calculation for a Randomized Controlled Trial of Disease Modification","volume":"36","author":"Wong","year":"2016","journal-title":"J. Neuroophthalmol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/mus.28177","article-title":"Short-term changes in serum miRNA levels and patient-reported clinical outcomes in myasthenia gravis","volume":"70","author":"Huang","year":"2024","journal-title":"Muscle Nerve"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.canlet.2018.07.027","article-title":"Recent findings regarding let-7 in immunity","volume":"434","author":"Jiang","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF03262205","article-title":"The clinico-pathologic role of microRNAs miR-9 and miR-151-5p in breast cancer metastasis","volume":"16","author":"Krell","year":"2012","journal-title":"Mol. Diagn. Ther."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13046-021-02233-w","article-title":"MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer","volume":"41","author":"Ferri","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_126","first-page":"6511","article-title":"MiRNA-210: A Current Overview","volume":"37","author":"Bavelloni","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1038\/emboj.2008.172","article-title":"Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells","volume":"27","author":"Ferretti","year":"2008","journal-title":"EMBO J."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Fernandes, J.C.R., Acu\u00f1a, S.M., Aoki, J.I., Floeter-Winter, L.M., and Muxel, S.M. (2019). Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease. Non-Coding RNA, 5.","DOI":"10.3390\/ncrna5010017"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/1440-1681.13280","article-title":"LncRNA XLOC_003810 modulates thymic Th17\/Treg balance in myasthenia gravis with thymoma","volume":"47","author":"Niu","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e12886","DOI":"10.1111\/sji.12886","article-title":"LncRNA XLOC_003810 promotes T cell activation and inhibits PD-1\/PD-L1 expression in patients with myasthenia gravis-related thymoma","volume":"92","author":"Hu","year":"2020","journal-title":"Scand. J. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/1759-7714.14201","article-title":"LncRNA and mRNA Expression Associated with Myasthenia Gravis in Patients with Thymoma","volume":"13","author":"Ke","year":"2022","journal-title":"Thorac. Cancer"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Wang, F., Zhang, H., Qiu, G., Li, Z., and Wang, Y. (2022). The LINC00452\/miR-204\/CHST4 Axis Regulating Thymic Tregs Might Be Involved in the Progression of Thymoma-Associated Myasthenia Gravis. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.828970"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Luo, Z., Li, Y., Liu, X., Luo, M., Xu, L., Luo, Y., Xiao, B., and Yang, H. (2015). Systems biology of myasthenia gravis, integration of aberrant lncRNA and mRNA expression changes. BMC Med. Genom., 8.","DOI":"10.1186\/s12920-015-0087-z"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jneuroim.2016.09.005","article-title":"Expression profile of long noncoding RNAs and mRNAs in peripheral blood mononuclear cells from myasthenia gravis patients","volume":"299","author":"Zhang","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.clim.2017.08.008","article-title":"IFNA-AS1 regulates CD4+ T cell activation in myasthenia gravis though HLA-DRB1","volume":"183","author":"Luo","year":"2017","journal-title":"Clin. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1002\/jcb.27838","article-title":"The long noncoding RNA MALAT-1 functions as a competing endogenous RNA to regulate MSL2 expression by sponging miR-338-3p in myasthenia gravis","volume":"120","author":"Kong","year":"2019","journal-title":"J. Cell Biochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e2457","DOI":"10.1002\/brb3.2457","article-title":"LncRNA GAS5 positively regulates IL-10 expression in patients with generalized myasthenia gravis","volume":"12","author":"Peng","year":"2022","journal-title":"Brain Behav."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3000605211053703","DOI":"10.1177\/03000605211053703","article-title":"Long non-coding RNA growth arrest specific 5 regulates the T helper 17\/regulatory T balance by targeting miR-23a in myasthenia gravis","volume":"50","author":"Xu","year":"2022","journal-title":"J. Int. Med. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.omtn.2020.01.005","article-title":"Identification of the Regulatory Role of lncRNA SNHG16 in Myasthenia Gravis by Constructing a Competing Endogenous RNA Network","volume":"19","author":"Wang","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1186\/s12967-021-03138-0","article-title":"Identification of the regulatory role of lncRNA HCG18 in myasthenia gravis by integrated bioinformatics and experimental analyses","volume":"19","author":"Li","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e23722","DOI":"10.1002\/jcla.23722","article-title":"Expression profiling and bioinformatics analysis of exosomal long noncoding RNAs in patients with myasthenia gravis by RNA sequencing","volume":"35","author":"Lu","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"12422","DOI":"10.1073\/pnas.1821116116","article-title":"Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection","volume":"116","author":"Zheng","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e13454","DOI":"10.7717\/peerj.13454","article-title":"LncRNA OIP5-AS1 modulates the proliferation and apoptosis of Jurkat cells by sponging miR-181c-5p to regulate IL-7 expression in myasthenia gravis","volume":"10","author":"Wang","year":"2022","journal-title":"PeerJ"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Wang, T., Xu, S., Zhang, H., Lu, X., Li, S., Liu, L., Kong, X., Gao, H., Wang, X., and Ning, S. (2021). Competitive endogenous RNA network and pathway-based analysis of LncRNA single-nucleotide polymorphism in myasthenia gravis. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-03357-x"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/23808993.2020.1804865","article-title":"Pharmacogenetic and pharmaco-miR biomarkers for tailoring and monitoring myasthenia gravis treatments","volume":"5","author":"Cavalcante","year":"2020","journal-title":"Expert Rev. Precis. Med. Drug Dev."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/bib\/bbs082","article-title":"Pharmaco-miR: Linking microRNAs and drug effects","volume":"15","author":"Rukov","year":"2014","journal-title":"Brief. Bioinform."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"104388","DOI":"10.1016\/j.phrs.2019.104388","article-title":"MicroRNA signature associated with treatment response in myasthenia gravis: A further step towards precision medicine","volume":"148","author":"Cavalcante","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41419-022-05075-2","article-title":"RNA-based therapeutics: An overview and prospectus","volume":"13","author":"Zhu","year":"2022","journal-title":"Cell Death Dis."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/18\/1550\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:56:21Z","timestamp":1760111781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/18\/1550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,14]]},"references-count":149,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["cells13181550"],"URL":"https:\/\/doi.org\/10.3390\/cells13181550","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,14]]}}}