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Key genes and biological processes in zebrafish that closely mirror those in humans, rapid development, and transparent embryos make zebrafish ideal for the in vivo studies of bone and muscle formation, as well as the molecular mechanisms underlying musculoskeletal disorders. This review focuses on the utility of zebrafish in modeling various musculoskeletal conditions, with an emphasis on bone diseases such as osteoporosis and osteogenesis imperfecta, as well as muscle disorders like Duchenne muscular dystrophy. These models have provided significant insights into the molecular pathways involved in these diseases, helping to identify the key genetic and biochemical factors that contribute to their progression. These findings have also advanced our understanding of disease mechanisms and facilitated the development of potential therapeutic strategies for musculoskeletal disorders.<\/jats:p>","DOI":"10.3390\/cells14010028","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T10:17:40Z","timestamp":1735640260000},"page":"28","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Modeling Musculoskeletal Disorders in Zebrafish: Advancements in Muscle and Bone Research"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3263-6671","authenticated-orcid":false,"given":"Luca","family":"Dalle Carbonare","sequence":"first","affiliation":[{"name":"Department of Engineering for the Innovation Medicine, University of Verona, 37100 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-6194","authenticated-orcid":false,"given":"Michele","family":"Braggio","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4610-1168","authenticated-orcid":false,"given":"Arianna","family":"Minoia","sequence":"additional","affiliation":[{"name":"Department of Engineering for the Innovation Medicine, University of Verona, 37100 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4315-0282","authenticated-orcid":false,"given":"Mattia","family":"Cominacini","sequence":"additional","affiliation":[{"name":"Department of Engineering for the Innovation Medicine, University of Verona, 37100 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7360-1195","authenticated-orcid":false,"given":"Maria Grazia","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9202-5728","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Institute of Biomedicine\u2014iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5444-9853","authenticated-orcid":false,"given":"Natascia","family":"Tiso","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Padua, 35131 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1166-8033","authenticated-orcid":false,"given":"Maria Teresa","family":"Valenti","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"ref_1","unstructured":"Parker, B. (2019). Origin and Evolution of Vertebrates, Scientific e-Resources."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/raq.12041","article-title":"The zebrafish (Danio rerio) as a model organism, with emphasis on applications for finfish aquaculture research","volume":"6","author":"Ribas","year":"2014","journal-title":"Rev. Aquac."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Crouzier, L., Richard, E.M., Sourbron, J., Lagae, L., Maurice, T., and Delprat, B. (2021). Use of zebrafish models to boost research in rare genetic diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413356"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0091-679X(08)60374-X","article-title":"Zebrafish: Genetic and embryological methods in a transparent vertebrate embryo","volume":"52","author":"Fishman","year":"1997","journal-title":"Methods Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/dvdy.24497","article-title":"Heart function and hemodynamic analysis for zebrafish embryos","volume":"246","author":"Yalcin","year":"2017","journal-title":"Dev. Dyn."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.reprotox.2009.04.013","article-title":"Zebrafish embryos as models for embryotoxic and teratological effects of chemicals","volume":"28","author":"Yang","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/zeb.2014.0976","article-title":"Growth and maturation in the zebrafish, Danio rerio: A staging tool for teaching and research","volume":"11","author":"Singleman","year":"2014","journal-title":"Zebrafish"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Maqsood, H.M., Jaias, I., Mattoo, A.I., Akram, T., Akram, W., and Ganai, N.A. (2024). Breeding of Zebrafish and Its Life Cycle. Zebrafish as a Model for Parkinson\u2019s Disease, CRC Press.","DOI":"10.1201\/9781003402893-4"},{"key":"ref_11","unstructured":"Mcdonald, G. (2024). Functional Studies of High Bone Mass Associated Genes in Both In Vitro and In Vivo Skeletal Systems. [Doctoral Dissertation, University of Bristol]."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Valenti, M.T., Marchetto, G., Mottes, M., and Dalle Carbonare, L. (2020). Zebrafish: A suitable tool for the study of cell signaling in bone. Cells, 9.","DOI":"10.3390\/cells9081911"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11914-020-00599-y","article-title":"Muscle, bone, and fat crosstalk: The biological role of myokines, osteokines, and adipokines","volume":"18","author":"Kirk","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Herrmann, M., Engelke, K., Ebert, R., M\u00fcller-Deubert, S., Rudert, M., Ziouti, F., Jundt, F., Felsenberg, D., and Jakob, F. (2020). Interactions between muscle and bone\u2014Where physics meets biology. Biomolecules, 10.","DOI":"10.3390\/biom10030432"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Yan, K., Guan, Q., Guo, Q., and Zhao, C. (2024). Mechanism and physical activities in bone-skeletal muscle crosstalk. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1287972"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00223-023-01146-4","article-title":"The Interconnection Between Muscle and Bone: A Common Clinical Management Pathway","volume":"114","author":"Smith","year":"2024","journal-title":"Calcif. Tissue Int."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Mou, K., Chan, S.M., and Vlahos, R. (2024). Musculoskeletal crosstalk in chronic obstructive pulmonary disease and comorbidities: Emerging roles and therapeutic potentials. Pharmacol. Ther., 108635.","DOI":"10.1016\/j.pharmthera.2024.108635"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11914-020-00600-8","article-title":"Myokines and osteokines in the pathogenesis of muscle and bone diseases","volume":"18","author":"Colaianni","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Cariati, I., Bonanni, R., Onorato, F., Mastrogregori, A., Rossi, D., Iundusi, R., Gasbarra, E., Tancredi, V., and Tarantino, U. (2021). Role of physical activity in bone\u2013muscle crosstalk: Biological aspects and clinical implications. J. Funct. Morphol. Kinesiol., 6.","DOI":"10.3390\/jfmk6020055"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bone.2015.04.014","article-title":"Bone and skeletal muscle: Key players in mechanotransduction and potential overlapping mechanisms","volume":"80","author":"Goodman","year":"2015","journal-title":"Bone"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s00018-024-05331-y","article-title":"Bone-muscle crosstalk under physiological and pathological conditions","volume":"81","author":"Dong","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Sui, H., Dou, J., Shi, B., and Cheng, X. (2024). The reciprocity of skeletal muscle and bone: An evolving view from mechanical coupling, secretory crosstalk to stem cell exchange. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1349253"},{"key":"ref_23","first-page":"4380","article-title":"Age-Related Changes in Bone Density, Muscle Mass, And Joint Integrity, And Their Implications for the Development of Age-Related Conditions like Osteoporosis and Sarcopenia","volume":"12","author":"Majeed","year":"2023","journal-title":"Eur. Chem. Bull."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"0465","DOI":"10.34133\/research.0465","article-title":"Imbalanced Skeletal Muscle Mitochondrial Proteostasis Causes Bone Loss","volume":"7","author":"Jin","year":"2024","journal-title":"Research"},{"key":"ref_25","first-page":"CD010899","article-title":"Interventions to prevent and treat corticosteroid-induced osteoporosis and prevent osteoporotic fractures in Duchenne muscular dystrophy","volume":"1","author":"Bell","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/bonekey.2015.114","article-title":"Osteogenic programs during zebrafish fin regeneration","volume":"4","author":"Watson","year":"2015","journal-title":"BoneKEy Rep."},{"key":"ref_27","unstructured":"Lowes, L.P., and Hay, K. (2016). Musculoskeletal development and adaptation. Campbell\u2019s Physical Therapy forChildren Expert Consult-E-Book, Elsevier."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Li, G., and Niu, W. (2020). Challenges toward musculoskeletal injuries and diseases. Nanoengineering in Musculoskeletal Regeneration, Elsevier.","DOI":"10.1016\/B978-0-12-820262-3.00001-3"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/jmedgenet-2018-105358","article-title":"Use of zebrafish models to investigate rare human disease","volume":"55","author":"Adamson","year":"2018","journal-title":"J. Med. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Phillips, J.B., and Westerfield, M. (2020). Zebrafish as a model to understand human genetic diseases. The Zebrafish in Biomedical Research, Elsevier.","DOI":"10.1016\/B978-0-12-812431-4.00047-6"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1161\/CIRCRESAHA.122.320396","article-title":"Zebrafish models of cardiac disease: From fortuitous mutants to precision medicine","volume":"130","year":"2022","journal-title":"Circ. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"101748","DOI":"10.1016\/j.bonr.2024.101748","article-title":"In vivo imaging of bone collagen dynamics in zebrafish","volume":"20","author":"Hino","year":"2024","journal-title":"Bone Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bone.2019.02.009","article-title":"Using zebrafish to study skeletal genomics","volume":"126","author":"Kwon","year":"2019","journal-title":"Bone"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"D758","DOI":"10.1093\/nar\/gkw1116","article-title":"The Zebrafish Model Organism Database: New support for human disease models, mutation details, gene expression phenotypes and searching","volume":"45","author":"Howe","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nature11992","article-title":"A systematic genome-wide analysis of zebrafish protein-coding gene function","volume":"496","author":"Kettleborough","year":"2013","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Morgan, E.F., and Gerstenfeld, L.C. (2021). The bone organ system: Form and function. Marcus and Feldman\u2019s Osteoporosis, Elsevier.","DOI":"10.1016\/B978-0-12-813073-5.00002-2"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"DuMez, R., and Skromne, I. (2023). Bone Biology: From a to Zebrafish Authors and reviewers. Front. Young Minds.","DOI":"10.3389\/frym.2023.963637"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Tonelli, F., Bek, J.W., Besio, R., De Clercq, A., Leoni, L., Salmon, P., Coucke, P.J., Willaert, A., and Forlino, A. (2020). Zebrafish: A resourceful vertebrate model to investigate skeletal disorders. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.00489"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jbmr.4256","article-title":"Skeletal biology and disease modeling in zebrafish","volume":"36","author":"Dietrich","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"151704","DOI":"10.1016\/j.aanat.2021.151704","article-title":"Bone tissue and histological and molecular events during development of the long bones","volume":"235","author":"Blumer","year":"2021","journal-title":"Ann. Anat. -Anat. Anz."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Le Pabic, P., Dranow, D.B., Hoyle, D.J., and Schilling, T.F. (2022). Zebrafish endochondral growth zones as they relate to human bone size, shape and disease. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1060187"},{"key":"ref_42","unstructured":"Niu, X., Kraus, J., Galloway, J., Youngstrom, D., Henke, K., and Farmer, D. (2023). Genetically Engineered Zebrafish as Models of Skeletal Development and Regeneration, University of California."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0012-1606(03)00399-3","article-title":"Radiographic analysis of zebrafish skeletal defects","volume":"264","author":"Fisher","year":"2003","journal-title":"Dev. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.exger.2003.10.022","article-title":"Comparative aspects of zebrafish (Danio rerio) as a model for aging research","volume":"38","author":"Gerhard","year":"2003","journal-title":"Exp. Gerontol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Verma, S.K., Nandi, A., Sinha, A., Patel, P., Mohanty, S., Jha, E., Jena, S., Kumari, P., Ghosh, A., and Jerman, I. (2024). The posterity of Zebrafish in paradigm of in vivo molecular toxicological profiling. Biomed. Pharmacother., 171.","DOI":"10.1016\/j.biopha.2024.116160"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Uemoto, T., Abe, G., and Tamura, K. (2020). Regrowth of zebrafish caudal fin regeneration is determined by the amputated length. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-57533-6"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/reg2.33","article-title":"The art of fin regeneration in zebrafish","volume":"2","author":"Pfefferli","year":"2015","journal-title":"Regeneration"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sehring, I.M., and Weidinger, G. (2020). Recent advancements in understanding fin regeneration in zebrafish. Wiley Interdiscip. Rev. Dev. Biol., 9.","DOI":"10.1002\/wdev.367"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbaexp.2005.03.008","article-title":"Identification and characterisation of two runx2 homologues in zebrafish with different expression patterns","volume":"1729","author":"Kranenbarg","year":"2005","journal-title":"Biochim. Et Biophys. Acta (BBA)-Gene Struct. Expr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.modgep.2004.01.016","article-title":"Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements","volume":"4","author":"Flores","year":"2004","journal-title":"Gene Expr. Patterns"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Yang, D.-C., Tsai, C.-C., Liao, Y.-F., Fu, H.-C., Tsay, H.-J., Huang, T.-F., Chen, Y.-H., and Hung, S.-C. (2011). Twist controls skeletal development and dorsoventral patterning by regulating runx2 in zebrafish. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027324"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Gistelinck, C., Gioia, R., Gagliardi, A., Tonelli, F., Marchese, L., Bianchi, L., Landi, C., Bini, L., Huysseune, A., and Witten, P.E. (2016). Zebrafish collagen type I: Molecular and biochemical characterization of the major structural protein in bone and skin. Sci. Rep., 6.","DOI":"10.1038\/srep21540"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1056\/NEJM196902062800605","article-title":"Skeletal renewal and metabolic bone disease","volume":"280","author":"Harris","year":"1969","journal-title":"N. Engl. J. Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Parfitt, A.M. (1982). The Coupling of Bone Formation to Bone Resorption: A Critical Analysis of the Concept and of Its Relevance to the Pathogenesis of Osteoporosis, Elsevier.","DOI":"10.1016\/0221-8747(82)90002-9"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Martin, T.J., and Rodan, G.A. (2001). Coupling of bone resorption and formation during bone remodeling. Osteoporosis, Elsevier.","DOI":"10.1016\/B978-012470862-4\/50013-1"},{"key":"ref_56","unstructured":"Silva, I., and Branco, J.C. (2011). Rank\/Rankl\/opg: Literature review. Acta Reumatol. Port., 36."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/nm.2489","article-title":"Suppression of bone formation by osteoclastic expression of semaphorin 4D","volume":"17","author":"Shinohara","year":"2011","journal-title":"Nat. Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Bergen, D.J., Kague, E., and Hammond, C.L. (2019). Zebrafish as an emerging model for osteoporosis: A primary testing platform for screening new osteo-active compounds. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00006"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/jbmr.4327","article-title":"Lrp5 mutant and Crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR-based functional screening of osteoporosis candidate genes","volume":"36","author":"Bek","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jbspin.2009.11.013","article-title":"Novel LRP5 gene mutation in a patient with osteoporosis-pseudoglioma syndrome","volume":"77","author":"Levasseur","year":"2010","journal-title":"Jt. Bone Spine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cbpa.2013.04.023","article-title":"Zebrafish scales respond differently to in vitro dynamic and static acceleration: Analysis of interaction between osteoblasts and osteoclasts","volume":"166","author":"Kitamura","year":"2013","journal-title":"Comp. Biochem. Physiol. Part A Mol. Integr. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Masiero, C., Aresi, C., Forlino, A., and Tonelli, F. (2024). Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery. Calcif. Tissue Int., 1\u201329.","DOI":"10.1007\/s00223-024-01282-5"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.matbio.2020.03.004","article-title":"Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype","volume":"90","author":"Tonelli","year":"2020","journal-title":"Matrix Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.matbio.2023.06.003","article-title":"Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure","volume":"121","author":"Daponte","year":"2023","journal-title":"Matrix Biol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Debaenst, S., Jarayseh, T., De Saffel, H., Bek, J.W., Boone, M., Josipovic, I., Kibleur, P., Kwon, R.Y., Coucke, P., and Willaert, A. (2024). Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility. bioRxiv.","DOI":"10.7554\/eLife.100060.1"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00018-022-04534-5","article-title":"Zebrafish: An important model for understanding scoliosis","volume":"79","author":"Xie","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.mehy.2008.09.052","article-title":"Idiopathic-type scoliosis is not exclusive to bipedalism","volume":"72","author":"Gorman","year":"2009","journal-title":"Med. Hypotheses"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.spinee.2011.03.010","article-title":"Experimental animal models in scoliosis research: A review of the literature","volume":"11","author":"Janssen","year":"2011","journal-title":"Spine J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/jor.22797","article-title":"Animal models of scoliosis","volume":"33","author":"Bobyn","year":"2015","journal-title":"J. Orthop. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"nwac152","DOI":"10.1093\/nsr\/nwac152","article-title":"Single-cell transcriptomes and runx2b\u2212\/\u2212 mutants reveal the genetic signatures of intermuscular bone formation in zebrafish","volume":"9","author":"Nie","year":"2022","journal-title":"Natl. Sci. Rev."},{"key":"ref_71","unstructured":"Tonelli, F. (2018). OI Zebrafish Models and Their Use to Develop New Pharmacological Treatments. [Ph.D. Thesis, Universit\u00e0 Di Pavia]."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Jarayseh, T., Debaenst, S., De Saffel, H., Rosseel, T., Milazzo, M., Bek, J.W., Hudson, D.M., Van Nieuwerburgh, F., Gansemans, Y., and Josipovic, I. (2024). Bmpr1aa modulates the severity of the skeletal phenotype in an fkbp10-deficient Bruck syndrome zebrafish model. J. Bone Miner. Res., zjae185.","DOI":"10.1093\/jbmr\/zjae185"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41467-019-14169-z","article-title":"Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1\/TFEB pathway","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ydbio.2013.11.028","article-title":"Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations","volume":"386","author":"Gray","year":"2014","journal-title":"Dev. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"18603","DOI":"10.18632\/aging.103856","article-title":"Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis","volume":"12","author":"Newham","year":"2020","journal-title":"Aging"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1534\/genetics.117.300187","article-title":"Genetic screen for postembryonic development in the zebrafish (Danio rerio): Dominant mutations affecting adult form","volume":"207","author":"Henke","year":"2017","journal-title":"Genetics"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Liu, Y., Sepich, D.S., and Solnica-Krezel, L. (2017). Stat3\/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation. PLoS Genet., 13.","DOI":"10.1371\/journal.pgen.1006564"},{"key":"ref_78","first-page":"S271","article-title":"Congenital myopathies: The current status","volume":"65","author":"Goebel","year":"2022","journal-title":"Indian J. Pathol. Microbiol."},{"key":"ref_79","first-page":"S74","article-title":"Acquired myopathy\/dystrophies","volume":"5","author":"Chiodo","year":"2013","journal-title":"PMR"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/BOR.0000000000000828","article-title":"Skeletal muscle immunohistochemistry of acquired and hereditary myopathies","volume":"33","author":"Danielsson","year":"2021","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(02)07815-7","article-title":"The muscular dystrophies","volume":"359","author":"Emery","year":"2002","journal-title":"Lancet"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ana.23528","article-title":"Evidence-based path to newborn screening for Duchenne muscular dystrophy","volume":"71","author":"Mendell","year":"2012","journal-title":"Ann. Neurol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/hgtb.2018.187","article-title":"Development of CRISPR-mediated systems in the study of Duchenne muscular dystrophy","volume":"30","author":"Cai","year":"2019","journal-title":"Hum. Gene Ther. Methods"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/nm.3990","article-title":"Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division","volume":"21","author":"Dumont","year":"2015","journal-title":"Nat. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nrm2024","article-title":"Molecular mechanisms of muscular dystrophies: Old and new players","volume":"7","author":"Davies","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0092-8674(87)90579-4","article-title":"Dystrophin: The protein product of the Duchenne muscular dystrophy locus","volume":"51","author":"Hoffman","year":"1987","journal-title":"Cell"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/hmg\/ddn337","article-title":"Genetic isolation and characterization of a splicing mutant of zebrafish dystrophin","volume":"18","author":"Guyon","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1242\/dev.00799","article-title":"Dystrophin is required for the formation of stable muscle attachments in the zebrafish embryo","volume":"130","author":"Bassett","year":"2003","journal-title":"Development"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10038-006-0374-9","article-title":"Diagnosis and cell-based therapy for Duchenne muscular dystrophy in humans, mice, and zebrafish","volume":"51","author":"Kunkel","year":"2006","journal-title":"J. Hum. Genet."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1242\/dev.123.1.399","article-title":"Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva","volume":"123","author":"Granato","year":"1996","journal-title":"Development"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1073\/pnas.1102116108","article-title":"Drug screening in a zebrafish model of Duchenne muscular dystrophy","volume":"108","author":"Kawahara","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1093\/hmg\/ddu185","article-title":"Fluoxetine prevents dystrophic changes in a zebrafish model of Duchenne muscular dystrophy","volume":"23","author":"Waugh","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1152\/physiolgenomics.00088.2016","article-title":"Muscle dysfunction in a zebrafish model of Duchenne muscular dystrophy","volume":"48","author":"Widrick","year":"2016","journal-title":"Physiol. Genom."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Aranda-Mart\u00ednez, P., Sayed, R.K., Fern\u00e1ndez-Mart\u00ednez, J., Ram\u00edrez-Casas, Y., Yang, Y., Escames, G., and Acu\u00f1a-Castroviejo, D. (2024). Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202405.1073.v1"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e62760","DOI":"10.7554\/eLife.62760","article-title":"Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy","volume":"11","author":"Kilroy","year":"2022","journal-title":"Elife"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.nmd.2012.04.007","article-title":"Muscle diseases in the zebrafish","volume":"22","author":"Lin","year":"2012","journal-title":"Neuromuscul. Disord."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"7092","DOI":"10.1073\/pnas.0700942104","article-title":"The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin \u03b12-deficient congenital muscular dystrophy","volume":"104","author":"Hall","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/jnen\/nlv020","article-title":"Skeletal muscle pathology in X-linked myotubular myopathy: Review with cross-species comparisons","volume":"75","author":"Lawlor","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Jungbluth, H., and Gautel, M. (2014). Pathogenic mechanisms in centronuclear myopathies. Front. Aging Neurosci., 6.","DOI":"10.3389\/fnagi.2014.00339"},{"key":"ref_100","first-page":"143","article-title":"Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1","volume":"7","author":"Todd","year":"2014","journal-title":"Dis. Models Mech."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1242\/dmm.004150","article-title":"Zebrafish deficient for Muscleblind-like 2 exhibit features of myotonic dystrophy","volume":"4","author":"Buxton","year":"2011","journal-title":"Dis. Models Mech."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1111\/febs.12412","article-title":"Swimming into prominence: The zebrafish as a valuable tool for studying human myopathies and muscular dystrophies","volume":"280","author":"Gibbs","year":"2013","journal-title":"FEBS J."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1242\/jcs.140194","article-title":"In vivo cell biology in zebrafish\u2013providing insights into vertebrate development and disease","volume":"127","author":"Vacaru","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Vinci, P., Panizon, E., Tosoni, L.M., Cerrato, C., Pellicori, F., Mearelli, F., Biasinutto, C., Fiotti, N., Di Girolamo, F.G., and Biolo, G. (2021). Statin-associated myopathy: Emphasis on mechanisms and targeted therapy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111687"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1534-5807(04)00032-2","article-title":"Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation","volume":"6","author":"Thorpe","year":"2004","journal-title":"Dev. Cell"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1177\/1535370216659944","article-title":"Alterations in zebrafish development induced by simvastatin: Comprehensive morphological and physiological study, focusing on muscle","volume":"241","author":"Campos","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"564705","DOI":"10.1155\/2012\/564705","article-title":"Ezetimibe and Simvastatin Reduce Cholesterol Levels in Zebrafish Larvae Fed a High-Cholesterol Diet","volume":"2012","author":"Baek","year":"2012","journal-title":"Cholesterol"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Palmio, J., and Udd, B. (2014). Borderlines between sarcopenia and mild late-onset muscle disease. Front. Aging Neurosci., 6.","DOI":"10.3389\/fnagi.2014.00267"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3233\/JND-190389","article-title":"Discovery of novel therapeutics for muscular dystrophies using zebrafish phenotypic screens","volume":"6","author":"Widrick","year":"2019","journal-title":"J. Neuromuscul. Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-015-1430-3","article-title":"Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function","volume":"130","author":"Sztal","year":"2015","journal-title":"Acta Neuropathol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1242\/dev.034561","article-title":"The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment","volume":"136","author":"Jacoby","year":"2009","journal-title":"Development"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Dowling, J.J., Vreede, A.P., Low, S.E., Gibbs, E.M., Kuwada, J.Y., Bonnemann, C.G., and Feldman, E.L. (2009). Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy. PLoS Genet., 5.","DOI":"10.1371\/journal.pgen.1000372"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/hmg\/ddg071","article-title":"The dystrophin associated protein complex in zebrafish","volume":"12","author":"Guyon","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1093\/hmg\/ddq126","article-title":"Zebrafish models of collagen VI-related myopathies","volume":"19","author":"Telfer","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.devcel.2011.12.008","article-title":"In vivo imaging of molecular interactions at damaged sarcolemma","volume":"22","author":"Roostalu","year":"2012","journal-title":"Dev. Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1093\/hmg\/ddr059","article-title":"Zebrafish Fukutin family proteins link the unfolded protein response with dystroglycanopathies","volume":"20","author":"Lin","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/brain\/awn078","article-title":"Developmental defects in a zebrafish model for muscular dystrophies associated with the loss of fukutin-related protein (FKRP)","volume":"131","author":"Thornhill","year":"2008","journal-title":"Brain"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/hmg\/ddp528","article-title":"Zebrafish models for human FKRP muscular dystrophies","volume":"19","author":"Kawahara","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1242\/dev.004531","article-title":"Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease","volume":"134","author":"Hirata","year":"2007","journal-title":"Development"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Callegari, S., Mirzaei, F., Agbaria, L., Shariff, S., Kantawala, B., Moronge, D., and Ogendi, B.M. (2023). Zebrafish as an Emerging Model for Sarcopenia: Considerations, Current Insights, and Future Directions. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202309.1738.v1"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Rutkove, S.B., Chen, Z.-Z., Pandeya, S., Callegari, S., Mourey, T., Nagy, J.A., and Nath, A.K. (2023). Surface Electrical Impedance Myography Detects Skeletal Muscle Atrophy in Aged Wildtype Zebrafish and Aged gpr27 Knockout Zebrafish. Biomedicines, 11.","DOI":"10.3390\/biomedicines11071938"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Rutkove, S.B., Callegari, S., Concepcion, H., Mourey, T., Widrick, J., Nagy, J.A., and Nath, A.K. (2023). Electrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-34119-6"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Henderson, T.D., Choi, J., Leonard, S.W., Head, B., Tanguay, R.L., Barton, C.L., and Traber, M.G. (2023). Chronic Vitamin E deficiency dysregulates purine, phospholipid, and amino acid metabolism in aging zebrafish skeletal muscle. Antioxidants, 12.","DOI":"10.3390\/antiox12061160"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Zou, Y.-Y., Chen, Z.-L., Sun, C.-C., Yang, D., Zhou, Z.-Q., Xiao, Q., Peng, X.-Y., and Tang, C.-F. (2022). A high-fat diet induces muscle mitochondrial dysfunction and impairs swimming capacity in zebrafish: A new model of sarcopenic obesity. Nutrients, 14.","DOI":"10.3390\/nu14091975"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"112265","DOI":"10.1016\/j.exger.2023.112265","article-title":"Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish","volume":"180","author":"Chen","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/febs.16637","article-title":"Exercise intervention mitigates zebrafish age-related sarcopenia via alleviating mitochondrial dysfunction","volume":"290","author":"Sun","year":"2023","journal-title":"FEBS J."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Dalle Carbonare, L., Minoia, A., Zouari, S., Piritore, F.C., Vareschi, A., Romanelli, M.G., and Valenti, M.T. (2023). Crosstalk between bone and muscles during physical activity. Cells, 12.","DOI":"10.3390\/cells12162088"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.medengphy.2015.05.015","article-title":"From mechanical stimulus to bone formation: A review","volume":"37","author":"Rosa","year":"2015","journal-title":"Med. Eng. Phys."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","article-title":"Mechanical regulation of bone remodeling","volume":"10","author":"Wang","year":"2022","journal-title":"Bone Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1586\/17434440.4.3.405","article-title":"Bioactive scaffolds for bone and ligament tissue","volume":"4","author":"Guarino","year":"2007","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Schwartzman, J.D., McCall, M., Ghattas, Y., Pugazhendhi, A.S., Wei, F., Ngo, C., Ruiz, J., Seal, S., and Coathup, M.J. (2024). Multifunctional Scaffolds for Bone Repair following Age-Related Biological Decline: Promising Prospects for Smart Biomaterial-Driven Technologies. Biomaterials.","DOI":"10.1016\/j.biomaterials.2024.122683"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Gargalionis, A.N., Adamopoulos, C., Vottis, C.T., Papavassiliou, A.G., and Basdra, E.K. (2024). Runx2 and Polycystins in Bone Mechanotransduction: Challenges for Therapeutic Opportunities. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105291"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"ziae098","DOI":"10.1093\/jbmrpl\/ziae098","article-title":"Altered extracellular matrix and mechanotransduction gene expression in rat bone tissue following long-term estrogen deficiency","volume":"8","author":"Naqvi","year":"2024","journal-title":"JBMR Plus"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00031.2003","article-title":"Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading","volume":"84","author":"Kjaer","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_135","first-page":"114","article-title":"Mechanical basis of bone strength: Influence of bone material, bone structure and muscle action","volume":"17","author":"Hart","year":"2017","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/19424280.2011.555248","article-title":"Biological tissue response to impact like mechanical loading","volume":"3","author":"Heinrich","year":"2011","journal-title":"Footwear Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.bpj.2020.06.036","article-title":"Mechanical characteristics of ultrafast zebrafish larval swimming muscles","volume":"119","author":"Mead","year":"2020","journal-title":"Biophys. J."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Saghiv, M.S., Sagiv, M.S., Saghiv, M.S., and Sagiv, M.S. (2020). Skeletal Muscles. Basic Exercise Physiology: Clinical and Laboratory Perspectives, Springer.","DOI":"10.1007\/978-3-030-48806-2"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Suniaga, S., Rolvien, T., Vom Scheidt, A., Fiedler, I.A., Bale, H.A., Huysseune, A., Witten, P.E., Amling, M., and Busse, B. (2018). Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-21776-1"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Carnovali, M., Banfi, G., and Mariotti, M. (2019). Zebrafish models of human skeletal disorders: Embryo and adult swimming together. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/1253710"},{"key":"ref_141","first-page":"221","article-title":"The molecular basis of bone mechanotransduction","volume":"16","author":"Yavropoulou","year":"2016","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Valenti, M.T., Deiana, M., Cheri, S., Dotta, M., Zamboni, F., Gabbiani, D., Schena, F., Dalle Carbonare, L., and Mottes, M. (2019). Physical exercise modulates miR-21-5p, miR-129-5p, miR-378-5p, and miR-188-5p expression in progenitor cells promoting osteogenesis. Cells, 8.","DOI":"10.3390\/cells8070742"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00223-020-00724-0","article-title":"Bone\u2019s response to mechanical loading in aging and osteoporosis: Molecular mechanisms","volume":"107","author":"Carina","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00223-021-00836-1","article-title":"Disuse osteoporosis: Clinical and mechanistic insights","volume":"110","author":"Rolvien","year":"2022","journal-title":"Calcif. Tissue Int."},{"key":"ref_145","unstructured":"Rogers, K. (2010). Bone and Muscle: Structure, Force, and Motion, Britannica Educational Publishing."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Zatsiorsky, V.M., and Prilutsky, B.I. (2012). Biomechanics of Skeletal Muscles, Human Kinetics.","DOI":"10.5040\/9781492595298"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Voesenek, C.J., Muijres, F.T., and Van Leeuwen, J.L. (2018). Biomechanics of swimming in developing larval fish. J. Exp. Biol., 221.","DOI":"10.1242\/jeb.149583"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"M\u00fcller, U.K. (2020). Swimming and muscle. Fish Larval Physiology, CRC Press.","DOI":"10.1201\/9780429061608-21"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"dmm042689","DOI":"10.1242\/dmm.042689","article-title":"Zebrafish models of sarcopenia","volume":"13","author":"Daya","year":"2020","journal-title":"Dis. Models Mech."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41413-021-00168-8","article-title":"Roles of mechanosensitive channel Piezo1\/2 proteins in skeleton and other tissues","volume":"9","author":"Qin","year":"2021","journal-title":"Bone Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"jcs250738","DOI":"10.1242\/jcs.250738","article-title":"Notch in mechanotransduction\u2013from molecular mechanosensitivity to tissue mechanostasis","volume":"133","author":"Stassen","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Yamamoto, M., Sakiyama, K., Kitamura, K., Yamamoto, Y., Takagi, T., Sekiya, S., Watanabe, G., Taniguchi, S., Ogawa, Y., and Ishizuka, S. (2022). Development and regeneration of muscle, tendon, and myotendinous junctions in striated skeletal muscle. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063006"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"23259671211020731","DOI":"10.1177\/23259671211020731","article-title":"Injuries in muscle-tendon-bone units: A systematic review considering the role of passive tissue fatigue","volume":"9","author":"Parente","year":"2021","journal-title":"Orthop. J. Sports Med."},{"key":"ref_154","unstructured":"Iwasaki, N. (2024). Strain Distribution Across the Myotendinous Junction and its Role in the Regeneration of the Junction. [Ph.D. Thesis, University of Portsmouth]."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Amemiya, H., Yamamoto, M., Higa, K., Watanabe, G., Taniguchi, S., Kitamura, K., Jeong, J., Yanagisawa, N., Fukuda, K.-i., and Abe, S. (2023). Effects of myostatin on nuclear morphology at the myotendinous junction. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076634"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.gep.2008.08.003","article-title":"Dynamic formation of microenvironments at the myotendinous junction correlates with muscle fiber morphogenesis in zebrafish","volume":"9","author":"Snow","year":"2009","journal-title":"Gene Expr. Patterns"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2022.03.002","article-title":"Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish","volume":"109","author":"Malbouyres","year":"2022","journal-title":"Matrix Biol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"112544","DOI":"10.1016\/j.exger.2024.112544","article-title":"Sarcopenic obesity and osteoporosis: Research progress and hot spots","volume":"195","author":"Fan","year":"2024","journal-title":"Exp. Gerontol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/andr.12359","article-title":"Osteocalcin, a bone-derived hormone with important andrological implications","volume":"5","author":"Rocca","year":"2017","journal-title":"Andrology"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Komori, T. (2020). Functions of osteocalcin in bone, pancreas, testis, and muscle. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207513"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.molmet.2016.07.002","article-title":"Osteocalcin is necessary and sufficient to maintain muscle mass in older mice","volume":"5","author":"Mera","year":"2016","journal-title":"Mol. Metab."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ncb1101-1009","article-title":"Mediation of IGF-1-induced skeletal myotube hypertrophy by PI (3) K\/Akt\/mTOR and PI (3) K\/Akt\/GSK3 pathways","volume":"3","author":"Rommel","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11914-014-0209-0","article-title":"Endocrine crosstalk between muscle and bone","volume":"12","author":"Brotto","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"148561","DOI":"10.1016\/j.gene.2024.148561","article-title":"Deletion of Asb15b gene can lead to a significant decrease in zebrafish intermuscular bone","volume":"923","author":"Niu","year":"2024","journal-title":"Gene"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Leyhr, J., Sanchez, S., Dollman, K.N., Tafforeau, P., and Haitina, T. (2023). Enhanced contrast synchrotron X-ray microtomography for describing skeleton-associated soft tissue defects in zebrafish mutants. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1108916"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.1096\/fj.201802654RR","article-title":"Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish","volume":"33","author":"Kague","year":"2019","journal-title":"FASEB J."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1242\/dev.062521","article-title":"Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome","volume":"138","author":"Maurya","year":"2011","journal-title":"Development"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.biochi.2021.10.014","article-title":"Musculoskeletal regeneration: A zebrafish perspective","volume":"196","author":"Ingham","year":"2022","journal-title":"Biochimie"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"a023267","DOI":"10.1101\/cshperspect.a023267","article-title":"Wound healing and skin regeneration","volume":"5","author":"Takeo","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Van Haele, M., Snoeck, J., and Roskams, T. (2019). Human liver regeneration: An etiology dependent process. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092332"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Daponte, V., Tylzanowski, P., and Forlino, A. (2021). Appendage regeneration in vertebrates: What makes this possible?. Cells, 10.","DOI":"10.3390\/cells10020242"},{"key":"ref_172","unstructured":"Sheen, J.R., Mabrouk, A., and Garla, V.V. (2023). Fracture healing overview. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s12015-016-9665-5","article-title":"Stem cells in bone regeneration","volume":"12","author":"Walmsley","year":"2016","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nrg3246","article-title":"The telomere syndromes","volume":"13","author":"Armanios","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0092-8674(01)80006-4","article-title":"Telomere shortening and tumor formation by mouse cells lacking telomerase RNA","volume":"91","author":"Blasco","year":"1997","journal-title":"Cell"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0092-8674(00)80580-2","article-title":"Longevity, stress response, and cancer in aging telomerase-deficient mice","volume":"96","author":"Rudolph","year":"1999","journal-title":"Cell"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1242\/dmm.025130","article-title":"Telomeres in aging and disease: Lessons from zebrafish","volume":"9","author":"Carneiro","year":"2016","journal-title":"Dis. Models Mech."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Carneiro, M.C., Henriques, C.M., Nabais, J., Ferreira, T., Carvalho, T., and Ferreira, M.G. (2016). Short telomeres in key tissues initiate local and systemic aging in zebrafish. PLoS Genet., 12.","DOI":"10.1371\/journal.pgen.1005798"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Sayer","year":"2019","journal-title":"Lancet"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2016.06.001","article-title":"Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults","volume":"50","author":"Angulo","year":"2016","journal-title":"Mol. Asp. Med."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e13223","DOI":"10.1111\/acel.13223","article-title":"Animal models of sarcopenia","volume":"19","author":"Christian","year":"2020","journal-title":"Aging Cell"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1159\/000228892","article-title":"Zebrafish as a genetic model in biological and behavioral gerontology: Where development meets aging in vertebrates\u2013a mini-review","volume":"55","author":"Kishi","year":"2009","journal-title":"Gerontology"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Kishi, S., Bayliss, P.E., Uchiyama, J., Koshimizu, E., Qi, J., Nanjappa, P., Imamura, S., Islam, A., Neuberg, D., and Amsterdam, A. (2008). The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet., 4.","DOI":"10.1371\/journal.pgen.1000152"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Montandon, M., Currie, P.D., and Ruparelia, A.A. (2021). Examining muscle regeneration in zebrafish models of muscle disease. JoVE (J. Vis. Exp.), e62071.","DOI":"10.3791\/62071-v"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Quach, T.K., Taylor, M.F., Currie, P.D., Eynon, N., and Ruparelia, A.A. (2024). Skeletal muscle ageing: Lessons from teleosts. J. Gerontol. Ser. A: Biol. Sci. Med. Sci., glae052.","DOI":"10.1093\/gerona\/glae052"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1113\/JP286530","article-title":"Characterization of ClC-1 chloride channels in zebrafish: A new model to study myotonia","volume":"602","author":"Muhaisen","year":"2024","journal-title":"J. Physiol."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Ichii, S., Matsuoka, I., Okazaki, F., and Shimada, Y. (2022). Zebrafish models for skeletal muscle senescence: Lessons from cell cultures and rodent models. Molecules, 27.","DOI":"10.3390\/molecules27238625"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"e596","DOI":"10.1002\/cpz1.596","article-title":"Animal Models of Osteoarthritis Part 1\u2013Preclinical Small Animal Models: Challenges and Opportunities for Drug Development","volume":"2","author":"Rios","year":"2022","journal-title":"Curr. Protoc."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Raman, R., Bahri, M.A., Degueldre, C., Caetano da Silva, C., Sanchez, C., Ostertag, A., Collet, C., Cohen-Solal, M., Plenevaux, A., and Henrotin, Y. (2023). A Zebrafish Mutant in the Extracellular Matrix Protein Gene efemp1 as a Model for Spinal Osteoarthritis. Animals, 14.","DOI":"10.3390\/ani14010074"},{"key":"ref_190","first-page":"2554","article-title":"Targeting cellular senescence in aging and age-related diseases: Challenges, considerations, and the emerging role of senolytic and senomorphic therapies","volume":"15","author":"Zheng","year":"2024","journal-title":"Aging Dis."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"e13835","DOI":"10.1111\/acel.13835","article-title":"A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo","volume":"22","author":"Morsli","year":"2023","journal-title":"Aging Cell"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1517\/17460441.2014.927435","article-title":"Recent advances using zebrafish animal models for muscle disease drug discovery","volume":"9","author":"Maves","year":"2014","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1002\/dvdy.22113","article-title":"Normal table of postembryonic zebrafish development: Staging by externally visible anatomy of the living fish","volume":"238","author":"Parichy","year":"2009","journal-title":"Dev. Dyn."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.devcel.2019.11.016","article-title":"NF-\u03baB signaling negatively regulates osteoblast dedifferentiation during zebrafish bone regeneration","volume":"52","author":"Mishra","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_195","first-page":"188","article-title":"Danio rerio: The Janus of the bone from embryo to scale","volume":"12","author":"Mariotti","year":"2015","journal-title":"Clin. Cases Miner. Bone Metab."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Yeh, S.-C.A., Wilk, K., Lin, C.P., and Intini, G. (2018). In vivo 3D histomorphometry quantifies bone apposition and skeletal progenitor cell differentiation. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-23785-6"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Cotti, S., Di Biagio, C., Huysseune, A., Koppe, W., Forlino, A., and Witten, P.E. (2024). Matrix first, minerals later: Fine-tuned dietary phosphate increases bone formation in zebrafish. JBMR Plus, ziae081.","DOI":"10.1093\/jbmrpl\/ziae081"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Chen, J.-R., Lai, Y.-H., Tsai, J.-J., and Hsiao, C.-D. (2017). Live fluorescent staining platform for drug-screening and mechanism-analysis in zebrafish for bone mineralization. Molecules, 22.","DOI":"10.20944\/preprints201709.0102.v1"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1002\/jbmr.3231","article-title":"Immune suppressive and bone inhibitory effects of prednisolone in growing and regenerating zebrafish tissues","volume":"32","author":"Geurtzen","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Bohns, F.R., Akhtar, R., Chuang, Y.-J., and Chen, P.-Y. (2024). Bone quality in zebrafish vertebrae improves after alendronate administration in a glucocorticoid-induced osteoporosis model. J. Mech. Behav. Biomed. Mater., 154.","DOI":"10.1016\/j.jmbbm.2024.106521"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"106366","DOI":"10.1016\/j.jff.2024.106366","article-title":"The role of the PI3K\/Akt pathway in adenosine\u2019s mechanism of action in osteoporosis with oxidative stress: A wet-dry experimental approach strategy","volume":"120","author":"Wang","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"116884","DOI":"10.1016\/j.taap.2024.116884","article-title":"Pinoresinol diglucoside mitigates dexamethasone-induced osteoporosis and chondrodysplasia in zebrafish","volume":"484","author":"Zuo","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"19373","DOI":"10.1021\/acsami.8b02792","article-title":"Accelerated bone regeneration by nitrogen-doped carbon dots functionalized with hydroxyapatite nanoparticles","volume":"10","author":"Khajuria","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.carbpol.2009.07.006","article-title":"Growth and osteogenic differentiation of adipose-derived and bone marrow-derived stem cells on chitosan and chitooligosaccharide films","volume":"78","author":"Ratanavaraporn","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carbpol.2019.04.002","article-title":"Sinapic acid-loaded chitosan nanoparticles in polycaprolactone electrospun fibers for bone regeneration in vitro and in vivo","volume":"216","author":"Balagangadharan","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Vimalraj, S., Govindarajan, D., Sudhakar, S., Suresh, R., Palanivel, P., and Sekaran, S. (2024). Chitosan derived chito-oligosaccharides promote osteoblast differentiation and offer anti-osteoporotic potential: Molecular and morphological evidence from a zebrafish model. Int. J. Biol. Macromol., 259.","DOI":"10.1016\/j.ijbiomac.2024.129250"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Modarresi Chahardehi, A., Arsad, H., and Lim, V. (2020). Zebrafish as a successful animal model for screening toxicity of medicinal plants. Plants, 9.","DOI":"10.3390\/plants9101345"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ddmod.2014.08.001","article-title":"Fish: A suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities","volume":"13","author":"Gavaia","year":"2014","journal-title":"Drug Discov. Today Dis. Models"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Kabir, A., Selvaraj, V., and Sudhakar, S. (2024). Protein Nano Coop Complexes Promote Fracture Healing and Bone Regeneration in a Zebrafish Osteoporosis Model. Biomacromolecules.","DOI":"10.1021\/acs.biomac.4c00931"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-016-1739-6","article-title":"CRISPR\/Cas9 in zebrafish: An efficient combination for human genetic diseases modeling","volume":"136","author":"Liu","year":"2017","journal-title":"Hum. Genet."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.csbj.2019.06.006","article-title":"The progress of CRISPR\/Cas9-mediated gene editing in generating mouse\/zebrafish models of human skeletal diseases","volume":"17","author":"Wu","year":"2019","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/hmg\/ddt579","article-title":"Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling","volume":"23","author":"Kawahara","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/jai.13661","article-title":"An overview on the teleost bone mechanophysiology","volume":"34","author":"Cardeira","year":"2018","journal-title":"J. Appl. Ichthyol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00709-006-0215-x","article-title":"Zebrafish and medaka as models for bone research including implications regarding space-related issues","volume":"229","author":"Renn","year":"2006","journal-title":"Protoplasma"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0925-4773(02)00149-1","article-title":"Some distinctive features of zebrafish myogenesis based on unexpected distributions of the muscle cytoskeletal proteins actin, myosin, desmin, \u03b1-actinin, troponin and titin","volume":"116","author":"Costa","year":"2002","journal-title":"Mech. Dev."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1440-1681.2004.04030.x","article-title":"Identification of a zebrafish model of muscular dystrophy","volume":"31","author":"Bassett","year":"2004","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1126\/science.282.5394.1711","article-title":"Zebrafish hox clusters and vertebrate genome evolution","volume":"282","author":"Amores","year":"1998","journal-title":"Science"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng0498-345","article-title":"Vertebrate genome evolution and the zebrafish gene map","volume":"18","author":"Postlethwait","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbadis.2006.07.003","article-title":"Modeling human muscle disease in zebrafish","volume":"1772","author":"Guyon","year":"2007","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1073\/pnas.1112163109","article-title":"Extensive genetic diversity and substructuring among zebrafish strains revealed through copy number variant analysis","volume":"109","author":"Brown","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1163\/157075608X328017","article-title":"Comparative anatomy, homologies and evolution of mandibular, hyoid and hypobranchial muscles of bony fish and tetrapods: A new insight","volume":"58","author":"Diogo","year":"2008","journal-title":"Anim. Biol."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/1\/28\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:56:59Z","timestamp":1760115419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/14\/1\/28"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":221,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["cells14010028"],"URL":"https:\/\/doi.org\/10.3390\/cells14010028","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]}}}