{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:07:25Z","timestamp":1791907645857,"version":"4.3.4"},"reference-count":287,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss government\u2019s ETH Board of the Swiss Federal Institutes of Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The regulation of energy in the brain has garnered substantial attention in recent years due to its significant implications in various disorders and aging. The brain\u2019s energy metabolism is a dynamic and tightly regulated network that balances energy demand and supply by engaging complementary molecular pathways. The crosstalk among these pathways enables the system to switch its preferred fuel source based on substrate availability, activity levels, and cell state-related factors such as redox balance. Brain energy production relies on multi-cellular cooperation and is continuously supplied by fuel from the blood due to limited internal energy stores. Astrocytes, which interface with neurons and blood vessels, play a crucial role in coordinating the brain\u2019s metabolic activity, and their dysfunction can have detrimental effects on brain health. This review characterizes the major energy substrates (glucose, lactate, glycogen, ketones and lipids) in astrocyte metabolism and their role in brain health, focusing on recent developments in the field.<\/jats:p>","DOI":"10.3390\/cells13201714","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T08:56:32Z","timestamp":1729155392000},"page":"1714","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-1732","authenticated-orcid":false,"given":"Polina","family":"Shichkova","sequence":"first","affiliation":[{"name":"Blue Brain Project, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1202 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2270-1989","authenticated-orcid":false,"given":"Jay S.","family":"Coggan","sequence":"additional","affiliation":[{"name":"Blue Brain Project, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1202 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Markram","sequence":"additional","affiliation":[{"name":"Blue Brain Project, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1202 Geneva, Switzerland"},{"name":"Laboratory of Neural Microcircuitry, Brain Mind Institute, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3280-6255","authenticated-orcid":false,"given":"Daniel","family":"Keller","sequence":"additional","affiliation":[{"name":"Blue Brain Project, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, 1202 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease","volume":"96","author":"Iadecola","year":"2017","journal-title":"Neuron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41583-020-0322-2","article-title":"Neuronal Regulation of the Blood\u2013Brain Barrier and Neurovascular Coupling","volume":"21","author":"Kaplan","year":"2020","journal-title":"Nat. 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