{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:52:25Z","timestamp":1793087545426,"version":"4.5.0"},"reference-count":48,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Background: Fibromyalgia (FM) is characterized by chronic pain and a complex array of symptoms, with neuroinflammation implicated in its pathophysiology. Methods: This study aimed to explore the association between neuroinflammation, measured through interleukin levels (IL-1, IL-6, IL-8), and clinical outcomes in FM patients. Using a cross-sectional study design, blood levels of these interleukins were correlated with pain severity and disability, assessed via the Fibromyalgia Impact Questionnaire (FIQ) and pain measures. Results: Results indicated that IL-6 and IL-8 may particularly serve as biomarkers for pain severity and disability in FM patients, showing significant associations with worse clinical outcomes. Elevated IL-8 levels, for instance, correlated strongly with increased pain perception and higher disability scores. Conclusions: These findings suggest that specific interleukins are not only elevated in FM but are actively involved in the modulation of pain and disability, underscoring the role of systemic neuroinflammation in the clinical severity of FM. This study contributes to a deeper understanding of the inflammatory mechanisms in FM and underscores the potential of targeting interleukins in therapeutic strategies.<\/jats:p>","DOI":"10.3390\/cells13201719","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T08:56:32Z","timestamp":1729155392000},"page":"1719","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Association Between Systemic Neuroinflammation, Pain Perception and Clinical Status in Fibromyalgia Patients: Cross-Sectional Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2823-8673","authenticated-orcid":false,"given":"Mar\u00eda Elena","family":"Gonz\u00e1lez-\u00c1lvarez","sequence":"first","affiliation":[{"name":"Escuela Internacional de Doctorado, Rey Juan Carlos University, 28008 Madrid, Spain"},{"name":"Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Rey Juan Carlos University, 28032 Madrid, Spain"},{"name":"Cognitive Neuroscience, Pain, and Rehabilitation Research Group (NECODOR), 28032 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3914-7355","authenticated-orcid":false,"given":"V\u00edctor","family":"Riquelme-Aguado","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences, Rey Juan Carlos University, 28933 Madrid, Spain"},{"name":"Grupo de Investigaci\u00f3n Consolidado de Bases Anat\u00f3micas, Moleculares y del Desarrollo Humano de la Universidad Rey Juan Carlos (GAMDES), 28922 Alcorc\u00f3n, Spain"},{"name":"Fisioterapia Oreka CB, 45200 Illescas, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Gonz\u00e1lez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratorio de An\u00e1lisis Cl\u00ednicos de la Dra. Gonz\u00e1lez P\u00e9rez, 28020 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Murillo-Llergo","sequence":"additional","affiliation":[{"name":"Laboratorio de An\u00e1lisis Cl\u00ednicos de la Dra. Gonz\u00e1lez P\u00e9rez, 28020 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Manj\u00f3n-Olmedillas","sequence":"additional","affiliation":[{"name":"Laboratorio de An\u00e1lisis Cl\u00ednicos de la Dra. 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