{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:31:59Z","timestamp":1789543919233,"version":"build-2803163510"},"reference-count":151,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of General Medical Sciences (NIGMS)","award":["P20 GM109005"],"award-info":[{"award-number":["P20 GM109005"]}]},{"name":"National Institute of General Medical Sciences (NIGMS)","award":["5U01AI170039"],"award-info":[{"award-number":["5U01AI170039"]}]},{"name":"National Institute of General Medical Sciences (NIGMS)","award":["80NSSC21M0323"],"award-info":[{"award-number":["80NSSC21M0323"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID)","award":["P20 GM109005"],"award-info":[{"award-number":["P20 GM109005"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID)","award":["5U01AI170039"],"award-info":[{"award-number":["5U01AI170039"]}]},{"name":"National Institute of Allergy and Infectious Diseases (NIAID)","award":["80NSSC21M0323"],"award-info":[{"award-number":["80NSSC21M0323"]}]},{"name":"NASA-EPSCoR","award":["P20 GM109005"],"award-info":[{"award-number":["P20 GM109005"]}]},{"name":"NASA-EPSCoR","award":["5U01AI170039"],"award-info":[{"award-number":["5U01AI170039"]}]},{"name":"NASA-EPSCoR","award":["80NSSC21M0323"],"award-info":[{"award-number":["80NSSC21M0323"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Highly conformal delivery of radiation therapy (RT) has revolutionized the treatment landscape for primary and metastatic liver cancers, yet concerns persist regarding radiation-induced liver disease (RILD). Despite advancements, RILD remains a major dose-limiting factor due to the potential damage to normal liver tissues by therapeutic radiation. The toxicity to normal liver tissues is associated with a multitude of physiological and pathological consequences. RILD unfolds as multifaceted processes, intricately linking various responses, such as DNA damage, oxidative stress, inflammation, cellular senescence, fibrosis, and immune reactions, through multiple signaling pathways. The DNA damage caused by ionizing radiation (IR) is a major contributor to the pathogenesis of RILD. Moreover, current treatment options for RILD are limited, with no established biomarker for early detection. RILD diagnosis often occurs at advanced stages, highlighting the critical need for early biomarkers to adjust treatment strategies and prevent liver failure. This review provides an outline of the diverse molecular and cellular mechanisms responsible for the development of RILD and points out all of the available biomarkers for early detection with the aim of helping clinicians decide on advance treatment strategies from a single literature recourse.<\/jats:p>","DOI":"10.3390\/cells13181560","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T10:56:57Z","timestamp":1726484217000},"page":"1560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Current Insights into Molecular Mechanisms and Potential Biomarkers for Treating Radiation-Induced Liver Damage"],"prefix":"10.3390","volume":"13","author":[{"given":"Biki","family":"Saha","sequence":"first","affiliation":[{"name":"Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai 603103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5649-1597","authenticated-orcid":false,"given":"Sneha","family":"Pallatt","sequence":"additional","affiliation":[{"name":"Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai 603103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antara","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai 603103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-1968","authenticated-orcid":false,"given":"Abhijit G.","family":"Banerjee","sequence":"additional","affiliation":[{"name":"R&D, Genomic Bio-Medicine Research and Incubation (GBMRI), Durg 491001, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6239-301X","authenticated-orcid":false,"given":"Rupak","family":"Pathak","sequence":"additional","affiliation":[{"name":"Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit","family":"Pathak","sequence":"additional","affiliation":[{"name":"Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai 603103, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1053\/j.gastro.2020.02.068","article-title":"Global Burden of 5 Major Types of Gastrointestinal Cancer","volume":"159","author":"Arnold","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3350\/cmh.2021.0395","article-title":"Hepatocellular carcinoma incidence is decreasing in Korea but increasing in the very elderly","volume":"29","author":"Chon","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jhep.2022.08.021","article-title":"Global burden of primary liver cancer in 2020 and predictions to 2040","volume":"77","author":"Rumgay","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3350\/cmh.2023.0070","article-title":"The latest global burden of liver cancer: A past and present threat","volume":"29","author":"Oh","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.3748\/wjg.v20.i15.4115","article-title":"Hepatocellular carcinoma review: Current treatment, and evidence-based medicine","volume":"20","author":"Raza","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrgastro.2012.199","article-title":"Medical therapies for hepatocellular carcinoma: A critical view of the evidence","volume":"10","author":"Villanueva","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/cncr.21811","article-title":"Radiation therapy for hepatocellular carcinoma","volume":"106","author":"Hawkins","year":"2006","journal-title":"Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/cncr.21324","article-title":"The role of radiotherapy in cancer treatment","volume":"104","author":"Delaney","year":"2005","journal-title":"Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3857\/roj.2023.00353","article-title":"Radiotherapy trend in elderly hepatocellular carcinoma: Retrospective analysis of patients diagnosed between 2005 and 2017","volume":"41","author":"Bae","year":"2023","journal-title":"Radiat. Oncol. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e12916","DOI":"10.1111\/sji.12916","article-title":"Irradiated and CCl4-treated bone marrow-derived liver macrophages exhibit different gene expression patterns and phenotypes","volume":"92","author":"Fan","year":"2020","journal-title":"Scand. J. Immunol."},{"key":"ref_11","first-page":"3395","article-title":"Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects (Review)","volume":"15","author":"Xiao","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"i40","DOI":"10.1093\/jrr\/rrx104","article-title":"Strategies for prediction and mitigation of radiation-induced liver toxicity","volume":"59","author":"Toesca","year":"2018","journal-title":"J. Radiat. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3904\/kjim.2016.412","article-title":"Clinical significance of radiation-induced liver disease after stereotactic body radiation therapy for hepatocellular carcinoma","volume":"33","author":"Jun","year":"2018","journal-title":"Korean J. Intern. Med."},{"key":"ref_14","first-page":"200","article-title":"Radiation Hepatitis","volume":"93","author":"Ingold","year":"1965","journal-title":"Am. J. Roentgenol. Radium Ther. Nucl. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Obrador, E., Salvador-Palmer, R., Villaescusa, J.I., Gallego, E., Pellicer, B., Estrela, J.M., and Montoro, A. (2022). Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry. Antioxidants, 11.","DOI":"10.3390\/antiox11061098"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/0016-5085(80)90911-7","article-title":"An analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantation","volume":"79","author":"Shulman","year":"1980","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yexmp.2014.12.008","article-title":"Evaluation of the effects of preconditioning regimens on hepatic veno-occlusive disease in mice after hematopoietic stem cell transplantation","volume":"98","author":"Qiao","year":"2015","journal-title":"Exp. Mol. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/15384101.2022.2131163","article-title":"Radiation-induced liver disease: Beyond DNA damage","volume":"22","author":"Zhou","year":"2022","journal-title":"Cell Cycle"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.radonc.2004.07.001","article-title":"Irradiation leads to susceptibility of hepatocytes to TNF-\u03b1 mediated apoptosis","volume":"72","author":"Christiansen","year":"2004","journal-title":"Radiother. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.ijrobp.2009.09.063","article-title":"Inactivation of Kupffer Cells by Gadolinium Chloride Protects Murine Liver From Radiation-Induced Apoptosis","volume":"76","author":"Du","year":"2010","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/hep.22573","article-title":"Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation","volume":"49","author":"Yamanouchi","year":"2008","journal-title":"Hepatology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijrobp.2008.04.035","article-title":"Radiotherapeutic Parameters Predictive of Liver Complications Induced by Liver Tumor Radiotherapy","volume":"73","author":"Lee","year":"2009","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jnci.2015.08.001","article-title":"Radiation induced liver disease: A clinical update","volume":"28","author":"Benson","year":"2016","journal-title":"J. Egypt. Natl. Cancer Inst."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1200\/JCO.2008.18.2931","article-title":"Radiation-Induced Liver Disease","volume":"26","author":"Khozouz","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.semradonc.2011.05.003","article-title":"Hepatic Radiation Toxicity: Avoidance and Amelioration","volume":"21","author":"Guha","year":"2011","journal-title":"Semin. Radiat. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.ijrobp.2009.06.092","article-title":"Radiation-Associated Liver Injury","volume":"76","author":"Pan","year":"2010","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/0360-3016(94)00418-K","article-title":"Hepatic toxicity resulting from cancer treatment","volume":"31","author":"Lawrence","year":"1995","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.radonc.2010.10.014","article-title":"Dosimetric predictor identification for radiation-induced liver disease after hypofractionated conformal radiotherapy for primary liver carcinoma patients with Child-Pugh Grade A cirrhosis","volume":"98","author":"Liang","year":"2011","journal-title":"Radiother. Oncol."},{"key":"ref_29","first-page":"240","article-title":"Hepatic Injury Following Irradiation\u2014A Morphologic Study","volume":"10","author":"Ogata","year":"1963","journal-title":"Tokushima J. Exp. Med."},{"key":"ref_30","first-page":"597","article-title":"The human liver after radiation injury. A form of veno-occlusive disease","volume":"48","author":"Reed","year":"1966","journal-title":"Am. J. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/hep.510260117","article-title":"Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: Activation of hepatic stellate cells as an early event","volume":"26","author":"Sempoux","year":"1997","journal-title":"Hepatology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.ijrobp.2004.05.048","article-title":"Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease","volume":"60","author":"Cheng","year":"2004","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1158\/1078-0432.CCR-06-2459","article-title":"Radiation-Induced Hepatitis B Virus Reactivation in Liver Mediated by the Bystander Effect from Irradiated Endothelial Cells","volume":"13","author":"Chou","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_34","first-page":"5871","article-title":"Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation","volume":"59","author":"Guha","year":"1999","journal-title":"Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pbiomolbio.2021.06.012","article-title":"The biological effects of radiation-induced liver damage and its natural protective medicine","volume":"167","author":"Li","year":"2021","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e359","DOI":"10.1038\/emm.2017.85","article-title":"Radiation-induced liver disease: Current understanding and future perspectives","volume":"49","author":"Kim","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2307\/3577586","article-title":"Transforming growth factor-beta 1 expression in irradiated liver","volume":"122","author":"Anscher","year":"1990","journal-title":"Radiat. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1136\/gut.2009.204354","article-title":"Signals from dying hepatocytes trigger growth of liver progenitors","volume":"59","author":"Jung","year":"2010","journal-title":"Gut"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Verdelho Machado, M., and Diehl, A.M. (2016). Role of Hedgehog Signaling Pathway in NASH. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17060857"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1667\/RR3091.1","article-title":"Hedgehog Signaling Regulates the Repair Response in Mouse Liver Damaged by Irradiation","volume":"179","author":"Wang","year":"2013","journal-title":"Radiat. Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wang, S., Lee, Y., Kim, J., Hyun, J., Lee, K., Kim, Y., and Jung, Y. (2013). Potential Role of Hedgehog Pathway in Liver Response to Radiation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074141"},{"key":"ref_42","first-page":"1275","article-title":"Study on the association between TGF-\u03b21 and liver fibrosis in patients with hepatic cystic echinococcosis","volume":"19","author":"Tian","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0360-3016(99)00401-0","article-title":"Early alteration in TGF-\u03b2 mRNA expression in irradiated rat liver","volume":"46","author":"Seong","year":"2000","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1269\/jrr.08075","article-title":"High LET Heavy Ion Radiation Induces p53-Independent Apoptosis","volume":"50","author":"Mori","year":"2009","journal-title":"J. Radiat. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mrfmmm.2010.10.009","article-title":"Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to X-rays","volume":"706","author":"Wang","year":"2011","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1667\/RR1324.1","article-title":"Bystander\/Abscopal Effects Induced in Intact Arabidopsis Seeds by Low-Energy Heavy-Ion Radiation","volume":"170","author":"Yang","year":"2008","journal-title":"Radiat. Res."},{"key":"ref_47","first-page":"49","article-title":"Biochemistry of Nitric Oxide and Peroxynitrite: Sources, Targets and Biological Implications","volume":"16","author":"Gelpi","year":"2016","journal-title":"Biochemistry of Oxidative Stress. Advances in Biochemistry in Health and Disease"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Chatzipapas, K.P., Papadimitroulas, P., Emfietzoglou, D., Kalospyros, S.A., Hada, M., Georgakilas, A.G., and Kagadis, G.C. (2020). Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations. Cancers, 12.","DOI":"10.3390\/cancers12040799"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2174\/1389557518666181015151350","article-title":"Radicals, Oxidative\/Nitrosative Stress and Preeclampsia","volume":"19","author":"Taysi","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.2174\/1389557522666220104151225","article-title":"Thymoquinone: A Review on its Pharmacological Importance, and its Association with Oxidative Stress, COVID-19, and Radiotherapy","volume":"22","author":"Taysi","year":"2022","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Mar\u00e9chal, A., and Zou, L. (2013). DNA Damage Sensing by the ATM and ATR Kinases. Cold Spring Harb. Perspect. Biol., 5.","DOI":"10.1101\/cshperspect.a012716"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2174\/092986709787002790","article-title":"Inflammation and Chronic Oxidative Stress in Radiation-Induced Late Normal Tissue Injury: Therapeutic Implications","volume":"16","author":"Zhao","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-med-081313-121208","article-title":"The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy","volume":"66","author":"Goldstein","year":"2015","journal-title":"Annu. Rev. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1269\/jrr.10039","article-title":"Involvement of DNA-PK and ATM in Radiation- and Heat-induced DNA Damage Recognition and Apoptotic Cell Death","volume":"51","author":"Tomita","year":"2010","journal-title":"J. Radiat. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1038\/sj.onc.1206701","article-title":"MAPK pathways in radiation responses","volume":"22","author":"Dent","year":"2003","journal-title":"Oncogene"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4161\/cc.10.3.14713","article-title":"ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks","volume":"10","author":"Khalil","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.febslet.2011.05.013","article-title":"Beyond ATM: The protein kinase landscape of the DNA damage response","volume":"585","author":"Bensimon","year":"2011","journal-title":"FEBS Lett."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1667\/RR14781.1","article-title":"Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation","volume":"189","author":"Nagane","year":"2018","journal-title":"Radiat. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/stem.125","article-title":"Loss of ATM Impairs Proliferation of Neural Stem Cells Through Oxidative Stress-Mediated p38 MAPK Signaling","volume":"27","author":"Kim","year":"2009","journal-title":"Stem Cells"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1474-9726.2010.00567.x","article-title":"Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status","volume":"9","author":"Le","year":"2010","journal-title":"Aging Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"876","DOI":"10.3109\/09553002.2014.922714","article-title":"Hepatocyte senescence induced by radiation and partial hepatectomy in rat liver","volume":"90","author":"Serra","year":"2014","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41420-021-00634-6","article-title":"Radiation-induced liver injury and hepatocyte senescence","volume":"7","author":"Zhu","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1667\/RR1948.1","article-title":"Novel Synthetic SOD\/Catalase Mimetics Can Mitigate Capillary Endothelial Cell Apoptosis Caused by Ionizing Radiation","volume":"173","author":"Vorotnikova","year":"2010","journal-title":"Radiat. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2011.12.012","article-title":"Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury","volume":"327","author":"Azzam","year":"2012","journal-title":"Cancer Lett."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/rpd\/ncr277","article-title":"Radiation dose measurement in gastrointestinal studies","volume":"147","author":"Sulieman","year":"2011","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3109\/09553002.2014.930536","article-title":"Effect of ionizing radiation on liver protein oxidation and metabolic function in C57BL\/6J mice","volume":"90","author":"Tipton","year":"2014","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1089\/ars.2012.5091","article-title":"Superoxide Mediates Acute Liver Injury in Irradiated Mice Lacking Sirtuin 3","volume":"20","author":"Coleman","year":"2014","journal-title":"Antiox. Redox Signal."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jgr.2016.02.006","article-title":"Panax ginseng Meyer prevents radiation-induced liver injury via modulation of oxidative stress and apoptosis","volume":"41","author":"Kim","year":"2016","journal-title":"J. Ginseng Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3109\/10715762.2012.684245","article-title":"Epicatechin ameliorates ionising radiation-induced oxidative stress in mouse liver","volume":"46","author":"Sinha","year":"2012","journal-title":"Free. Radic. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.redox.2017.09.009","article-title":"Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration","volume":"14","author":"Bartesaghi","year":"2017","journal-title":"Redox Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: A concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.freeradbiomed.2014.01.019","article-title":"Protein and miRNA profiling of radiation-induced skin injury in rats: The protective role of peroxiredoxin-6 against ionizing radiation","volume":"69","author":"Zhang","year":"2014","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/cbin.10627","article-title":"MiRNA expression profile of ionizing radiation-induced liver injury in mouse using deep sequencing","volume":"40","author":"Lu","year":"2016","journal-title":"Cell Biol. Int."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: Biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1089\/dna.2014.2401","article-title":"microRNA Expression and Biogenesis in Cellular Response to Ionizing Radiation","volume":"33","author":"Mao","year":"2014","journal-title":"DNA Cell Biol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Martin, N.T., Nakamura, K., Davies, R., Nahas, S.A., Brown, C., Tunuguntla, R., Gatti, R.A., and Hu, H. (2013). ATM\u2013Dependent MiR-335 Targets CtIP and Modulates the DNA Damage Response. PLOS Genet., 9.","DOI":"10.1371\/journal.pgen.1003505"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/nature05939","article-title":"A microRNA component of the p53 tumour suppressor network","volume":"447","author":"He","year":"2007","journal-title":"Nature"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"10105","DOI":"10.1158\/0008-5472.CAN-08-1846","article-title":"Coordinated Regulation of Cell Cycle Transcripts by p53-Inducible microRNAs, miR-192 and miR-215","volume":"68","author":"Georges","year":"2008","journal-title":"Cancer Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.critrevonc.2016.11.017","article-title":"Emergence of miR-34a in radiation therapy","volume":"109","author":"Lacombe","year":"2016","journal-title":"Crit. Rev. Oncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2407-11-33","article-title":"MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma","volume":"11","author":"Tivnan","year":"2011","journal-title":"BMC Cancer"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-213X-10-20","article-title":"Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: Correlation with embryonic p53 genotype and limb phenotype","volume":"10","author":"Gueta","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.biopha.2018.06.159","article-title":"Thymoquinone: A novel strategy to combat cancer: A review","volume":"106","author":"Imran","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"221","DOI":"10.7150\/ijbs.7.221","article-title":"MiR-34a in Age and Tissue Related Radio-Sensitivity and Serum miR-34a as a Novel Indicator of Radiation Injury","volume":"7","author":"Liu","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Szatm\u00e1ri, T., Hargitai, R., S\u00e1fr\u00e1ny, G., and Lumniczky, K. (2019). Extracellular Vesicles in Modifying the Effects of Ionizing Radiation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225527"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41419-017-0038-z","article-title":"MicroRNA-146a-5p attenuates irradiation-induced and LPS-induced hepatic stellate cell activation and hepatocyte apoptosis through inhibition of TLR4 pathway","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Xu, D., Di, K., Fan, B., Wu, J., Gu, X., Sun, Y., Khan, A., Li, P., and Li, Z. (2022). MicroRNAs in extracellular vesicles: Sorting mechanisms, diagnostic value, isolation, and detection technology. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.948959"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1080\/15476286.2015.1100795","article-title":"Exosome-mediated microRNA transfer plays a role in radiation-induced bystander effect","volume":"12","author":"Xu","year":"2015","journal-title":"RNA Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1091\/mbc.E18-02-0130","article-title":"Extracellular vesicles transfer nuclear Abl-dependent and radiation-induced miR-34c into unirradiated cells to cause bystander effects","volume":"29","author":"Rastogi","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ijrobp.2008.11.029","article-title":"Extrapolation of Normal Tissue Complication Probability for Different Fractionations in Liver Irradiation","volume":"74","author":"Tai","year":"2009","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.freeradbiomed.2013.07.024","article-title":"Effects of ionizing radiation on mitochondria","volume":"65","author":"Kam","year":"2013","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmet.2005.12.001","article-title":"Mitochondrial medicine: A metabolic perspective on the pathology of oxidative phosphorylation disorders","volume":"3","author":"Smeitink","year":"2006","journal-title":"Cell Metab."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"100508","DOI":"10.1016\/j.jhepr.2022.100508","article-title":"A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus","volume":"4","author":"Melin","year":"2022","journal-title":"JHEP Rep."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"LoBianco, F.V., Krager, K.J., Carter, G.S., Alam, S., Yuan, Y., Lavoie, E.G., Dranoff, J.A., and Aykin-Burns, N. (2020). The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury. Antioxidants, 9.","DOI":"10.3390\/antiox9050409"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1128\/MCB.00426-08","article-title":"SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70","volume":"28","author":"Sundaresan","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"291","DOI":"10.7150\/ijbs.4.291","article-title":"SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression","volume":"4","author":"Jacobs","year":"2008","journal-title":"Int. J. Biol. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1089\/ars.2013.5482","article-title":"Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis","volume":"20","author":"Tao","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.molcel.2010.12.013","article-title":"Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress","volume":"40","author":"Tao","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3390\/ijms15010927","article-title":"The Effect of Radiation on the Immune Response to Cancers","volume":"15","author":"Park","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ijrobp.2012.01.011","article-title":"Stimulation of Hepatoma Cell Invasiveness and Metastatic Potential by Proteins Secreted from Irradiated Nonparenchymal Cells","volume":"84","author":"Zhou","year":"2012","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1667\/RR13869.1","article-title":"Radioprotective Effect of Kupffer Cell Depletion on Hepatic Sinusoidal Endothelial Cells","volume":"183","author":"Chen","year":"2015","journal-title":"Radiat. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: The master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Wu, Y., Wang, W., Peng, X.-M., He, Y., Xiong, Y.-X., Liang, H.-F., Chu, L., Zhang, B.-X., Ding, Z.-Y., and Chen, X.-P. (2018). Rapamycin Upregulates Connective Tissue Growth Factor Expression in Hepatic Progenitor Cells Through TGF-\u03b2-Smad2 Dependent Signaling. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00877"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.ijrobp.2010.06.046","article-title":"Radiation-Induced Liver Fibrosis Is Mitigated by Gene Therapy Inhibiting Transforming Growth Factor-\u03b2 Signaling in the Rat","volume":"78","author":"Du","year":"2010","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"982","DOI":"10.15252\/embr.201438463","article-title":"Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming","volume":"15","author":"Allam","year":"2014","journal-title":"Embo Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/nsr\/nwt025","article-title":"Apoptosome and inflammasome: Conserved machineries for caspase activation","volume":"1","author":"Chai","year":"2014","journal-title":"Natl. Sci. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Ha, C.T., Li, X.-H., Fu, D., Moroni, M., Fisher, C., Arnott, R., Srinivasan, V., and Xiao, M. (2014). Circulating Interleukin-18 as a Biomarker of Total-Body Radiation Exposure in Mice, Minipigs, and Nonhuman Primates (NHP). PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109249"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.coi.2007.09.002","article-title":"The inflammasome: A danger sensing complex triggering innate immunity","volume":"19","author":"Dostert","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/eji.200940168","article-title":"Signaling by ROS drives inflammasome activation","volume":"40","author":"Martinon","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/cr.2011.20","article-title":"Mitochondrial ROS fuel the inflammasome","volume":"21","author":"Sorbara","year":"2011","journal-title":"Cell Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.immuni.2013.08.004","article-title":"Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing","volume":"39","author":"Gehrke","year":"2013","journal-title":"Immunity"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1755-1536-3-21","article-title":"Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis","volume":"3","author":"Guo","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1667\/RR13630.1","article-title":"TLR4-Dependent Immune Response Promotes Radiation-Induced Liver Disease by Changing the Liver Tissue Interstitial Microenvironment during Liver Cancer Radiotherapy","volume":"182","author":"Yong","year":"2014","journal-title":"Radiat. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12072-010-9219-x","article-title":"The role of lipopolysaccharide\/toll-like receptor 4 signaling in chronic liver diseases","volume":"4","author":"Soares","year":"2010","journal-title":"Hepatol. Int."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00262-013-1504-9","article-title":"TLR4-dependant immune response, but not hepatitis B virus reactivation, is important in radiation-induced liver disease of liver cancer radiotherapy","volume":"63","author":"Wu","year":"2013","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.canlet.2015.02.019","article-title":"The Nuclear Factor \u03baB pathway: A link to the immune system in the radiation response","volume":"368","author":"Hellweg","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jphotobiol.2016.10.029","article-title":"Novel amino acid derivatives bearing thieno[2,3-d]pyrimidine moiety down regulate NF-\u03baB in \u03b3-irradiation mediated rat liver injury","volume":"165","author":"Zaher","year":"2016","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1038\/s41423-020-0395-x","article-title":"DNA sensing and associated type 1 interferon signaling contributes to progression of radiation-induced liver injury","volume":"18","author":"Du","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri.2017.52","article-title":"The non-canonical NF-\u03baB pathway in immunity and inflammation","volume":"17","author":"Sun","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ijbiomac.2014.05.001","article-title":"Astragalus polysaccharide ameliorates ionizing radiation-induced oxidative stress in mice","volume":"68","author":"Liu","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"40568","DOI":"10.18632\/oncotarget.16501","article-title":"Glibenclamide, a diabetic drug, prevents acute radiation-induced liver injury of mice via up-regulating intracellular ROS and subsequently activating Akt-NF-\u03baB pathway","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1465-9921-14-95","article-title":"The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells","volume":"14","author":"Yamada","year":"2013","journal-title":"Respir. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/gut.2004.051169","article-title":"Inhibition of Rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression","volume":"54","author":"Bourgier","year":"2005","journal-title":"Gut"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bbadis.2009.06.004","article-title":"TGF-\u03b2 and fibrosis in different organs\u2014Molecular pathway imprints","volume":"1792","author":"Pohlers","year":"2009","journal-title":"Biochim. Biophys. Acta BBA Mol. Basis Dis."},{"key":"ref_129","first-page":"383","article-title":"Th2-like immune response in radiation-induced lung fibrosis","volume":"26","author":"Xie","year":"2011","journal-title":"Oncol. Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.2174\/13894501113149990198","article-title":"Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis","volume":"14","author":"Ding","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"ref_131","first-page":"584","article-title":"Pathogenesis of veno-occlusive liver disease after radiation","volume":"104","author":"Fajardo","year":"1980","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1182\/blood.V89.6.2184","article-title":"Plasminogen Activator Inhibitor-1 Confirms the Diagnosis of Hepatic Veno-Occlusive Disease in Patients With Hyperbilirubinemia After Bone Marrow Transplantation","volume":"89","author":"Salat","year":"1997","journal-title":"Blood"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/sj.bmt.1703544","article-title":"Impaired activity of plasma von Willebrand factor-cleaving protease may predict the occurrence of hepatic veno-occlusive disease after stem cell transplantation","volume":"29","author":"Park","year":"2002","journal-title":"Bone Marrow Transplant."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1016\/j.ijrobp.2015.07.271","article-title":"High-Serum HGF and Low-Serum CD40L Are Associated With Liver Toxicity After Stereotactic Body Radiation Therapy","volume":"93","author":"Cuneo","year":"2015","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_135","first-page":"229","article-title":"MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects. Food Chem","volume":"110","author":"Lin","year":"2017","journal-title":"Toxicol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Ng, S.S., Jang, G.H., Kurland, I.J., Qiu, Y., Guha, C., and Dawson, L.A. (2020). Plasma metabolomic profiles in liver cancer patients following stereotactic body radiotherapy. EBioMedicine.","DOI":"10.1016\/j.ebiom.2020.102973"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ijrobp.2005.12.031","article-title":"Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: The risk factors and hepatic radiation tolerance","volume":"65","author":"Liang","year":"2006","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/0360-3016(89)90530-0","article-title":"194 Hepatocellular cancers treated by radiation and chemotherapy combinations: Toxicity and response: A radiation therapy oncology group study","volume":"17","author":"Stillwagon","year":"1989","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40364-024-00601-0","article-title":"FGL1 and FGL2: Emerging regulators of liver health and disease","volume":"12","author":"Chen","year":"2024","journal-title":"Biomark. Res."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Han, N.-K., Jung, M.G., Jeong, Y.J., Son, Y., Han, S.C., Park, S., Lim, Y.-B., Lee, Y.-J., Kim, S.-H., and Park, S.C. (2019). Plasma Fibrinogen-Like 1 as a Potential Biomarker for Radiation-Induced Liver Injury. Cells, 8.","DOI":"10.3390\/cells8091042"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0168-8278(03)00296-4","article-title":"Quantitative liver-spleen scan using single photon emission computerized tomography (SPECT) for assessment of hepatic function in cirrhotic patients","volume":"39","author":"Zuckerman","year":"2003","journal-title":"J. Hepatol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"100498","DOI":"10.1016\/j.jhepr.2022.100498","article-title":"Stereotactic body radiation therapy for hepatocellular carcinoma: From infancy to ongoing maturity","volume":"4","author":"Lewis","year":"2022","journal-title":"JHEP Rep."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13550-016-0212-9","article-title":"Measuring total liver function on sulfur colloid SPECT\/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients","volume":"6","author":"Bowen","year":"2016","journal-title":"EJNMMI Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijrobp.2007.05.078","article-title":"Liver Function After Irradiation Based on Computed Tomographic Portal Vein Perfusion Imaging","volume":"70","author":"Cao","year":"2008","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijrobp.2012.02.037","article-title":"Prediction of Liver Function by Using Magnetic Resonance-based Portal Venous Perfusion Imaging","volume":"85","author":"Cao","year":"2013","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Kurland, I.J., Broin, P., Golden, A., Su, G., Meng, F., Liu, L., Mohney, R., Kulkarni, S., and Guha, C. (2015). Integrative Metabolic Signatures for Hepatic Radiation Injury. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124795"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1118\/1.4953831","article-title":"A mouse radiation-induced liver disease model for stereotactic body radiation therapy validated in patients with hepatocellular carcinoma","volume":"43","author":"Wu","year":"2016","journal-title":"Med. Phys."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.tranon.2019.04.003","article-title":"Serum Levels of Hepatocyte Growth Factor and CD40 Ligand Predict Radiation-Induced Liver Injury","volume":"12","author":"Cuneo","year":"2019","journal-title":"Transl. Oncol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00534-004-0965-9","article-title":"Assessment of hepatic reserve for indication of hepatic resection: Decision tree incorporating indocyanine green test","volume":"12","author":"Imamura","year":"2005","journal-title":"J. Hepato Biliary Pancreat. Surg."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.radonc.2015.04.011","article-title":"Differential hepatic avoidance radiation therapy: Proof of concept in hepatocellular carcinoma patients","volume":"115","author":"Bowen","year":"2015","journal-title":"Radiother. Oncol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijrobp.2015.09.044","article-title":"Local and Global Function Model of the Liver","volume":"94","author":"Wang","year":"2015","journal-title":"Int. J. Radiat. Oncol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/18\/1560\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:57:35Z","timestamp":1760111855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/18\/1560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":151,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["cells13181560"],"URL":"https:\/\/doi.org\/10.3390\/cells13181560","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]}}}