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and Chongqing Science and Technology Cooperation Project","award":["CSTB2023TIAD-LDX0029"],"award-info":[{"award-number":["CSTB2023TIAD-LDX0029"]}]},{"name":"Shandong and Chongqing Science and Technology Cooperation Project","award":["202202084830"],"award-info":[{"award-number":["202202084830"]}]},{"name":"Shandong and Chongqing Science and Technology Cooperation Project","award":["S202410542176"],"award-info":[{"award-number":["S202410542176"]}]},{"name":"Hunan Provincial Health Commission Project","award":["32270760"],"award-info":[{"award-number":["32270760"]}]},{"name":"Hunan Provincial Health Commission Project","award":["81902844"],"award-info":[{"award-number":["81902844"]}]},{"name":"Hunan Provincial Health Commission Project","award":["2022YFF0710700"],"award-info":[{"award-number":["2022YFF0710700"]}]},{"name":"Hunan Provincial Health Commission Project","award":["2021CDJYGRH-004"],"award-info":[{"award-number":["2021CDJYGRH-004"]}]},{"name":"Hunan Provincial Health 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As a deubiquitination enzyme, ubiquitin-specific protease 1 (USP1) is associated with tumor progression; however, its role in bladder cancer is unknown. This study aimed to analyze USP1 expression and study its roles in bladder cancer. Methods: The web server GEPIA was used to analyze the USP1 expression. To explore USP1\u2019s function in bladder cancer, we constructed USP1-knockout cell lines in UMUC3 cells. A FLAG-USP1 (WT USP1) plasmid and a plasmid FLAG-USP1 C90S (catalytic\u2013inactive mutant) were used to overexpress USP1 in T24 cells. CCK8, colony formation, and Transwell assays were used to assess cell viability, proliferation, and migration. RNA-sequencing (RNA-seq) and dual-luciferase reporter assays were performed to screen the pathway. Co-immunoprecipitation and immunofluorescence were used to explore the interaction between USP1 and c-MYC. A xenograft mouse model was used to study the role of USP1 in bladder cancer. Results: USP1 expression was upregulated in human bladder cancer cells and correlated with poor patient prognosis. USP1 overexpression promoted cell proliferation, clone formation, and migration, and this was attenuated by genetic ablation of USP1. Furthermore, we observed that USP1 deficiency inhibited tumor formation in vivo. Mechanistically, the c-MYC pathway was remarkably activated compared with the other pathways. Furthermore, USP1 could interact with c-MYC and increase c-MYC\u2019s stability depending on the catalytic activity of USP1. Conclusions: Our results suggested that high expression of USP1 promotes bladder cancer progression by stabilizing c-MYC; hence, USP1 may serve as a novel therapeutic target for treating bladder cancer.<\/jats:p>","DOI":"10.3390\/cells13211798","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T09:11:24Z","timestamp":1730279484000},"page":"1798","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ubiquitin-Specific Protease 1 Promotes Bladder Cancer Progression by Stabilizing c-MYC"],"prefix":"10.3390","volume":"13","author":[{"given":"Xia","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Hunan Normal University, Changsha 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Hunan Normal University, Changsha 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Wei","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Hunan Normal University, Changsha 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Hunan Normal University, Changsha 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Hunan Normal University, Changsha 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Hunan Normal University, Changsha 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Hunan Normal University, Changsha 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7691-5651","authenticated-orcid":false,"given":"Hui-Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Hunan Normal University, Changsha 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3134-532X","authenticated-orcid":false,"given":"Shang-Ze","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, School of Medicine, Hunan Normal University, Changsha 410013, China"},{"name":"School of Medicine, Chongqing University, Chongqing 400030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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