{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:49Z","timestamp":1787027869197,"version":"build-2736575974"},"reference-count":63,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The development of fetal organs can be impacted by systemic changes in maternal circulation, with the placenta playing a pivotal role in maintaining pregnancy homeostasis and nutrient exchange. In clinical obstetrics, oxytocin (OXT) is commonly used to induce labor. To explore the potential role of OXT in the placental homeostasis of OXT, we compared OXT levels in neonatal cord blood among neonates (23\u201342 weeks gestation) whose mothers either received prenatal OXT or experienced spontaneous labor. Our previous research revealed that the oxytocin receptor (OXTR), essential in forming the blood\u2013retina barrier, is expressed in the retinal pigment epithelium (RPE). We hypothesized that perinatal OXT administration might influence the development of the neural retina and its vasculature, offering therapeutic potential for retinal diseases such as retinopathy of prematurity (ROP). Plasma OXT levels were measured using a commercial OXT ELISA kit. Human fetal RPE (hfRPE) cells treated with OXT (10 \u00b5M) were assessed for gene expression via RNA sequencing, revealing 14 downregulated and 32 upregulated genes. To validate these differentially expressed genes (DEGs), hfRPE cells were exposed to OXT (0.01, 0.1, 1, or 10 \u00b5M) for 12 h, followed by RNA analysis via real-time PCR. Functional, enrichment, and network analyses (Gene Ontology term, FunRich, Cytoscape) were performed to predict the affected pathways. This translational study suggests that OXT likely crosses the placenta, altering fetal OXT concentrations. RNA sequencing identified 46 DEGs involved in vital metabolic and signaling pathways and critical cellular components. Our results indicate that the perinatal administration of OXT may affect neural retina and retinal vessel development, making OXT a potential therapeutic option for developmental eye diseases, including ROP.<\/jats:p>","DOI":"10.3390\/cells13201735","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T03:57:09Z","timestamp":1729483029000},"page":"1735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transplacental Transfer of Oxytocin and Its Impact on Neonatal Cord Blood and In Vitro Retinal Cell Activity"],"prefix":"10.3390","volume":"13","author":[{"given":"Claudette O.","family":"Adegboro","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Newborn Nursery, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Illinois at Chicago, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meha","family":"Kabra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Newborn Nursery, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"},{"name":"McPherson Eye Research Institute, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9579-1698","authenticated-orcid":false,"given":"Ryan M.","family":"McAdams","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Newborn Nursery, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel W.","family":"York","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Newborn Nursery, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"},{"name":"Endocrine and Reproductive Physiology Program, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruwandi I.","family":"Wijenayake","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Newborn Nursery, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiana M.","family":"Suchla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Newborn Nursery, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Ann M.","family":"Pillers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Illinois at Chicago, Chicago, IL 60612, USA"},{"name":"Children\u2019s Hospital University of Illinois, University of Illinois Hospital & Health Sciences System, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5385-358X","authenticated-orcid":false,"given":"Bikash R.","family":"Pattnaik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Newborn Nursery, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"},{"name":"McPherson Eye Research Institute, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"},{"name":"Endocrine and Reproductive Physiology Program, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"},{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin\u2013Madison, 1300 University Avenue, SMI 112, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Prevost, M., Zelkowitz, P., Tulandi, T., Hayton, B., Feeley, N., Carter, C.S., Joseph, L., Pournajafi-Nazarloo, H., Yong Ping, E., and Abenhaim, H. (2014). Oxytocin in pregnancy and the postpartum: Relations to labor and its management. Front. Public Health, 2.","DOI":"10.3389\/fpubh.2014.00001"},{"key":"ref_2","first-page":"245","article-title":"Human placental transport of oxytocin","volume":"5","author":"Malek","year":"1996","journal-title":"J. Matern. Fetal Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0006-8993(81)91251-8","article-title":"Vasopressin and oxytocin content of human fetal brain at different stages of gestation","volume":"213","author":"Schubert","year":"1981","journal-title":"Brain Res."},{"key":"ref_4","first-page":"4421","article-title":"Endocrinology of parturition","volume":"85","author":"Weiss","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The oxytocin receptor system: Structure, function, and regulation","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0014-4835(75)90075-5","article-title":"The prenatal development of the human eye","volume":"21","year":"1975","journal-title":"Exp. Eye Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0196-9781(83)90056-6","article-title":"Presence of vasopressin, oxytocin and neurophysin in the retina of mammals, effect of light and darkness, comparison with the neuropeptide content of the neurohypophysis and the pineal gland","volume":"4","author":"Gauquelin","year":"1983","journal-title":"Peptides"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2174\/156652410793937813","article-title":"The retinal pigment epithelium in health and disease","volume":"10","author":"Sparrow","year":"2010","journal-title":"Curr. Mol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1167\/iovs.14-15646","article-title":"Oxytocin expression and function in the posterior retina: A novel signaling pathway","volume":"56","author":"Halbach","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zhong, S., Monakhov, M., Mok, H.P., Tong, T., Lai, P.S., Chew, S.H., and Ebstein, R.P. (2012). U-shaped relation between plasma oxytocin levels and behavior in the trust game. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051095"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/PSY.0b013e31821df0c2","article-title":"Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin","volume":"73","author":"Szeto","year":"2011","journal-title":"Psychosom. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/jne.12413","article-title":"Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers","volume":"28","author":"Leng","year":"2016","journal-title":"J. Neuroendocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Aitkin, M., Francis, B., and Hinde, J. (2005). Statistical Modelling in GLIM 4, Oxford University Press (OUP).","DOI":"10.1093\/oso\/9780198524137.001.0001"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jiang, H., Lei, R., Ding, S.W., and Zhu, S. (2014). Skewer: A fast and accurate adapter trimmer for next-generation sequencing paired-end reads. BMC Bioinform., 15.","DOI":"10.1186\/1471-2105-15-182"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9546","DOI":"10.1073\/pnas.0914005107","article-title":"Independent filtering increases detection power for high-throughput experiments","volume":"107","author":"Bourgon","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Robinson, M.D., and Oshlack, A. (2010). A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol., 11.","DOI":"10.1186\/gb-2010-11-3-r25"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Li, B., and Dewey, C.N. (2011). RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinform., 12.","DOI":"10.1186\/1471-2105-12-323"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: A Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/bioinformatics\/btf877","article-title":"Identifying differentially expressed genes using false discovery rate controlling procedures","volume":"19","author":"Reiner","year":"2003","journal-title":"Bioinformatics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"g:Profiler: A web server for functional enrichment analysis and conversions of gene lists (2019 update)","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"W60","DOI":"10.1093\/nar\/gky311","article-title":"GeneMANIA update 2018","volume":"46","author":"Franz","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.exer.2013.09.003","article-title":"Retinal pigment epithelium development, plasticity, and tissue homeostasis","volume":"123","author":"Fuhrmann","year":"2014","journal-title":"Exp. Eye Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1177\/1535370215587530","article-title":"Retinal pigment epithelial cell proliferation","volume":"240","author":"Stern","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"100057","DOI":"10.1194\/jlr.TR120000979","article-title":"Cholesterol homeostasis in the vertebrate retina: Biology and pathobiology","volume":"62","author":"Fliesler","year":"2021","journal-title":"J. Lipid Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.preteyeres.2014.03.002","article-title":"Cholesterol in the retina: The best is yet to come","volume":"41","author":"Pikuleva","year":"2014","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1073\/pnas.1915923117","article-title":"A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate","volume":"117","author":"Yoshioka","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1073\/pnas.76.7.3330","article-title":"Receptor-mediated endocytosis: Insights from the lipoprotein receptor system","volume":"76","author":"Brown","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9476","DOI":"10.1073\/pnas.1133426100","article-title":"Insig-1 \u201cbrakes\u201d lipogenesis in adipocytes and inhibits differentiation of preadipocytes","volume":"100","author":"Li","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.ajhg.2021.04.006","article-title":"Impaired cholesterol efflux in retinal pigment epithelium of individuals with juvenile macular degeneration","volume":"108","author":"Tsai","year":"2021","journal-title":"Am. J. Hum. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zheng, W., Reem, R.E., Omarova, S., Huang, S., DiPatre, P.L., Charvet, C.D., Curcio, C.A., and Pikuleva, I.A. (2012). Spatial distribution of the pathways of cholesterol homeostasis in human retina. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037926"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1194\/jlr.M053439","article-title":"Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments","volume":"56","author":"Zheng","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1080\/15548627.2018.1490851","article-title":"Compromised phagosome maturation underlies RPE pathology in cell culture and whole animal models of Smith-Lemli-Opitz Syndrome","volume":"14","author":"Pfeffer","year":"2018","journal-title":"Autophagy"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1093\/hmg\/ddx319","article-title":"Retinal pigment epithelium cholesterol efflux mediated by the 18 kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration","volume":"26","author":"Biswas","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kwon, W., and Freeman, S.A. (2020). Phagocytosis by the Retinal Pigment Epithelium: Recognition, Resolution, Recycling. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.604205"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Roehlecke, C., Schumann, U., Ader, M., Brunssen, C., Bramke, S., Morawietz, H., and Funk, R.H. (2013). Stress reaction in outer segments of photoreceptors after blue light irradiation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071570"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.exer.2011.11.007","article-title":"Roles of alphavbeta5, FAK and MerTK in oxidative stress inhibition of RPE cell phagocytosis","volume":"94","author":"Qin","year":"2012","journal-title":"Exp. Eye Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1093\/emboj\/cdg416","article-title":"Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors","volume":"22","author":"Finnemann","year":"2003","journal-title":"EMBO J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1189\/jlb.0110028","article-title":"The role of calcium signaling in phagocytosis","volume":"88","author":"Nunes","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.cellsig.2008.02.005","article-title":"Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium","volume":"20","author":"Karl","year":"2008","journal-title":"Cell Signal"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.stemcr.2018.01.017","article-title":"Quantified F-Actin Morphology Is Predictive of Phagocytic Capacity of Stem Cell-Derived Retinal Pigment Epithelium","volume":"10","author":"Charniga","year":"2018","journal-title":"Stem Cell Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"296450","DOI":"10.1155\/2012\/296450","article-title":"Focal adhesion kinases in adhesion structures and disease","volume":"2012","author":"Eleniste","year":"2012","journal-title":"J. Signal Transduct."},{"key":"ref_45","first-page":"3852","article-title":"Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium","volume":"127","author":"Meschede","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ikarashi, R., Akechi, H., Kanda, Y., Ahmad, A., Takeuchi, K., Morioka, E., Sugiyama, T., Ebisawa, T., Ikeda, M., and Ikeda, M. (2017). Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca(2+) signaling in human retinal pigment epithelial cells. Sci. Rep., 7.","DOI":"10.1038\/srep44175"},{"key":"ref_47","first-page":"191","article-title":"Effect of oxytocin and its analogues on the phagocytosis of Tetrahymena: Outstanding impact of isotocin","volume":"41","author":"Kovacs","year":"2002","journal-title":"Acta Protozool."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1167\/iovs.07-1099","article-title":"Essential roles of the PI3 kinase\/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE","volume":"49","author":"Wang","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1167\/iovs.06-0140","article-title":"Oxidant-mediated Akt activation in human RPE cells","volume":"47","author":"Yang","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/bph.14078","article-title":"Insulin-like growth factor-1 activates PI3K\/Akt signalling to protect human retinal pigment epithelial cells from amiodarone-induced oxidative injury","volume":"175","author":"Liao","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"16754","DOI":"10.1073\/pnas.1419576111","article-title":"Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-alpha","volume":"111","author":"Sur","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1167\/iovs.10-5715","article-title":"Differential effects of PPARgamma ligands on oxidative stress-induced death of retinal pigmented epithelial cells","volume":"52","author":"Rodrigues","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/B978-0-12-394309-5.00004-3","article-title":"Mechanisms for countering oxidative stress and damage in retinal pigment epithelium","volume":"298","author":"Plafker","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Bellezza, I. (2018). Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01280"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jcp.20439","article-title":"Effects of different types of oxidative stress in RPE cells","volume":"206","author":"Lu","year":"2006","journal-title":"J. Cell Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1038\/sj.onc.1205765","article-title":"cAMP inhibits the proliferation of retinal pigmented epithelial cells through the inhibition of ERK1\/2 in a PKA-independent manner","volume":"21","author":"Hecquet","year":"2002","journal-title":"Oncogene"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"16346","DOI":"10.1523\/JNEUROSCI.0402-13.2013","article-title":"Klotho regulates retinal pigment epithelial functions and protects against oxidative stress","volume":"33","author":"Kokkinaki","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.preteyeres.2013.07.003","article-title":"Aging is not a disease: Distinguishing age-related macular degeneration from aging","volume":"37","author":"Ardeljan","year":"2013","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1167\/iovs.05-1590","article-title":"Retinal pigment epithelial cells synthesize laminins, including laminin 5, and adhere to them through alpha3- and alpha6-containing integrins","volume":"47","author":"Aisenbrey","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1167\/iovs.10-6112","article-title":"Cell-deposited matrix improves retinal pigment epithelium survival on aged submacular human Bruch\u2019s membrane","volume":"52","author":"Sugino","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: One syndrome, many causes","volume":"345","author":"Romero","year":"2014","journal-title":"Science"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1177\/1099800417718266","article-title":"Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization","volume":"19","author":"Weber","year":"2017","journal-title":"Biol. Res. Nurs."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF00931436","article-title":"Oxytocin levels in maternal and fetal plasma, amniotic fluid, and neonatal plasma and urine","volume":"241","author":"Kuwabara","year":"1987","journal-title":"Arch. Gynecol. Obstet."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/20\/1735\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:16:47Z","timestamp":1760113007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/20\/1735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,19]]},"references-count":63,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["cells13201735"],"URL":"https:\/\/doi.org\/10.3390\/cells13201735","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,19]]}}}