{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:27:52Z","timestamp":1793122072604,"version":"4.5.0"},"reference-count":189,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The correlation between epigenetic alterations and the pathophysiology of human infertility is progressively being elucidated with the discovery of an increasing number of target genes that exhibit altered expression patterns linked to reproductive abnormalities. Several genes and molecules are emerging as important for the future management of human infertility. In men, microRNAs (miRNAs) like miR-34c, miR-34b, and miR-122 regulate apoptosis, sperm production, and germ cell survival, while other factors, such as miR-449 and sirtuin 1 (SIRT1), influence testicular health, oxidative stress, and mitochondrial function. In women, miR-100-5p, miR-483-5p, and miR-486-5p are linked to ovarian reserve, PCOS, and conditions like endometriosis. Mechanisms such as DNA methylation, histone modification, chromatin restructuring, and the influence of these non-coding RNA (ncRNA) molecules have been identified as potential perturbators of normal spermatogenesis and oogenesis processes. In fact, alteration of these key regulators of epigenetic processes can lead to reproductive disorders such as defective spermatogenesis, failure of oocyte maturation and embryonic development alteration. One of the primary factors contributing to changes in the key epigenetic regulators appear to be oxidative stress, which arises from environmental exposure to toxic substances or unhealthy lifestyle choices. This evidence-based study, retracing the major epigenetic processes, aims to identify and discuss the main epigenetic biomarkers of male and female fertility associated with an oxidative imbalance, providing future perspectives in the diagnosis and management of infertile couples.<\/jats:p>","DOI":"10.3390\/cells13221846","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T09:24:13Z","timestamp":1730971453000},"page":"1846","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Crosstalk Between Oxidative Stress and Epigenetics: Unveiling New Biomarkers in Human Infertility"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-5282","authenticated-orcid":false,"given":"Sulagna","family":"Dutta","sequence":"first","affiliation":[{"name":"Basic Medical Sciences Department, College of Medicine, Ajman University, Ajman 346, United Arab Emirates"},{"name":"Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman 346, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-5048","authenticated-orcid":false,"given":"Pallav","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman 4184, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-9398","authenticated-orcid":false,"given":"Filomena","family":"Mottola","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2596-3674","authenticated-orcid":false,"given":"Sandipan","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0851-4845","authenticated-orcid":false,"given":"Arif","family":"Hussain","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Manipal Academy of Higher Education (MAHE), Dubai 345050, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-2795","authenticated-orcid":false,"given":"Ahmed","family":"Ashour","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman 4184, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6250-4798","authenticated-orcid":false,"given":"Lucia","family":"Rocco","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-695X","authenticated-orcid":false,"given":"Kadirvel","family":"Govindasamy","sequence":"additional","affiliation":[{"name":"ICAR-Agricultural Technology Application Research Institute, Guwahati 781017, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-6176","authenticated-orcid":false,"given":"Israel Maldonado","family":"Rosas","sequence":"additional","affiliation":[{"name":"Citmer Reproductive Medicine, Mexico City 11520, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-1852","authenticated-orcid":false,"given":"Shubhadeep","family":"Roychoudhury","sequence":"additional","affiliation":[{"name":"Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sinha, A., Singh, V., and Yadav, S. (2017). Multi-omics and male infertility: Status, integration and future prospects. Front. Biosci., 9.","DOI":"10.2741\/s493"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.juro.2016.07.014","article-title":"Re: The \u201comics\u201d of human male infertility: Integrating big data in a systems biology approach","volume":"196","author":"Niederberger","year":"2016","journal-title":"J. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00441-015-2320-7","article-title":"The \u201comics\u201d of human male infertility: Integrating big data in a systems biology approach","volume":"363","author":"Carrell","year":"2016","journal-title":"Cell Tissue Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Das, S., Guha, P., Nath, M., Das, S., Sen, S., Sahu, J., Kopanska, M., Dutta, S., Jamal, Q.M.S., and Kesari, K.K. (2022). A Comparative Cross-Platform Analysis to Identify Potential Biomarker Genes for Evaluation of Teratozoospermia and Azoospermia. Genes, 13.","DOI":"10.3390\/genes13101721"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e201695546","DOI":"10.15252\/embj.201695546","article-title":"Non-coding RNAs: The dark side of nuclear\u2013mitochondrial communication","volume":"36","author":"Vendramin","year":"2017","journal-title":"EMBO J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Dvoran, M., Nemcova, L., and Kalous, J. (2022). An Interplay between Epigenetics and Translation in Oocyte Maturation and Embryo Development: Assisted Reproduction Perspective. Biomedicines, 10.","DOI":"10.3390\/biomedicines10071689"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mrrev.2011.04.002","article-title":"Epigenetics, spermatogenesis and male infertility","volume":"727","author":"Rajender","year":"2011","journal-title":"Mutat. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1093\/nar\/gni180","article-title":"Footprinting of mammalian promoters: Use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level","volume":"33","author":"Fatemi","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.13181\/mji.v25i4.1504","article-title":"Epigenetic: A new approach to etiology of infertility","volume":"25","author":"Lestari","year":"2016","journal-title":"Med. J. Indones."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1210\/jc.2018-01869","article-title":"Genetics and epigenetics of infertility and treatments on outcomes","volume":"104","author":"Pisarska","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_11","first-page":"7","article-title":"Relationship between recurrence pregnancy loss and microRNA expression","volume":"5","author":"Yari","year":"2020","journal-title":"Pers. Med. J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Guha, P., Roychoudhury, S., Singha, S., Kalita, J.C., Kolesarova, A., Jamal, Q.M.S., Jha, N.K., Kumar, D., Ruokolainen, J., and Kesari, K.K. (2021). A comparative cross-platform meta-analysis to identify potential biomarker genes common to endometriosis and recurrent pregnancy loss. Appl. Sci., 11.","DOI":"10.3390\/app11083349"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.2217\/epi-2016-0056","article-title":"Establishment and functions of DNA methylation in the germline","volume":"8","author":"Stewart","year":"2016","journal-title":"Epigenomics"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sang, Q., Li, X., Wang, H., Zhang, S., Feng, R., Xu, Y., Li, Q., Zhao, X., Xing, Q., and Jin, L. (2014). Quantitative methylation level of the EPHX1 promoter in peripheral blood DNA is associated with polycystic ovary syndrome. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088013"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.rbmo.2012.10.011","article-title":"Quantitative analysis of follistatin (FST) promoter methylation in peripheral blood of patients with polycystic ovary syndrome","volume":"26","author":"Sang","year":"2013","journal-title":"Reprod. Biomed. Online"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000355314","article-title":"Promoter methylation of CYP19A1 gene in Chinese polycystic ovary syndrome patients","volume":"76","author":"Yu","year":"2013","journal-title":"Gynecol. Obs. Invest."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e5768","DOI":"10.1097\/MD.0000000000005768","article-title":"Promoter methylation of yes-associated protein (YAP1) gene in polycystic ovary syndrome","volume":"96","author":"Jiang","year":"2017","journal-title":"Medicine"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Agarwal, A., Leisegang, K., and Sengupta, P. (2020). Oxidative stress in pathologies of male reproductive disorders. Pathology, Academic Press.","DOI":"10.1016\/B978-0-12-815972-9.00002-0"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"216","DOI":"10.14336\/AD.2014.0924","article-title":"Mechanisms of superoxide signaling in epigenetic processes: Relation to aging and cancer","volume":"6","year":"2015","journal-title":"Aging Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10815-009-9346-2","article-title":"Oxidative DNA damage impairs global sperm DNA methylation in infertile men","volume":"26","author":"Tunc","year":"2009","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"R189","DOI":"10.1530\/REP-19-0452","article-title":"Impact of oxidative stress on male and female germ cells: Implications for fertility","volume":"159","author":"Aitken","year":"2020","journal-title":"Reproduction"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/rmb2.12013","article-title":"Equilibrium between anti-oxidants and reactive oxygen species: A requisite for oocyte development and maturation","volume":"16","author":"Kala","year":"2017","journal-title":"Reprod. Med. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Vo, K.C.T., Sato, Y., and Kawamura, K. (2023). Improvement of oocyte quality through the SIRT signaling pathway. Reprod. Med. Biol., 22.","DOI":"10.1002\/rmb2.12510"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2174\/1389450116666150113121054","article-title":"ROS-mediated DNA methylation pattern alterations in carcinogenesis","volume":"16","author":"Wu","year":"2015","journal-title":"Curr. Drug Targets"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1242\/jcs.1995.Supplement_19.5","article-title":"Studies of DNA methylation in animals","volume":"19","author":"Bird","year":"1995","journal-title":"J. Cell Sci. Suppl."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2164\/jandrol.106.002048","article-title":"Epigenetics in male germ cells","volume":"28","author":"Biermann","year":"2007","journal-title":"J. Androl."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.rbmo.2016.09.006","article-title":"Oxidative stress and alterations in DNA methylation: Two sides of the same coin in reproduction","volume":"33","author":"Menezo","year":"2016","journal-title":"Reprod. Biomed. Online"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferases dnmt3a and dnmt3b are essential for de novo methylation and mammalian development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1242\/dev.122.10.3195","article-title":"De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells","volume":"122","author":"Lei","year":"1996","journal-title":"Development"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0022-2836(88)90122-2","article-title":"Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases","volume":"203","author":"Bestor","year":"1988","journal-title":"J. Mol. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"16916","DOI":"10.1073\/pnas.262443999","article-title":"The DNA methyltransferase-like protein dnmt3l stimulates de novo methylation by dnmt3a","volume":"99","author":"Chedin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1365-2443.2006.01012.x","article-title":"Dnmt3a2 targets endogenous dnmt3l to es cell chromatin and induces regional DNA methylation","volume":"11","author":"Nimura","year":"2006","journal-title":"Genes Cells"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Adamczyk, M., Wender-Ozegowska, E., and Kedzia, M. (2022). Epigenetic factors in eutopic endometrium in women with endometriosis and infertility. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073804"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.cell.2011.08.042","article-title":"DNA demethylation dynamics","volume":"146","author":"Bhutani","year":"2011","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1210\/jc.2007-0494","article-title":"Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5\u2032 CpG island in endometriosis","volume":"92","author":"Xue","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Baldi, E., and Muratori, M. (2013). Genetic Damage in Human Spermatozoa, Springer.","DOI":"10.1007\/978-1-4614-7783-9"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Zini, A., and Agarwal, A. (2011). Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction, Springer.","DOI":"10.1007\/978-1-4419-6857-9"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1101\/gad.1110503","article-title":"Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by polycomb and HP1 chromodomains","volume":"17","author":"Fischle","year":"2003","journal-title":"Genes Dev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1126\/science.1064150","article-title":"Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries","volume":"293","author":"Noma","year":"2001","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0959-437X(02)00279-4","article-title":"Histone modifications in transcriptional regulation","volume":"12","author":"Berger","year":"2002","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/sj.embor.7400146","article-title":"Structures of protein domains that create or recognize histone modifications","volume":"5","author":"Bottomley","year":"2004","journal-title":"EMBO Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1534-5807(03)00093-5","article-title":"H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis","volume":"4","author":"Mahadevaiah","year":"2003","journal-title":"Dev. Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1128\/MCB.23.4.1151-1162.2003","article-title":"Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase","volume":"23","author":"Baarends","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.molcel.2005.09.025","article-title":"Monoubiquitination of human histone H2B: The factors involved and their roles in HOX gene regulation","volume":"20","author":"Zhu","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"13225","DOI":"10.1073\/pnas.1735528100","article-title":"Histone sumoylation is associated with transcriptional repression","volume":"100","author":"Shiio","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.cell.2013.07.011","article-title":"Mechanisms and functions of ATP-dependent chromatin remodeling enzymes","volume":"154","author":"Narlikar","year":"2013","journal-title":"Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nrm828","article-title":"The in vivo functions of ATP-dependent chromatin-remodelling factors","volume":"3","author":"Tsukiyama","year":"2002","journal-title":"Nat. Rev. Mol. Cell Bio."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1101\/gad.1613108","article-title":"A single HOX locus in Drosophila produces functional microRNAs from opposite DNA strands","volume":"22","author":"Stark","year":"2008","journal-title":"Genes Dev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.brainres.2009.05.074","article-title":"Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury","volume":"1284","author":"Lei","year":"2009","journal-title":"Brain Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.gene.2019.05.027","article-title":"The dynamics and regulation of chromatin remodeling during spermiogenesis","volume":"706","author":"Hao","year":"2019","journal-title":"Gene"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbagrm.2013.08.004","article-title":"Chromatin dynamics during spermiogenesis","volume":"1839","author":"Rathke","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1095\/biolreprod.109.076836","article-title":"DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2\u2032-deoxyguanosine, a marker of oxidative stress","volume":"81","author":"Thomson","year":"2009","journal-title":"Biol. Reprod."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.01.008","article-title":"Chromatin modifications in the germinal vesicle (GV) of mammalian oocytes","volume":"292","year":"2006","journal-title":"Dev. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ydbio.2004.08.028","article-title":"Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function","volume":"275","author":"Viveiros","year":"2004","journal-title":"Dev. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.fertnstert.2013.09.009","article-title":"MicroRNA expression profiles in human testicular tissues of infertile men with different histopathologic patterns","volume":"101","author":"Backesm","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.fertnstert.2012.11.054","article-title":"Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments","volume":"99","author":"Hammadeh","year":"2013","journal-title":"Fertil. Steril."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Sengupta, P., Dutta, S., Liew, F.F., Dhawan, V., Das, B., Mottola, F., Slama, P., Rocco, L., and Roychoudhury, S. (2023). Environmental and Genetic Traffic in the Journey from Sperm to Offspring. Biomolecules, 13.","DOI":"10.3390\/biom13121759"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1101\/gad.1262504","article-title":"The Drosha-DGCR8 complex in primary microRNA processing","volume":"18","author":"Han","year":"2004","journal-title":"Genes Dev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.1093\/nar\/gkt361","article-title":"Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing","volume":"41","author":"Lee","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrm2632","article-title":"Biogenesis of small RNAs in animals","volume":"10","author":"Kim","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/molehr\/gaaa016","article-title":"Using miRNAs as diagnostic biomarkers for male infertility: Opportunities and challenges","volume":"26","author":"Vashisht","year":"2020","journal-title":"Mol. Hum. Reprod."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Zhu, Q., Kirby, J.A., Chu, C., and Gou, L.T. (2021). Small Noncoding RNAs in Reproduction and Infertility. Biomedicines, 9.","DOI":"10.3390\/biomedicines9121884"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Mottola, F., Palmieri, I., Carannante, M., Barretta, A., Roychoudhury, S., and Rocco, L. (2024). Oxidative Stress Biomarkers in Male Infertility: Established Methodologies and Future Perspectives. Genes, 15.","DOI":"10.3390\/genes15050539"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Lu, H., Huo, Z., Ma, Z., Dang, J., Dang, W., Pan, L., Chen, J., and Zhong, H. (2016). MicroRNA-16 inhibits feto-maternal angiogenesis and causes recurrent spontaneous abortion by targeting vascular endothelial growth factor. Sci. Rep., 6.","DOI":"10.1038\/srep35536"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s43032-024-01467-1","article-title":"Understanding the Mechanisms of Diminished Ovarian Reserve: Insights from Genetic Variants and Regulatory Factors","volume":"31","author":"Zhu","year":"2024","journal-title":"Reprod. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bib\/bbs075","article-title":"Identifying miRNAs, targets and functions","volume":"15","author":"Liu","year":"2014","journal-title":"Brief Bioinform."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature08170","article-title":"Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps","volume":"460","author":"Chi","year":"2009","journal-title":"Nature"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1073\/pnas.0607521104","article-title":"A unique configuration of genome-wide DNA methylation patterns in the testis","volume":"104","author":"Oakes","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmet.2018.02.006","article-title":"Sperm epigenetics and influence of environmental factors","volume":"14","author":"Donkin","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bbrc.2008.07.087","article-title":"Differential methylation of TSP50 and MTSP50 genes in different types of human tissues and mouse spermatic cells","volume":"374","author":"Huang","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0888-7543(03)00105-8","article-title":"Methylation dynamics of repetitive DNA elements in the mouse germ cell lineage","volume":"82","author":"Walsh","year":"2003","journal-title":"Genomics"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.ygeno.2004.08.012","article-title":"Timing of establishment of paternal methylation imprints in the mouse","volume":"84","author":"Li","year":"2004","journal-title":"Genomics"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000090831","article-title":"The H19 gene: Regulation and function of a non-coding RNA","volume":"113","author":"Gabory","year":"2006","journal-title":"Cytogenet. Genome Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(04)16256-9","article-title":"Genomic imprinting in disruptive spermatogenesis","volume":"363","author":"Marques","year":"2004","journal-title":"Lancet"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/molehr\/gam093","article-title":"Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia","volume":"14","author":"Marques","year":"2008","journal-title":"Mol. Hum. Reprod."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/ejhg.2009.68","article-title":"DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm","volume":"17","author":"Kobayashi","year":"2009","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10815-006-9096-3","article-title":"Silver-Russell syndrome in a girl born after in vitro fertilization: Partial hypermethylation at the differentially methylated region of PEG1\/MEST","volume":"24","author":"Kagami","year":"2007","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Wu, W., Shen, O., Qin, Y., Niu, X., Lu, C., Xia, Y., Song, L., Wang, S., and Wang, X. (2010). Idiopathic male infertility is strongly associated with aberrant promoter methylation of methylenetetrahydrofolate reductase (MTHFR). PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013884"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.fertnstert.2009.09.010","article-title":"Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility","volume":"94","author":"Hammoud","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1101\/gad.1.10.1039","article-title":"Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse","volume":"1","author":"Sanford","year":"1987","journal-title":"Genes Dev."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Hayashi, K., de Sousa Lopes, S.M.C., Kaneda, M., Tang, F., Hajkova, P., Lao, K., O\u2019Carroll, D., Das, P.P., Tarakhovsky, A., and Miska, E.A. (2008). MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001738"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2164\/jandrol.109.008128","article-title":"MicroRNAs in the testis: Building up male fertility","volume":"31","author":"Papaioannou","year":"2010","journal-title":"J. Androl."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10815-009-9305-y","article-title":"Microarray profiling of microRNAs expressed in testis tissues of developing primates","volume":"26","author":"Yan","year":"2009","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/REP-07-0056","article-title":"A microarray for microRNA profiling in mouse testis tissues","volume":"134","author":"Yan","year":"2007","journal-title":"Reproduction"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Lian, J., Zhang, X., Tian, H., Liang, N., Wang, Y., Liang, C., Li, X., and Sun, F. (2009). Altered microRNA expression in patients with non-obstructive azoospermia. Reprod. Biol. Endocrinol., 7.","DOI":"10.1186\/1477-7827-7-13"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1016\/j.fertnstert.2009.01.069","article-title":"Aberration of blastocyst microRNA expression is associated with human infertility","volume":"93","author":"McCallie","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1373\/clinchem.2011.169714","article-title":"Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility","volume":"57","author":"Wang","year":"2011","journal-title":"Clin. Chem."},{"key":"ref_88","first-page":"399","article-title":"Overexpression of hsa-miR-30a-5p and non-obstructive azoospermia: A case-control study","volume":"20","author":"Arefnia","year":"2022","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.12659\/MSM.897340","article-title":"Up-regulation of microRNA-210 is associated with spermatogenesis by targeting IGF2 in male infertility","volume":"22","author":"Tang","year":"2016","journal-title":"Med Sci. Monit."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/aja.aja_35_19","article-title":"Altered microRNA profiles of testicular biopsies from patients with nonobstructive azoospermia","volume":"22","author":"Zhang","year":"2020","journal-title":"Asian J. Androl."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1093\/humrep\/det099","article-title":"Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: Significant up-regulation of miR-141, miR-429 and miR-7-1-3p","volume":"28","author":"Wu","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/molehr\/gas022","article-title":"Seminal plasma microRNAs: Potential biomarkers for spermatogenesis status","volume":"18","author":"Wu","year":"2012","journal-title":"Mol. Hum. Reprod."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.fertnstert.2014.07.001","article-title":"Panel of five microRNAs as potential biomarkers for the diagnosis and assessment of male infertility","volume":"102","author":"Hammadeh","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/andr.12573","article-title":"Expressions of miR-525-3p and its target gene SEMG 1 in the spermatozoa of patients with asthenozoospermia","volume":"7","author":"Zhou","year":"2019","journal-title":"Andrology"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Zhou, R., Wang, R., Qin, Y., Ji, J., Xu, M., Wu, W., Chen, M., Wu, D., Song, L., and Shen, H. (2015). Mitochondria-related miR-151a-5p reduces cellular ATP production by targeting CYTB in asthenozoospermia. Sci. Rep., 5.","DOI":"10.1038\/srep17743"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"591","DOI":"10.4103\/1008-682X.185001","article-title":"MicroRNA-27a-mediated repression of cysteine-rich secretory protein 2 translation in asthenoteratozoospermic patients","volume":"19","author":"Zhou","year":"2017","journal-title":"Asian J. Androl."},{"key":"ref_97","first-page":"681","article-title":"Altered of microRNA expression level in oligospermic patients","volume":"12","author":"Abhari","year":"2014","journal-title":"Iran J. Reprod. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1071\/RD07181","article-title":"Epigenetic regulation during mammalian oogenesis","volume":"20","author":"Bromfield","year":"2007","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1042\/EBC20190043","article-title":"The role and mechanisms of DNA methylation in the oocyte","volume":"63","author":"Kelsey","year":"2019","journal-title":"Essays Biochem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1242\/dev.061416","article-title":"Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes","volume":"138","author":"Tomizawa","year":"2011","journal-title":"Development"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1387\/ijdb.120152gk","article-title":"DNA methylation establishment during oocyte growth: Mechanisms and significance","volume":"56","author":"Tomizawa","year":"2013","journal-title":"Int. J. Dev. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10815-012-9780-4","article-title":"Abnormal DNA methylation in oocytes could be associated with a decrease in reproductive potential in old mice","volume":"29","author":"Yue","year":"2012","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1210\/en.2013-1764","article-title":"Hypomethylation of the LH\/choriogonadotropin receptor promoter region is a potential mechanism underlying susceptibility to polycystic ovary syndrome","volume":"155","author":"Wang","year":"2014","journal-title":"Endocrinology"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Chamani, I.J., and Keefe, D.L. (2019). Epigenetics and female reproductive aging. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00473"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.theriogenology.2010.09.031","article-title":"Acetylation of H4K12 in porcine oocytes during in vitro aging: Potential role of ooplasmic reactive oxygen species","volume":"75","author":"Cui","year":"2011","journal-title":"Theriogenology"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/humrep\/der030","article-title":"Defective deacetylation of histone 4 K12 in human oocytes is associated with advanced maternal age and chromosome misalignment","volume":"26","author":"Eleveld","year":"2011","journal-title":"Hum. Reprod."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/rmb2.12047","article-title":"Epigenetic regulation of the pathological process in endometriosis","volume":"16","author":"Hsiao","year":"2017","journal-title":"Reprod. Med. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Abur, U., and Gunes, S. (2021). Aberrant Epigenetics and Reproductive Disorders. Epigenetics and Reproductive Health, Academic Press.","DOI":"10.1016\/B978-0-12-819753-0.00005-2"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fertnstert.2010.06.024","article-title":"Demethylation of a nonpromoter cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant up-regulation in endometriotic tissues","volume":"95","author":"Izawa","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1177\/1933719111404614","article-title":"Hypermethylation of the CpG island spanning from exon II to intron III is associated with steroidogenic factor 1 expression in stromal cells of endometriosis","volume":"18","author":"Xue","year":"2011","journal-title":"Reprod. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2047-783X-17-12","article-title":"DNA hypomethylation of the COX-2 gene promoter is associated with up-regulation of its mRNA expression in eutopic endometrium of endometriosis","volume":"17","author":"Wang","year":"2012","journal-title":"Eur. J. Med Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3892\/ijmm.2014.1637","article-title":"DNA methylation patterns of steroid receptor genes ESR1, ESR2 and PGR in deep endometriosis compromising the rectum","volume":"33","author":"Meyer","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.bbrc.2016.12.059","article-title":"Deregulation of RUNX2 by miR-320a deficiency impairs steroidogenesis in cumulus granulosa cells from polycystic ovary syndrome (PCOS) patients","volume":"482","author":"Zhang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"E729","DOI":"10.1210\/jc.2014-3827","article-title":"MicroRNA-93 promotes ovarian granulosa cells proliferation through targeting CDKN1A in polycystic ovarian syndrome","volume":"100","author":"Jiang","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.2337\/db12-0963","article-title":"miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance","volume":"62","author":"Chen","year":"2013","journal-title":"Diabetes"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.3892\/mmr.2020.11590","article-title":"miR-132 is upregulated in polycystic ovarian syndrome and inhibits granulosa cells viability by targeting Foxa1","volume":"22","author":"Cui","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Wang, Q., Fang, C., Zhao, Y., and Liu, Z. (2022). Correlation study on serum miR-222-3p and glucose and lipid metabolism in patients with polycystic ovary syndrome. BMC Women\u2019s Health, 22.","DOI":"10.1186\/s12905-022-01912-w"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/1933719117715129","article-title":"Abnormality of klotho signaling is involved in polycystic ovary syndrome","volume":"25","author":"Mao","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.repbio.2015.10.005","article-title":"miRNA-592 is downregulated and may target LHCGR in polycystic ovary syndrome patients","volume":"15","author":"Song","year":"2015","journal-title":"Reprod. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.7754\/Clin.Lab.2015.150122","article-title":"Circulating miRNA-21 as a biomarker predicts polycystic ovary syndrome (PCOS) in patients","volume":"61","author":"Jiang","year":"2015","journal-title":"Clin. Lab."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3892\/ijmm.2015.2082","article-title":"miR-29c is downregulated in the ectopic endometrium and exerts its effects on endometrial cell proliferation, apoptosis and invasion by targeting c-Jun","volume":"35","author":"Long","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1210\/en.2018-00374","article-title":"miR-194-3p represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis","volume":"159","author":"Pei","year":"2018","journal-title":"Endocrinology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"915","DOI":"10.12659\/MSM.893872","article-title":"MiR-191 modulates malignant transformation of endometriosis through regulating TIMP3","volume":"21","author":"Dong","year":"2015","journal-title":"Med Sci. Monit."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/path.4295","article-title":"miRNA-199a-5p regulates VEGFA in endometrial mesenchymal stem cells and contributes to the pathogenesis of endometriosis","volume":"232","author":"Hsu","year":"2013","journal-title":"J. Pathol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1007\/s11033-014-3452-7","article-title":"miR-20a contributes to endometriosis by regulating NTN4 expression","volume":"41","author":"Zhao","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"145334","DOI":"10.1016\/j.gene.2020.145334","article-title":"Differentially expressed circulating microRNAs associated with idiopathic recurrent pregnancy loss","volume":"768","author":"Jairajpuri","year":"2021","journal-title":"Gene"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1593\/neo.07712","article-title":"Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation","volume":"9","author":"Campos","year":"2007","journal-title":"Neoplasia"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1053\/j.gastro.2008.07.027","article-title":"Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: Methylation of the E-cadherin promoter","volume":"135","author":"Lim","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1016\/j.febslet.2011.09.035","article-title":"Reactive oxygen species downregulate catalase expression via methylation of a CpG island in the OCT-1 promoter","volume":"585","author":"Quan","year":"2011","journal-title":"FEBS Lett."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mrfmmm.2011.02.015","article-title":"Reactive oxygen species (ROS)-induced genetic and epigenetic alterations in human carcinogenesis","volume":"711","author":"Ziech","year":"2011","journal-title":"Mutat. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e00400","DOI":"10.1016\/j.heliyon.2017.e00400","article-title":"Oxidative stress and repetitive element methylation changes in artisanal gold miners occupationally exposed to mercury","volume":"3","author":"Groot","year":"2017","journal-title":"Heliyon"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ccr.2011.09.012","article-title":"Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG islands","volume":"20","author":"Wang","year":"2011","journal-title":"Cancer Cell"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e12903","DOI":"10.1111\/and.12903","article-title":"Association between promoter methylation of MLH1 and MSH2 and reactive oxygen species in oligozoospermic men\u2014A pilot study","volume":"50","author":"Gunes","year":"2017","journal-title":"Andrologia"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"deq226","DOI":"10.1093\/humrep\/deq226","article-title":"Protamine contents and P1\/P2 ratio in human spermatozoa from smokers and non-smokers","volume":"25","author":"Hammadeh","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s10815-016-0767-4","article-title":"Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: Mechanisms, clinical results, insights on gene-environment interactions and the role of diet","volume":"33","author":"Dattilo","year":"2016","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/humupd\/dml009","article-title":"Protamines and male infertility","volume":"12","author":"Oliva","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2164\/jandrol.05171","article-title":"Sperm nuclear histone to protamine ratio in fertile and infertile men: Evidence of heterogeneous subpopulations of spermatozoa in the ejaculate","volume":"27","author":"Zhang","year":"2006","journal-title":"J. Androl."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.fertnstert.2006.05.070","article-title":"The histone to protamine ratio in human spermatozoa: Comparative study of whole and processed semen","volume":"87","author":"Zini","year":"2007","journal-title":"Fertil. Steril."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.fertnstert.2013.09.001","article-title":"Cigarette smoking is associated with abnormal histone-to-protamine transition in human sperm","volume":"101","author":"Yu","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1101\/gad.257840.114","article-title":"DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination","volume":"29","author":"Zamudio","year":"2015","journal-title":"Genes Dev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/aja.2011.1","article-title":"Meiotic recombination and male infertility: From basic science to clinical reality?","volume":"13","author":"Hann","year":"2011","journal-title":"Asian J. Androl."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Coluzzi, E., Colamartino, M., Cozzi, R., Leone, S., Meneghini, C., O\u2019Callaghan, N., and Sgura, A. (2014). Oxidative stress induces persistent telomeric DNA damage responsible for nuclear morphology change in mammalian cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110963"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1089\/ars.2007.1964","article-title":"Redox considerations in female reproductive function and assisted reproduction: From molecular mechanisms to health implications","volume":"10","author":"Agarwal","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"ref_144","first-page":"219","article-title":"Studies on free radicals, antioxidants, and co-factors","volume":"2","author":"Rahman","year":"2007","journal-title":"Clin. Interv. Aging"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"M\u00e1t\u00e9, G., Bernstein, L.R., and T\u00f6r\u00f6k, A.L. (2018). Endometriosis is a cause of infertility: Does reactive oxygen damage to gametes and embryos play a key role in the pathogenesis of infertility caused by endometriosis?. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00725"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.freeradbiomed.2015.01.028","article-title":"Oxidative stress alters global histone modification and DNA methylation","volume":"82","author":"Niu","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1177\/1933719117704909","article-title":"Role of oxidative stress in epigenetic modification in endometriosis","volume":"24","author":"Ito","year":"2017","journal-title":"Reprod. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.cell.2009.12.003","article-title":"Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells","volume":"139","author":"Shen","year":"2009","journal-title":"Cell"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1071\/RD16428","article-title":"Intracytoplasmic oxidative stress reverses epigenetic modifications in polycystic ovary syndrome","volume":"29","author":"Eini","year":"2017","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Barciszewska, A.-M., Giel-Pietraszuk, M., Perrigue, P.M., and Naskr\u0119t-Barciszewska, M. (2019). Total DNA methylation changes reflect random oxidative DNA damage in gliomas. Cells, 8.","DOI":"10.3390\/cells8091065"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1261\/rna.1963810","article-title":"Role of miR-34c microRNA in the late steps of spermatogenesis","volume":"16","author":"Bouhallier","year":"2010","journal-title":"Rna"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1101\/gr.2845604","article-title":"Microrna expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissues","volume":"14","author":"Barad","year":"2004","journal-title":"Genome Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/j.1939-4640.2001.tb03441.x","article-title":"Requirement of notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes","volume":"22","author":"Hayashi","year":"2001","journal-title":"J. Androl."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.autrev.2010.09.026","article-title":"Testicular autoimmunity","volume":"10","author":"Jacobo","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.rbmo.2010.05.011","article-title":"Implication of apoptosis in sperm cryoinjury","volume":"21","author":"Said","year":"2010","journal-title":"Reprod. Biomed. Online"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1095\/biolreprod.105.040998","article-title":"Microrna mirn122a reduces expression of the posttranscriptionally regulated germ cell transition protein 2 (tnp2) messenger RNA (mRNA) by mRNA cleavage","volume":"73","author":"Yu","year":"2005","journal-title":"Biol. Reprod."},{"key":"ref_157","first-page":"3341","article-title":"Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction","volume":"81","author":"Anawalt","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1093\/humrep\/12.11.2376","article-title":"Inhibin B in men with normal and disturbed spermatogenesis","volume":"12","author":"Klingmuller","year":"1997","journal-title":"Hum. Reprod."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"12740","DOI":"10.1073\/pnas.1109987108","article-title":"Microrna-21 regulates the self-renewal of mouse spermatogonial stem cells","volume":"108","author":"Niu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/j.1939-4640.2001.tb03439.x","article-title":"Impairment of spermatogenesis in transgenic mice with selective overexpression of Bcl-2 in the somatic cells of the testis","volume":"22","author":"Yamamoto","year":"2001","journal-title":"J. Androl."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1095\/biolreprod.105.044610","article-title":"Caspase 2 activity contributes to the initial wave of germ cell apoptosis during the first round of spermatogenesis","volume":"74","author":"Zheng","year":"2006","journal-title":"Biol. Reprod."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/sj.onc.1201915","article-title":"E2f-1-induced p53-independent apoptosis in transgenic mice","volume":"17","author":"Holmberg","year":"1998","journal-title":"Oncogene"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/ncb2241","article-title":"Control of vertebrate multiciliogenesis by mir-449 through direct repression of the delta\/notch pathway","volume":"13","author":"Marcet","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/sj.cdd.4401362","article-title":"E2f1 deficiency impairs murine spermatogenesis and augments testicular degeneration in scp3-nullizygous mice","volume":"11","author":"Hoja","year":"2004","journal-title":"Cell Death Differ."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/humupd\/dmr041","article-title":"Mirna and mammalian male germ cells","volume":"18","author":"McIver","year":"2012","journal-title":"Hum. Reprod. Updat."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1476-4598-10-29","article-title":"Mir-449 inhibits cell proliferation and is down-regulated in gastric cancer","volume":"10","author":"Kheir","year":"2011","journal-title":"Mol. Cancer"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"17319","DOI":"10.3390\/ijms140917319","article-title":"Oxidative stress and microRNAs in vascular diseases","volume":"14","author":"Magenta","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.4161\/cc.7.14.6267","article-title":"Emerging roles of SIRT1 in vascular endothelial homeostasis","volume":"7","author":"Potente","year":"2008","journal-title":"Cell Cycle"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"13421","DOI":"10.1073\/pnas.0801613105","article-title":"Mir-34a repression of SIRT1 regulates apoptosis","volume":"105","author":"Yamakuchi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.jacc.2012.02.033","article-title":"Micro-RNA-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease","volume":"59","author":"Xu","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Gebremedhn, S., Ali, A., Hossain, M., Hoelker, M., Salilew-Wondim, D., Anthony, R.V., and Tesfaye, D. (2021). MicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020938"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Abu-Halima, M., Becker, L.S., Ayesh, B.M., Baus, S.L., Hamza, A., Fischer, U., Hammadeh, M., Keller, A., and Meese, E. (2021). Characterization of micro-RNA in women with different ovarian reserve. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-92901-w"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Takebayashi, K., Nasu, K., Okamoto, M., Aoyagi, Y., Hirakawa, T., and Narahara, H. (2020). hsa-miR-100-5p, an overexpressed miRNA in human ovarian endometriotic stromal cells, promotes invasion through attenuation of SMARCD1 expression. Reprod. Biol. Endocrinol., 18.","DOI":"10.1186\/s12958-020-00590-3"},{"key":"ref_174","first-page":"1","article-title":"Exosomal MicroRNAs in Serum as Potential Biomarkers for Ectopic Pregnancy","volume":"2020","author":"Sun","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.rbmo.2015.06.023","article-title":"miR-483\u20135p and miR-486\u20135p are down-regulated in cumulus cells of metaphase II oocytes from women with polycystic ovary syndrome","volume":"31","author":"Shi","year":"2015","journal-title":"Reprod. Biomed. Online"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Tu, J., Cheung, A.H.-H., Chan, C.L.-K., and Chan, W.-Y. (2019). The role of microRNAs in ovarian granulosa cells in health and disease. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00174"},{"key":"ref_177","first-page":"2468","article-title":"miR-28-5p suppresses cell proliferation and weakens the progression of polycystic ovary syndrome by targeting prokineticin 1","volume":"20","author":"Meng","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.fertnstert.2020.01.026","article-title":"Identification of candidate microRNA markers of endometriosis with the use of next-generation sequencing and quantitative real-time PCR","volume":"113","author":"Papari","year":"2020","journal-title":"Fertil. Steril."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Vezza, T., de Mara\u00f1\u00f3n, A.M., Canet, F., D\u00edaz-Pozo, P., Marti, M., D\u2019ocon, P., Apostolova, N., Rocha, M., and V\u00edctor, V.M. (2021). MicroRNAs and oxidative stress: An intriguing crosstalk to be exploited in the management of type 2 diabetes. Antioxidants, 10.","DOI":"10.3390\/antiox10050802"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/14728222.2018.1420168","article-title":"MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications","volume":"22","author":"Regazzi","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-1-4939-7046-9_17","article-title":"Involvement of microRNAs in diabetes and its complications","volume":"1617","author":"Wu","year":"2017","journal-title":"Bioinform. MicroRNA Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"19575","DOI":"10.1074\/jbc.M611841200","article-title":"MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines","volume":"282","author":"Baroukh","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1089\/ars.2016.6643","article-title":"Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1, and eNOS","volume":"27","author":"Carlomosti","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.canlet.2018.01.010","article-title":"Redox regulation of microRNAs in cancer","volume":"418","author":"Lan","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Mar\u00ed-Alexandre, J., Carcel\u00e9n, A.P., Agababyan, C., Moreno-Manuel, A., Garc\u00eda-Oms, J., Calabuig-Fari\u00f1as, S., and Gilabert-Estell\u00e9s, J. (2019). Interplay between microRNAs and oxidative stress in ovarian conditions with a focus on ovarian cancer and endometriosis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20215322"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.rbmo.2017.02.006","article-title":"Potential role of green tea catechins in the management of oxidative stress-associated infertility","volume":"34","author":"Roychoudhury","year":"2017","journal-title":"Reprod. Biomed. Online"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Mottola, F., Santonastaso, M., Iovine, C., Rossetti, C., Ronga, V., and Rocco, L. (2021). DNA Damage in Human Amniotic Cells: Antigenotoxic Potential of Curcumin and \u03b1-Lipoic Acid. Antioxidants, 10.","DOI":"10.3390\/antiox10071137"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Mottola, F., Iovine, C., Carannante, M., Santonastaso, M., and Rocco, L. (2022). In Vitro Combination of Ascorbic and Ellagic Acids in Sperm Oxidative Damage Inhibition. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314751"},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Ferramosca, A., and Zara, V. (2022). Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052542"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/22\/1846\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:28:15Z","timestamp":1760113695000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/22\/1846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":189,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["cells13221846"],"URL":"https:\/\/doi.org\/10.3390\/cells13221846","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]}}}