{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:06:17Z","timestamp":1789513577030,"version":"build-2803163510"},"reference-count":234,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2014Next Generation EU PRIN 2022 PNRR","award":["P2022LPT3R"],"award-info":[{"award-number":["P2022LPT3R"]}]},{"name":"European Union\u2014Next Generation EU PRIN 2022 PNRR","award":["202089LLEH"],"award-info":[{"award-number":["202089LLEH"]}]},{"name":"Italian Ministry of University and Research (MUR)\u2014PRIN 2020","award":["P2022LPT3R"],"award-info":[{"award-number":["P2022LPT3R"]}]},{"name":"Italian Ministry of University and Research (MUR)\u2014PRIN 2020","award":["202089LLEH"],"award-info":[{"award-number":["202089LLEH"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Pyroptosis is a gasdermin-mediated pro-inflammatory programmed cell death that, during microbial infections, aims to restrict the spreading of bacteria. Nevertheless, excessive pyroptosis activation leads to inflammation levels that are detrimental to the host. Pathogen-associated molecular patterns (PAMPs) present in bacteria and outer membrane vesicles (OMVs) can trigger pyroptosis pathways in different cell types with different outcomes. Moreover, some pathogens have evolved virulence factors that directly interfere with pyroptosis pathways, like Yersinia pestis YopM and Shigella flexneri IpaH7.8. Other virulence factors, such as those of Neisseria meningitidis, Neisseria gonorrhoeae, Salmonella enterica, and Helicobacter pylori affect pyroptosis pathways indirectly with important differences between pathogenic and commensal species of the same family. These pathogens deserve special attention because of the increasing antimicrobial resistance of S. flexneri and N. gonorrhoeae, the high prevalence of S. enterica and H. pylori, and the life-threatening diseases caused by N. meningitidis and Y. pestis. While inflammation due to macrophage pyroptosis has been extensively addressed, the effects of activation of pyroptosis pathways on modulation of cell cytoskeleton and cell\u2013cell junctions in epithelia and endothelia and on the bacterial crossing of epithelial and endothelial barriers have only been partly investigated. Another important point is the diverse consequences of pyroptosis pathways on calcium influx, like activation of calcium-dependent enzymes and mitochondria dysregulation. This review will discuss the pyroptotic pathways activated by Gram-negative bacteria and their OMVs, analyzing the differences between pathogens and commensal bacteria. Particular attention will also be paid to the experimental models adopted and the main results obtained in the different models. Finally, strategies adopted by pathogens to modulate these pathways will be discussed with a perspective on the use of pyroptosis inhibitors as adjuvants in the treatment of infections.<\/jats:p>","DOI":"10.3390\/cells13211758","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T12:04:22Z","timestamp":1729685062000},"page":"1758","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Beyond Inflammation: Role of Pyroptosis Pathway Activation by Gram-Negative Bacteria and Their Outer Membrane Vesicles (OMVs) in the Interaction with the Host Cell"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-4151","authenticated-orcid":false,"given":"Silvia Caterina","family":"Resta","sequence":"first","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3379-7469","authenticated-orcid":false,"given":"Flora","family":"Guerra","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3275-8660","authenticated-orcid":false,"given":"Adelfia","family":"Tal\u00e0","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-6183","authenticated-orcid":false,"given":"Cecilia","family":"Bucci","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine (DiMeS), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Alifano","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine (DiMeS), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.cell.2011.10.033","article-title":"Programmed Cell Death in Animal Development and Disease","volume":"147","author":"Fuchs","year":"2011","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev.genet.42.110807.091533","article-title":"Genetic Control of Programmed Cell Death During Animal Development","volume":"43","author":"Conradt","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"aaf2154","DOI":"10.1126\/science.aaf2154","article-title":"Programmed Necrosis in Inflammation: Toward Identification of the Effector Molecules","volume":"352","author":"Wallach","year":"2016","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/358167a0","article-title":"Shigella flexneri Induces Apoptosis in Infected Macrophages","volume":"358","author":"Zychlinsky","year":"1992","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/ni.1960","article-title":"Caspase-1-Induced Pyroptosis Is an Innate Immune Effector Mechanism against Intracellular Bacteria","volume":"11","author":"Miao","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1126\/science.1230751","article-title":"Caspase-11 Protects Against Bacteria That Escape the Vacuole","volume":"339","author":"Aachoui","year":"2013","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The Inflammasomes: Guardians of the Body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0306164","article-title":"DAMPs, PAMPs and Alarmins: All We Need to Know about Danger","volume":"81","author":"Bianchi","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.4110\/in.2018.18.e27","article-title":"Damage-Associated Molecular Patterns in Inflammatory Diseases","volume":"18","author":"Roh","year":"2018","journal-title":"Immune Netw."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zito, G., Buscetta, M., Cimino, M., Dino, P., Bucchieri, F., and Cipollina, C. (2020). Cellular Models and Assays to Study NLRP3 Inflammasome Biology. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124294"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.immuni.2024.03.012","article-title":"The NLR Family of Innate Immune and Cell Death Sensors","volume":"57","author":"Sundaram","year":"2024","journal-title":"Immunity"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The Inflammasome: A Caspase-1-Activation Platform That Regulates Immune Responses and Disease Pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Kelley, N., Jeltema, D., Duan, Y., and He, Y. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133328"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1016\/j.molcel.2024.08.001","article-title":"Consecutive Palmitoylation and Phosphorylation Orchestrates NLRP3 Membrane Trafficking and Inflammasome Activation","volume":"84","author":"Nie","year":"2024","journal-title":"Mol. Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"114070","DOI":"10.1016\/j.celrep.2024.114070","article-title":"NLRP3 Cys126 Palmitoylation by ZDHHC7 Promotes Inflammasome Activation","volume":"43","author":"Yu","year":"2024","journal-title":"Cell Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"114516","DOI":"10.1016\/j.celrep.2024.114516","article-title":"Fatty Acid Synthesis Promotes Inflammasome Activation through NLRP3 Palmitoylation","volume":"43","author":"Leishman","year":"2024","journal-title":"Cell Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory Caspases Are Innate Immune Receptors for Intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 Cleaves Gasdermin D for Non-Canonical Inflammasome Signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-Forming Activity and Structural Autoinhibition of the Gasdermin Family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41556-024-01397-9","article-title":"A Palmitoylation\u2013Depalmitoylation Relay Spatiotemporally Controls GSDMD Activation in Pyroptosis","volume":"26","author":"Zhang","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41586-024-07373-5","article-title":"ROS-Dependent S-Palmitoylation Activates Cleaved and Intact Gasdermin D","volume":"630","author":"Du","year":"2024","journal-title":"Nature"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-Activated Gasdermin D Causes Pyroptosis by Forming Membrane Pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: Host Cell Death and Inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.smim.2013.10.018","article-title":"Interleukin-1\u03b2 in Innate Inflammation, Autophagy and Immunity","volume":"25","author":"Joosten","year":"2013","journal-title":"Semin. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Dinarello, C.A., Novick, D., Kim, S., and Kaplanski, G. (2013). Interleukin-18 and IL-18 Binding Protein. Front. Immunol., 4.","DOI":"10.3389\/fimmu.2013.00289"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41420-022-00998-3","article-title":"Cell Pyroptosis in Health and Inflammatory Diseases","volume":"8","author":"Wu","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The Gasdermins, a Protein Family Executing Cell Death and Inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14128","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by Caspase-3 during Apoptosis Mediates Progression to Secondary Necrotic\/Pyroptotic Cell Death","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy Drugs Induce Pyroptosis through Caspase-3 Cleavage of a Gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-020-2071-9","article-title":"Gasdermin E Suppresses Tumour Growth by Activating Anti-Tumour Immunity","volume":"579","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"eaaz7548","DOI":"10.1126\/science.aaz7548","article-title":"Granzyme A from Cytotoxic Lymphocytes Cleaves GSDMB to Trigger Pyroptosis in Target Cells","volume":"368","author":"Zhou","year":"2020","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1084\/jem.20151613","article-title":"Pyroptosis Triggers Pore-Induced Intracellular Traps (PITs) That Capture Bacteria and Lead to Their Clearance by Efferocytosis","volume":"213","author":"Jorgensen","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e1526","DOI":"10.1038\/cddis.2014.488","article-title":"Revisiting Caspases in Sepsis","volume":"5","author":"Aziz","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1164\/rccm.201308-1535OC","article-title":"Simultaneous Targeting of IL-1 and IL-18 Is Required for Protection against Inflammatory and Septic Shock","volume":"189","author":"Berghe","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41572-019-0128-6","article-title":"Gonorrhoea","volume":"5","author":"Unemo","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Unemo, M., del Rio, C., and Shafer, W.M. (2016). Antimicrobial Resistance Expressed by Neisseria gonorrhoeae: A Major Global Public Health Problem in the 21st Century. Microbiol. Spectr., 4.","DOI":"10.1128\/microbiolspec.EI10-0009-2015"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/cid\/cix492","article-title":"Continued Evolution of Gonococcal Antimicrobial Resistance","volume":"65","author":"Hook","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Fletcher-Lartey, S., Dronavalli, M., Alexander, K., Ghosh, S., Boonwaat, L., Thomas, J., Robinson, A., Patel, Z., Forssman, B., and Pal, N. (2019). Trends in Antimicrobial Resistance Patterns in Neisseria gonorrhoeae in Australia and New Zealand: A Meta-Analysis and Systematic Review. Antibiotics, 8.","DOI":"10.3390\/antibiotics8040191"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13756-020-00805-7","article-title":"Azithromycin Resistant Gonococci: A Literature Review","volume":"9","author":"Derbie","year":"2020","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Tal\u00e0, A., Calcagnile, M., Resta, S.C., Pennetta, A., De Benedetto, G.E., and Alifano, P. (2023). Thiostrepton, a Resurging Drug Inhibiting the Stringent Response to Counteract Antibiotic-Resistance and Expression of Virulence Determinants in Neisseria gonorrhoeae. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1104454"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Mikucki, A., McCluskey, N.R., and Kahler, C.M. (2022). The Host-Pathogen Interactions and Epicellular Lifestyle of Neisseria meningitidis. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.862935"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1128\/CMR.13.1.144","article-title":"Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management","volume":"13","author":"Brandtzaeg","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2186111","DOI":"10.1080\/21645515.2023.2186111","article-title":"Changing Patterns of Invasive Meningococcal Disease and Future Immunization Strategies","volume":"19","author":"Taha","year":"2023","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.jadohealth.2016.04.013","article-title":"Treatment of Meningococcal Disease","volume":"59","author":"Nadel","year":"2016","journal-title":"J. Adolesc. Health"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Custodio, R., Johnson, E., Liu, G., Tang, C.M., and Exley, R.M. (2020). Commensal Neisseria cinerea Impairs Neisseria meningitidis Microcolony Development and Reduces Pathogen Colonisation of Epithelial Cells. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008372"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.1128\/IAI.01062-06","article-title":"Immunization with Live Neisseria lactamica Protects Mice against Meningococcal Challenge and Can Elicit Serum Bactericidal Antibodies","volume":"74","author":"Li","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Aho, E.L., Ogle, J.M., and Finck, A.M. (2020). The Human Microbiome as a Focus of Antibiotic Discovery: Neisseria mucosa Displays Activity Against Neisseria gonorrhoeae. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.577762"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.chom.2019.07.003","article-title":"Commensal Neisseria Kill Neisseria gonorrhoeae through a DNA-Dependent Mechanism","volume":"26","author":"Kim","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1071\/MA21024","article-title":"Neisseria Species and Their Complicated Relationships with Human Health","volume":"42","author":"Kahler","year":"2021","journal-title":"Microbiol. Aust."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/imr.12902","article-title":"NOD1 and NOD2 in Inflammatory and Infectious Diseases","volume":"297","author":"Trindade","year":"2020","journal-title":"Immunol. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1016\/S0021-9258(17)41763-7","article-title":"G(Anh)MTetra, a Natural Bacterial Cell Wall Breakdown Product, Induces Interleukin-1 Beta and Interleukin-6 Expression in Human Monocytes. A Study of the Molecular Mechanisms Involved in Inflammatory Cytokine Expression","volume":"269","author":"Dokter","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00007435-199903000-00007","article-title":"Gonococcal Infection of Human Fallopian Tube Mucosa in Organ Culture: Relationship of Mucosal Tissue TNF-\u03b1 Concentration to Sloughing of Ciliated Cells","volume":"26","author":"Mcgee","year":"1999","journal-title":"Sex. Transm. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1021\/acsinfecdis.6b00088","article-title":"Neisseria gonorrhoeae Lytic Transglycosylases LtgA and LtgD Reduce Host Innate Immune Signaling through TLR2 and NOD2","volume":"3","author":"Knilans","year":"2017","journal-title":"ACS Infect. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1128\/IAI.00279-13","article-title":"Peptidoglycan Fragment Release from Neisseria meningitidis","volume":"81","author":"Woodhams","year":"2013","journal-title":"Infect. Immun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e00354-17","DOI":"10.1128\/JB.00354-17","article-title":"Attention Seeker: Production, Modification, and Release of Inflammatory Peptidoglycan Fragments in Neisseria Species","volume":"199","author":"Chan","year":"2017","journal-title":"J. Bacteriol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/cmi.12529","article-title":"Neisseria gonorrhoeae Survives within and Modulates Apoptosis and Inflammatory Cytokine Production of Human Macrophages","volume":"18","author":"Seifert","year":"2016","journal-title":"Cell Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.4049\/jimmunol.0802696","article-title":"Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome","volume":"182","author":"Duncan","year":"2009","journal-title":"J. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Li, L.-H., Lin, J.-S., Chiu, H.-W., Lin, W.-Y., Ju, T.-C., Chen, F.-H., Chernikov, O.V., Liu, M.-L., Chang, J.-C., and Hsu, C.-H. (2019). Mechanistic Insight Into the Activation of the NLRP3 Inflammasome by Neisseria gonorrhoeae in Macrophages. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01815"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"117906601775090","DOI":"10.1177\/1179066017750902","article-title":"Neisseria gonorrhoeae\u2014Induced Inflammatory Pyroptosis in Human Macrophages Is Dependent on Intracellular Gonococci and Lipooligosaccharide","volume":"11","author":"Ritter","year":"2018","journal-title":"J. Cell Death"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Escobar, A., Rodas, P.I., and Acu\u00f1a-Castillo, C. (2018). Macrophage\u2013Neisseria gonorrhoeae Interactions: A Better Understanding of Pathogen Mechanisms of Immunomodulation. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.03044"},{"key":"ref_62","first-page":"1258504","article-title":"ATP Induces IL-1 \u03b2 Secretion in Neisseria gonorrhoeae\u2014Infected Human Macrophages by a Mechanism Not Related to the NLRP3\/ASC\/Caspase-1 Axis","volume":"2016","author":"Escobar","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1128\/IAI.00890-13","article-title":"Hexa-Acylated Lipid A Is Required for Host Inflammatory Response to Neisseria gonorrhoeae in Experimental Gonorrhea","volume":"82","author":"Zhou","year":"2014","journal-title":"Infect. Immun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1128\/IAI.00732-15","article-title":"Neisseria gonorrhoeae Modulates Cell Death in Human Endocervical Epithelial Cells through Export of Exosome-Associated CIAP2","volume":"83","author":"Nudel","year":"2015","journal-title":"Infect. Immun."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kepp, O., Gottschalk, K., Churin, Y., Rajalingam, K., Brinkmann, V., Machuy, N., Kroemer, G., and Rudel, T. (2009). Bim and Bmf Synergize To Induce Apoptosis in Neisseria gonorrhoeae Infection. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000348"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Walker, E., van Niekerk, S., Hanning, K., Kelton, W., and Hicks, J. (2023). Mechanisms of Host Manipulation by Neisseria gonorrhoeae. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1119834"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Deo, P., Chow, S.H., Hay, I.D., Kleifeld, O., Costin, A., Elgass, K.D., Jiang, J.-H., Ramm, G., Gabriel, K., and Dougan, G. (2018). Outer Membrane Vesicles from Neisseria gonorrhoeae Target PorB to Mitochondria and Induce Apoptosis. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1006945"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1462-5822.2003.00257.x","article-title":"Neisserial PorB Is Translocated to the Mitochondria of HeLa Cells Infected with Neisseria meningitidis and Protects Cells from Apoptosis","volume":"5","author":"Massari","year":"2003","journal-title":"Cell Microbiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1093\/emboj\/21.8.1916","article-title":"VDAC and the Bacterial Porin PorB of Neisseria gonorrhoeae Share Mitochondrial Import Pathways","volume":"21","author":"Muller","year":"2002","journal-title":"EMBO J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/emboj\/18.2.339","article-title":"Neisserial Porin (PorB) Causes Rapid Calcium Influx in Target Cells and Induces Apoptosis by the Activation of Cysteine Proteases","volume":"18","author":"Muller","year":"1999","journal-title":"EMBO J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1073\/pnas.1818598116","article-title":"Calpain Drives Pyroptotic Vimentin Cleavage, Intermediate Filament Loss, and Cell Rupture That Mediates Immunostimulation","volume":"116","author":"Davis","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/cbin.11422","article-title":"Acid-sensing Ion Channel 1a Mediates Acid-induced Pyroptosis through Calpain-2\/Calcineurin Pathway in Rat Articular Chondrocytes","volume":"44","author":"Zu","year":"2020","journal-title":"Cell Biol. Int."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jcp.1041590206","article-title":"Calpain Activation in Apoptosis","volume":"159","author":"Squier","year":"1994","journal-title":"J. Cell Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1111\/j.1742-4658.2006.05352.x","article-title":"Implication of Calpain in Neuronal Apoptosis","volume":"273","author":"Raynaud","year":"2006","journal-title":"FEBS J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"103192","DOI":"10.1016\/j.jri.2020.103192","article-title":"Inhibition of TLR2\/TLR4 Alleviates the Neisseria gonorrhoeae Infection Damage in Human Endometrial Epithelial Cells via Nrf2 and NF-K\u03b2signaling","volume":"142","author":"Yang","year":"2020","journal-title":"J. Reprod. Immunol."},{"key":"ref_76","first-page":"255","article-title":"Screening Females for Asymptomatic Gonorrhea Infection","volume":"70","author":"Pedersen","year":"1971","journal-title":"Northwest Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0140-6736(77)92720-9","article-title":"Clinical Spectrum of Gonococcal Infection in Women","volume":"309","author":"McCormack","year":"1977","journal-title":"Lancet"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM197401172900301","article-title":"Asymptomatic Gonorrhea in Men","volume":"290","author":"Handsfield","year":"1974","journal-title":"N. Engl. J. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/infdis\/161.5.938","article-title":"Behavioral Contributions to Acquisition of Gonorrhea in Patients Attending an Inner City Sexually Transmitted Disease Clinic","volume":"161","author":"Upchurch","year":"1990","journal-title":"J. Infect. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10096-010-1040-x","article-title":"The Relationship between the Symptoms of Female Gonococcal Infections and Serum Progesterone Level and the Genotypes of Neisseria gonorrhoeae Multi-Antigen Sequence Type (NG-MAST) in Wuhan, China","volume":"30","author":"Wu","year":"2011","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Zhang, S., Zhang, Y., Gan, L., Wei, F., Chai, B., A Aljaafreh, A.A.H., Liu, X., Duan, X., Jiang, J., and Wang, X. (2021). Progesterone Suppresses Neisseria gonorrhoeae-Induced Inflammation Through Inhibition of NLRP3 Inflammasome Pathway in THP-1 Cells and Murine Models. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.570093"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.4049\/jimmunol.1000805","article-title":"Distinct Cell Death Programs in Monocytes Regulate Innate Responses Following Challenge with Common Causes of Invasive Bacterial Disease","volume":"185","author":"Webster","year":"2010","journal-title":"J. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1084\/jem.184.1.51","article-title":"Net Inflammatory Capacity of Human Septic Shock Plasma Evaluated by a Monocyte-Based Target Cell Assay: Identification of Interleukin-10 as a Major Functional Deactivator of Human Monocytes","volume":"184","author":"Brandtzaeg","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1128\/IAI.00386-12","article-title":"Global Effect of Interleukin-10 on the Transcriptional Profile Induced by Neisseria meningitidis in Human Monocytes","volume":"80","author":"Gopinathan","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1462-5822.2010.01554.x","article-title":"Neisseria lactamica Attenuates TLR-1\/2-Induced Cytokine Responses in Nasopharyngeal Epithelial Cells Using PPAR-\u03b3","volume":"13","author":"Tezera","year":"2011","journal-title":"Cell Microbiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"ftx030","DOI":"10.1093\/femspd\/ftx030","article-title":"Innate Immune Response to Lipooligosaccharide: Pivotal Regulator of the Pathobiology of Invasive Neisseria meningitidis Infections","volume":"75","author":"John","year":"2017","journal-title":"Pathog. Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1074\/jbc.M115.666214","article-title":"Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage","volume":"291","author":"John","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1128\/IAI.00506-12","article-title":"Lack of Lipid A Pyrophosphorylation and Functional LptA Reduces Inflammation by Neisseria Commensals","volume":"80","author":"John","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-\u039aB-Dependent Induction of MicroRNA MiR-146, an Inhibitor Targeted to Signaling Proteins of Innate Immune Responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.4049\/jimmunol.1301648","article-title":"Induction of Endotoxin Tolerance by Pathogenic Neisseria Is Correlated with the Inflammatory Potential of Lipooligosaccharides and Regulated by MicroRNA-146a","volume":"192","author":"Liu","year":"2014","journal-title":"J. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1073\/pnas.1321700111","article-title":"Guanylate Binding Proteins Promote Caspase-11\u2013Dependent Pyroptosis in Response to Cytoplasmic LPS","volume":"111","author":"Pilla","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s41590-020-0697-2","article-title":"Guanylate-Binding Proteins Convert Cytosolic Bacteria into Caspase-4 Signaling Platforms","volume":"21","author":"Wandel","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1038\/s41467-022-32127-0","article-title":"Pathogen-Selective Killing by Guanylate-Binding Proteins as a Molecular Mechanism Leading to Inflammasome Signaling","volume":"13","author":"Feng","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Tal\u00e0, A., Guerra, F., Calcagnile, M., Romano, R., Resta, S.C., Paiano, A., Chiariello, M., Pizzolante, G., Bucci, C., and Alifano, P. (2022). HrpA Anchors Meningococci to the Dynein Motor and Affects the Balance between Apoptosis and Pyroptosis. J. Biomed. Sci., 29.","DOI":"10.1186\/s12929-022-00829-8"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1128\/IAI.00501-13","article-title":"Serogroup-Specific Interaction of Neisseria meningitidis Capsular Polysaccharide with Host Cell Microtubules and Effects on Tubulin Polymerization","volume":"82","author":"Cogli","year":"2014","journal-title":"Infect. Immun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1111\/j.1462-5822.2008.01222.x","article-title":"The HrpB-HrpA Two-Partner Secretion System Is Essential for Intracellular Survival of Neisseria meningitidis","volume":"10","author":"Progida","year":"2008","journal-title":"Cell Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Pagliuca, C., Colicchio, R., Resta, S.C., Tal\u00e0, A., Scaglione, E., Mantova, G., Continisio, L., Pagliarulo, C., Bucci, C., and Alifano, P. (2024). Neisseria meningitidis Activates Pyroptotic Pathways in a Mouse Model of Meningitis: Role of a Two-Partner Secretion System. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1384072"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Moxley, R.A. (2022). Enterobacteriaceae. Veterinary Microbiology, Wiley.","DOI":"10.1002\/9781119650836.ch6"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/19490976.2019.1667726","article-title":"Mechanisms of Bacillary Dysentery: Lessons Learnt from Infant Rabbits","volume":"11","author":"Yum","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.femsre.2003.07.002","article-title":"Shigella flexneri Infection: Pathogenesis and Vaccine Development","volume":"28","author":"Jennison","year":"2004","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Cunha, L.D., and Zamboni, D.S. (2013). Subversion of Inflammasome Activation and Pyroptosis by Pathogenic Bacteria. Front. Cell. Infect. Microbiol., 3.","DOI":"10.3389\/fcimb.2013.00076"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Suzuki, T., Franchi, L., Toma, C., Ashida, H., Ogawa, M., Yoshikawa, Y., Mimuro, H., Inohara, N., Sasakawa, C., and Nu\u00f1ez, G. (2007). Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages. PLoS Pathog., 3.","DOI":"10.1371\/journal.ppat.0030111"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Suzuki, S., Franchi, L., He, Y., Mu\u00f1oz-Planillo, R., Mimuro, H., Suzuki, T., Sasakawa, C., and N\u00fa\u00f1ez, G. (2014). Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkc\u03b4. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1003926"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.chom.2013.04.012","article-title":"The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection","volume":"13","author":"Kobayashi","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-021-04020-1","article-title":"Shigella Evades Pyroptosis by Arginine ADP-Riboxanation of Caspase-11","volume":"599","author":"Li","year":"2021","journal-title":"Nature"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.chom.2021.08.010","article-title":"Shigella Ubiquitin Ligase IpaH7.8 Targets Gasdermin D for Degradation to Prevent Pyroptosis and Enable Infection","volume":"29","author":"Luchetti","year":"2021","journal-title":"Cell Host Microbe"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1016\/j.cell.2021.04.036","article-title":"Pathogenic Ubiquitination of GSDMB Inhibits NK Cell Bactericidal Functions","volume":"184","author":"Hansen","year":"2021","journal-title":"Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature24467","article-title":"Ubiquitination and Degradation of GBPs by a Shigella Effector to Suppress Host Defence","volume":"551","author":"Li","year":"2017","journal-title":"Nature"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.chom.2017.09.007","article-title":"GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8","volume":"22","author":"Wandel","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Hurley, D., McCusker, M.P., Fanning, S., and Martins, M. (2014). Salmonella\u2014Host Interactions\u2014Modulation of the Host Innate Immune System. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00481"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/mmi.14361","article-title":"A Role for the Salmonella Type III Secretion System 1 in Bacterial Adaptation to the Cytosol of Epithelial Cells","volume":"112","author":"Chong","year":"2019","journal-title":"Mol. Microbiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.chom.2017.07.009","article-title":"Salmonella SPI-2 Type III Secretion System Effectors: Molecular Mechanisms And Physiological Consequences","volume":"22","author":"Jennings","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.tim.2017.10.008","article-title":"Compartmentalized Antimicrobial Defenses in Response to Flagellin","volume":"26","author":"Vijayan","year":"2018","journal-title":"Trends Microbiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature10510","article-title":"The NLRC4 Inflammasome Receptors for Bacterial Flagellin and Type III Secretion Apparatus","volume":"477","author":"Zhao","year":"2011","journal-title":"Nature"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/s41564-022-01142-8","article-title":"Group 3 Innate Lymphoid Cell Pyroptosis Represents a Host Defence Mechanism against Salmonella Infection","volume":"7","author":"Xiong","year":"2022","journal-title":"Nat. Microbiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.immuni.2014.01.003","article-title":"The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria","volume":"40","author":"Behnsen","year":"2014","journal-title":"Immunity"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","article-title":"Epithelium-Intrinsic NAIP\/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa","volume":"16","author":"Sellin","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.immuni.2017.03.016","article-title":"NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8","volume":"46","author":"Rauch","year":"2017","journal-title":"Immunity"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41385-019-0247-0","article-title":"Intestinal Epithelial NAIP\/NLRC4 Restricts Systemic Dissemination of the Adapted Pathogen Salmonella typhimurium Due to Site-Specific Bacterial PAMP Expression","volume":"13","author":"Hausmann","year":"2020","journal-title":"Mucosal Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1128\/IAI.00417-06","article-title":"Caspase-1-Mediated Activation of Interleukin-1\u03b2 (IL-1\u03b2) and IL-18 Contributes to Innate Immune Defenses against Salmonella enterica Serovar Typhimurium Infection","volume":"74","author":"Raupach","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Pandeya, A., Zhang, Y., Cui, J., Yang, L., Li, J., Zhang, G., Wu, C., Li, Z., and Wei, Y. (2023). Inflammasome Activation and Pyroptosis Mediate Coagulopathy and Inflammation in Salmonella Systemic Infection. Microbiol. Res., 275.","DOI":"10.1016\/j.micres.2023.127460"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature10394","article-title":"Innate Immune Recognition of Bacterial Ligands by NAIPs Determines Inflammasome Specificity","volume":"477","author":"Kofoed","year":"2011","journal-title":"Nature"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.4049\/jimmunol.1301549","article-title":"Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein","volume":"191","author":"Rayamajhi","year":"2013","journal-title":"J. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"14408","DOI":"10.1073\/pnas.1306376110","article-title":"Human NAIP and Mouse NAIP1 Recognize Bacterial Type III Secretion Needle Protein for Inflammasome Activation","volume":"110","author":"Yang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1084\/jem.20151809","article-title":"NAIP Proteins Are Required for Cytosolic Detection of Specific Bacterial Ligands in Vivo","volume":"213","author":"Rauch","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1084\/jem.20160006","article-title":"Genetic Functions of the NAIP Family of Inflammasome Receptors for Bacterial Ligands in Mice","volume":"213","author":"Zhao","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Diamond, C.E., Leong, K.W.K., Vacca, M., Rivers-Auty, J., Brough, D., and Mortellaro, A. (2017). Salmonella typhimurium-Induced IL-1 Release from Primary Human Monocytes Requires NLRP3 and Can Occur in the Absence of Pyroptosis. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-07081-3"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e0066321","DOI":"10.1128\/iai.00663-21","article-title":"Salmonella enterica Serovar Typhimurium Induces NAIP\/NLRC4- and NLRP3\/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells","volume":"90","author":"Naseer","year":"2022","journal-title":"Infect. Immun."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Zuo, L., Zhou, L., Wu, C., Wang, Y., Li, Y., Huang, R., and Wu, S. (2020). Salmonella spvC Gene Inhibits Pyroptosis and Intestinal Inflammation to Aggravate Systemic Infection in Mice. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.562491"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1462-5822.2011.01733.x","article-title":"Salmonella Type III Effector SpvC, a Phosphothreonine Lyase, Contributes to Reduction in Inflammatory Response during Intestinal Phase of Infection","volume":"14","author":"Haneda","year":"2012","journal-title":"Cell Microbiol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1126\/science.1138960","article-title":"The Phosphothreonine Lyase Activity of a Bacterial Type III Effector Family","volume":"315","author":"Li","year":"2007","journal-title":"Science"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1365-2958.2008.06134.x","article-title":"SpvC Is a Salmonella Effector with Phosphothreonine Lyase Activity on Host Mitogen-activated Protein Kinases","volume":"67","author":"Mazurkiewicz","year":"2008","journal-title":"Mol. Microbiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.chom.2009.07.007","article-title":"The S. typhimurium Effector SopE Induces Caspase-1 Activation in Stromal Cells to Initiate Gut Inflammation","volume":"6","author":"Hoffmann","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Hoffmann, C., Galle, M., Dilling, S., K\u00e4ppeli, R., M\u00fcller, A.J., Songhet, P., Beyaert, R., and Hardt, W.-D. (2010). In Macrophages, Caspase-1 Activation by SopE and the Type III Secretion System-1 of S. typhimurium Can Proceed in the Absence of Flagellin. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012477"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"R\u00f6der, J., and Hensel, M. (2020). Presence of SopE and Mode of Infection Result in Increased Salmonella-containing Vacuole Damage and Cytosolic Release during Host Cell Infection by Salmonella enterica. Cell. Microbiol., 22.","DOI":"10.1111\/cmi.13155"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2180315","DOI":"10.1080\/19490976.2023.2180315","article-title":"Salmonella Effector SopF Regulates PANoptosis of Intestinal Epithelial Cells to Aggravate Systemic Infection","volume":"15","author":"Yuan","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Mylona, E., Sanchez-Garrido, J., Hoang Thu, T.N., Dongol, S., Karkey, A., Baker, S., Shenoy, A.R., and Frankel, G. (2021). Very Long O-antigen Chains of Salmonella Paratyphi A Inhibit Inflammasome Activation and Pyroptotic Cell Death. Cell. Microbiol., 23.","DOI":"10.1111\/cmi.13306"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.celrep.2018.01.016","article-title":"Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars","volume":"22","author":"Hiyoshi","year":"2018","journal-title":"Cell Rep."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Zhu, X., Li, Y., Jiang, Y., Zhang, J., Duan, R., Liu, L., Liu, C., Xu, X., Yu, L., and Wang, Q. (2021). Prediction of Gut Microbial Community Structure and Function in Polycystic Ovary Syndrome with High Low-Density Lipoprotein Cholesterol. Front. Cell Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.665406"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"108717","DOI":"10.1016\/j.intimp.2022.108717","article-title":"Gut Microbiota Dysbiosis-Derived Macrophage Pyroptosis Causes Polycystic Ovary Syndrome via Steroidogenesis Disturbance and Apoptosis of Granulosa Cells","volume":"107","author":"Huang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e00044-19","DOI":"10.1128\/CMR.00044-19","article-title":"Yersinia pestis: The Natural History of Plague","volume":"34","author":"Barbieri","year":"2020","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"Yersinia pestis -- Etiologic Agent of Plague","volume":"10","author":"Perry","year":"1997","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3201\/eid1603.091106","article-title":"Yersinia pseudotuberculosis and Y. enterocolitica Infections, FoodNet, 1996\u20132007","volume":"16","author":"Long","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Riahi, S.M., Ahmadi, E., and Zeinali, T. (2021). Global Prevalence of Yersinia enterocolitica in Cases of Gastroenteritis: A Systematic Review and Meta-Analysis. Int. J. Microbiol., 2021.","DOI":"10.1155\/2021\/1499869"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1128\/MMBR.62.4.1315-1352.1998","article-title":"The Virulence Plasmid of Yersinia, an Antihost Genome","volume":"62","author":"Cornelis","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"17786","DOI":"10.1073\/pnas.0506840102","article-title":"Progression of Primary Pneumonic Plague: A Mouse Model of Infection, Pathology, and Bacterial Transcriptional Activity","volume":"102","author":"Lathem","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"10880","DOI":"10.1073\/pnas.191214498","article-title":"A Role for IL-1\u03b1 in Inducing Pathologic Inflammation during Bacterial Infection","volume":"98","author":"Dube","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1128\/IAI.72.3.1645-1656.2004","article-title":"Characterization of Oral Yersinia enterocolitica Infection in Three Different Strains of Inbred Mice","volume":"72","author":"Handley","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0171-2985(11)80241-X","article-title":"Immunohistological Characterization of the Cellular Immune Response against Yersinia enterocolitica in Mice: Evidence for the Involvement of T Lymphocytes","volume":"187","author":"Autenrieth","year":"1993","journal-title":"Immunobiology"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Balada-Llasat, J.-M., and Mecsas, J. (2006). Yersinia Has a Tropism for B and T Cell Zones of Lymph Nodes That Is Independent of the Type III Secretion System. PLoS Pathog., 2.","DOI":"10.1371\/journal.ppat.0020086"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0092-8674(03)00521-X","article-title":"Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes","volume":"114","author":"Micheau","year":"2003","journal-title":"Cell"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.immuni.2013.06.018","article-title":"The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism","volume":"39","author":"Murphy","year":"2013","journal-title":"Immunity"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1073\/pnas.1403252111","article-title":"Caspase-8 Mediates Caspase-1 Processing and Innate Immune Defense in Response to Bacterial Blockade of NF-\u039aB and MAPK Signaling","volume":"111","author":"Philip","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"9894","DOI":"10.1074\/jbc.M115.697698","article-title":"Manipulation of Interleukin-1\u03b2 and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence","volume":"291","author":"Ratner","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 Induces Cleavage of Gasdermin D to Elicit Pyroptosis during Yersinia Infection","volume":"115","author":"Sarhan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s10495-007-0100-x","article-title":"Catalytically Active Yersinia Outer Protein P Induces Cleavage of RIP and Caspase-8 at the Level of the DISC Independently of Death Receptors in Dendritic Cells","volume":"12","author":"Adkins","year":"2007","journal-title":"Apoptosis"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.chom.2010.04.009","article-title":"A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System","volume":"7","author":"Brodsky","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Philip, N.H., and Brodsky, I.E. (2012). Cell Death Programs in Yersinia Immunity and Pathogenesis. Front. Cell Infect. Microbiol., 2.","DOI":"10.3389\/fcimb.2012.00149"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Malireddi, R.K.S., Kesavardhana, S., and Kanneganti, T.-D. (2019). ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome\/Pyroptosis, Apoptosis, and Necroptosis (PAN-Optosis). Front. Cell Infect. Microbiol., 9.","DOI":"10.3389\/fcimb.2019.00406"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Samir, P., Malireddi, R.K.S., and Kanneganti, T.-D. (2020). The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis). Front. Cell Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00238"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Christgen, S., Zheng, M., Kesavardhana, S., Karki, R., Malireddi, R.K.S., Banoth, B., Place, D.E., Briard, B., Sharma, B.R., and Tuladhar, S. (2020). Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis). Front. Cell Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00237"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"789","DOI":"10.4049\/immunohorizons.2000097","article-title":"RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis","volume":"4","author":"Malireddi","year":"2020","journal-title":"Immunohorizons"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1038\/s41564-024-01734-6","article-title":"Yersinia Infection Induces Glucose Depletion and AMPK-Dependent Inhibition of Pyroptosis in Mice","volume":"9","author":"Yang","year":"2024","journal-title":"Nat. Microbiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e2113872119","DOI":"10.1073\/pnas.2113872119","article-title":"ZBP1 Promotes Inflammatory Responses Downstream of TLR3\/TLR4 via Timely Delivery of RIPK1 to TRIF","volume":"119","author":"Muendlein","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature13449","article-title":"Innate Immune Sensing of Bacterial Modifications of Rho GTPases by the Pyrin Inflammasome","volume":"513","author":"Xu","year":"2014","journal-title":"Nature"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"e00822-18","DOI":"10.1128\/IAI.00822-18","article-title":"Characterization of Pyrin Dephosphorylation and Inflammasome Activation in Macrophages as Triggered by the Yersinia Effectors YopE and YopT","volume":"87","author":"Medici","year":"2019","journal-title":"Infect. Immun."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"9982","DOI":"10.1073\/pnas.0602081103","article-title":"The B30.2 Domain of Pyrin, the Familial Mediterranean Fever Protein, Interacts Directly with Caspase-1 to Modulate IL-1\u03b2 Production","volume":"103","author":"Chae","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_168","unstructured":"Boyanova, L. (2011). Historical Data. Helicobacter pylori, Caister Academic Press."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev.pathol.1.110304.100125","article-title":"The Pathogenesis of Helicobacter pylori\u2014Induced Gastro-Duodenal Diseases","volume":"1","author":"Atherton","year":"2006","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.3748\/wjg.v25.i32.4629","article-title":"Review of Current Diagnostic Methods and Advances in Helicobacter pylori Diagnostics in the Era of next Generation Sequencing","volume":"25","author":"Pohl","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"ftu024","DOI":"10.1093\/femspd\/ftu024","article-title":"Helicobacter pylori Induces IL-1\u03b2 and IL-18 Production in Human Monocytic Cell Line through Activation of NLRP3 Inflammasome via ROS Signaling Pathway","volume":"73","author":"Li","year":"2015","journal-title":"Pathog. Dis."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/1753425917738043","article-title":"Helicobacter pylori Controls NLRP3 Expression by Regulating Hsa-MiR-223-3p and IL-10 in Cultured and Primary Human Immune Cells","volume":"24","author":"Pachathundikandi","year":"2018","journal-title":"Innate Immun."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1753425915619475","article-title":"Activation of NLRP3 Inflammasome in Human Neutrophils by Helicobacter pylori Infection","volume":"22","author":"Torres","year":"2016","journal-title":"Innate Immun."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1136\/gutjnl-2014-307175","article-title":"The MUC1 Mucin Protects against Helicobacter pylori Pathogenesis in Mice by Regulation of the NLRP3 Inflammasome","volume":"65","author":"Ng","year":"2016","journal-title":"Gut"},{"key":"ref_175","first-page":"785","article-title":"The Expressions of NLRP3 Inflammasome and Its Downstream Molecules in the Mouse Model of Helicobacter pylori Infection","volume":"29","author":"Jiang","year":"2013","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1016\/j.celrep.2017.12.015","article-title":"NLRP3 Controls the Development of Gastrointestinal CD11b + Dendritic Cells in the Steady State and during Chronic Bacterial Infection","volume":"21","author":"Arnold","year":"2017","journal-title":"Cell Rep."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.4049\/jimmunol.1400362","article-title":"Helicobacter pylori\u2014Induced IL-1\u03b2 Secretion in Innate Immune Cells Is Regulated by the NLRP3 Inflammasome and Requires the Cag Pathogenicity Island","volume":"193","author":"Semper","year":"2014","journal-title":"J. Immunol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1742-4658.2011.08038.x","article-title":"Structural and Functional Aspects of Unique Type IV Secretory Components in the Helicobacter pylori Cag -pathogenicity Island","volume":"278","author":"Cendron","year":"2011","journal-title":"FEBS J."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"B\u00f6nig, T., Olbermann, P., Bats, S.H., Fischer, W., and Josenhans, C. (2016). Systematic Site-Directed Mutagenesis of the Helicobacter pylori CagL Protein of the Cag Type IV Secretion System Identifies Novel Functional Domains. Sci. Rep., 6.","DOI":"10.1038\/srep38101"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1002\/eji.201243281","article-title":"The Cag Pathogenicity Island and Interaction between TLR2\/NOD2 and NLRP3 Regulate IL-1\u03b2 Production in Helicobacter pylori Infected Dendritic Cells","volume":"43","author":"Kim","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00011-021-01522-6","article-title":"Pylori CagA Activates the NLRP3 Inflammasome to Promote Gastric Cancer Cell Migration and Invasion","volume":"71","author":"Zhang","year":"2022","journal-title":"Inflamm. Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1365-2036.1996.22164006.x","article-title":"The Role of Helicobacter pylori Urease in the Pathogenesis of Gastritis and Peptic Ulceration","volume":"10","author":"Mobley","year":"1996","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1172\/JCI79337","article-title":"Helicobacter Urease\u2013Induced Activation of the TLR2\/NLRP3\/IL-18 Axis Protects against Asthma","volume":"125","author":"Koch","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Xie, J., Fan, L., Xiong, L., Chen, P., Wang, H., Chen, H., Zhao, J., Xu, Z., Geng, L., and Xu, W. (2021). Rabeprazole Inhibits Inflammatory Reaction by Inhibition of Cell Pyroptosis in Gastric Epithelial Cells. BMC Pharmacol. Toxicol., 22.","DOI":"10.1186\/s40360-021-00509-7"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1097\/MS9.0000000000001802","article-title":"Research Progress on Molecular Mechanism of Pyroptosis Caused by Helicobacter pylori in Gastric Cancer","volume":"86","author":"Gu","year":"2024","journal-title":"Ann. Med. Surg."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"507","DOI":"10.48022\/mbl.2307.07007","article-title":"Emodin Attenuates Inflammasome Activation Induced by Helicobacter pylori Infection through Inhibition of VacA Translocation","volume":"51","author":"Van","year":"2023","journal-title":"Microbiol. Biotechnol. Lett."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2313770","DOI":"10.1080\/19490976.2024.2313770","article-title":"Weizmannia Coagulans BCF-01: A Novel Gastrogenic Probiotic for Helicobacter pylori Infection Control","volume":"16","author":"Chen","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"16658","DOI":"10.1021\/acsnano.4c01520","article-title":"Alleviating Pyroptosis of Intestinal Epithelial Cells to Restore Mucosal Integrity in Ulcerative Colitis by Targeting Delivery of 4-Octyl-Itaconate","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.gendis.2022.05.039","article-title":"Protective Effects of IRG1\/Itaconate on Acute Colitis through the Inhibition of Gasdermins-Mediated Pyroptosis and Inflammation Response","volume":"10","author":"Yang","year":"2023","journal-title":"Genes. Dis."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/jcpe.13162","article-title":"Butyrate Rather than LPS Subverts Gingival Epithelial Homeostasis by Downregulation of Intercellular Junctions and Triggering Pyroptosis","volume":"46","author":"Liu","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"How, K.Y., Song, K.P., and Chan, K.G. (2016). Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00053"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Churchill, M.J., Mitchell, P.S., and Rauch, I. (2022). Epithelial Pyroptosis in Host Defense. J. Mol. Biol., 434.","DOI":"10.1016\/j.jmb.2021.167278"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1053\/j.gastro.2011.01.004","article-title":"The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding","volume":"140","author":"Marchiando","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/gutjnl-2014-307226","article-title":"Caspase-8 Controls the Gut Response to Microbial Challenges by Tnf-\u03b1-Dependent and Independent Pathways","volume":"64","author":"Buchen","year":"2015","journal-title":"Gut"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"e2013963118","DOI":"10.1073\/pnas.2013963118","article-title":"Bacterial Detection by NAIP\/NLRC4 Elicits Prompt Contractions of Intestinal Epithelial Cell Layers","volume":"118","author":"Geiser","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1039\/D4FO00611A","article-title":"Fucoxanthin Alleviates Lipopolysaccharide-Induced Intestinal Barrier Injury in Mice","volume":"15","author":"Du","year":"2024","journal-title":"Food Funct."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10571-008-9322-x","article-title":"Detachment of Brain Pericytes from the Basal Lamina Is Involved in Disruption of the Blood\u2013Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice","volume":"29","author":"Nishioku","year":"2009","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.03.010","article-title":"The Blood-Brain Barrier in Systemic Inflammation","volume":"60","author":"Varatharaj","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/s41586-024-07314-2","article-title":"Brain Endothelial GSDMD Activation Mediates Inflammatory BBB Breakdown","volume":"629","author":"Wei","year":"2024","journal-title":"Nature"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1002\/eji.200324270","article-title":"Endothelial Expression of PD-L1 and PD-L2 Down-regulates CD8+ T Cell Activation and Cytolysis","volume":"33","author":"Rodig","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"114047","DOI":"10.1016\/j.yexcr.2024.114047","article-title":"Unveiling the Role of PD-L1 in Vascular Endothelial Dysfunction: Insights into the Mtros\/NLRP3\/Caspase-1 Mediated Pyroptotic Pathway","volume":"438","author":"Tao","year":"2024","journal-title":"Exp. Cell Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1146\/annurev-micro-052821-031444","article-title":"Bacterial Outer Membrane Vesicles: From Discovery to Applications","volume":"75","author":"Sartorio","year":"2021","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.immuni.2015.10.008","article-title":"Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria","volume":"43","author":"Tan","year":"2015","journal-title":"Immunity"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.immuni.2018.08.016","article-title":"The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis","volume":"49","author":"Deng","year":"2018","journal-title":"Immunity"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.2174\/092986710791331086","article-title":"RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease","volume":"17","author":"Alexiou","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.cell.2016.04.015","article-title":"Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation","volume":"165","author":"Vanaja","year":"2016","journal-title":"Cell"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s10753-023-01928-w","article-title":"Galectin-3 Mediates Endotoxin Internalization and Caspase-4\/11 Activation in Tubular Epithelials and Macrophages During Sepsis and Sepsis-Associated Acute Kidney Injury","volume":"47","author":"Wang","year":"2024","journal-title":"Inflammation"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jacbts.2019.06.005","article-title":"Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway","volume":"4","author":"Coutrot","year":"2019","journal-title":"JACC Basic. Transl. Sci."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"e01188-17","DOI":"10.1128\/mBio.01188-17","article-title":"Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins","volume":"8","author":"Finethy","year":"2017","journal-title":"mBio"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Yang, J., Hwang, I., Lee, E., Shin, S.J., Lee, E.-J., Rhee, J.H., and Yu, J.-W. (2020). Bacterial Outer Membrane Vesicle-Mediated Cytosolic Delivery of Flagellin Triggers Host NLRC4 Canonical Inflammasome Signaling. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.581165"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/s41564-020-0773-2","article-title":"Mitochondrial Dysfunction Caused by Outer Membrane Vesicles from Gram-Negative Bacteria Activates Intrinsic Apoptosis and Inflammation","volume":"5","author":"Deo","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1128\/IAI.68.12.6917-6923.2000","article-title":"Gene Expression and Production of Tumor Necrosis Factor Alpha, Interleukin-1\u03b2 (IL-1\u03b2), IL-8, Macrophage Inflammatory Protein 1\u03b1 (MIP-1\u03b1), MIP-1\u03b2, and Gamma Interferon-Inducible Protein 10 by Human Neutrophils Stimulated with Group B Meningococcal Outer Membrane Vesicles","volume":"68","author":"Lapinet","year":"2000","journal-title":"Infect. Immun."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.thromres.2019.03.019","article-title":"Bacteria-Released Outer Membrane Vesicles Promote Disseminated Intravascular Coagulation","volume":"178","author":"Wang","year":"2019","journal-title":"Thromb. Res."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.thromres.2020.08.013","article-title":"Bacterial Outer Membrane Vesicles Induce Disseminated Intravascular Coagulation through the Caspase-11-Gasdermin D Pathway","volume":"196","author":"Peng","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.immuni.2019.11.005","article-title":"Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure","volume":"51","author":"Yang","year":"2019","journal-title":"Immunity"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Nie, Y., Xie, X.-Q., Zhou, L., Guan, Q., Ren, Y., Mao, Y., Shi, J.-S., Xu, Z.-H., and Geng, Y. (2022). Desulfovibrio fairfieldensis-Derived Outer Membrane Vesicles Damage Epithelial Barrier and Induce Inflammation and Pyroptosis in Macrophages. Cells, 12.","DOI":"10.3390\/cells12010089"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Fleetwood, A.J., Lee, M.K.S., Singleton, W., Achuthan, A., Lee, M.-C., O\u2019Brien-Simpson, N.M., Cook, A.D., Murphy, A.J., Dashper, S.G., and Reynolds, E.C. (2017). Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles. Front. Cell Infect. Microbiol., 7.","DOI":"10.3389\/fcimb.2017.00351"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/s41419-021-04240-3","article-title":"A Long Way to Go: Caspase Inhibitors in Clinical Use","volume":"12","author":"Dhani","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/apt.15030","article-title":"Randomised Clinical Trial: Emricasan versus Placebo Significantly Decreases ALT and Caspase 3\/7 Activation in Subjects with Non-alcoholic Fatty Liver Disease","volume":"49","author":"Shiffman","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jhep.2019.12.010","article-title":"Randomized Placebo-Controlled Trial of Emricasan for Non-Alcoholic Steatohepatitis-Related Cirrhosis with Severe Portal Hypertension","volume":"72","author":"Bosch","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/ddr.22099","article-title":"An Oral Caspase Inhibitor as Monotherapy or with Antibiotics Eradicates MRSA Skin Infections in Mice","volume":"84","author":"Cahill","year":"2023","journal-title":"Drug Dev. Res."},{"key":"ref_222","first-page":"568","article-title":"The Potential for Caspases in Drug Discovery","volume":"13","author":"MacKenzie","year":"2010","journal-title":"Curr. Opin. Drug Discov. Devel"},{"key":"ref_223","first-page":"345","article-title":"Intrinsic\/Extrinsic Apoptosis and Pyroptosis Contribute to the Selective Depletion of B Cell Subsets in Septic Shock Patients","volume":"60","author":"Dong","year":"2023","journal-title":"Shock"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.bbi.2019.05.038","article-title":"Caspase-1 Inhibitor Exerts Brain-Protective Effects against Sepsis-Associated Encephalopathy and Cognitive Impairments in a Mouse Model of Sepsis","volume":"80","author":"Xu","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Yang, M., Fang, J., Zhang, N., Qin, L., Zhuang, Y., Wang, W., Zhu, H., Zhang, Y., Xia, P., and Zhang, Y. (2021). Caspase-1-Inhibitor AC-YVAD-CMK Inhibits Pyroptosis and Ameliorates Acute Kidney Injury in a Model of Sepsis. Biomed. Res. Int., 2021.","DOI":"10.1155\/2021\/6636621"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Perera, A.P., Fernando, R., Shinde, T., Gundamaraju, R., Southam, B., Sohal, S.S., Robertson, A.A.B., Schroder, K., Kunde, D., and Eri, R. (2018). MCC950, a Specific Small Molecule Inhibitor of NLRP3 Inflammasome Attenuates Colonic Inflammation in Spontaneous Colitis Mice. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-26775-w"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1007\/s10753-022-01706-0","article-title":"Phenotyping of Fecal Microbiota of Winnie, a Rodent Model of Spontaneous Chronic Colitis, Reveals Specific Metabolic, Genotoxic, and Pro-Inflammatory Properties","volume":"45","author":"Guerra","year":"2022","journal-title":"Inflammation"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1887720","DOI":"10.1080\/19490976.2021.1887720","article-title":"Gut Microbiota Shape the Inflammatory Response in Mice with an Epithelial Defect","volume":"13","author":"Wang","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1038\/s41467-020-15983-6","article-title":"SGLT2 Inhibition Modulates NLRP3 Inflammasome Activity via Ketones and Insulin in Diabetes with Cardiovascular Disease","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Duan, L., An, X., Zhang, Y., Jin, D., Zhao, S., Zhou, R., Duan, Y., Zhang, Y., Liu, X., and Lian, F. (2021). Gut Microbiota as the Critical Correlation of Polycystic Ovary Syndrome and Type 2 Diabetes Mellitus. Biomed. Pharmacother., 142.","DOI":"10.1016\/j.biopha.2021.112094"},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Sun, Y., Gao, S., Ye, C., and Zhao, W. (2023). Gut Microbiota Dysbiosis in Polycystic Ovary Syndrome: Mechanisms of Progression and Clinical Applications. Front. Cell Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1142041"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-Approved Disulfiram Inhibits Pyroptosis by Blocking Gasdermin D Pore Formation","volume":"21","author":"Hu","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"eaat2738","DOI":"10.1126\/sciimmunol.aat2738","article-title":"Chemical Disruption of the Pyroptotic Pore-Forming Protein Gasdermin D Inhibits Inflammatory Cell Death and Sepsis","volume":"3","author":"Rathkey","year":"2018","journal-title":"Sci. Immunol."},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Gong, W., Fu, H., Yang, K., Zheng, T., Guo, K., and Zhao, W. (2024). 4-Octyl Itaconate Blocks GSDMB-mediated Pyroptosis and Restricts Inflammation by Inactivating Granzyme A. Cell Prolif., e13711.","DOI":"10.1111\/cpr.13711"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/21\/1758\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:18:59Z","timestamp":1760113139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/21\/1758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":234,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["cells13211758"],"URL":"https:\/\/doi.org\/10.3390\/cells13211758","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,23]]}}}