{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:49:25Z","timestamp":1780318165098,"version":"3.54.1"},"reference-count":126,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013302","name":"King Abdullah International Medical Research Center","doi-asserted-by":"publisher","award":["RC20\/346\/R"],"award-info":[{"award-number":["RC20\/346\/R"]}],"id":[{"id":"10.13039\/501100013302","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Stem cell-based therapies hold significant potential for cancer treatment due to their unique properties, including migration toward tumor niche, secretion of bioactive molecules, and immunosuppression. Mesenchymal stem cells (MSCs) from adult tissues can inhibit tumor progression, angiogenesis, and apoptosis of cancer cells. We have previously reported the isolation and characterization of placenta-derived decidua basalis mesenchymal stem cells (DBMSCs), which demonstrated higher levels of pro-migratory and anti-apoptotic genes, indicating potential anti-cancer effects. In this study, we analyzed the anti-cancer effects of DBMSCs on human breast cancer cell lines MDA231 and MCF7, with MCF 10A used as control. We also investigated how these cancer cells lines affect the functional competence of DBMSCs. By co-culturing DBMSCs with cancer cells, we analyzed changes in functions of both cell types, as well as alterations in their genomic and proteomic profile. Our results showed that treatment with DBMSCs significantly reduced the functionality of MDA231 and MCF7 cells, while MCF 10A cells remained unaffected. DBMSC treatment decreased epithelial-to-mesenchymal transition (EMT)-related protein levels in MDA231 cells and modulated expression of other cancer-related genes in MDA231 and MCF7 cells. Although cancer cells reduced DBMSC proliferation, they increased their expression of anti-apoptotic genes. These findings suggest that DBMSCs can inhibit EMT-related proteins and reduce the invasive characteristics of MDA231 and MCF7 breast cancer cells, highlighting their potential as candidates for cell-based cancer therapies.<\/jats:p>","DOI":"10.3390\/cells13242131","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T05:58:27Z","timestamp":1734933507000},"page":"2131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Partial Inhibition of Epithelial-to-Mesenchymal Transition (EMT) Phenotypes by Placenta-Derived DBMSCs in Human Breast Cancer Cell Lines, In Vitro"],"prefix":"10.3390","volume":"13","author":[{"given":"Yasser","family":"Basmaeil","sequence":"first","affiliation":[{"name":"Stem Cells and Regenerative Medicine Unit, Blood and Cancer Research (BCR) Department, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences (KSAU), Ministry of National Guard Health Affairs (MNGHA), Riyadh 11426, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Al","family":"Subayyil","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Unit, Blood and Cancer Research (BCR) Department, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences (KSAU), Ministry of National Guard Health Affairs (MNGHA), Riyadh 11426, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haya Bin","family":"Kulayb","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Unit, Blood and Cancer Research (BCR) Department, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences (KSAU), Ministry of National Guard Health Affairs (MNGHA), Riyadh 11426, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5516-6951","authenticated-orcid":false,"given":"Altaf A.","family":"Kondkar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Alrodayyan","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Unit, Blood and Cancer Research (BCR) Department, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences (KSAU), Ministry of National Guard Health Affairs (MNGHA), Riyadh 11426, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9320-5579","authenticated-orcid":false,"given":"Tanvir","family":"Khatlani","sequence":"additional","affiliation":[{"name":"Stem Cells and Regenerative Medicine Unit, Blood and Cancer Research (BCR) Department, King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences (KSAU), Ministry of National Guard Health Affairs (MNGHA), Riyadh 11426, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9636897231220072","DOI":"10.1177\/09636897231220073","article-title":"The Role of Mesenchymal Stem Cells in Modulating the Breast Cancer Microenvironment","volume":"32","author":"Zhang","year":"2023","journal-title":"Cell Transplant."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/JTO.0b013e3181c6f035","article-title":"First-Line Systemic Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer: A Systematic Review","volume":"5","author":"Goffin","year":"2010","journal-title":"J. Thorac. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrc3775","article-title":"Non-Small-Cell Lung Cancers: A Heterogeneous Set of Diseases","volume":"14","author":"Chen","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nature03095","article-title":"Targeted Cancer Therapy","volume":"432","author":"Sawyers","year":"2004","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/hon.2591","article-title":"CAR T-Cell Therapy: Full Speed Ahead","volume":"37","author":"Sermer","year":"2019","journal-title":"Hematol. Oncol."},{"key":"ref_6","first-page":"4747","article-title":"Deepening a Simple Question: Can MSCs Be Used to Treat Cancer?","volume":"37","author":"Gomes","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Javan, M.R., Khosrojerdi, A., and Moazzeni, S.M. (2019). New Insights Into Implementation of Mesenchymal Stem Cells in Cancer Therapy: Prospects for Anti-Angiogenesis Treatment. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00840"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1634\/stemcells.22-3-377","article-title":"Mesenchymal Stem Cells Can Be Differentiated into Endothelial Cells in Vitro","volume":"22","author":"Oswald","year":"2004","journal-title":"Stem Cells"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jcyt.2012.11.005","article-title":"Mesenchymal Stromal Cells: Misconceptions and Evolving Concepts","volume":"15","author":"Phinney","year":"2013","journal-title":"Cytotherapy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.20892\/j.issn.2095-3941.2016.0033","article-title":"Mesenchymal Stromal Cells\u2019 Role in Tumor Microenvironment: Involvement of Signaling Pathways","volume":"14","author":"Kamga","year":"2017","journal-title":"Cancer Biol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-3-030-37184-5_3","article-title":"Mesenchymal Stem Cells in the Tumor Microenvironment","volume":"1234","author":"Atiya","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s000180050322","article-title":"Factor(s) from Nonmacrophage Bone Marrow Stromal Cells Inhibit Lewis Lung Carcinoma and B16 Melanoma Growth in Mice","volume":"55","author":"Maestroni","year":"1999","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.gt.3302276","article-title":"Antitumor Effect of Genetically Engineered Mesenchymal Stem Cells in a Rat Glioma Model","volume":"11","author":"Nakamura","year":"2004","journal-title":"Gene Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cellbi.2007.08.002","article-title":"Human Mesenchymal Stem Cells Isolated from the Umbilical Cord","volume":"32","author":"Qiao","year":"2008","journal-title":"Cell Biol. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/cr.2008.40","article-title":"Suppression of Tumorigenesis by Human Mesenchymal Stem Cells in a Hepatoma Model","volume":"18","author":"Qiao","year":"2008","journal-title":"Cell Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1182\/blood-2008-09-176198","article-title":"Concentration-Dependent Inhibition of Angiogenesis by Mesenchymal Stem Cells","volume":"113","author":"Otsu","year":"2009","journal-title":"Blood"},{"key":"ref_17","first-page":"453","article-title":"Human Umbilical Cord Blood Stem Cells Show PDGF-D-Dependent Glioma Cell Tropism in Vitro and in Vivo","volume":"12","author":"Gondi","year":"2010","journal-title":"Neuro-Oncology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1089\/scd.2012.0486","article-title":"Umbilical Cord Blood-Derived Mesenchymal Stem Cells Inhibit, but Adipose Tissue-Derived Mesenchymal Stem Cells Promote, Glioblastoma Multiforme Proliferation","volume":"22","author":"Akimoto","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Basmaeil, Y., Al Subayyil, A., Abumaree, M., and Khatlani, T. (2021). Conditions Mimicking the Cancer Microenvironment Modulate the Functional Outcome of Human Chorionic Villus Mesenchymal Stem\/Stromal Cells in Vitro. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.650125"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5184601","DOI":"10.1155\/2016\/5184601","article-title":"Phenotypic and Functional Characterization of Mesenchymal Stem\/Multipotent Stromal Cells from Decidua Basalis of Human Term Placenta","volume":"2016","author":"Abomaray","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.placenta.2017.04.003","article-title":"Immunomodulatory Properties of Human Placental Mesenchymal Stem\/Stromal Cells","volume":"59","author":"Abumaree","year":"2017","journal-title":"Placenta"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s13770-019-00207-w","article-title":"Cancer Conditioned Medium Modulates Functional and Phenotypic Properties of Human Decidua Parietalis Mesenchymal Stem\/Stromal Cells","volume":"16","author":"Bahattab","year":"2019","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9268","DOI":"10.1111\/jcmm.16848","article-title":"Human Placental Mesenchymal Stem\/Stromal Cells (PMSCs) Inhibit Agonist-Induced Platelet Functions Reducing Atherosclerosis and Thrombosis Phenotypes","volume":"25","author":"Basmaeil","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1111\/jcmm.15248","article-title":"Human Decidua Basalis Mesenchymal Stem\/Stromal Cells Reverse the Damaging Effects of High Level of Glucose on Endothelial Cells in Vitro","volume":"25","author":"Basmaeil","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-1-61779-108-6_6","article-title":"The XCELLigence System for Real-Time and Label-Free Monitoring of Cell Viability","volume":"740","author":"Ke","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"ref_26","first-page":"121","article-title":"The Comparison of Impedance-Based Method of Cell Proliferation Monitoring with Commonly Used Metabolic-Based Techniques","volume":"30","author":"Vistejnova","year":"2009","journal-title":"Neuroendocrinol. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.toxrep.2020.02.002","article-title":"Real-Time Cell Analysis System in Cytotoxicity Applications: Usefulness and Comparison with Tetrazolium Salt Assays","volume":"7","author":"Ochocka","year":"2020","journal-title":"Toxicol. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Dowling, C.M., Herranz Ors, C., and Kiely, P.A. (2014). Using Real-Time Impedance-Based Assays to Monitor the Effects of Fibroblast-Derived Media on the Adhesion, Proliferation, Migration and Invasion of Colon Cancer Cells. Biosci. Rep., 34.","DOI":"10.1042\/BSR20140031"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Basmaeil, Y., Bahattab, E., Al Subayyil, A., Kulayb, H.B., Alrodayyan, M., Abumaree, M., and Khatlani, T. (2021). Decidua Parietalis Mesenchymal Stem\/Stromal Cells and Their Secretome Diminish the Oncogenic Properties of MDA231 Cells In Vitro. Cells, 10.","DOI":"10.3390\/cells10123493"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s13770-020-00239-7","article-title":"Preconditioning of Human Decidua Basalis Mesenchymal Stem\/Stromal Cells with Glucose Increased Their Engraftment and Anti-Diabetic Properties","volume":"17","author":"Basmaeil","year":"2020","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"156106","DOI":"10.1016\/j.cyto.2022.156106","article-title":"CXCL11 Negatively Regulated by MED19 Favours Antitumour Immune Infiltration in Breast Cancer","volume":"162","author":"Zhang","year":"2023","journal-title":"Cytokine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1089\/scd.2015.0103","article-title":"IL-21-Expressing Mesenchymal Stem Cells Prevent Lethal B-Cell Lymphoma Through Efficient Delivery of IL-21, Which Redirects the Immune System to Target the Tumor","volume":"24","author":"Kim","year":"2015","journal-title":"Stem Cells Dev."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Xiong, F., Wang, Q., Wu, G.-H., Liu, W.-Z., Wang, B., and Chen, Y.-J. (2022). Direct and Indirect Effects of IFN-A2b in Malignancy Treatment: Not Only an Archer but Also an Arrow. Biomark. Res., 10.","DOI":"10.1186\/s40364-022-00415-y"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9447","DOI":"10.1007\/s13277-014-2407-x","article-title":"Multifunctional CD40L: Pro- and Anti-Neoplastic Activity","volume":"35","author":"Korniluk","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/j.ymthe.2020.08.005","article-title":"Targeted Delivery of CXCL9 and OX40L by Mesenchymal Stem Cells Elicits Potent Antitumor Immunity","volume":"28","author":"Yin","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1080\/21645515.2019.1710413","article-title":"Targeting the IL-9 Pathway in Cancer Immunotherapy","volume":"16","author":"Zheng","year":"2020","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ye, T., Zhang, X., Dong, Y., Liu, J., Zhang, W., Wu, F., Bo, H., Shao, H., Zhang, R., and Shen, H. (2022). Chemokine CCL17 Affects Local Immune Infiltration Characteristics and Early Prognosis Value of Lung Adenocarcinoma. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.816927"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1158\/0008-5472.CAN-15-1498","article-title":"IL15 and T-Cell Stemness in T-Cell-Based Cancer Immunotherapy","volume":"75","author":"Pilipow","year":"2015","journal-title":"Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kourko, O., Seaver, K., Odoardi, N., Basta, S., and Gee, K. (2019). IL-27, IL-30, and IL-35: A Cytokine Triumvirate in Cancer. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00969"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3892\/ol.2011.300","article-title":"The Emerging Role of CXCL10 in Cancer (Review)","volume":"2","author":"Liu","year":"2011","journal-title":"Oncol. Lett."},{"key":"ref_41","first-page":"168712","article-title":"High Expression of Complement Component 5 (C5) at Tumor Site Associates with Superior Survival in Ewing\u2019s Sarcoma Family of Tumour Patients","volume":"2011","author":"Savola","year":"2011","journal-title":"ISRN Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/bjc.2013.822","article-title":"G-CSF and G-CSFR Are Highly Expressed in Human Gastric and Colon Cancers and Promote Carcinoma Cell Proliferation and Migration","volume":"110","author":"Morris","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.2147\/CMAR.S249738","article-title":"Targeted Inhibition of CCL22 by MiR-130a-5p Can Enhance the Sensitivity of Cisplatin-Resistant Gastric Cancer Cells to Chemotherapy","volume":"12","author":"Fang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e24125","DOI":"10.1097\/MD.0000000000024125","article-title":"Over-Expression of CXCL2 Is Associated with Poor Prognosis in Patients with Ovarian Cancer","volume":"100","author":"Zhang","year":"2021","journal-title":"Medicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17039","DOI":"10.1038\/cddiscovery.2017.39","article-title":"BMP-2 Induces EMT and Breast Cancer Stemness through Rb and CD44","volume":"3","author":"Huang","year":"2017","journal-title":"Cell Death Discov."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"168","DOI":"10.21037\/jtd-22-1825","article-title":"Lipopolysaccharide and Lipoteichoic Acid Regulate the PI3K\/AKT Pathway through Osteopontin\/Integrin \u03923 to Promote Malignant Progression of Non-Small Cell Lung Cancer","volume":"15","author":"Zhang","year":"2023","journal-title":"J. Thorac. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.3324\/haematol.2018.192062","article-title":"Arrayed Molecular Barcoding Identifies TNFSF13 as a Positive Regulator of Acute Myeloid Leukemia-Initiating Cells","volume":"104","author":"Chapellier","year":"2019","journal-title":"Haematologica"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"61183","DOI":"10.18632\/oncotarget.11282","article-title":"IL-13\/STAT6 Signaling Plays a Critical Role in the Epithelial-Mesenchymal Transition of Colorectal Cancer Cells","volume":"7","author":"Cao","year":"2016","journal-title":"Oncotarget"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Meehan, E.V., and Wang, K. (2022). Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer. Genes, 13.","DOI":"10.3390\/genes13091643"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Tsai, H.-C., Lai, Y.-Y., Hsu, H.-C., Fong, Y.-C., Lien, M.-Y., and Tang, C.-H. (2021). CCL4 Stimulates Cell Migration in Human Osteosarcoma via the Mir-3927-3p\/Integrin Av\u03b23 Axis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312737"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Gao, S.-H., Liu, S.-Z., Wang, G.-Z., and Zhou, G.-B. (2021). CXCL13 in Cancer and Other Diseases: Biological Functions, Clinical Significance, and Therapeutic Opportunities. Life, 11.","DOI":"10.3390\/life11121282"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wang, C., Kong, L., Kim, S., Lee, S., Oh, S., Jo, S., Jang, I., and Kim, T.-D. (2022). The Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810412"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Ciummo, S.L., D\u2019Antonio, L., Sorrentino, C., Fieni, C., Lanuti, P., Stassi, G., Todaro, M., and Di Carlo, E. (2021). The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.689286"},{"key":"ref_54","first-page":"540","article-title":"Overexpression of CAMK2N1 Indicates Good Prognosis for Glioma and Regulates Androgen Receptor-Associated Cell Proliferation and Apoptosis","volume":"12","author":"Bao","year":"2019","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/sj.bjc.6605141","article-title":"Expression of a Protease-Resistant Insulin-like Growth Factor-Binding Protein-4 Inhibits Tumour Growth in a Murine Model of Breast Cancer","volume":"101","author":"Ryan","year":"2009","journal-title":"Br. J. Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/jcb.24964","article-title":"RGS2 Suppresses Breast Cancer Cell Growth via a MCPIP1-Dependent Pathway","volume":"116","author":"Lyu","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10555-018-9760-y","article-title":"WNT5A as a Therapeutic Target in Breast Cancer","volume":"37","author":"Prasad","year":"2018","journal-title":"Cancer Metastasis Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"10477","DOI":"10.2147\/CMAR.S208818","article-title":"CDH1 (E-Cadherin) Mutation and Gastric Cancer: Genetics, Molecular Mechanisms and Guidelines for Management","volume":"11","author":"Shenoy","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104270","DOI":"10.1016\/j.phrs.2019.104270","article-title":"The Unconventional Role of Akt1 in the Advanced Cancers and in Diabetes-Promoted Carcinogenesis","volume":"145","author":"Alwhaibi","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.21037\/atm-21-4192","article-title":"CALD1 Promotes the Expression of PD-L1 in Bladder Cancer via the JAK\/STAT Signaling Pathway","volume":"9","author":"Li","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"100773","DOI":"10.1016\/j.tranon.2020.100773","article-title":"Epithelial-Mesenchymal Transition in Cancer: A Historical Overview","volume":"13","author":"Ribatti","year":"2020","journal-title":"Transl. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Yuan, X., He, Y., and Wang, W. (2023). CeRNA Network-Regulated COL1A2 High Expression Correlates with Poor Prognosis and Immune Infiltration in Colon Adenocarcinoma. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-43507-x"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jid.2017.07.847","article-title":"The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation","volume":"138","author":"Schmidt","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_64","first-page":"93","article-title":"High Expression of Fibronectin 1 Indicates Poor Prognosis in Gastric Cancer","volume":"19","author":"Sun","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.drudis.2021.12.008","article-title":"Unlocking the Wnt Pathway: Therapeutic Potential of Selective Targeting FZD(7) in Cancer","volume":"27","author":"Larasati","year":"2022","journal-title":"Drug Discov. Today"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.2147\/IJGM.S314911","article-title":"Assessment of Significant Pathway Signaling and Prognostic Value of GNG11 in Ovarian Serous Cystadenocarcinoma","volume":"14","author":"Jiang","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Domoto, T., Uehara, M., Bolidong, D., and Minamoto, T. (2020). Glycogen Synthase Kinase 3\u03b2 in Cancer Biology and Treatment. Cells, 9.","DOI":"10.3390\/cells9061388"},{"key":"ref_68","first-page":"211","article-title":"ITGAV Targeting as a Therapeutic Approach for Treatment of Metastatic Breast Cancer","volume":"10","author":"Cheuk","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Jiang, H., and Li, H. (2021). Prognostic Values of Tumoral MMP2 and MMP9 Overexpression in Breast Cancer: A Systematic Review and Meta-Analysis. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-07860-2"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1038\/s41467-020-16936-9","article-title":"NOTCH1 Activation Compensates BRCA1 Deficiency and Promotes Triple-Negative Breast Cancer Formation","volume":"11","author":"Miao","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1038\/sj.onc.1203621","article-title":"Rac1 in Human Breast Cancer: Overexpression, Mutation Analysis, and Characterization of a New Isoform, Rac1b","volume":"19","author":"Schnelzer","year":"2000","journal-title":"Oncogene"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Li, L., Li, F., Xu, Z., Li, L., Hu, H., Li, Y., Yu, S., Wang, M., and Gao, L. (2023). Identification and Validation of SERPINE1 as a Prognostic and Immunological Biomarker in Pan-Cancer and in CcRCC. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1213891"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41420-021-00722-7","article-title":"FBXL10 Promotes EMT and Metastasis of Breast Cancer Cells via Regulating the Acetylation and Transcriptional Activity of SNAI1","volume":"7","author":"Yang","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12964-020-0527-z","article-title":"Role of STAT3 Signaling Pathway in Breast Cancer","volume":"18","author":"Ma","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"141747","DOI":"10.1155\/2014\/141747","article-title":"Two Faces of TGF-Beta1 in Breast Cancer","volume":"2014","author":"Zarzynska","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Winter, M., Meignan, S., V\u00f6lkel, P., Angrand, P.-O., Chopin, V., Bidan, N., Toillon, R.-A., Adriaenssens, E., Lagadec, C., and Le Bourhis, X. (2021). Vimentin Promotes the Aggressiveness of Triple Negative Breast Cancer Cells Surviving Chemotherapeutic Treatment. Cells, 10.","DOI":"10.3390\/cells10061504"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s13046-021-02187-z","article-title":"WNT11\/ROR2 Signaling Is Associated with Tumor Invasion and Poor Survival in Breast Cancer","volume":"40","author":"Menck","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1038\/s41467-022-29723-5","article-title":"Cooperative Interaction between ER\u03b1 and the EMT-Inducer ZEB1 Reprograms Breast Cancer Cells for Bone Metastasis","volume":"13","author":"Sznurkowska","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1089\/scd.2010.0093","article-title":"Human Mesenchymal Stem Cells Efficiently Manage Oxidative Stress","volume":"19","author":"Conget","year":"2010","journal-title":"Stem Cells Dev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1756-9966-30-9","article-title":"Stem Cells in Clinical Practice: Applications and Warnings","volume":"30","author":"Lodi","year":"2011","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1634\/stemcells.2006-0066","article-title":"Concise Review: Recent Advances on the Significance of Stem Cells in Tissue Regeneration and Cancer Therapies","volume":"24","author":"Mimeault","year":"2006","journal-title":"Stem Cells"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1177\/1933719116632924","article-title":"Phenotypic and Functional Characterization of Mesenchymal Stem\/Multipotent Stromal Cells From Decidua Parietalis of Human Term Placenta","volume":"23","author":"Abumaree","year":"2016","journal-title":"Reprod. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Abumaree, M.H., Al Harthy, S., Al Subayyil, A.M., Alshabibi, M.A., Abomaray, F.M., Khatlani, T., Kalionis, B., El-Muzaini, M.F., Al Jumah, M.A., and Jawdat, D. (2019). Decidua Basalis Mesenchymal Stem Cells Favor Inflammatory M1 Macrophage Differentiation In Vitro. Cells, 8.","DOI":"10.3390\/cells8020173"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1089\/scd.2017.0096","article-title":"Mesenchymal Stem\/Multipotent Stromal Cells from Human Decidua Basalis Reduce Endothelial Cell Activation","volume":"26","author":"Alshabibi","year":"2017","journal-title":"Stem Cells Dev."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Aboelella, N.S., Brandle, C., Kim, T., Ding, Z.-C., and Zhou, G. (2021). Oxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy. Cancers, 13.","DOI":"10.3390\/cancers13050986"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3390\/cancers2020693","article-title":"Role of Inflammation and Oxidative Stress Mediators in Gliomas","volume":"2","author":"Conti","year":"2010","journal-title":"Cancers"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Fiorilla, I., Martinotti, S., Todesco, A.M., Bonsignore, G., Cavaletto, M., Patrone, M., Ranzato, E., and Audrito, V. (2023). Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma. Cells, 12.","DOI":"10.3390\/cells12162048"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"29034","DOI":"10.18632\/oncotarget.4732","article-title":"IL-1\u03b2 Produced by Aggressive Breast Cancer Cells Is One of the Factors That Dictate Their Interactions with Mesenchymal Stem Cells through Chemokine Production","volume":"6","author":"Escobar","year":"2015","journal-title":"Oncotarget"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Lieblein, J.C., Ball, S., Hutzen, B., Sasser, A.K., Lin, H.-J., Huang, T.H., Hall, B.M., and Lin, J. (2008). STAT3 Can Be Activated through Paracrine Signaling in Breast Epithelial Cells. BMC Cancer, 8.","DOI":"10.1186\/1471-2407-8-302"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/sj.onc.1206113","article-title":"IL-8 Expression and Its Possible Relationship with Estrogen-Receptor-Negative Status of Breast Cancer Cells","volume":"22","author":"Freund","year":"2003","journal-title":"Oncogene"},{"key":"ref_91","first-page":"3821","article-title":"Matrix Metalloproteinases (MMPs) in Breast Cancer Cell Lines of Different Tumorigenicity","volume":"21","author":"Bachmeier","year":"2001","journal-title":"Anticancer Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1096\/fj.201700237RR","article-title":"Endothelial Cells Promote Triple-Negative Breast Cancer Cell Metastasis via PAI-1 and CCL5 Signaling","volume":"32","author":"Zhang","year":"2018","journal-title":"FASEB J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/ijc.20056","article-title":"Breast Cancer Cells Induce Osteoclast Formation by Stimulating Host IL-11 Production and Downregulating Granulocyte\/Macrophage Colony-Stimulating Factor","volume":"109","author":"Morgan","year":"2004","journal-title":"Int. J. Cancer"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.4049\/jimmunol.148.4.1143","article-title":"IL-10 Inhibits Human T Cell Proliferation and IL-2 Production","volume":"148","author":"Taga","year":"1992","journal-title":"J. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.biocel.2008.01.028","article-title":"Plasminogen Activator Inhibitor Type 1 Inhibits Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension","volume":"40","author":"Kouri","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejogrb.2007.08.005","article-title":"The Transient Increase of Oxidative Stress during Normal Pregnancy Is Higher and Persists after Delivery in Women with Pre-Eclampsia","volume":"138","author":"Raijmakers","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bpobgyn.2010.10.016","article-title":"Oxidative Stress","volume":"25","author":"Burton","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9142","DOI":"10.1158\/0008-5472.CAN-06-4690","article-title":"Human Bone Marrow Derived Mesenchymal Stem Cells Do Not Undergo Transformation after Long-Term in Vitro Culture and Do Not Exhibit Telomere Maintenance Mechanisms","volume":"67","author":"Bernardo","year":"2007","journal-title":"Cancer Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0008-6363(00)00287-X","article-title":"Effects of Interleukin-10 on Monocyte\/Endothelial Cell Adhesion and MMP-9\/TIMP-1 Secretion","volume":"49","author":"Oudghiri","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Zhuang, W.Z., Lin, Y.H., Su, L.J., Wu, M.S., Jeng, H.Y., Chang, H.C., Huang, Y.H., and Ling, T.Y. (2021). Mesenchymal Stem\/Stromal Cell-Based Therapy: Mechanism, Systemic Safety and Biodistribution for Precision Clinical Applications. J. Biomed. Sci., 28.","DOI":"10.1186\/s12929-021-00725-7"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11552-011-9321-0","article-title":"Erratum to: Why I Hate the Index Finger","volume":"6","author":"White","year":"2011","journal-title":"Hand"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4161\/cam.3.4.9246","article-title":"The Roles of Cell Adhesion Molecules in Tumor Suppression and Cell Migration: A New Paradox","volume":"3","author":"Moh","year":"2009","journal-title":"Cell Adhes. Migr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(00)81279-9","article-title":"Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis","volume":"84","author":"Gumbiner","year":"1996","journal-title":"Cell"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10522-021-09910-5","article-title":"Aging and Age-Related Diseases: From Mechanisms to Therapeutic Strategies","volume":"22","author":"Li","year":"2021","journal-title":"Biogerontology"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Subayyil, A.A., Basmaeil, Y.S., Kulayb, H.B., Alrodayyan, M., Alhaber, L.A.A., Almanaa, T.N., and Khatlani, T. (2023). Preconditioned Chorionic Villus Mesenchymal Stem\/Stromal Cells (CVMSCs) Minimize the Invasive Phenotypes of Breast Cancer Cell Line MDA231 In Vitro. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119569"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Yang, C., Lei, D., Ouyang, W., Ren, J., Li, H., Hu, J., and Huang, S. (2014). Conditioned Media from Human Adipose Tissue-Derived Mesenchymal Stem Cells and Umbilical Cord-Derived Mesenchymal Stem Cells Efficiently Induced the Apoptosis and Differentiation in Human Glioma Cell Lines in Vitro. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/109389"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1158\/0008-5472.CAN-08-2750","article-title":"Rat Umbilical Cord Stern Cells Completely Abolish Rat Mammary Carcinomas with No Evidence of Metastasis or Recurrence 100 Days Post-Tumor Cell Inoculation","volume":"69","author":"Ganta","year":"2009","journal-title":"Cancer Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1002\/jcb.24073","article-title":"Human Umbilical Cord Wharton\u2019s Jelly Stem Cell (HWJSC) Extracts Inhibit Cancer Cell Growth in Vitro","volume":"113","author":"Gauthaman","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4842134","DOI":"10.1155\/2016\/4842134","article-title":"Wharton\u2019s Jelly-Derived Mesenchymal Stromal Cells and Fibroblast-Derived Extracellular Matrix Synergistically Activate Apoptosis in a P21-Dependent Mechanism in WHCO1 and MDA MB 231 Cancer Cells In Vitro","volume":"2016","author":"Dzobo","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_110","first-page":"8536","article-title":"Suppression of Tumor Cell Proliferation and Migration by Human Umbilical Cord Mesenchymal Stem Cells: A Possible Role for Apoptosis and Wnt Signaling","volume":"15","author":"Yuan","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4103\/0028-3886.79134","article-title":"Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Inhibit C6 Glioma via Downregulation of Cyclin D1","volume":"59","author":"Jiao","year":"2011","journal-title":"Neurol. India"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Velpula, K.K., Dasari, V.R., Tsung, A.J., Gondi, C.S., Klopfenstein, J.D., Mohanam, S., and Rao, J.S. (2011). Regulation of Glioblastoma Progression by Cord Blood Stem Cells Is Mediated by Downregulation of Cyclin D1. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018017"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3727\/096368915X687787","article-title":"Paracrine Effects of Mesenchymal Stem Cells Induce Senescence and Differentiation of Glioblastoma Stem-like Cells","volume":"24","author":"Motaln","year":"2015","journal-title":"Cell Transplant."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13048-019-0546-9","article-title":"Anti-Proliferative Effects of Mesenchymal Stem Cells (MSCs) Derived from Multiple Sources on Ovarian Cancer Cell Lines: An In-Vitro Experimental Study","volume":"12","author":"Khalil","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc865","article-title":"Dissemination and Growth of Cancer Cells in Metastatic Sites","volume":"2","author":"Chambers","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ceb.2005.08.002","article-title":"Cell Migration in Tumors","volume":"17","author":"Yamaguchi","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nrc1075","article-title":"Tumour-Cell Invasion and Migration: Diversity and Escape Mechanisms","volume":"3","author":"Friedl","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Liu, J., Han, G., Liu, H., and Qin, C. (2013). Suppression of Cholangiocarcinoma Cell Growth by Human Umbilical Cord Mesenchymal Stem Cells: A Possible Role of Wnt and Akt Signaling. PLoS ONE, 8.","DOI":"10.1371\/annotation\/7fff93fa-8e80-41f3-b35a-e658cb7256a9"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.biocel.2017.12.013","article-title":"The Inhibitory Influence of Adipose Tissue-Derived Mesenchymal Stem Cell Environment and Wnt Antagonism on Breast Tumour Cell Lines","volume":"95","author":"Visweswaran","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-Mesenchymal Transitions in Development and Disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jcp.21223","article-title":"Epithelial--Mesenchymal and Mesenchymal--Epithelial Transitions in Carcinoma Progression","volume":"213","author":"Hugo","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1158\/1078-0432.CCR-05-2722","article-title":"Twist Overexpression Correlates with Hepatocellular Carcinoma Metastasis through Induction of Epithelial-Mesenchymal Transition","volume":"12","author":"Lee","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"245","DOI":"10.5487\/TR.2010.26.4.245","article-title":"Epithelial-Mesenchymal Transition and Cell Invasion","volume":"26","author":"Son","year":"2010","journal-title":"Toxicol. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1242\/dev.01907","article-title":"The Snail Genes as Inducers of Cell Movement and Survival: Implications in Development and Cancer","volume":"132","author":"Nieto","year":"2005","journal-title":"Development"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/cr.2009.5","article-title":"TGF-Beta-Induced Epithelial to Mesenchymal Transition","volume":"19","author":"Xu","year":"2009","journal-title":"Cell Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13046-014-0062-0","article-title":"Central Role of Snail1 in the Regulation of EMT and Resistance in Cancer: A Target for Therapeutic Intervention","volume":"33","author":"Kaufhold","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/24\/2131\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:58:20Z","timestamp":1760115500000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/13\/24\/2131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":126,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["cells13242131"],"URL":"https:\/\/doi.org\/10.3390\/cells13242131","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]}}}