{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T18:25:08Z","timestamp":1788805508153,"version":"build-2803163510"},"reference-count":53,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Swedish Research Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Background: ST-elevation myocardial infarction (STEMI) and Takotsubo syndrome (TS) are two distinct cardiac conditions that both result in sudden loss of cardiac dysfunction and that are difficult to distinguish clinically. This study compared plasma protein changes in 24 women with STEMI and 12 women with TS in the acute phase (days 0\u20133 post symptom onset) and the stabilization phase (days 7, 14, and 30) to examine the molecular differences between these conditions. Methods: Plasma proteins from STEMI and TS patients were extracted during the acute and stabilization phases and analyzed via quantitative proteomics. Differential expression and functional significance were assessed. Data are accessible on ProteomeXchange, ID PXD051367. Results: During the acute phase, STEMI patients showed higher levels of myocardial inflammation and tissue damage proteins compared to TS patients, along with reduced tissue repair and anti-inflammatory proteins. In the stabilization phase, STEMI patients exhibited ongoing inflammation and disrupted lipid metabolism. Notably, ADIPOQ was consistently downregulated in STEMI patients in both phases. When comparing the acute to the stabilization phase, STEMI patients showed increased inflammatory proteins and decreased structural proteins. Conversely, TS patients showed increased proteins involved in inflammation and the regulatory response to counter excessive inflammation. Consistent protein changes between the acute and stabilization phases in both conditions, such as SAA2, CRP, SAA1, LBP, FGL1, AGT, MAN1A1, APOA4, COMP, and PCOLCE, suggest shared underlying pathophysiological mechanisms. Conclusions: This study presents protein changes in women with STEMI or TS and identifies ADIPOQ, SAA2, CRP, SAA1, LBP, FGL1, AGT, MAN1A1, APOA4, COMP, and PCOLCE as candidates for further exploration in both therapeutic and diagnostic contexts.<\/jats:p>","DOI":"10.3390\/cells13211764","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T03:46:04Z","timestamp":1729827964000},"page":"1764","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Analysis of Plasma Protein Dynamics in Women with ST-Elevation Myocardial Infarction and Takotsubo Syndrome"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-7262","authenticated-orcid":false,"given":"Shafaat","family":"Hussain","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-6293","authenticated-orcid":false,"given":"Sandeep","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"},{"name":"Department of Cardiology, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6223-8845","authenticated-orcid":false,"given":"Evelin","family":"Berger","sequence":"additional","affiliation":[{"name":"Proteomics Core Facility, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnea","family":"Molander","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-4216","authenticated-orcid":false,"given":"Valentyna","family":"Sevastianova","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Sheybani","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-5045","authenticated-orcid":false,"given":"Aaron Shekka","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elmahdy","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3199-2634","authenticated-orcid":false,"given":"Amin","family":"Al-Awar","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalda","family":"Kakaei","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5180-3951","authenticated-orcid":false,"given":"Mana","family":"Kalani","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermir","family":"Zulfaj","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirali","family":"Nejat","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-8690","authenticated-orcid":false,"given":"Tetiana","family":"Pylova","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna","family":"Krasnikova","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Axel","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-8621","authenticated-orcid":false,"given":"Elmir","family":"Omerovic","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Department of Cardiology, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Redfors","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, 413 45 Gothenburg, Sweden"},{"name":"Wallenberg Centre for Molecular and Translational Medicine, Institute of Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden"},{"name":"Department of Cardiology, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jacc.2020.10.060","article-title":"Pathophysiology of Takotsubo Syndrome: JACC State-of-the-Art Review","volume":"77","author":"Lyon","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/CIRCULATIONAHA.116.027121","article-title":"Pathophysiology of Takotsubo Syndrome","volume":"135","author":"Pelliccia","year":"2017","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1089\/jwh.2017.6754","article-title":"Comparison of Complications and In-Hospital Mortality in Female Patients with Takotsubo Syndrome and ST-Segment Elevation Myocardial Infarction","volume":"27","author":"Budnik","year":"2018","journal-title":"J. Womens Health"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Rawish, E., Stiermaier, T., Santoro, F., Brunetti, N.D., and Eitel, I. (2021). Current Knowledge and Future Challenges in Takotsubo Syndrome: Part 1-Pathophysiology and Diagnosis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030479"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/CIR.0000000000000226","article-title":"Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement from the American Heart Association","volume":"132","author":"Lindsey","year":"2015","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Liu, Y., Huang, D., Li, Z., Zhou, L., Cen, T., Wei, B., Wei, L., Wu, H., Su, L., and Sooranna, S.R. (2023). A plasma proteomic approach in patients with heart failure after acute myocardial infarction: Insights into the pathogenesis and progression of the disease. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1153625"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/MCA.0000000000001053","article-title":"Impact of renin-angiotensin system inhibitors after revascularization of patients with left main coronary artery disease","volume":"31","author":"Chen","year":"2022","journal-title":"Coron. Artery Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ejhf.424","article-title":"Current state of knowledge on Takotsubo syndrome: A Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology","volume":"18","author":"Lyon","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100279","DOI":"10.1016\/j.mcpro.2022.100279","article-title":"Rapid and In-Depth Coverage of the (Phospho-)Proteome with Deep Libraries and Optimal Window Design for dia-PASEF","volume":"21","author":"Skowronek","year":"2022","journal-title":"Mol. Cell Proteom."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: A graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/ije\/dyp212","article-title":"Elevated serum creatine kinase predicts first-ever myocardial infarction: A 12-year population-based cohort study in Japan, the Suita study","volume":"38","author":"Watanabe","year":"2009","journal-title":"Int. J. Epidemiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/jmcc.1997.0573","article-title":"Attenuation of interleukin-8 expression in C6-deficient rabbits after myocardial ischemia\/reperfusion","volume":"30","author":"Kilgore","year":"1998","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1080\/21655979.2022.2037365","article-title":"Quantitative proteomics reveal three potential biomarkers for risk assessment of acute myocardial infarction","volume":"13","author":"Xie","year":"2022","journal-title":"Bioengineered"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.cardfail.2003.11.003","article-title":"Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: Correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction","volume":"10","author":"Squire","year":"2004","journal-title":"J. Card. Fail."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e22864","DOI":"10.1002\/jcla.22864","article-title":"Increased serum adiponectin predicts improved coronary flow and clinical outcomes in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention","volume":"33","author":"Liang","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.atherosclerosis.2009.05.007","article-title":"Serum amyloid A induction of cytokines in monocytes\/macrophages and lymphocytes","volume":"207","author":"Song","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ijcard.2016.11.220","article-title":"Higher post-acute myocardial infarction plasma haptoglobin level is associated with poor long-term overall survival","volume":"229","author":"Chiang","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bbrc.2009.05.053","article-title":"Overexpression of apolipoprotein-B improves cardiac function and increases survival in mice with myocardial infarction","volume":"385","author":"Ramunddal","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.atherosclerosis.2015.02.017","article-title":"Elevated baseline plasma phospholipid protein (PLTP) levels are an independent predictor of long-term all-cause mortality in patients with diabetes mellitus and known or suspected coronary artery disease","volume":"239","author":"Cavusoglu","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/eurheartj\/ehac223","article-title":"Left ventricular remodelling post-myocardial infarction: Pathophysiology, imaging, and novel therapies","volume":"43","author":"Frantz","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ijcard.2011.11.032","article-title":"MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans","volume":"166","author":"Zhang","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/eurheartj\/ehp070","article-title":"C-reactive protein, infarct size, microvascular obstruction, and left-ventricular remodelling following acute myocardial infarction","volume":"30","author":"Orn","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ehf2.12266","article-title":"Acute heart failure following myocardial infarction: Complement activation correlates with the severity of heart failure in patients developing cardiogenic shock","volume":"5","author":"Orrem","year":"2018","journal-title":"ESC Heart Fail."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Pagowska-Klimek, I., and Cedzynski, M. (2014). Mannan-binding lectin in cardiovascular disease. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/616817"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/CIRCRESAHA.111.243162","article-title":"Regulation of the inflammatory response in cardiac repair","volume":"110","author":"Frangogiannis","year":"2012","journal-title":"Circ. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/0004563219827620","article-title":"Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia","volume":"56","author":"Cobbaert","year":"2019","journal-title":"Ann. Clin. Biochem."},{"key":"ref_27","first-page":"e68","article-title":"Deposition of nonsarcomeric alpha-actinin in cardiomyocytes from patients with dilated cardiomyopathy or chronic pressure overload","volume":"14","author":"Hein","year":"2009","journal-title":"Exp. Clin. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.devcel.2021.01.001","article-title":"Cardiac Morphogenesis: Crowding and Tension Resolved through Social Distancing","volume":"56","author":"Bloomekatz","year":"2021","journal-title":"Dev. Cell."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11274","DOI":"10.1073\/pnas.0702000104","article-title":"Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin","volume":"104","author":"Miyasaka","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.matbio.2018.02.023","article-title":"Cartilage oligomeric matrix protein: COMPopathies and beyond","volume":"71\u201372","author":"Posey","year":"2018","journal-title":"Matrix Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e028866","DOI":"10.1161\/JAHA.122.028866","article-title":"Peptidase Inhibitor 16 Attenuates Left Ventricular Injury and Remodeling After Myocardial Infarction by Inhibiting the HDAC1-Wnt3a-beta-Catenin Signaling Axis","volume":"12","author":"Wang","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.matbio.2017.12.001","article-title":"Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes","volume":"75\u201376","author":"Nielsen","year":"2019","journal-title":"Matrix Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.biocel.2005.10.007","article-title":"Expression of procollagen C-proteinase enhancer-1 in the remodeling rat heart is stimulated by aldosterone","volume":"38","author":"Schlesinger","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Hardy, S.A., Mabotuwana, N.S., Murtha, L.A., Coulter, B., Sanchez-Bezanilla, S., Al-Omary, M.S., Senanayake, T., Loering, S., Starkey, M., and Lee, R.J. (2019). Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0212230"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Murtha, L.A., Hardy, S.A., Mabotuwana, N.S., Bigland, M.J., Bailey, T., Raguram, K., Liu, S., Ngo, D.T., Sverdlov, A.L., and Tomin, T. (2023). Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-41894-9"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1161\/CIRCULATIONAHA.118.037975","article-title":"Myocardial and Systemic Inflammation in Acute Stress-Induced (Takotsubo) Cardiomyopathy","volume":"139","author":"Scally","year":"2019","journal-title":"Circulation"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Jumeau, C., Awad, F., Assrawi, E., Cobret, L., Duquesnoy, P., Giurgea, I., Valeyre, D., Grateau, G., Amselem, S., and Bernaudin, J.F. (2019). Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes and monocyte-derived macrophages. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217005"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.36628\/ijhf.2023.0033","article-title":"C-Reactive Protein Can Predict Outcomes in Patients with Takotsubo Syndrome","volume":"6","author":"Moady","year":"2024","journal-title":"Int. J. Heart Fail."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.thromres.2020.08.040","article-title":"Knockdown of liver-derived factor XII by GalNAc-siRNA ALN-F12 prevents thrombosis in mice without impacting hemostatic function","volume":"196","author":"Liu","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1161\/ATVBAHA.122.317164","article-title":"Fibrinogen and Factor XIII in Venous Thrombosis and Thrombus Stability","volume":"42","author":"Wolberg","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"ENEURO.0057-20.2020","DOI":"10.1523\/ENEURO.0057-20.2020","article-title":"Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity","volume":"7","author":"Graham","year":"2020","journal-title":"eNeuro"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12944-024-02028-w","article-title":"Adiponectin protects against myocardial ischemia-reperfusion injury: A systematic review and meta-analysis of preclinical animal studies","volume":"23","author":"Yue","year":"2024","journal-title":"Lipids Health Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.15420\/ecr.2020.49","article-title":"The Role of C-reactive Protein in Patient Risk Stratification and Treatment","volume":"16","author":"Avanzas","year":"2021","journal-title":"Eur. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12933-017-0545-3","article-title":"Lipopolysaccharide-binding protein is associated with arterial stiffness in patients with type 2 diabetes: A cross-sectional study","volume":"16","author":"Sakura","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13045-021-01161-8","article-title":"Fibrinogen-like protein 1 (FGL1): The next immune checkpoint target","volume":"14","author":"Qian","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/bjc.2017.472","article-title":"Reduced mannosidase MAN1A1 expression leads to aberrant N-glycosylation and impaired survival in breast cancer","volume":"118","author":"Legler","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.7156\/v4i4p183","article-title":"Molecular and Pathophysiological Features of Angiotensinogen: A Mini Review","volume":"4","author":"Wu","year":"2011","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Qu, J., Ko, C.W., Tso, P., and Bhargava, A. (2019). Apolipoprotein A-IV: A Multifunctional Protein Involved in Protection against Atherosclerosis and Diabetes. Cells, 8.","DOI":"10.3390\/cells8040319"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Cui, J., and Zhang, J. (2022). Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169253"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Lagoutte, P., Bettler, E., Vadon-Le Goff, S., and Moali, C. (2021). Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis. Matrix Biol. Plus, 11.","DOI":"10.1016\/j.mbplus.2021.100062"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"N\u00fa\u00f1ez-Gil, I.J., Santoro, F., Vazirani, R., Novo, G., Blanco-Ponce, E., Arcari, L., Uribarri, A., Cacciotti, L., Guerra, F., and Salamanca, J. (2023). Smoking influence in Takotsubo syndrome: Insights from an international cohort. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1282018"},{"key":"ref_52","first-page":"610","article-title":"Acute response of the noninfarcted myocardium and surrounding tissue assessed by T2 mapping after STEMI","volume":"17","author":"Bergamaschi","year":"2024","journal-title":"JACC: Cardiovasc. Imaging"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: A hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Bai","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/21\/1764\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:19:54Z","timestamp":1760113194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/21\/1764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":53,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["cells13211764"],"URL":"https:\/\/doi.org\/10.3390\/cells13211764","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]}}}