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There have been attempts to overcome these barriers by using multiple concentrations of adenine-supplemented diets or by performing prolonged experiments up to 20 weeks. Here, we demonstrate that SKH1 Elite mice develop clinically relevant CKD phenotypes (e.g., polyuria, proteinuria, inflammation, and renal fibrosis) over the course of only 6 weeks of low-dose (0.15%) adenine supplementation. As a docile, immunocompetent, and hairless strain, SKH1 Elite mice offer several logistical advantages over C57BL\/6 mice, including ease of handling and the ability to study dermal conditions, which are often secondary to CKD.<\/jats:p>","DOI":"10.3390\/cells13242117","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T05:58:27Z","timestamp":1734933507000},"page":"2117","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Simplified Model of Adenine-Induced Chronic Kidney Disease Using SKH1 Mice"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7861-6740","authenticated-orcid":false,"given":"Benjamin W.","family":"French","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, 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BMC Nephrol., 19.","DOI":"10.1186\/s12882-018-1155-3"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Rahman, A., Yamazaki, D., Sufiun, A., Kitada, K., Hitomi, H., Nakano, D., and Nishiyama, A. (2018). A novel approach to adenine-induced chronic kidney disease associated anemia in rodents. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0192531"},{"key":"ref_11","first-page":"62","article-title":"Cutaneous manifestations of end-stage renal disease","volume":"3","author":"Sahadevan","year":"2021","journal-title":"J. Ski. Sex. Transm. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s13555-022-00819-6","article-title":"Burden of Atopic Dermatitis in Adults and Adolescents: A Systematic Literature Review","volume":"12","author":"Fasseeh","year":"2022","journal-title":"Dermatol. 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