{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:28:33Z","timestamp":1792124913498,"version":"4.4.0"},"reference-count":80,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Thyroid dysfunction is associated with a number of neuropsychiatric manifestations. Cognitive decline is a common feature of hypothyroidism and clinical or subclinical hyperthyroidism. In addition, there is a significant association between thyroid hormone (TH) levels and the degree of cognitive impairment in Parkinson\u2019s disease (PD). The pathophysiology of TH-related neurodegeneration include changes in the blood\u2013brain barrier, increased cellular stress, altered processing of \u03b2-amyloid precursor protein and the effect of TH on neuronal cell viability. The neurotoxicity of TH is partially mediated by the thyroid hormone responsive protein (THRP). This protein is 83% homologous to mouse c-Abl-interacting protein-2 (Abi2), a c-Abl-modulating protein with tumor suppressor activity. In cell cultures, increasing THRP expression either with TH treatment or exogenously through transfecting neuronal or PC 12 cells causes cell necrosis. The expression of exogenous THRP in other cells such as the colonic epithelial cell line Caco-2 and the glial cell line U251 has no effect on cell viability. The effect of THRP on cell viability is not modulated by c-Abl tyrosine kinase. The causal relationship between specific biochemical perturbations in cerebral tissue and thyroid dysfunction remains to be elucidated.<\/jats:p>","DOI":"10.3390\/cells14020140","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T04:04:12Z","timestamp":1737345852000},"page":"140","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Role of Thyroid Hormone in Neurodegenerative Disorders of Older People"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8177-7668","authenticated-orcid":false,"given":"Arshag D.","family":"Mooradian","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, 653-1 West 8th Street, Jacksonville, FL 32209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Haas","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, 653-1 West 8th Street, Jacksonville, FL 32209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"bvab194","DOI":"10.1210\/jendso\/bvab194","article-title":"Pathophysiology and Clinical Features of Neuropsychiatric Manifestations of Thyroid Disease","volume":"6","author":"Warda","year":"2022","journal-title":"J. Endocr. Soc."},{"key":"ref_2","first-page":"45","article-title":"Thyroid hormones, the brain, and affective disorders","volume":"8","author":"Joffe","year":"1994","journal-title":"Crit. Rev. Neurobiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/j.1365-2826.2008.01774.x","article-title":"The thyroid-brain interaction in thyroid disorders and mood disorders","volume":"20","author":"Bauer","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31975","DOI":"10.1038\/srep31975","article-title":"Higher FT4 or TSH below the normal range are associated with increased risk of dementia: A meta-analysis of 11 studies","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3233\/JAD-150561","article-title":"Thyroid-stimulating hormone and mild cognitive impairment: Results of the Heinz Nixdorf Recall study","volume":"49","author":"Winkler","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1210\/jc.2008-2702","article-title":"Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism","volume":"94","author":"Correia","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1210\/jc.2016-2129","article-title":"Subclinical thyroid dysfunction and the risk of cognitive decline: A meta-analysis of prospective cohort studies","volume":"101","author":"Rieben","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000324522","article-title":"Serum thyroid-stimulating hormone as a predictor of cognitive impairment in an elderly cohort","volume":"58","author":"Forti","year":"2011","journal-title":"Gerontology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1210\/jc.2015-2046","article-title":"Subclinical hypothyroidism and cognitive impairment: Systematic review and meta-analysis","volume":"100","author":"Pasqualetti","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/ageing\/afv160","article-title":"Serum thyroid-stimulating hormone and cognition in older people","volume":"45","author":"Ojala","year":"2016","journal-title":"Age Ageing"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1001\/jama.292.21.2591","article-title":"Thyroid status, disability and cognitive function, and survival in old age","volume":"292","author":"Gussekloo","year":"2004","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1001\/jama.295.9.1033","article-title":"Thyroid status, cardiovascular risk, and mortality in older adults","volume":"295","author":"Cappola","year":"2006","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.archger.2006.02.001","article-title":"Subclinical hypothyroidism increases the risk for depression in the elderly","volume":"44","author":"Chueire","year":"2007","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1089\/thy.2008.0226","article-title":"Mildly elevated TSH and cognition in middle-aged and older adults","volume":"19","author":"Henderson","year":"2009","journal-title":"Thyroid"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1210\/jc.2005-1775","article-title":"Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment","volume":"91","author":"Jorde","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-145-8-200610170-00006","article-title":"Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction?","volume":"145","author":"Roberts","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1210\/jc.2012-2284","article-title":"Clinical review: The thyroid in mind: Cognitive function and low thyrotropin in older people","volume":"97","author":"Gan","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1210\/jc.2013-3385","article-title":"Lower-but-normal serum TSH level is associated with the development or progression of cognitive impairment in elderly: Korean Longitudinal Study on Health and Aging (KLoSHA)","volume":"99","author":"Moon","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_19","first-page":"760","article-title":"Cognitive functions and mood during chronic thyrotropin-suppressive therapy with L-thyroxine in patients with differentiated thyroid carcinoma","volume":"35","author":"Jaracz","year":"2012","journal-title":"J. Endocrinol. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1210\/jc.2013-4454","article-title":"The effect of long-term thyroid-stimulating hormone suppressive therapy on the cognitive function of elderly patients with differentiated thyroid carcinoma","volume":"99","author":"Moon","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1507\/endocrj.EJ15-0458","article-title":"Does low-normal serum TSH level adversely impact cognition in elderly adults and might methimazole therapy improve outcomes?","volume":"63","author":"Fagundes","year":"2016","journal-title":"Endocr. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/cei\/uxac044","article-title":"Genetic correlation between thyroid hormones and Parkinson\u2019s disease","volume":"208","author":"Xu","year":"2022","journal-title":"Clin. Exp. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.parkreldis.2020.04.001","article-title":"Risk of Parkinson\u2019s disease in patients with hypothyroidism: A nationwide population-based cohort study","volume":"74","author":"Chen","year":"2020","journal-title":"Park. Relat. Disord."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Charoenngam, N., Rittiphairoj, T., Ponvilawan, B., and Prasongdee, K. (2022). Thyroid dysfunction and risk of Parkinson\u2019s disease: A systematic review and meta-analysis. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.863281"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40618-020-01314-5","article-title":"Shedding light on thyroid hormone disorders and Parkinson disease pathology: Mechanisms and risk factors","volume":"44","author":"Mohammadi","year":"2021","journal-title":"J. Endocrinol. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Peng, Y., Zhu, L., Bai, Q., Wang, L., and Li, Q. (2024). Associations between thyroid hormones and cognitive impairment in patients with Parkinson\u2019s disease. eNeuro, 11.","DOI":"10.1523\/ENEURO.0239-24.2024"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Serra, M., Pinna, A., Costa, G., Usiello, A., Pasqualetti, M., Avallone, L., Morelli, M., and Napolitano, F. (2021). Involvement of the protein Ras homolog enriched in the striatum, Rhes, in dopaminergic neurons\u2019 degeneration: Link to Parkinson\u2019s disease. Int. J. Mol. Sci., 22.","DOI":"10.20944\/preprints202104.0379.v1"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"13659","DOI":"10.1038\/s41598-019-49876-6","article-title":"Dopamine neuron induction and the neuroprotective effects of thyroid hormone derivatives","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1016\/j.cell.2024.07.041","article-title":"Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration","volume":"187","author":"Hochbaum","year":"2024","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Valc\u00e1rcel-Hern\u00e1ndez, V., Mayerl, S., Guada\u00f1o-Ferraz, A., and Remaud, S. (2024). Thyroid hormone action in adult neurogliogenic niches: The known and unknown. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1347802"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.stem.2017.04.002","article-title":"Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier","volume":"20","author":"Vatine","year":"2017","journal-title":"Cell Stem Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1210\/en.2009-0209","article-title":"A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport","volume":"150","author":"Liao","year":"2009","journal-title":"Endocrinology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1210\/en.2012-1628","article-title":"Tetrac can replace thyroid hormone during brain development in mouse mutants deficient in the thyroid hormone transporter mct8","volume":"154","author":"Horn","year":"2013","journal-title":"Endocrinology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1210\/en.2016-1842","article-title":"A thyroid hormone\u2014Based strategy for correcting the biochemical abnormality in X-linked adrenoleukodystrophy (X-ALD)","volume":"158","author":"Hartley","year":"2017","journal-title":"Endocrinology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0047-6374(90)90120-5","article-title":"Blood-brain transport of triiodothyronine is reduced in aged rats","volume":"52","author":"Mooradian","year":"1990","journal-title":"Mech. Ageing Dev."},{"key":"ref_36","first-page":"156","article-title":"Metabolic fuel and amino acid transport into the brain in experimental hypothyroidism","volume":"122","author":"Mooradian","year":"1990","journal-title":"Acta Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/01.STR.0000181772.78492.07","article-title":"Thyroid diseases and cerebrovascular disease","volume":"36","author":"Squizzato","year":"2005","journal-title":"Stroke"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1210\/jc.2015-1438","article-title":"Subclinical hypothyroidism and the risk of stroke events and fatal stroke: An individual participant data analysis","volume":"100","author":"Chaker","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pharmthera.2018.01.007","article-title":"Thyroid hormone and the brain: Mechanisms of action in development and role in protection and promotion of recovery after brain injury","volume":"186","author":"Liu","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.mce.2017.05.023","article-title":"Thyroid hormone treatment activates protective pathways in both in vivo and in vitro models of neuronal injury","volume":"452","author":"Li","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.phrs.2012.12.009","article-title":"Exogenous T3 administration provides neuroprotection in a murine model of traumatic brain injury","volume":"70","author":"Crupi","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1210\/en.2019-00125","article-title":"Thyroid hormone protects primary cortical neurons exposed to hypoxia by reducing DNA methylation and apoptosis","volume":"160","author":"Li","year":"2019","journal-title":"Endocrinology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"bvac139","DOI":"10.1210\/jendso\/bvac139","article-title":"Thyroid hormone\u2013mediated histone modification protects cortical neurons from the toxic effects of hypoxic injury","volume":"6","author":"Abe","year":"2022","journal-title":"J. Endocr. Soc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jns.2015.04.042","article-title":"Antiedema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation","volume":"354","author":"Sadana","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00221-004-2027-6","article-title":"Thyroid hormone responsive protein (THRP) mediates thyroid hormone-induced cytotoxicity in primary neuronal cultures","volume":"160","author":"Haas","year":"2005","journal-title":"Exp. Brain Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00221-003-1406-8","article-title":"Effect of thyroid hormone responsive protein (THRP) expression on PC12 cell survival","volume":"150","author":"Haas","year":"2003","journal-title":"Exp. Brain Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1042\/bj3270617","article-title":"Cloning and characterization of a complementary DNA for a thyroid hormone-responsive protein in mature rat cerebral tissue","volume":"327","author":"Shah","year":"1997","journal-title":"Biochem. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/abbi.2001.2750","article-title":"Partial characterization of a cerebral thyroid hormone-responsive protein","volume":"399","author":"Haas","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/mcne.2000.0865","article-title":"Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system","volume":"16","author":"Courtney","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"10905","DOI":"10.1128\/MCB.24.24.10905-10922.2004","article-title":"Abi2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory","volume":"24","author":"Grove","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neulet.2010.11.044","article-title":"The thyroid hormone responsive protein (THRP) has a critical role in the embryogenesis of Xenopus laevis","volume":"488","author":"Lim","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1530\/eje.0.1390649","article-title":"Novel translational repressor (NAT-1) expression is modified by thyroid state and age in brain and liver","volume":"139","author":"Shah","year":"1998","journal-title":"Eur. J. Endocrinol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0006-8993(98)00144-9","article-title":"Age-related changes in thyroid hormone responsive protein (THRP) expression in cerebral tissue of rats","volume":"793","author":"Mooradian","year":"1998","journal-title":"Brain Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"100132","DOI":"10.1016\/j.endmts.2023.100132","article-title":"Age-related thyroid hormone resistance: A friend or foe","volume":"11","author":"Mooradian","year":"2023","journal-title":"Endocr. Metab. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1210\/en.2011-1372","article-title":"Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea","volume":"152","author":"Sharlin","year":"2011","journal-title":"Endocrinology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/me.2010-0095","article-title":"Minireview: Thyroid hormone transporters: The knowns and the unknowns","volume":"25","author":"Visser","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s00018-007-7396-0","article-title":"Activation and inactivation of thyroid hormone by deiodinases: Local action with general consequences","volume":"65","author":"Gereben","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1210\/er.2008-0019","article-title":"Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling","volume":"29","author":"Gereben","year":"2008","journal-title":"Endodrc. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.1210\/en.2007-0652","article-title":"Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis","volume":"148","author":"Hernandez","year":"2007","journal-title":"Endocrinology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1210\/en.2010-1396","article-title":"Thyroid hormone regulates the expression of the sonic hedgehog signaling pathway in the embryonic and adult mammalian brain","volume":"152","author":"Desouza","year":"2011","journal-title":"Endocrinology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/S0140-6736(04)17226-7","article-title":"Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation","volume":"364","author":"Friesema","year":"2004","journal-title":"Lancet"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1172\/JCI42113","article-title":"Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion","volume":"120","author":"Liao","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/01.med.0000433069.09294.e8","article-title":"Nonthyroidal illness syndrome","volume":"20","author":"Farwell","year":"2013","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0002-9343(88)90414-7","article-title":"Thyroid test abnormalities in traumatic brain injury: Correlation with neurologic impairment and sympathetic nervous system activation","volume":"84","author":"Woolf","year":"1988","journal-title":"Am. J. Med."},{"key":"ref_65","first-page":"e51781","article-title":"Controlled cortical impact model for traumatic brain injury","volume":"90","author":"Romine","year":"2014","journal-title":"J. Vis. Exp."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1677\/joe.1.06022","article-title":"Thyroid status and nitric oxide in rat arterial vessels","volume":"185","author":"McAllister","year":"2005","journal-title":"J. Endocrinol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1210\/er.2003-0033","article-title":"Thyroid hormone action in the heart","volume":"26","author":"Kahaly","year":"2005","journal-title":"Endocr. Rev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.mcn.2009.09.002","article-title":"Thyroxin regulates BDNF expression to promote survival of injured neurons","volume":"42","author":"Shulga","year":"2009","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF00965565","article-title":"\u03b2-Adrenergic receptor activity of cerebral microvessels is reduced in aged rats","volume":"16","author":"Mooradian","year":"1991","journal-title":"Neurochem. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0304-3940(93)90150-J","article-title":"3,5,3\u2032-l-Triiodothyronine regulation of \u03b2-adrenergic receptor density and adenylyl cyclase activity in synaptosomal membranes of aged rats","volume":"161","author":"Mooradian","year":"1993","journal-title":"Neurosci. Lett."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s11011-021-00760-1","article-title":"Association between thyroid function and Alzheimer\u2019s disease: A systematic review","volume":"36","author":"Figueroa","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"6757154","DOI":"10.1155\/2016\/6757154","article-title":"Thyroid hormones, oxidative stress, and inflammation","volume":"2016","author":"Mancini","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","article-title":"Oxidative stress and the amyloid beta peptide in Alzheimer\u2019s disease","volume":"14","author":"Cheignon","year":"2018","journal-title":"Redox Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1152\/jappl.1994.77.1.160","article-title":"Effect of age on L-3,5,3\u2019-triiodothyronine-induced ethane exhalation","volume":"77","author":"Mooradian","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0006-8993(99)01368-2","article-title":"Malondialdehyde binding of rat cerebral proteins is reduced in experimental hypothyroidism","volume":"829","author":"Chehade","year":"1999","journal-title":"Brain Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0306-4522(01)00461-4","article-title":"Mild traumatic brain injury induces apoptotic cell death in the cortex that is preceded by decreases in cellular Bcl-2 immunoreactivity","volume":"110","author":"Raghupathi","year":"2002","journal-title":"Neuroscience"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10741-008-9125-7","article-title":"Cardiac hypertrophy and thyroid hormone signaling","volume":"15","author":"Dillmann","year":"2010","journal-title":"Heart Fail. Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1210\/endo.139.6.6033","article-title":"Thyroid hormones regulate beta-amyloid gene splicing and protein secretion in neuroblastoma cells","volume":"139","author":"Latasa","year":"1998","journal-title":"Endocrinology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s12020-022-03190-w","article-title":"Thyroid hormone levels in Alzheimer disease: A systematic review and meta-analysis","volume":"79","author":"Dolatshahi","year":"2023","journal-title":"Endocrine"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s43440-022-00377-w","article-title":"Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions","volume":"74","author":"Zawalna","year":"2022","journal-title":"Pharmacol. 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